Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

ea0073aep782 | Late Breaking | ECE2021

Heterozygous 461A> T (p.Asp154Val) Mutation in POR gene in a male case

Müge Keskin , Ahmadova Konul , Nurcanİnce , Narin Nasirogluİmga , Cevdet Ceylan Ahmet , Aydin Cevdet , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

BackgroundCytochrome P450 oxidoreductase (POR) deficiency is an autosomal recessive steroidogenesis disorder similar to combined deficiencies of 17a-hydroxylase, 17, 20-lyase, 21-hydroxylase. POR deficiency (PORD) is a very rare type of congenital adrenal hyperplasia(CAH) characterized by sexual development disorders and skeletal anomalies. We present a case that was evaluated with a prediagnosis of nonclassical CAH and was found to have a heterozygo...

ea0073aep783 | Late Breaking | ECE2021

Cortisol measurement post steroids (Dexamethasone) treatment for COVID-19

Eltayeb Randa , Marwood Oliver , Kellam Shaun , Simpson Helen

IntroductionWe are currently mid Covid-19 pandemic. In the last year there have been 116, 135, 492 confirmed Covid-19 cases worldwide, with an estimated 2, 581, 976 deaths.The RECOVERY trial reported for patients hospitalized with Covid-19, the use of dexamethasone (6 mg for 10 days) resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomisation. Adrenal ins...

ea0073aep784 | Late Breaking | ECE2021

New biomarkers to predict cardiovasculer risk in patients with adrenal incidentaloma; irisin and nesfatin-1

Can Mustafa , Kocabas Muhammet , Karakose Mellia , Alsancak Yakup , Fatma Hümeyra Yerlikaya Aydemir , HaticeÇalışkan Burgucu , Cordan Ilker , Cengiz Kadıyoran , Kulaksizoglu Mustafa , Karakurt Feridun

ObjectivesEvidence from recent studies suggests that patients with adrenal incidentaloma have increased cardiovascular risk. In our study, we aimed to investigate the levels of irisin, nesfatin-1 and the relationship between levels of these relatively new molecules with cardiometabolic risk markers; carotid intima-media thickness (CIMT), epicardial adipose tissue (EAT) thickness and abdominal subcutaneous adipose tissue (SCAT) thickness in patients with ...

ea0073aep785 | Late Breaking | ECE2021

The role of radiological assessment with CT in the characterisation of adrenal nodules: use of size, pre-contrast attenuation and washout studies

Younger Amy , Elsaify Wael , Shawgi Mohamed , Alfifi Sara , Nsengimana Jeremie , Macauley Mavin

BackgroundAdvances in imaging techniques combined with the increase in the number of patients undergoing radiological investigations have contributed to the increased detection of adrenal nodules. Prior to the publication of the European Society of Endocrinology (ESE) guidelines on the management of adrenal incidentalomas in 2016, there was marked variability in the management of adrenal nodules. The objective of this study is to validate the diagnostic ...

ea0073aep786 | Late Breaking | ECE2021

Prevalence of primary aldosteronism in patients with acute stroke: A prospective study

Nguyen Van , Ming Tu Tian , Jane Marlie , Lai Jovan , Zhang Meifen , Kiat Puar Hai

BackgroundPrimary aldosteronism (PA) affects 5-20% of all patients with hypertension, and is likely the most common treatable cause of hypertension. Patients with PA have higher risk of cardiovascular disease, atrial fibrillation and stroke. We aimed to estimate the prevalence of PA in patients with recent stroke.MethodsWe prospectively recruited 300 patients who were admitted to the acute stroke unit of a si...

ea0073aep787 | Late Breaking | ECE2021

Prospective clinical trial comparing 11c-metomidate pet-ct and adrenal vein sampling in identifying unilateral surgically-curable primary aldosteronism

Kiat Puar Hai , Tan Colin , Tong Aaron , Meng Khoo Chin , Tan Alvin , Ming Loh Lih , Chin Kek Peng , Yee Szemen , Lee Daphne , Chuah Matthew , Reilhac Anthonin , Robins Edward , Foo Roger

IntroductionUnilateral PA can be cured with unilateral adrenalectomy. Adrenal vein sampling (AVS) is the current reference test to identify unilateral PA, but it is invasive and technically-difficult. 11C-metomidate PET-CT offers a non-invasive alternative to AVS. We compared the accuracy of AVS and PET-CT in identifying patients with unilateral surgically-curable PA.MethodsIn this prospective multi-centre cl...

ea0073aep788 | Late Breaking | ECE2021

Significant regression of primary adrenal lymphoma after acute steroid replacement therapy: a case with an insufficient initial biopsy

Helvaci Burcak , Durmus Bugra , Ozcelik Ozgur , Narin Nasirogluİmga , Ali Sendur Mehmet , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

ObjectiveThere is limited clinical data available on bilateral adrenal masses (BAM). Here we present a case with BAC and adrenal insufficiency. The patient’s lesions disappeared after steroids, re-grew in the follow-up, allowing a biopsy.CaseA 60-year-old male patient presented with abdominal pain, nausea, and weakness to another hospital. Hyponatremia and hyperkalemia accompanied by hypotension were det...

ea0073aep789 | Late Breaking | ECE2021

Admission of patients with chest pain and/or breathlessness from the emergency department in relation to risk stratification and Copeptin; a prospective observational study

