Searchable abstracts of presentations at key conferences in endocrinology
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21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

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18-21 May 2019, Lyon, France

Poster Presentations

Calcium and Bone 1

ea0063p61 | Calcium and Bone 1 | ECE2019

Vitamin D status and linear growth in a sample of Egyptian adolescents

Aboromia Maram M , Malak Raef , Hindawy Laila , Abdelmonem Heba , Sabry Inas

Vitamin D deficiency is a worldwide health problem. The lack of appreciation of the importance of sensible sun exposure for providing children and adults with their vitamin D requirement has led to a worldwide vitamin D deficiency pandemic,vitamin D deficiency can have a negative influence on bone development, causing not only rickets, but also interfering with attainment of genetically programmed height.Aim of the study: To assess vitamin D status among...

ea0063p62 | Calcium and Bone 1 | ECE2019

The effectiveness of colecalciferol and selective vitamin D receptor agonists treatment on secondary hyperparathyroidism in chronic kidney diseases patients

Egshatyan Lilit , Mokrisheva Natalia , Lutsenko Alexander

Background: Secondary hyperparathyroidism (SHPT) is an early complication of chronic kidney disease (CKD). Maintaining the level of 25(OH)D and parathyroid hormone concentrations in the target range reduce its associated complications (fractures and cardiovascular calcification).Aims: To examine the effectiveness of vitamin D supplementation and selective vitamin D receptor agonists treatment on SHPT in CKD.Materials and methods: P...

ea0063p63 | Calcium and Bone 1 | ECE2019

Osteoporosis in developing-nations: need for centralized-data-collection & treatment-guidance centers to study epidemiology

Pal S , Gupta G , Roy T

Issues: This is non-interventional, Demographic, observational study in asian population. Osteoporosis common in Developing-nations. Not-a-single Center exist designated for diagnosis/treatment. No proper epidemiological, mortality/morbidity data available. In asian population Osteoporosis is diagnosed at advanced stage hence poor-prognosis. Worsened by High incidence of malnourished. Increased awareness/improved diagnosis needed to identify cases.Aim: T...

ea0063p64 | Calcium and Bone 1 | ECE2019

Prevalence and the main risk factors for vitamin D deficiency in pregnant women living in a locality of Algiers

Mezoued Mouna , Meskine Djamila , Belaidoumou Ramezzedine

Introduction: Vitamin D deficiency seems to be common in pregnant women and would be associated with an increased risk of maternal and fetal poor outcomes.Aim of the study: Determine the prevalence and the main risk factors for vitamin D deficiency in pregnant women living in a locality of Algiers.Material and method: It is a cross-sectional prospective and descriptive study. 310 pregnant women of west Algiers were followed during ...

ea0063p65 | Calcium and Bone 1 | ECE2019

Effects of dexamethasone for calcium channels and mucin-related genes regulation on A549 cell line

Jeon Bo-Hui , Tran Dinh Nam , Yoo Yeong-Min , Jeung Eui-Bae

Calcium is important for physiological functioning in many tissues and is essential in mucus secretion. Previously reported, Mucin secretion is regulated predominantly by cytosolic calcium-dependent pathways. Cytosolic of calcium are regulated by calcium channels such as TRPV6, NCX1, and PMCA1. A549 cell line was treated with 10−8 M dexamethasone (DEX) and 10−6 M RU486. Subsequently, the expression of TRPV6, NCX1, and PMCA1 in A549 cell line w...

ea0063p66 | Calcium and Bone 1 | ECE2019

Regulatory effect of dexamethasone on tracheal calcium processing proteins and mucosal secretion

Jeon Bo-Hui , Lee Bonn , Jung Eui-Man , Jeung Eui-Bae

Introduction: Dexamethasone inhibits mucin secretion considering the primary option for treating acute asthma exacerbation. However, the mechanism underlying dexamethasone-induced decreased in mucosecretion is unclear. Recent studies have reported that dexamethasone exerts an inhibitory effect on mucosecretion in the lung by modulating the expression of calcium-processing genes. However, the expression of the calcium-processing genes in trachea are not examined yet. Thus, the ...

ea0063p67 | Calcium and Bone 1 | ECE2019

The effect of steroid hormone on the expression of the calcium-processing proteins in the immature rat brain

Go Seon Myeong , Park Seon Young , Lee Jae-Hwan , Jeung Eui-Bae

The cytosolic calcium concentration is regulated by calcium-processing proteins such as transient receptor potential cation channel subfamily V member 5 (TRPV5), TRPV6, sodium-calcium exchanger 1 (NCX1) and plasma membrane Ca2+ ATPase 1 (PMCA1). Those calcium-processing proteins are important for physiological functions in the brain. The effects of steroid hormones on calcium-processing protein expressions in the brains are undescribed. Thus, the effects of steroid ...

ea0063p68 | Calcium and Bone 1 | ECE2019

Distribution of and steroid hormone effects on calbindin-D9k in the immature rat brain

Park Seon Mi , Park Seon Young , Tran Dinh Nam , Jeung Eui-Bae

Calbindin-D9k (CaBP-9k), one of the major calcium-binding and calcium-buffering proteins, is important in the physiological functioning of organs. The neuroanatomical localization of CaBP-9k in the rodent brain has not been reported; thus, this study investigated the neuroanatomical distribution of CaBP-9k and the regulation of CaBP-9k expression on steroid hormones in the immature rat brain. To confirm the influence of steroid hormones on CaBP-9k expression, immatu...

