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Endocrine Abstracts (2021) 73 AEP804 | DOI: 10.1530/endoabs.73.AEP804

ECE2021 Audio Eposter Presentations Late Breaking (114 abstracts)

Effects of Christian Orthodox versus intermittent fasting on plasma irisin concentrations in overweight adults

Spyridon Karras 1 , Theocharis Koufakis 1 , Lilian Adamidou 2 , Georgios Dimakopoulos 3 , Paraskevi Karalazou 4 , Katerina Thisiadou 4 , Kali Makedou 4 & Kalliopi Kotsa 1

1Division of Endocrinology and Metabolism, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece; 2Department of Dietetics and Nutrition, AHEPA University Hospital, Thessaloniki, Greece; 3Medical Statistics, Epirus Science and Technology Park Campus of the University of Ioannina, Ioannina, Greece; 4Laboratory of Biological Chemistry, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece

Irisin is an adipomyokine produced during physical activity and implicated in the browning of adipose tissue. Existing evidence suggests an inverse relationship between irisin plasma levels and adverse metabolic outcomes; however, the exact impact of diet on irisin levels remains unclear. We aimed to assess the effects of two dietary patterns, Christian Orthodox fasting (OF) and 16:8 time-restricted eating (TRE), on irisin concentrations among overweight, metabolically healthy, subjects. Plasma irisin, glycemic indices, lipid parameters, calcium homeostasis markers, and anthropometry were measured in 29 Orthodox fasters and 14 age- and body mass index (BMI)-matched TRE controls (mean age and BMI 48.8 years and 28.7 kg/m2, respectively) at three time points: before the implementation of the energy-restricted diets (baseline), at the end of the dietary intervention (7 weeks) and 5 weeks after participants returned to their standard dietary habits (12 weeks from baseline). At 12 weeks, the OF group had higher irisin concentrations than both its baseline values (64.3 ± 54.4 vs 43.6 ± 42.2 ng/ml, P = 0.01) and those of the TRE group at the same time point (64.3 ± 54.4 vs 44.2 ± 26.6 ng/ml, P = 0.04). Glycemic, lipid, and anthropometric markers were not found to correlate with irisin levels. Parathyroid hormone (PTH) concentrations at 12 weeks correlated with irisin levels (P = 0.04), with lower values of irisin expected for higher PTH. Our findings suggest favorable long-term effects of OF on irisin status. The interaction between irisin, PTH, and nutrition deserves further investigation.

Volume 73

European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

European Society of Endocrinology 

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