Ti Davidson Lee , Gauffin Emilia , Henanger Preben , Wajda Maciej , Wilhelms Daniel , Ekman Bertil , Arnqvist Hans , Schilling Martin , Ioana Chisalita Simona

BackgroundAccurate identification of patients at risk in the Emergency Department (ED) is crucial in order to avoid delays in treatment which may result in poor outcomes. Our aim was to study the association of the decision in ED to admit patients with chest pain and/or breathlessness in the ED to a ward with risk stratification by RETTS or NEWS and level of the surrogate biomarkers Copeptin, MR-proADM and MR-proANP of vasoregulatory hormones.<p clas...

ea0073aep790 | Late Breaking | ECE2021

Patients susceptible to an adrenal crisis show marked differences in urinary cortisol excretion and glucocorticoid sensitive pathways

Vulto Annet , van Faassen Martijn , Kerstens Michiel , van Beek Andre

BackgroundAdrenal crisis (AC) is a life threatening medical situation caused by an absolute or relative cortisol deficiency. A biological predisposition may be of importance, because some patients never experience an AC, whereas others are admitted repeatedly to the hospital for an AC. Differences in cortisol pharmacokinetics (PK) and/or pharmacodynamics (PD) may underlie this vulnerability.ObjectiveTo study ...

ea0073aep791 | Late Breaking | ECE2021

Histopathology and post-surgical outcomes of surgically treated patients for primary aldosteronism

S Meyer Lucie , Handgriff Laura , Reincke Martin , Ann Williams Tracy

BackgroundUnilateral forms of primary aldosteronism (PA) are usually surgically treated to remove the source of aldosterone excess. After adrenalectomy, aldosteronism persists in a subset of patients indicating abnormal aldosterone production from the unresected gland.ObjectiveTo retrospectively analyze histopathology and post-surgical outcomes in a 3-year prospective cohort of patients diagnosed with unilate...

ea0073aep792 | Late Breaking | ECE2021

Long-term follow-up in primary aldosteronism: the major determinant of the haemodynamic phenotype is volume load

Kokko Eeva , Mutanen Aapo , Choudhary Manoj , Tikkakoski Antti , Onni Niemelä , Viukari Marianna , Matikainen Niina , Mustonen Jukka , Nevalainen Pasi , Ilkka Pörsti

BackgroundAldosterone excess causes volume retention and cardiovascular damage. We evaluated the long-term haemodynamic changes in patients with targeted treatment of primary aldosteronism (PA) (n = 40) in comparison with essential hypertension (EH) (n = 40) and untreated normotensive controls (n = 40).MethodsPA patients were subjected to adrenal vein sampling and allocated to adren...

ea0073aep793 | Late Breaking | ECE2021

Pheochromocytoma crisis precipitated by invasive coronary angiography in a patient with ventricular tachycardia and raised troponin

Jolapara Nikita , Lazari Jonathan , Ibrahim Hassan , Whelan Carol

A 63-year-old female with cardiovascular risk factors presented with tremor, sweating, lower back discomfort, nausea and dyspnoea. ECG showed sinus tachycardia with lateral ST-depression. High-sensitivity troponin was dynamically elevated (72 ng/l to 112ng/l on one-hour repeat). Computed tomography aortogram ruled out aortic dissection but identified a 6.6cm lesion in the left adrenal gland. Ventricular tachycardia was detected on cardiac monitoring. Differential diagnoses inc...

ea0073aep794 | Late Breaking | ECE2021

Cushing’s syndrome presenting with dilated cardiomyopathy: A case report

Turan Erdogan Beril , Houssein Mehdi , Ozcelik Ozgur , Cuhaci Seyrek Neslihan , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

BackgroundCardiovascular complications of Cushing’s syndrome (CS) include; hypertension, left ventricular hypertrophy, and myocardial ischaemia. Also, CS can cause structural and functional changes in the heart, leading to dilated cardiomyopathy in rare cases. Here, we present a case with dilated cardiomyopathy related to Cushing’s syndrome.CaseA 31-year-old male patient applied to the cardiology de...

ea0073aep795 | Late Breaking | ECE2021

Severe hypercholesterolemia with primary sclerosing cholangitis

Durmaz Himmet , Arifoglu Unzile , Keskin Caglar , Baser Husniye , Akdogan Kayhan Meral , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

IntroductionHypercholesterolemia may develop due to primary and secondary causes. Diabetes mellitus, hypothyroidism, nephrotic syndrome and liver diseases are among the most common causes of secondary hyperlipidemia. Here, we will present a case with severe hyperlipidemia due to primary sclerosing cholangitis(PSC).CaseA 36-year-old male patient was admitted to our outpatient clinic due to severe hypercholeste...

ea0073aep796 | Late Breaking | ECE2021

A case of non-familial pheochromocytoma presenting one of the identical twin at young age

Turan Kubra , Copuroglu Esra , Sacikara Muhammed , Nasiroglu Imga Narin , Tuncel Altug , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

BackgroundPheochromocytomas are rare tumors originating from chromaffin cells and characterized by excessive catecholamine synthesis. They are usually benign lesions. Hypertension(HT), tachycardia, sweating and headache are frequently observed. We aimed to present a high malignancy suspected pheochromocytoma case diagnosed in a young age female.Case presentationA 20-year-old female patient was admitted to the...

ea0073aep797 | Late Breaking | ECE2021

Effect of dexamethasone’s and triptorelin’s treatment in 9-year-old girl with congenital adrenal hyperplasia due to 21- hydroxylase deficiency- case report