ea0063p69 | Calcium and Bone 1 | ECE2019

Pledoary for using Trabecular Bone Score as a method for osteoporosis diagnosis, not only for the risk

Sarbu Adrian , Motoiu Serban , Carsote Mara , Ilie Cosmina , Tocilescu Mihaela , Cristina Staicu Dana , Peretianu Dan , Oprisan Bogdan

Introduction: Trabecular bone score (TBS) was introduced in FRAX, to evaluate more precisely the risk for fracture. However, FRAX is a method for editing a risk, not for making a diagnosis. WHO established conventionally, based on the level of standard deviation (SD), named T score, for Bone Mineral Density (BMD) that <−2,5 SD is compatible with the diagnosis of osteoporosis.Aim: Our aim was to analyze if it is possible to used T score (SD) for...

ea0063p70 | Calcium and Bone 1 | ECE2019

Relationship between leptin level, body mass index and parathyroid hormone in chronic hemodialysis patients

Risovic Ivona , Pejicic Snjezana Popovic , Vlatkovic Vlastimir , Malesevic Gabrijela

Bone metabolism disorders in hemodialysed patients (HD) involve several humoral factors, of which PTH plays the central role. Leptin is a protein hormon secreted by the adipocytes and related to malnutrition, anemia and bone metabolism disorders in chronic kidney disease patients. The aim of the study was to was to evaluate serum leptin levels and bone metabolism in chronic HD patients depending on body mass index (BMI). This cross section study included 93 HD patients distrib...

ea0063p71 | Calcium and Bone 1 | ECE2019

Challenging clinical case of primary hyperparathyroidism caused by atypical adenoma

Elfekih Hamza , Sayadi Hanene , El Hak Abid Dhia , Kechida Malak , Sallem Om Kalthoum , Marmouche Hela , Klii Rim , Khochtali Ines

Introduction: Primary hyperparathyroidism (PHPT) is a frequent endocrinopathy caused mostly by parathyroid adenoma. Classic manifestations, less prevalent nowadays, may have a misleading aspect. Here we describe the case of a patient presenting nephrolithiasis, multiple brown tumors revealing PHPT.Observation: A 37-years-old female was diagnosed with nephrolithiasis treated by shockwave lithotripsy without success. CT scan showed coralliform lithiasis in...

ea0063p72 | Calcium and Bone 1 | ECE2019

Severe hypocalcemia: when the skin expresses itself

Askaoui Sara , Lmghari Guizlane , Rafi Sana , Ansari Nawal El

Introduction: Impetigo herpetiformis is a rare dermatological disorder, mimicking generalized pustular psoriasis. It is characterized by a generalized erythema-pustular eruption accompanied by fever. Its etiopathogenesis is poorly coded but triggers have been identified such as hypocalcemia in more than half of cases and pregnancy. We report a case of severe hypocalcemia secondary to hypoparathyroidism revealed by impetigo herpetiformis.Case report: Fort...

ea0063p73 | Calcium and Bone 1 | ECE2019

Ultrasound detection of parathyroid hyperplasia in patients with chronic kidney disease treated by dialysis

Tosheva Gergana , Siderova Mira , Hristozov Kiril

Aim: The aim of this prospective study is to assess if there is any correlation between parathyroid hyperplasia detected by ultrasound and variables connected with secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD) stage 5, treated by dialysis and to determine the PTH level, above which the hyperplasia of parathyroid glands could be visualized.Methods: Thirty-one patients (14 men and 17 women) with CKD stage 5, treated by ...

ea0063p74 | Calcium and Bone 1 | ECE2019

Multiple fragility fractures in young female patients caused by FGF23-induced hypophoshatemic osteomalacia

Grebennikova Tatiana , Slashchuk Konstantin , Tarbaeva Natalia , Rozhinskaya Liudmila , Rodionova Svetlana , Melnichenko Galina , Rumjantsev Pavel , Belaya Zhanna

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of abnormal phosphate metabolism caused by a small mesenchymal tumor that secrete fibroblast growth factor 23 (FGF23). A 29-year-old female has suffered from two low-traumatic hip fractures, multiple fractures at the pelvic and sacrum, and diffuse bone pain for more than 3 years. Her mobility was limited in the last year (used crutches) because she had severe muscle weakness. Laboratory examination at the time ...

ea0063p75 | Calcium and Bone 1 | ECE2019

Clinical significance of parathyroid incidentalomas during thyroidectomy: a South Indian experience

Panchangam Ramakanth Bhargav , B Chakrapani , M Sabaretnam

Background: Often parathyroid indicentalomas (PI) in the form macroscopically enlarged single or multiple parathyroid glands are encountered during surgical thyroidectomy. The reported incidence in literature is variable (0.4–4.5%), but we feel its underreported compared to its frequency, as only less than 500 cases were reported thus far. Another enigma about PI is their clinical significance and natural history. In this context, we analysed our own experience and tried ...

ea0063p76 | Calcium and Bone 1 | ECE2019

Value of ultrasonography guided fine-needle-aspiration in the diagnosis of an intrathyroidal parathyroid adenoma associated with thyroid pathology

Larumbe Maria Concepcion Terroba , Soto Cristina Crespo , Mures Jose Maria Palacio , Garcia Manuel Acuna , Gonzalez Marcelino Mendo , Vina Marta Ventosa , Goyogana Itciar Anacabe , Baranda Mar Calleja , Sanudo Elisa Gil-Carcedo , Olmedo Luis Cuellar

