Endocrine Abstracts

Background: An activation of the hypothalamic-pituitary-adrenal (HPA) axis is a common observation in obese individuals. GLP-1 agonists, such as semaglutide, and SGLT-2 inhibitors, such as empagliflozin, are well known to be beneficial in obesity, while other incretins, like peptide tyrosine tyrosine 3-36 (PYY 3-36), might be also useful for the treatment of obesity. However, the effect of these substances on the adrenal gland is largely unknown. We directly compared the effec...

Within the adrenal gland, chromaffin cells and their progenitors are exposed to a wide variety of growth factors and hormones, including adrenal androgens such as DHEA. The DHEA producing-zona reticularis of the adrenal cortex is in close proximity to the neural crest-derived catecholamine-producing chromaffin cells of the medulla, enabling strong paracrine interactions. In vivo studies in humans revealed that congenital adrenal hyperplasia due to 21-hydroxylase ...

Sepsis and septic shock remain a major health concern worldwide, and an intact adrenal cortex glucocorticoid (GC) stress response, is critical for organism to survive. Recently, we and others have shown that adrenal gland expresses members of toll-like receptors (TLRs) family which are known to sense pathogens and induce inflammatory response. Data performed on TLRs deficient mice clearly demonstrate a critical involvement of these receptors in immune-neuroendocrine bidirectio...

Background: The crosstalk between the adrenal gland and different fat depots is largely unknown. As primary hyperaldosteronism leads to an increased risk of cardiovascular disease and associated pathologies (glucose intolerance, diabetes, hyperlipidemia), elucidating the interaction between aldosterone producing adenomas (APAs) and different fat depots might help to understand causality and open new diagnostic and treatment strategies.Methods: Subcutaneo...

Background: Non-alcoholic fatty liver disease (NAFLD) is a common comorbidity in obese individuals. GLP-1 agonists, such as semaglutide, and SGLT-2 inhibitors, such as empagliflozin, are well known to be beneficial in NAFLD, while other incretins, like peptide tyrosine tyrosine 3-36 (PYY3-36), might be also useful for the treatment of NAFLD. We directly compared the effects of semaglutide alone and in combination with peptide tyrosine tyrosine 3-36 (PYY3-36), empagliflozin and...

Irisin is an adipomyokine produced during physical activity and implicated in the browning of adipose tissue. Existing evidence suggests an inverse relationship between irisin plasma levels and adverse metabolic outcomes; however, the exact impact of diet on irisin levels remains unclear. We aimed to assess the effects of two dietary patterns, Christian Orthodox fasting (OF) and 16:8 time-restricted eating (TRE), on irisin concentrations among overweight, metabolically healthy...

Aim: To evaluate the effect of PPARG2 Pro12Ala, TNFα G(308)A and G(238)A, LIPC C(-514)T, ACE I/D, SLCO1B1 Val174Ala polymorphism on the response to statins therapy in patients with type 2 diabetes mellitus (T2DM).Methods: We consecutively recruited patients with type 2 DM requiring lipid-lowering therapy according to current guidelines. Patients were started on either atorvastatin 10 or 20 mg. After 12 month of st...

Introduction: Recent data indicate that women affected by the polycystic ovary syndrome (PCOS) are at a greater risk for cardiovascular disease (CVD). The objective of this study was to evaluate the effect of the association ethinylestradiol 30 μg–drospirenone 3 mg (DRP/EE30 μg) plus metformin and weight loss on surrogate markers of CVD in PCOS.Methods: Twenty-five young women with PCOS (mean age 22.76±0.83 years, body mass index (BMI...

In this study we employed a novel bioluminescence resonance energy transfer (BRET) biosensor to study the coupling specificity of somatostatin receptor 5 (SST5) and its naturally occurring mutant R240W in living cells. Our previous data demonstrated that SST5 carrying the R240W mutation as well as other mutations in the third intracellular loop maintained the ability to inhibit intracellular cAMP levels similarly to the wild-type but failed to mediate the inhibition of intrace...

Annexin I (ANXA1), a Ca2+- and phospholipid-binding protein is an important mediator of glucocorticoid (GC) action in the host defence and neuroendocrine systems. In the anterior pituitary ANXA1 is highly expressed by the folliculo-stellate (FS) cells (1). We have shown that GCs cause the externalization of annexin I in a FS cell line (murine TtT/GF) despite the fact that ANXA1 lacks a signal sequence and is not packaged in secretory granules. In bacteria and yeast ...