Sawicka Beata , Hanna Borysewicz-Sanczyk , Bossowski Artur

Congenital adrenal hyperplasia due to 21-hydroxylase deficiency is the most common disorder, in which lack of the enzyme causes deficiency aldosterone and cortisol. The result of this deficiency is an increased level of ACTH. The classic form appears in early childhood and may be associated with the development of abnormal genitalia. Clinically older patients present the GnRH-independent precocious puberty with rapid growth and advanced bone age. We present the case of 9-year-...

ea0073aep798 | Late Breaking | ECE2021

Evaluation of subclinical cardiovascular disease by carotid intima media thickness, epicardial adipose tissue thickness, serum endocan, and nesfatin-1 levels in patients with primary hyperparathyroidism

Kocabas Muhammet , Alsancak Yakup , Can Mustafa , Cordan Ilker , HaticeÇalışkan Burgucu , Karakose Mellia , Fatma Hümeyra Yerlikaya Aydemir , Kulaksizoglu Mustafa , Karakurt Feridun

BackgroundPrimary hyperparathyroidism (PHPT) is known to be associated with cardiac and metabolic morbidities. Chronic hypercalcemia in PHPT patients has been reported to be associated with an increased risk of mortality, particularly due to cardiovascular disease, during long-term follow-up. Endocan is secreted by vascular endothelial cells and is involved in the regulation of important endothelial functions. Endocan secretion increases in a variety of ...

ea0073aep799 | Late Breaking | ECE2021

Comparison of patients with normocalcemic and hypercalcemic primary hyperparathyroidism

leyla akdoğan , Burcak Polat Sefika , Aydin Cevdet , Ogmen Berna , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

ObjectivePrimary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia. A group of patients who were followed up with a diagnosis of PHPT had normal calcium levels with high parathyroid hormone (PTH) levels. For the diagnosis of normocalcemic PHPT, secondary causes of hyperparathyroidism such as vitamin D deficiency should be excluded. In this study, the data of 318 PHPT patients who were operated were retrospectively analyzed, and biochem...

ea0073aep800 | Late Breaking | ECE2021

Vitamin D deficit in type 2 diabetes patients during the winter in Northern Gran Canaria with and without supplementation

Alba Hernández Lázaro , Paula María Fernandez-Trujillo-Comenge , Ricardo de Leon-Durango , Kuzior Agnieszka , Manuel Esteban Nivelo Rivadeneira , Carmen Acosta-Calero , Claudia Arnas-Leon , Sara Quintana-Arroyo , Paula Gonzalez-Diaz , Francisco Javier Martinez-Martin

IntroductionVitamin D deficiency is associated with higher risk of COVID-19, and type 2 diabetic patients are a vulnerable group. We described an alarming rate of vitamin D deficiency (81.0% < 30 ng/ml plasma calcifediol) in unsupplemented type 2 diabetes patients during the 2020 spring lockdown in Northern Gran Canaria. During the winter period (December 2020 to February 2021) some restrictions for social gatherings and a nightly curfew have been en...

ea0073aep801 | Late Breaking | ECE2021

A case report of Primary hyperparathyroidism presenting as a brown tumor in the mandible

Miranda Gonzalo

Brown tumor (BT) is a rare bony benign lesion caused by excess osteoclast activity and hemosiderin deposition because of uncontrolled primary or secondary hyperparathyroidism. 71-year-old man with no significant pathological history, twelve months before admission presented with growing mandibular brown tumor and bone pain in lower limbs. He was referred to Endocrinology unit. Physical examination found left facial paralysis, absence of horizontal branches and left jaw ascendi...

ea0073aep802 | Late Breaking | ECE2021

Hypovitaminosis D in patients with SARS-CoV2: Correlation with inflammatory markers and severity of the disease

Saponaro Federica , Franzini Maria , Okoye Chukwuma , Antognoli Rachele , Monzani Fabio , Celi Alessandro , Zucchi Riccardo , Paolicchi Aldo , Saba Alessandro

In March 2020, the infection due to COVID-19 spread as a pandemic emergence showing a mutable phenotype ranging from asymptomatic to lethal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Among multiple biological and environmental investigated factors, vitamin D status was proposed as a credible candidate, since hypovitaminosis D could be identified as a modifiable risk factor and a potential tool in SARS-CoV-2 ...

ea0073aep803 | Late Breaking | ECE2021

Physical activity and female sexual dysfunction: too much of a good thing?

Maseroli Elisa , Rastrelli Giulia , Di Stasi Vincenza , Cipriani Sarah , Scavello Irene , Todisco Tommaso , Gironi Veronica , Castellini Giovanni , Ricca Valdo , Sorbi Flavia , Fambrini Massimiliano , Petraglia Felice , Maggi Mario , Vignozzi Linda

BackgroundResearch on the relationship between physical activity (PA) and female sexual dysfunction (FSD) is lacking.AimTo investigate the clinical, psychological, and sexual correlates of PA in women with FSD.MethodsA non-selected series of n = 322 pre- and post-menopausal patients consulting for FSD was retrospectively studied. Regular involvement in PA...

ea0073aep804 | Late Breaking | ECE2021

Effects of Christian Orthodox versus intermittent fasting on plasma irisin concentrations in overweight adults

Karras Spyridon , Koufakis Theocharis , Adamidou Lilian , Dimakopoulos Georgios , Karalazou Paraskevi , Thisiadou Katerina , Makedou Kali , Kotsa Kalliopi