Introduction: Intrathyroidal parathyroid adenomas (IPA) are a rare cause of primary hyperparathyroidism (PHP) and their differential diagnosis includes other parathyroid and thyroid lesions. Although <7% of parathyroid adenomas are intrathyroidal, this location represents almost 20% of ectopic cases and their preoperative identification can pose difficulties, often being an intraoperative finding.Clinical case: A 70-year-old woman diagnosed with brea...

ea0063p77 | Calcium and Bone 1 | ECE2019

The effect of parathyroidectomy on the BMD in postmenopausal women with mild primary hyperparathyroidism: the results of comparative retrospective dynamic study

Brutskaya-Stempkovskaya Elena , Shepelkevich Alla , Leonova Tatiana , Rekechinskaya Natalia , Pisarenko Artur , Vasilieva Natalia

Objective: To study the effect of parathyroidectomy (PTE) on the BMD in postmenopausal women with primary hyperparathyroidism (PHPT).Materials and methods: We studied 38 postmenopausal women with mild PHPT without osteoporosis (T-score ≥ −2,5 by DXA). In 20 patients was performed PTE, the comparison group:18 postmenopausal patients with PHPT. The duration of observation was 1 year. Examination: total calcium, Ca++, phosphorus, PTH,...

ea0063p78 | Calcium and Bone 1 | ECE2019

Obstructive urolithiasis as first sign of primary hyperparathyroidism caused by a large parathyroid hyperplasia

Nemes Codruta Ioana , Muntean Valentin , Dragomir Laura , Feciche Bogdan , Ghervan Cristina

Introduction: Primary hyperparathyroidism (PHPT) is a well-known risk factor for urolithiasis and nephrocalcinosis, wich are now less commonly reported due to an early detection of hypercalcemia by routine measurement of serum calcium. PHPT is most commonly caused by a single adenoma of the parathyroid gland. The incidence of multiglandular disease (MGD) range from 2.4–34%. In case of large tumor differential diagnosis is necessary to rule out malignancy.<p class="abs...

ea0063p79 | Calcium and Bone 1 | ECE2019

Parathyroid adenoma in pregnancy: a case report

Dokmetas Hatice Sebile , Kilicli Fatih , Dokmetas Meric , Ozdenkaya Yasar , Karaipek Kubra , Erol Bugra

Although primary hyperparathyroidism (PHPT) is seen in young women at 8/million ratio, it is more rare to be seen with pregnancy. If diagnosed and not treated during pregnancy, the mother may have nephrolithiasis, hypercalcemic crisis, hypertension, preeclampsia, pancreatitis, death and intrauterine growth retardation in the fetus, low birth weight, preterm delivery, intrauterine death or postpartum tetany. Forty-year-old woman at the 14th week of gestation was diagnosed with ...

ea0063p80 | Calcium and Bone 1 | ECE2019

Effects of bariatric surgery on bone health

Exposito Maria Rosa Alhambra , Martin Ana Barrera , Jimenez Concepcion Munoz , Puerta Maria Jose Molina , Moreno Maria Angeles Galvez

Introduction: Bariatric surgery has important metabolic complications such as bone mass loss.Goal: To assess bone mineral density (BMD) after Roux-en-Y gastric by-pass (RYGB) in patients under standard calcium and vitamin D supplementation.Method: In patients with morbid obesity submitted to RYGB, we measured BMD with a dual X-ray densitometer. Using World Health Organization (WHO) criteria’s, values were compared with young c...

ea0063p81 | Calcium and Bone 1 | ECE2019

A rare case of hypoparathyroidism due to MELAS syndrome

Grebennikova Tatiana , Zenkova Tatjana , Tarbaeva Natalia , Sorkina Ekaterina , Belaya Zhanna

MELAS syndrome is a progressive neurodegenerative disorder characterized by a combination of mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes and endocrine disorders. The frequency of hypoparathyroidism in MELAS syndrome is less than 0.5%. A 22-year-old female was admitted to our center due to episodes of seizures. At admission her height was 147.5 cm, weight 30.5 kg, BMI 13.8 kg/m2. She reported whole life weight and growth retardation, hearin...

ea0063p82 | Calcium and Bone 1 | ECE2019

A case report of tumor-induced osteomalacia

Zhukov Artem , Pigarova Ekaterina , Petrushkina Alexandra , Rozhinskaya Liudmila , Beltsevich Dmitry , Slashuk Konstantin , Rumyantsev Pavel , Kogan Evgeniya , Osmanov Yusif , Melnichenko Galina

Objective: Tumor-induced osteomalacia is a rare paraneoplastic syndrome in which fibroblast growth factor 23 (FGF-23) hyperproduction by tumor causes renal phosphate wasting, severe hypophosphatemia and osteomalacia. Localization of the tumor can be a major diagnostic challenge.Material and methods: We present a clinical case concerning a 62-year old woman previously diagnosed with hypophosphatemic osteomalacia, with a slight improvement of clinical and ...

ea0063p83 | Calcium and Bone 1 | ECE2019

Pregnancy-related osteoporosis: a series of cases

Petrushkina Alexandra , Pigarova Ekaterina , Dzeranova Larisa , Rozhinskaya Liudmila

Objective: Pregnancy-related osteoporosis is a rare disorder with potentially severe complications. There is lack of clinical practice guidelines due to low incidence of this disease and few published cases.Material and methods: We present eight cases of pregnancy-related osteoporosis in women aged between 28–42 years. Six of them were diagnosed between 1 month and 3 years postpartum and two were diagnosed in the third trimester of pregnancy. Most o...

ea0063p84 | Calcium and Bone 1 | ECE2019

Bone mineral density, prevalence of fractures, antiosteoporotic drugs effectiveness and Ca/Vit D supplementations intake in elder patients with osteoporosis: a cross-sectional study on Moscow population

Machekhina Lubov , Onuchina Yulia , Dudinskaya Ekaterina , Brailova Natalia , Eruslanova Ksenia , Tkacheva Olga

Aim of the study: To investigate osteoporosis features in elder patients in Moscow population.Materials and Methods: It was a retrospective study, during which we analyzed the data of 192 outpatients (183 women and 9 men) admitted to Gerontology Research and Clinical Centre in 2018. In the focus of our attention was patients’ past medical history, such as any antiosteoporotic treatment received, vitamin D and Ca supplementations, any fractures in pr...

ea0063p85 | Calcium and Bone 1 | ECE2019

Brown tumor of the palate as first manifestation of a primary hyperparathyroidism

Novac Elena Roxana

Brown tumors represent a late-stage bone change caused by primary hyperparathyroidism, presenting in only 2–3 percent of the cases. Therefore as primary manifestations there is even a smaller percent. The common sites of brown tumor are the long bones, ribs, clavicle or pelvic girdle. The solitary palate brown tumor as initial presentation of a primary hyperparathyroidism is rare and often accompanied by tumors of other facial bones. We present the case of a 67 year old w...

ea0063p86 | Calcium and Bone 1 | ECE2019

Difference in trabecular bone score according to spine-femur bone mineral density discordances in healthy postmenopausal women

Kim Keunyoung , Pak Kyoungjune , Kim Bo Hyun , Kim Mijin , Jeon Yun Kyung , Kim In-Joo , Kim Sang Soo , Goh Tae Sik

Purpose: The purpose of this study was to evaluate the prevalence and characteristics of individuals with spine–femur bone mineral density (BMD) discordance and to examine whether trabecular bone score (TBS) is associated with major and minor BMD discordance in postmenopausal women.Methods: This retrospective study included 533 healthy postmenopausal women (median age, 60 years; range, 55–82 years) who visited our hospital for a health check-up...

ea0063p87 | Calcium and Bone 1 | ECE2019

Heterogenous clinical presentation of primary hyperparathyroidism in Romania

Grigorie Daniel , Sucaliuc Alina

Introduction: In the last decades, primary hyperparathyroidism (PHPT) has changed in its clinical presentation, being mostly asymptomatic in western countries; in Romania is still common to see various clinical presentations.Objective: To characterize a retrospective cohort of PHPT Romanian patients.Patients and methods: 271 patients were included: 88% women, ratio F/M 7.5/1, mean age 60.6±12 yrs (15–83), mean BMI 26.3&#1...

ea0063p88 | Calcium and Bone 1 | ECE2019

A case of primary hyperparathyroidism due to a giant parathyroid adenoma extending into the mediastinum

Ghammem Monia , Houas Jihene , Bellakhdhar Mouna , Meherzi Abir , Kermani Wassim , Abdelkafi Mohamed

Introduction: Primary hyperparathyroidism is a common disease. It is generally caused by a solitary parathyroid adenoma. Adenomas weighing more than 3.5 g are classified as giant. These giant parathyroid adenomas constitute a rare clinical entity.Case report: A 54-year-old woman was referred to our ENT department for management of newly diagnosed hypercalcaemia. She had no significant medical history. She reported mild constipation, muscular weakness, na...

ea0063p89 | Calcium and Bone 1 | ECE2019

Diagnostic and treatment delay in primary hyperparathyroidism (phpt): a pending issue

Paja Miguel , Martinez Adela L , Monzon Andoni , Arrizabalaga Cristina , Zabalegui Alba , Iglesias Natalia C , Calles Laura A , Etxeberria Eider M , Gutierrez Teresa

Background: PHPT is the leading cause of hypercalcemia in outpatients. Its clinical presentation varies from asymptomatic forms to renal or bone complications. The only curative treatment is surgical resection, and delayed diagnosis can lead to serious morbidity.Objective: Identify the presence of PHPT at least one year prior to referral to endocrinology consultation. Secondly, determine whether diagnostic delay leads to increased complications.<p cl...

ea0063p90 | Calcium and Bone 1 | ECE2019

Epidemiology of hypoparathyroidism in Korea

Jee Eun Hyun , Lee Joon-Hyop , Park So Young , Ahn Song Vogue , Lee Sihoon

Background: The National Health Insurance Service of South Korea is considered to be one of the most effective systems in the world with high accessibility to health care for all Koreans including foreign residents in the country as many as 50 M people. The accumulative information on the behaviors and the statistics of healthcare use based on the National Health Insurance Sharing Service Database has become important for medical research as a nationwide surveillance.<p cl...

ea0063p91 | Calcium and Bone 1 | ECE2019

Effectiveness of intramuscular Ergocalciferol treatment in a patient with o steomalaciadueto severe vitamin D deficiencyafterbariatric surgery

Papanastasiou Labrini , Gravvanis Christos , Tournis Symeon , Markou Athina , Kalantzi Athanasia , Zoulias Manolis , Georgakopoulou Georgia , Pagoni Stamatina , Kounadi Theodora