Irisin is an adipomyokine produced during physical activity and implicated in the browning of adipose tissue. Existing evidence suggests an inverse relationship between irisin plasma levels and adverse metabolic outcomes; however, the exact impact of diet on irisin levels remains unclear. We aimed to assess the effects of two dietary patterns, Christian Orthodox fasting (OF) and 16:8 time-restricted eating (TRE), on irisin concentrations among overweight, metabolically healthy...

ea0073aep805 | Late Breaking | ECE2021

Self-management behavior of the patients with type 2 diabetes: A cross-sectional survey in the eastern european population (Belarus)

Yaroma Andrei , Larissa I. Danilova

BackgroundThe prevention of complications and improvement of metabolic control and state of health in diabetes cannot be effective only with medications. And now we need to develop different approaches – not only up to date pharmacological treatment of diabetes, but change the Self-Management Behavior among patients with Type 2 Diabetes.AimsTo assess the current status of diabetic self-management behavio...

ea0073aep806 | Late Breaking | ECE2021

Rapid onset of severe diabetes in adult patients with prior, mild SARS‑COV-2 infection

Pecori Giraldi Francesca

COVID-19 is affecting Northern Italy since early 2020 and long-term consequences of the pandemia are progressively coming to light. Over the past months, a marked increase in the number of adults with rapid-onset severe diabetes has been observed at the Diabetes Clinic thus prompting an evalutation into possible links with COVID-19. Of note, diabetes and hyperglycaemia are known to worsen during COVID-19 and there are several reports of new-onset hyperglycaemia during SARSCoV2...

ea0073aep807 | Late Breaking | ECE2021

Abstract withdrawn...

ea0073aep808 | Late Breaking | ECE2021

Significance of technology in diabetes care during pandemic in our county hospital

Azhar Al-Shaibany

IntroductionIn last two decades, new technological advances have permitted the use of novel approaches to the management of diabetes. Continuous Glucose Monitoring (CGM) has been linked to improved HbA1c and overall quality of life. The evidence, however, is limited to retrospective studies. This audit was designed to evaluate the effectiveness and impact of CGM before and after on HbA1c and quality of life in clinical practice setting during pandemic in...

ea0073aep809 | Late Breaking | ECE2021

Comparison of the clinical efficacy of Semaglutide between DPP4-inhibitor-naive and DPP4-inhibitor-experienced patients in a real world setting in Spain

Roberto Miguel Sierra Poyatos , Jersy Jair Cardenas Salas , Luiza Luca Bogdana , Nancy María Sanchez Gomez , Naiara Modroño Mostoles , Begoña Sánchez Lechuga , Cruces Vega Eva , Maria Jesus Silva Rodriguez , María De La Paz Gómez Montes , Diego Meneses González , Montoya Alvarez Teresa , María de los Angeles Velez Romero , Estrella Santos Alicia , Ortega Juaristi Maite , Maria De Los Angeles Gonzalo Redondo , Vazquez Martinez Clotilde

IntroductionGlucose and weight control effectiveness in patients with Type 2 diabetes (T2D) in treatment with DPP4 inhibitors (DPP4i) that switch to semaglutide is scarce. We aim to assess it in a real-world setting of DPP4i-experienced patients and compare it to DPP4i-naive patients.MethodsPatients with T2D that were prescribed Once-Weekly semaglutide in 4 hospitals in Madrid-Spain were identified. Patients ...

ea0073aep810 | Late Breaking | ECE2021

Peripheral serotonin and its interaction with other hormones, in male Wistar rats with obesity and obesity-induced diabetes, studied by using of LP533401

Bogomilov Ivaylo , Daskalova Ivona , Mihneva Vesela , Nikolov Rumen , Boyadjieva Nadka

Background and aims95% of serotonin is produced in the periphery. Serotonin system in the periphery regulates multiple physiological aspects. In previous researches that we made, using the Tph1 inhibitor - LP533401 (peripheral serotonin inhibitor) it shows that this agent could be use for treatment of obesity and obesity-induced diabetes in male Wistar rats. With current study we aimed to look more detailed in to fine mechanisms of action of serotonin re...

ea0073aep811 | Late Breaking | ECE2021

Post-transplant dyslipidemia in two cases

Ince Nurcan , Durmus Bugra , Ozcelik Ozgur , Dirikoc Ahmet , Cevdet Aydın , Topaloglu Oya , Ersoy Reyhan , Bekir Cakır

IntroductionLung transplantation was associated with a 32% prevalence of hypercholesterolemia and a 41% prevalence of hypertriglyceridemia. The prevalence of dyslipidemia in liver transplant recipients is 43% and 31% –51%. In this report, we present 2 cases who developed dyslipidemia after transplantation.Case 1The blood test of a 73-year-old male patient who had lung transplantation about 3 years ago re...

ea0073aep812 | Late Breaking | ECE2021

Psychological factors in type 2 diabetes mellitus: A cross-sectional survey in the eastern european population (Belarus)

Yaroma Andrei , Larissa I. Danilova

BackgroundIt has often been argued that important psychosocial factors such as depression, anxiety and emotional stress can influence self-help behavior and therefore negatively affect glycemic control. In turn, the reduced quality of life due to chronic illness is a mediated cause of poor glycemic control. Also, attention is drawn to the prevalence of cognitive impairments and dementia.Aims1) to assess the p...