Bariatric surgery is a common treatment for morbidly obese patients requiring weight loss and/or metabolic control. Vitamin D (VitD) deficiency and bone loss may occur post-operatively and supplementation with high oral doses of Vitamin D is required. Alternatively, intramuscular depot ergocalciferol (vitamin D2) which slowly releases VitD and overcomes the gastrointestinal tract, could be administrated in such patients.Aim: To present a case of severe V...

ea0063p92 | Calcium and Bone 1 | ECE2019

A rare case of hypercalcemia associated with dysgerminoma with elevation of 1,25(OH)2 Vitamin D

Hara Natsuko , Abe Hironori , Suwanai Hirotsugu , Ishikawa Takuya , Yakou Fumiyoshi , Shikuma Jumpei , Sakai Hiroyuki , Suzuki Ryo , Miwa Takashi , Odawara Masato

We hereby report a rare case of hypercalcemia-associated with dysgerminoma with elevation of 1,25(OH)2 Vitamin D. A 27-year-old nulliparous woman presented with hypercalcemia during examination of a right ovarian tumour. As the serum calcium level increased gradually, she started complaining of nausea and anorexia. The laboratory data at first-visit showed that serum calcium, LDH, ALP, 1,25(OH)2 Vitamin D and fractional excretion of calcium were elevated and intact PTH was sup...

ea0063p93 | Calcium and Bone 1 | ECE2019

Analysis of non-invasive DXA-derived bone structure parameters in patients with acromegaly with regards to vitamin D levels

Kužma Martin , Vaňuga Peter , Sagova Ivana , Pavai Dušan , Jackuliak Peter , Killinger Zdenko , Binkley Neil , Winzenrieth Renaud , Genant Harry , Payer Juraj

Introduction: Patients suffering from acromegaly, despite normal or even higher bone mineral density (BMD), have prevalent vertebral fractures (VFs). Impaired bone microarchitecture is involved fragility fracture development, but vitamin D status could be involved in this impairment.Aim of the study: Comparison of bone parameters such as BMD, trabecular bone score (TBS) and 3D-SHAPER parameters in acromegaly patients according to level of 25(OH)D3.<p...

ea0063p94 | Calcium and Bone 1 | ECE2019

Osteitis Fibrosa Cystica – A Forgotten Clinical And Radiological Feature Of Primary Hyperparathyroidism

Katharina Flugel Anna , Mondorf Antonia , Bojunga Jorg

Introduction: Manifestations of primary hyperparathyroidism (PHPT) such as osteoporosis and stone diseases are common primary diagnostic findings beyond a hypercalcemia. Classical skeletal involvement can be the first sign of PHPT, but not recognized because osteitis fibrosa cystica (bone cysts, brown tumors of the long bones) is rarely seen today in Western Europe.Case report: A 34-year old women from Afghanistan was presented to our out-patient-clinic ...

ea0063p95 | Calcium and Bone 1 | ECE2019

Clinical use of Cinacalcet in patients with complex primary hyperparathyroidism

Soong Elaine , Tauni Rahat

Background: Primary hyperparathyroidism is one of the most common disorders encountered in endocrine clinics and primarily affects women. The current recommendation for patients with primary hyperparathyroidism is to undergo parathyroidectomy which has a 97% success rate. However, there is a small group of patients where surgery is contraindicated, or patients who have a disease pattern not amenable to surgery or patients who refuse surgery. These patients would require an alt...

ea0063p96 | Calcium and Bone 1 | ECE2019

A rare case of Graves’ disease in a patient with type 1B pseudohypoparathyroidism and associated TSH resistance

Moron-Diaz Marta , Maria Garcia-Cruz Loida , Boronat Mauro

Introduction: Pseudohypoparathyroidism (PHP) is a heterogeneous group of endocrine disorders characterized by target-organ resistance to the action of PTH, manifesting with hypocalcemia, hyperphosphatemia, and increased serum concentrations of PTH. PTH receptor couples with the stimulatory G protein (Gsα), leading to cAMP formation. Most cases of PHP are caused by heterozygous inactivating mutations in the GNAS gene, encoding Gs〈 (PHP type 1A) or methylatio...

ea0063p97 | Calcium and Bone 1 | ECE2019

Primary hyperparathyroidism: clinical manifistation in Russian population

Yanevskaya Liubov , Bakhtiyarova Aluza , Ivanova Ekaterina , Pogosyan Karina , Andreeva Alena , Boriskova Marina , Farafonova Uliana , Sleptsov Ilya , Karonova Tatiana , Grineva Elena

Hypothesis: The clinical presentation of primary hyperparathyroidism (PHPT) changed lately but we don’t know if more patients in our population have asymptomatic form of PHPT.Materials and methods: Medical records of 449 patients with PHPT who were operated in three Medical Centers (Saint-Petersburg, Russia) between Jan 2011– Jun 2018 were screened. We analyzed anthropometric data, laboratory tests (PTH, 25(OH)D, Ca, iCa, P, 24-h calciuria, ALP...

ea0063p98 | Calcium and Bone 1 | ECE2019

The effect of vitamin D supplementation on sarcopenia indices: a systematic review and meta-analysis of randomized controlled trials

Gkekas Nifon K , Anagnostis Panagiotis , Siolos Pavlos , Kenanidis Eustathios , Potoupnis Michael , Tsiridis Eleftherios , Goulis Dimitrios G