ea0073aep813 | Late Breaking | ECE2021

Three faces of the metabolic syndrome in children

Ioana Arhire Amalia

IntroductionAs the incidence of pediatric obesity is increasing, so is the incidence of metabolic syndrome in the pediatric population. We present the management of 3 such cases.Case reportThree 14 (D.D), 15 (C.A.), 16 (C.M) year-old males presented for weight and metabolic management.DD had a medical history weight gain since 2 years old, obesity, dyslipidemia, hyperuricemia. C.A., obese since 2018, with hyp...

ea0073aep814 | Late Breaking | ECE2021

Awareness of normal weight, overweight and obese patients about complications, risk factors and prevention of obesity

Dirikoc Ahmet , Genc Birgul , Ozdemir Didem , Evranos Ogmen Berna , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

BackgroundWe aimed to determine the awareness of obese, overweight and normal weight patients about the complications, causes and prevention of obesity.MethodsPatients who admitted to our clinic during a four months period were included. Demographical features, familial histories of obesity, smoking, alcohol use, chronic diseases, medications, medical nutrition therapy and exercise habits were determined. Ans...

ea0073aep815 | Late Breaking | ECE2021

Correlation between the wrist circumference and waist circumference in patients with and without diabetes

Shaikh Salomi , Shaikh Asma , Siddiqui Shazia , Shaikh Shayaan

IntroductionContemporary literature highlights the importance of wrist circumference as an easy-to-use marker of general and abdominal obesityMethodsWe measured the wrist circumference and the waist circumference in a heavy volume outpatient department of a specialised endocrine centre in 467 subjects with and without diabetes over a period of one month. Patients with known medical conditions, that were confo...

ea0073aep816 | Late Breaking | ECE2021

24-week impact of dapagliflozin treatment on body weight, body composition, and cardiac risk indicators of patients with type-2 diabetes mellitus

Akhanli Pinar , Hepsen Sema , Emre Arslan Ismail , Duger Hakan , Bostan Hayri , Kizilgul Muhammed , Ucan Bekir , Cakal Erman

AimsWe aimed to reveal the impacts of dapagliflozin, a sodium glucose transporter inhibitor (SGLT2i), on the body weight and body composition, cardiovascular risk indexes, and carotis intima-media thickness (CIMT).MethodsBody weights, body compositions measured by means of bioelectrical impedance, and CIMT in the baseline, the 12th, and the 24th week of 42 patients with type-2 diabetes mellitus receiving SGLT...

ea0073aep817 | Late Breaking | ECE2021

Vitamin B12 deficiency in type two diabetes patients using metformin at kenyatta national hospital

Njagi Ellen , Amayo Erastus , Otieno Fredrick , Githanga Jessie , Kuria Julius

BackgroundMetformin is most frequently prescribed first line therapy for individuals with type 2 diabetes. Continuous use of metformin is associated with vitamin B12 deficiency, yet the prevalence of this side effect and subsequent clinical implications has not been estimated.ObjectiveTo determine the prevalence of vitamin B12 deficiency and the variables associated with it in patients with type 2 DM on metfo...

ea0073aep818 | Late Breaking | ECE2021

Relevance of non-invasive central pressure measurements with vascular stiffness indicators to predict future cardiovascular risk in children with type 1 diabetes

Noiszewska Klaudyna , Bossowski Artur

IntroductionModern diabetology is focused on preventing late complications of diabetes and to find research tools to detect discrete changes, with the possibility of early entry with treatment. Type 1 diabetes (DM1) causes oxidative stress, affects the cardiovascular system and increases vascular stiffness. The non-invasive measurement of central blood pressure (CBP) together with augumentation and aplification indicators, more accurately reflects the co...

ea0073aep819 | Late Breaking | ECE2021

The impact of endocrine-disrupting chemicals on the prevalence of diabetes

Heshmati Hassan

IntroductionEndocrine-disrupting chemicals (EDCs) are a heterogeneous group of exogenous chemicals or chemical mixtures that interfere with the action of hormones and cause adverse effects. Humans are constantly exposed to hundreds of EDCs mainly through air, water, and food. Pregnant women are exposed to multiple EDCs that can cross the placenta and enter the fetus. The developing fetus and neonate are more sensitive than adults to perturbation by EDCs....

ea0073aep820 | Late Breaking | ECE2021

Ethnicity and its influence on post-oral glucose tolerance test glucagon-like peptide-1 responses

Chin Chong Shiau , Sukor Norlela , Anne Robert Sarah , Fong Ng Kim , Azmi Kamaruddin Nor

IntroductionGlucagon-like peptide-1 (GLP-1) plays an important role in the pathophysiology of type 2 diabetes mellitus (T2DM). Results from some studies on post-OGTT GLP-1 responses involving East Asians with abnormal glucose tolerance states tend to differ from the West. This may be attributed to the different diabetic phenotypes found in East Asians.AimTo examine post-OGTT GLP-1 responses in subjects with n...

ea0073aep821 | Late Breaking | ECE2021

Gender differences in ghrelin levels in patients with type 2 diabetes mellitus

Lobashova Veranika , Shepelkevich Alla , Dydyshko Yulia

IntroductionGhrelin has an important role in insulin resistance, glucose and lipid metabolism and cardiovascular morbidity and mortality. It is still unclear whether insulin and glucose per se play a direct inhibitory role in ghrelin secretion. The decrease in ghrelin levels after an oral glucose load is modulated by sex, status of obesity, and level of insulin resistance. The aim of our study was to evaluate gender differences in ghrelin levels in type ...