Objective: To systematically review and meta-analyze the best available evidence regarding the effect of vitamin D supplementation, either as monotherapy or in combination with protein and exercise, on sarcopenia indices (muscle strength, muscle mass, muscle performance).Materials and methods: A comprehensive search was conducted in Medline, Cochrane Central, and Scopus databases, up to December 31st, 2018. Data were expressed as standardized ...

ea0063p99 | Calcium and Bone 1 | ECE2019

The factors affecting balance function in patients with osteoporotic vertebral fractures

Marchenkova Larisa , Makarova Ekaterina , Eryomushkin Mikhail , Shakurova Lilia

Aim: The aim of the study was to estimate the main factors influence on static and dynamic balance function in osteoporotic patient with vertebral fractures (VF).Methods: 90 patients aged 43-80 with primary osteoporosis were enrolled. Study group comprised of 56 women and 4 men (age 65.4±7.1 years, BMI 26.7±4.4 kg/m2) with at least 1 VF confirmed by X-rays. Control group included 28 women and 2 men (age 62.0±5.2 years, BMI 28.7&...

ea0063p100 | Calcium and Bone 1 | ECE2019

Evaluation of trabecular bone score in men with type 1 diabetes

Karytska Nadzeya , Dydyshka Yuliya , Shepelkevich Alla , Vasilyeva Natallia , Vadzianava Volha , Zhukouskaya Volha

Background and aims: According to modern researchers, in patients with type 1 diabetes (T1D), the presence of diabetic osteopathy and an increasing fracture risk is evident. However, the determination of bone mineral density only is not enough to adequately assess the quality of the bone. Thus, the aim of the study was to study of the lumbar spine trabecular bone score as qualitative bone characteristic in T1DM men.Materials and methods: 52 males with T1...

ea0063p101 | Calcium and Bone 1 | ECE2019

Association between body mass index and the risk of falls: a nationwide population-based study

Hwa Kim Se , Kyung Kim Soo , Mee Kim Yoo , Jun Won Young

Background: This study examined the associations between body mass index (BMI) and falls in Korean adults using data from a large population-based survey.Methods: We analyzed 113,353 men and women (aged ≥50 years) who participated in Korean Community Health Survey in 2013. The BMI groups were classified as underweight (<18.5), normal weight (18.5≤ BMI< 24.9), overweight (25≤ BMI< 29.9), and obese (≥30). Logistic regres...

ea0063p102 | Calcium and Bone 1 | ECE2019

Various clinical features of Digeorge syndrome

Mokrysheva Natalia , Mirnaya Svetlana , Eremkina Anna , Dobreva Ekaterina , Bibik Ekaterina

Background: DiGeorge syndrome (DGS) is the rare genetic disorder caused by a 22q11.2 chromosome microdeletion. The main clinical features are associated with defective development of the pharyngeal pouch system and usually include congenital heart disease, hypoplasia of thymus resulting in immune deficiency and hypoparathyroidism. Also DGS patient has characteristic long face with narrow palpebral fissures, broad nasal bridge, micrognathia and small mouth, small dysmorphic ear...

ea0063p103 | Calcium and Bone 1 | ECE2019

About a case of familial hypocalciuric hypercalcemia (FHH) type 3 with neurological involvement

Hoth Guechot Helene , Kohler Florence , Humbert Linda , Kwapich Maxime , Francoise Odou Marie , Christine Vantyghem Marie

Background: FHH is a genetically heterogeneous condition mimicking primary hyperparathyroidism at the difference of low urine calcium excretion. FHH types 1, 2, and 3 are due to loss-of-function mutations of the CASR, GNA11, or AP2S1 genes, respectively. FFH 3, the rarest of the 3, is usually associated to 3 recurrent mutations affecting the arginine residue in position 15. The clinical phenotype has not been well described. We report a new case striking by the neurological in...

ea0063p104 | Calcium and Bone 1 | ECE2019

Verified data on parathyroid hyperplasia incidence not related to primary hyperparathyroidism in persons exposed to ionizing radiation

Kaminskyi Oleksii , Kopilova Olga , Afanasyev Dmitrii , Loganovskyi Konstantin , Talko Viktoria , Muravyova Irina , Chikalova Irina , Tepla Olena , Kiselova Iryna

During the Chernobyl nuclear power plant accident (ChNPPA) a mixture of radioactive isotopes, mainly the iodine and cesium, were released, which through inhalation and food, and in some cases along with external exposure had affected the hormone-producing cells of endocrine system. Within days and months after the accident, the thyroid and parathyroids accumulated a significant amount of these isotopes with thyroid gland becoming a secondary emitter, which further increased th...

ea0063p105 | Calcium and Bone 1 | ECE2019

Parathyroid carcinoma: identity with diagnostic difficulties and therapeutic strategies

Maria Diaz Perdigones Cristina , Maria Gomez Perez Ana , Maria Cornejo Pareja Isabel , Munoz Garach Araceli , Damas Fuentes Miguel , Molina Vega Maria , Maraver Selfa Silvia

Blackground: Parathyroid carcinoma is a malignant neoplasm affecting 0.5 to 5.0% of all patients suffering from primary hyperparathyroidism. This cancer continues to cause challenges for diagnosis and treatment because of its rarity, overlapping features with benign parathyroid disease.Case report: 50 years-old-woman, without relevant previous history. She begins to present asthenia, weakness of lower limbs, arthralgias, cramps and appearance of a painfu...

ea0063p106 | Calcium and Bone 1 | ECE2019

Case Report of a large family with hyperparathyroidism- jaw tumor syndrome (HPT-JT) and a deletion of the third exon of CDC73

Le Collen Lauriane , Barraud Sara , Francoise Odou Marie , Spodenkiewicz Marta , Braconnier Antoine , Zalzali Mohamad , Poirsier Celine , Delemer Brigitte

Heterozygote mutations of the gene CDC73 are responsible for 3 types of parathyroid diseases: familial hyperparathyroidism, parathyroid carcinoma, hyperparathyroidism-jaw tumor syndrome (and uterine or kidney lesions). The goal of our study was to describe the phenotype associated with the deletion of the 3rd exon of CDC73 found in a large family.Patients: We have medical records for 25 patients of a large family composed of 44 individu...

ea0063p107 | Calcium and Bone 1 | ECE2019

Pseudohypoparathyroidism- a tale of hypo- and hypercalcemia with a genetic solution

Chava Rosenblum Rachel , Einbinder Yael , Twito Orit , Mantovani Giovanna , Marta Elli Francesca , Rotman-Pikielny Pnina

Introduction: Pseudohypoparathyroidism (PHP) is a rare genetic disease characterized by renal resistance to parathyroid hormone (PTH), presenting with hypocalcemia, hyperphosphatemia and elevated PTH levels. We describe a PHP patient who presented with clinically significant hypercalcemia.Case description: A 46-year-old woman with a prior history of hypocalcemia presented to the emergency department with new-onset hypercalcemia, renal failure and anemia....

ea0063p108 | Calcium and Bone 1 | ECE2019

Generalized skeletal hyperostosis mimicking acromegaly

Pandzic Jaksic Vlatka , Aljinovic Ratkovic Naranda , Kusec Rajko , Jaksic Ozren , Korsic Mirko

A female patient presented at the age of 30 years with an incidental radiological finding of hyperostosis after a traumatic knee ligament injury. Her large facial contours with wide hands and fingers reminded acromegalic features but without typical soft tissue changes. Hormone evaluation discovered an elevated IGF-1, growth hormone (GH) was non-suppressed on glucose load, but pituitary MRI was normal. The imaging revealed remarkable cortical thickening of long bones with prom...

ea0063p109 | Calcium and Bone 1 | ECE2019

Evaluation of bone quality in acromegaly and thyrotoxicosis using trabecular bone score

Sorohan Madalina , Dusceac Roxana , Sorohan Bogdan , Poiana Catalina

Trabecular bone score (TBS) evaluates bone microarchitecture by measuring the grey-level variations from lumbar spine dual-energy X-ray absorbtiometry (DXA) images. Bone mineral density (BMD) in various endocrinopathies might not be sufficient in assessing bone fragility, especially in patients with acromegaly (ACM) but also in thyrotoxicosis. The aim of our study was to evaluate bone quality and quantity by BMD and TBS in patients with acromegaly and thyrotoxicosis.<p cla...

ea0063p110 | Calcium and Bone 1 | ECE2019

Primary hyperparathyroidism and vitamin D

Draoui Najat , Assarrar Imane , Rouf Siham , Latrech Hanane

Introduction: Several studies suggest an association between primary hyperparathyroidism (HPTP) and vitamin D deficiency. Our goal is to study the clinical and biological consequences of vitamin D deficiency in patients with primary hyperparathyroidism, and to determine the impact of Vitamin D deficiency on bone, kidney and heart functions.Materials and methods: It is a retrospective study of 17 cases with HPTP associated with a vitamin D deficiency. We ...

ea0063p111 | Calcium and Bone 1 | ECE2019

The coincidence of primary hyperparathyroidism and primary hyperaldosteronism is not infrequent: a retrospective case analysis

Barrio Elvira , Ramos Elvira , Crespo Irene , Pallares Raquel , Pazos Mario , de Miguel Paz , Cuesta Martin , Jose Torrejon Maria , Calle Alfonso , Runkle Isabelle

Introduction: Primary hyperparathyroidism (PHP) has been postulated to be a cause of primary hyperaldosteronism (PHA). In fact, PTH receptors have been detected in aldosteronoma tissue. Hyperaldosteronism can also induce elevation of PTH levels, as increased circulating volume increases calciuria, with secondary elevation of PTH levels as serum calcium levels rise. We studied the prevalence of PHP in a group of patients diagnosed with PHA either following or simultaneously wit...

ea0063p112 | Calcium and Bone 1 | ECE2019

Bilateral hip fractures and osteoporosis in a 40-year old man – identification of a novel TMEM38B mutation causing osteogenesis imperfecta

Cederberg-Tamminen Henna , Bensch Frank V , Pekkarinen Tuula , Kroger Heikki , Schalin-Jantti Camilla

Context: It is mandatory to rule out secondary causes of osteoporosis in young adult males presenting with osteoporotic fractures. If no such causes are identified, it is important to remember that an underlying genetic defect might explain the phenotype. This has implications for treatment, follow-up, as well as screening of family members.Case: A 40-year old male (172 cm, 78 kg) with a past medical history of asthma and pollen allergies, initially pres...

ea0063p113 | Calcium and Bone 1 | ECE2019

Hypomagnesemia induced disturbance of consciousness in alcoholic cirrhosis

Muzurovic Emir , Boskovic Olivera

Introduction: Serum calcium (Ca) is a major regulator of PTH secretion, but serum magnesium (Mg)also can modulate PTH secretion. Intracellular Mg depletion impairs the ability of the parathyroid to secrete PTH,which subsequently cause fall in the serum Ca concentration.Case report: A 67 year old male patient was admitted to intensive care unit because of disturbance of consciousness, due to suspected hepatic encephalopathy. In his previous history, he ha...

ea0063p114 | Calcium and Bone 1 | ECE2019

Is any body composition parameter a risk factor for symptomatic hypocalcemia after thyroidectomy?