ea0073aep822 | Late Breaking | ECE2021

Influence of physician-related factors on the “Glycemic Happiness” of persons with T2DM: Interim analysis of an observational survey

Kalra Sanjay , Kumar Das Ashok , Priya Gagan , Krishna Polavarapu Nareen , Gaurav Kumar , Mane Amey , Stephen Pinto Colette

BackgroundApart from long-term complications associated with diabetes(T2DM), the psychological impact also significantly contributes to poor outcomes in persons living with diabetes. An observational survey was undertaken to assess various physician-related factors that can help define “glycemic happiness” for persons living with T2DM.MethodsA prospective, multicentric, cross sectional, observationa...

ea0073aep823 | Late Breaking | ECE2021

A case of euglycaemic ketoacidosis and concomitant acute pancreatitis in a diabetic patient treated with SGLT2i and GLP-1RA

Moustaki Melpomeni , Kalogeris Nikolaos , Katsafyloudi Maria , Papanikola Nektaria , Rigana Maria , Spanou Loukia , Angelopoulos Theodoros , Kalantzis Ioannis , Vryonidou Andromahi

IntroductionGlucagon-like peptide 1 receptor agonists (GLP-1RA) and sodium-glucose cotransporter-2 inhibitors (SGLT2i) are the two novel classes of anti-diabetic agents with compelling efficacy, in terms of glucose-lowering and cardio-renal protection. Euglycemic diabetic ketoacidosis (EDKA) is a serious rare adverse effect of SLT2i while the use of GLP-1RA has been scarcely linked with acute pancreatitis in humans.Case presentatio...

ea0073aep824 | Late Breaking | ECE2021

Diabetes care during COVID-19 pandemic using a telehealth approach

Chawla Rajeev , Chawla Shubhaa , Jaggi Shalini , Chawla Aastha , Trehan Siddhant , Kumar Rohit

IntroductionCOVID-19 pandemic has rapidly changed the landscape of diabetes care to quickly adapt to continue providing optimal care to patients with diabetes in an efficient and effective mannerMethodsWe describe a retrospective assessment of patients with diabetes, with and without COVID-19 infection, during the lockdown period March 2020 to February 2021 managed through a dedicated comprehensive dedicated ...

ea0073aep825 | Late Breaking | ECE2021

Mucormycosis in a patient with newly diagnosed diabetes mellitus and diabetic ketoacidosis

Turan Kubra , Copuroglu Esra , Abbas Tam Ali , Keskin Caglar , Ozdemir Didem , Onak Kandemir Nilufer , Sancak Mecit , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

BackgroundMucormycosis is an opportunistic fungal infection that can be aggressive and mortal. Diabetic ketoacidosis(DKA) is a risk factor for mucormycosis. We present a case with mucormycosis presenting with newly diagnosed diabetes mellitus and DKA.Case presentationA 34-year-old male patient presented with confusion and vomiting. He had no comorbiditiy. On admission the patient was afebrile, hypotensive (85...

ea0073aep826 | Late Breaking | ECE2021

The promising role of Agouti related peptide in the differentiation of ACTH-independent Cushing syndrome

Detomas Mario , Altieri Barbara , Fassnacht Martin , Dischinger Ulrich

BackgroundAgouti related peptide (AgRP) is a neuropeptide, produced by the hypothalamus and by the adrenal glands. AgRP is an antagonist of proopiomelanocortin (POMC) and its principal role is to stimulate appetite. Although current evidences suggest that AgRP levels are influenced by glucocorticoids, it is still not clear, whether they depend on adrenocorticotropic hormone (ACTH) or cortisol. One of the aims of this study was to address this issue. Furt...

ea0073aep827 | Late Breaking | ECE2021

Germline variants of the MEN1 gene in 132 subjects with clinical indication of genetic diagnosis, born in Argentina

Patricia Fainstein-Day , Lorena Viale Maria , Pia Serra Maria , Kozak Andrea

Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant inherited disease with a high degree of penetrance. The three most common locations of tumors are the parathyroid glands, the gastro-duodenum pancreas and/or the anterior pituitary gland. The gene involved in this disease is MEN 1, a tumor suppressor gene located on chromosome 11q13. The objective of our work was to describe the genotype of patients with MEN 1 born in Argentina.Subjects ...

ea0073aep828 | Late Breaking | ECE2021

Duodenal neuroendocrine tumor (siNET) and Rothmund-Thomson syndrome: a new association of a rare genetic disorder

Paja Fano Miguel , Adela L. Martínez-Martínez , Andoni Monzón , Josune Rodríguez-Soto , Merlo Ignacio , María J García-Barcina , Merino Sonia , M. Carmen González-Serrano

Rothmund-Thomson syndrome (RTS) usually presents with physical stigmata (poikiloderma, ectodermal dysplasia, juvenile cataracts…) and it´s associated with malignancies in patients with homozygous or compound heterozygous mutations in the RECQL4 helicase gene (RTS-II). Neoplasms include osteosarcoma in childhood and skin cancer later in life, with occasional malignancies affecting other tissues (leukemia, lymphoma and gastrointestinal adenocarcinomas). To ou...

ea0073aep829 | Late Breaking | ECE2021

Papillary thyroid cancer in adolescents after neuroblastoma in childhood: Description of the two cases

Enikeeva Sofia , Pankratova Maria , Slashchuk Konstantin , Kareva Maria , Peterkova Valentina