Celik Suleyman Utku , Akkan Tolga , Konca Can , Genc Volkan

Objective: Postoperative hypocalcemia is one of the major concerns following total thyroidectomy as well as the most frequent cause of prolonged hospital stay. The first purpose of this study was to evaluate the relationship between body composition parameters and symptomatic hypocalcemia following total thyroidectomy. In addition, the effects of disease- and patient-related factors on hypocalcemia were investigated.Methods: In this cohort study, a total...

ea0063p115 | Calcium and Bone 1 | ECE2019

Severe diffuse tissue calcifications in a patient with pseudohypoparathyroidism type 1 A due to a novel large deletion of GNAS gene

Brancatella Alessandro , Mantovani Giovanna , Marcocci Claudio , Cetani Filomena

Pseudohypoparathyroidism type 1 A (PHP-1A) is a rare genetic disorder characterized by hypocalcemia, hyperphosfatemia, multi hormones resistance (PTH, TSH, Calcitonin, GH) associated with Albright hereditary osteodystrophy (AHO) features. The disease is caused by GNAS haploinsufficiency due to inherited inactivating mutation of GNAS-gene that codes for the stimulatory alfa subunit of G protein. A positive genotype-phenotype correlation was recently hypothesized. The purpose of...

ea0063p116 | Calcium and Bone 1 | ECE2019

Successful removal of parathyroid cancer metastasis from VI thoracic vertebra

Mokrysheva Natalia , Krupinova Julia , Gorbacheva Anna , Teplyakov Valeriy , Rumyantsev Pavel

Background: Approximately 25% of patients with parathyroid carcinoma (PC) have metastases; the most frequent sites include cervical lymph nodes (30%) and lungs (40%). Less common are liver, bones and brain. Surgical resection of local or distant metastases (if possible) provides the best control of hypercalcemia and enhances long-term survival.Case description: A 70-year old patient was admitted to hospital with a primary hyperparathyroidism (PH). He did...

ea0063p117 | Calcium and Bone 1 | ECE2019

Primary Hyperparathyroidism: about 34 observations

Zargni Asma , Zouaoui Chadia , Arbi Kawthar El , Jaidane Amel , Ouertani Haroun

Introduction: Primary hyperparathyroidism (PHP) is the result of excessive, independent, and inappropriate production of parathyroid hormone (PTH). The aim of this work is to study the epidemiological, clinico-biological and therapeutic aspects of PHP.Materials and methods: This is a retrospective study of 34 patients hospitalized for the management of PHP in the Endocrinology Department of the Military Hospital of Tunis between March 1999 and July 2018....

ea0063p118 | Calcium and Bone 1 | ECE2019

The clinical spectrum and endocrine profile of pseudohypoparathyroidism: ACTH resistance should not be ignored

Magdalini Kyritsi Eleni , Kanaka-Gantenbein Christina

Backround: Pseudohypoparathyroidism (PHP) type 1A is a rare disorder characterized by end-organ resistance to the action of parathyroid hormone (PTH), resistance to other hormones that activate Gs-coupled receptors, such as TSH and gonadotropins and phenotypic features of Albright hereditary osteodystrophy (AHO), including short stature, obesity, round face, brachydactyly and subcutaneous ossifications. PHP type 1A is caused by heterozygous loss-of-function mutations in the ge...

ea0063p119 | Calcium and Bone 1 | ECE2019

Biochemical and clinical features of a family with a novel mutation of CYP24A1

Brancatella Alessandro , Cappellani Daniele , Kaufmann Martin , Borsari Simona , Jones Glenville , Marcocci Claudio , Cetani Filomena

Context: Mutations of cytochrome P450 24 subfamily A member 1 (CYP24A1) gene are associated with Idiopathic Infantile Hypercalcemia (IIH), a disease recently related to vitamin D catabolism impairment.Aim of the study: Report of clinical and biochemical features of a large family with a novel mutation of CYP24A1.Methods: We performed dosage of total calcium, ionized calcium, 24 h urinary calcium, PTH, 25-OH-Vitamin D (25-O...

ea0063p120 | Calcium and Bone 1 | ECE2019

A case of primary hyperparathyroidism in a patient with Lobstein’s disease

Mekni Sabrine , Oueslati Ibtissem , Grira Wafa , Rejeb Ons , Yazidi Meriem , Chaker Fatma , Chihaoui Melika

Introduction: Osteogenesis imperfecta also known as Lobstein’s disease (LD) is a rare disorder of type 1 collagen characterized by an increased susceptibility to bone fractures. Its coexistencewith primary hyperparathyroidism (PHP) was rarely described. Herein we report a new case of a primary hyperparathyroidismin a patient with a history of Lobstein’s disease.Observation: A 35-year-old woman was referred to our departmentfor hypercalcemia. He...