BackgroundIt is known that the thyroid gland is sensitive to the damaging effects of irradiation, and patients who have received radiotherapy for tumor treatment require regular thyroid screening subsequently. A few cases of thyroid cancer after receiving 131I-metaiodobenzylguanidine (MIBG) therapy in the treatment of neuroblastoma in childhood have been described (HM van Santen et al 2012; SC Clement et al, 2013). Here, we report the two cases of papill...

ea0073aep830 | Late Breaking | ECE2021

Clinical case of insulinoma in patient with germline mutation in the ADCY1 gene

Yukina Marina , Vasilyev Evgeny , Nuralieva Nurana , Troshina Ekaterina

IntroductionThe clinical cases of insulinoma patients with well-studied hereditary syndromes due to mutations in the MEN1, VHL, TSC1, and TSC2 genes are repeatedly described in the literature. At the same time, the hereditary nature of the pathology is highly probable in young patients with primary multiple lesions without mutations in these genes. In such cases, one can assume the presence of germline mutations in genes with the descr...

ea0073aep831 | Late Breaking | ECE2021

Paraneoplastic Cushing syndrome: Diagnostic and management challenge

Bourguiba hospital Fattouma , department Endocrinology , Monastir , Tunisia

IntroductionParaneoplastic Cushing syndrome (CS) due to ectopic ACTH secretion is a rare syndrome usually associated with severe hypercortisolism which is responsible for life-threatening comorbidities. These tumors are often difficult to locate. Among all ACTH-secreting thoracic tumors, well differentiated neuroendocrine tumors located in the bronchi are the most common and account for 20% to 40% of all cases.Case<p class="abs...

ea0073aep832 | Late Breaking | ECE2021

The management of pituitary macro adenoma in a patient with multiple myeloma-a diagnostic and treatment dilemma and a 2 year journey

Mlawa Gideon , Monteiro Mariza , Asare Priscilla , Imran Ahmad , Shafique Saqib , Stojanovic N

IntroductionMultiple myeloma is a haematological malignancy arising from plasma cells. It accounts for 10% of all haematological malignancies. Myeloma usually occurs in people over the age of 65, however, we have noted an increase occurrence of people with a younger age.Case ReportA 68 year old male, with background of hypertension and right total hip replacement, was referred to the outpatient haematology; a...

ea0073aep833 | Late Breaking | ECE2021

Treatment of severe symptomatic hyponatraemia using hypertonic saline; real world findings from 2017–2020 in two university hospitals in the UK

Fahad Arshad Muhammad , Iqbal Ahmed , Weeks James , Fonseca Ines , Munir Alia , Bennet William

Introduction & aimHypertonic saline (HTS) is an effective treatment for severe symptomatic hyponatraemia. European Society of Endocrinology (ESE) published guidelines to standardise HTS administration in 2014, however, evidence behind the guidelines is limited by virtue of being largely derived from small retrospective studies and expert opinion. The aim of this study was to evaluate the ’real-world’ safety and efficacy of these guidelines....

ea0073aep834 | Late Breaking | ECE2021

Perception of the speciality of endocrinology and nutrition among students training for the medical internship examination

Lourdes García-Blasco , Pedro Pinés Corrales , Irene Bretón Lesmes , Hanzu Felicia , Javier Escalada San Martín

IntroductionThe choice of a specialty in medicine is a decision that is imposed on new graduates. The aim of our study was to assess the perception of the specialty of Endocrinology and Nutrition among a large sample of medical students in their final year of their degree or prior to taking their Medical Internship Examination in order to know if they would choose Endocrinology and Nutrition for their specialised training, as well as the most and least a...

ea0073aep835 | Late Breaking | ECE2021

Preliminary evidence of the role of circulating testosterone levels in a cohort of women with SARS-CoV-2 infection

Rastrelli Giulia , Di Stasi Vincenza , Inglese Francesco , Beccaria Massimiliano , Garuti Martina , Di Costanzo Domenica , Spreafico Fabio , Francesca Greco Graziana , Pecoriello Antonietta , Todisco Tommaso , Cipriani Sarah , Maseroli Elisa , Scavello Irene , Glingani Claudia , Franchini Massimo , Maggi Mario , De Donno Giuseppe , Vignozzi Linda

PurposeObjective of this study was to assess the association between testosterone (T) levels and biochemical markers in a cohort of female patients admitted for SARS-CoV-2 infection in a respiratory intensive care unit (RICU).MethodsA consecutive series of 17 women affected by SARSCoV-2 pneumonia and recovered in the RICU of the Hospital of Mantua (Italy) were analyzed. Biochemical inflammatory markers as wel...

ea0073aep836 | Late Breaking | ECE2021

Lithium-induced hypercalcaemia

Ali Sana , Monteiro Mariza , Lunda Ngandu Danny , Crepostnaia Daria , Shirin Patel Md.Humayun Kabir , Mitchell Alan , Saleem Muhammed , Elshowaya Suhier , Rehmani Hassan , Mlawa Gideon

IntroductionLithium remains a first-line treatment for several mental disorders.Hypercalcaemia has been associated with long-term lithium treatment, yet it is often unrecognized. The manifestations of hypercalcaemia can develop insidiously and mimic psychiatric disturbances.CasesCase Report 1 – A 53-year-old Caucasian gentlemen referred by his GP following routine bloods with an adjusted calcium of 3.46 ...

ea0073aep837 | Late Breaking | ECE2021

How has the covid-19 pandemic affected training in endocrinology and nutrition

Zugasti Ana , María Ballesteros-Pomar , Breton Irene , Javier Escalada San Martín , Miguel Angel Rubio Herrera , Tejera Cristina , Pedro Pinés Corrales , Hanzu Felicia , Dios Elena

IntroductionThe pandemic has altered the day-to-day running of hospitals and most of the material and human resources have been made available for COVID-19 care. So have the residents in Endocrinology and Nutrition (MIR), who have been working on the front line, and this has led to alterations in their training programme. In addition, this unexpected and stressful work situation has had psychological consequences. The Spanish Society of Endocrinology and...

ea0073aep838 | Late Breaking | ECE2021

Consecutive development of adrenal Cushing´s syndrome and Cushing´s disease in a female patient with somatic CTNNB1, USP8, and NR3C1 mutations

Detomas Mario , Altieri Barbara , Schlötelburg Wiebke , Appenzeller Silke , Sven-Martin Schlaffer , Roland Coras , Andreas Schirbel , Wild Vanessa , Kroiss Matthias , Sbiera Silviu , Fassnacht Martin , Deutschbein Timo

ContextThe occurrence of different subtypes of endogenous Cushing’s syndrome (CS) in single individuals is extremely rare. We here present the case of a female patient who was successfully cured from adrenal CS 4 years before being diagnosed with Cushing’s disease (CD).Case DescriptionA 50-year-old female was diagnosed with ACTH-independent CS and a left-sided adrenal adenoma in January 2015. After ...

ea0073aep839 | Late Breaking | ECE2021

Neuroendocrine neoplasm of the pancreas as a manifestation of familial isolated pituitary adenoma: A case report

Coopmans Eva , Korpershoek Esther , M.F. van Velthuysen , Adrian F. Daly , Beckers Albert , Aart Jan Van der Lely , Neggers Sebastian , Hofland Hans , Feelders Richard , Wouter W de Herder

ContextGermline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) have been identified in patients with pituitary adenomas, most frequently presenting as somatotropinomas in the setting of familial isolated pituitary adenoma (FIPA). Our current understanding of AIP related tumorigenesis indicates that it leads to isolated pituitary adenomans, while other associated tumors have not typically been considered part of the...

ea0073aep840 | Late Breaking | ECE2021

Markers of humoral and cell-mediated immune response in primary autoimmune hypophysitis: A pilot study

Chiloiro Sabrina , Giampietro Antonella , Angelini Flavia , Paolo Mattogno Pier , Tartaglione Tommaso , Lauretti Liverana , Pontecorvi Alfredo , De Marinis Laura , Bianchi Antonio

IntroductionPrimary autoimmune hypophysitis (PAHs) is a rare inflammatory disease of the pituitary gland. Although largely investigated, the pathogenesis of PAH is not completely clarified. We aimed to investigate the immune response in PAHs.Material and methodsSerum anti-pituitary and anti-hypothalamus antibodies (respectively APAs and AHAs) were investigated though an indirect immunofluorescence on monkey h...

ea0073aep841 | Late Breaking | ECE2021

Natural course and surveillance of non-functioning pituitary microadenomas

Iyer Rishi , Kumar Rakshit , Velusamy Anand

In the current era of multi-modal imaging being performed for various pathologies, incidental non-functioning pituitary microadenomas (NFPAs) are being increasingly identified. The available literature and guidance is limited on the long-term surveillance and monitoring and hence there is a wide variation in clinical practice across the UK. We conducted a retrospective study in our institution to compare the outcome in our cohort to the current literature.<p class="abstext...

ea0073aep842 | Late Breaking | ECE2021

The first comprehensive study of the clinical response of a cohort of acromegalic patients with somatostatin responsive headache

Sonia Kaniuka-Jakubowska , J Levy Miles , Pal Aparna , Abeyaratne Dayakshi , Drake William , Kyriakakis Nikolaos , D Murray Robert , M Orme Steve , Gohil Shailesh , Brook Antonia , Leese Graham , Márta Korbonits , Wass John

It is known that acromegaly may be associated with headache as a significant co-morbidity. Amongst all acromegaly headache patients, there is a unique group with specific types of severe headache that fail to improve despite acromegaly therapy and are resistant to conventional analgesics, however, immediately respond to subcutaneous short-acting (SA) somatostatin analogue (SSA) treatment. We have surveyed 8 tertiary specialist UK centres and identified 18 patients (6 females) ...

ea0073aep843 | Late Breaking | ECE2021

The stimulatory effects of glucagon on cortisol and GH secretion occur independently from FGF-21

Akkar Ilyas , Karaca Zuleyha , Taheri Serpil , Unluhizarci Kursad , Hacioglu Aysa , Kelestimur Fahrettin

AimGlucagon stimulation test (GST) is used to assess hypothalamo-pituitary-adrenal (HPA) and GH axis with an incompletely defined mechanism. Glucagon has physiological effects on body weight and metabolic parameters and some of these effects are suggested to occur via fibroblast growth factor-21 (FGF-21) which is a circulating hepatokine. FGF-21 was also shown to affect HPA and GH axis in rodents. The aim of the present study was assess if glucagon acted...

ea0073aep844 | Late Breaking | ECE2021

The relative’s viewpoint on acromegaly in remission : A psychosocial dimension of a chronic disease

Fourneaux Rachel , Marie Vermalle , Albarel Frederique , Morange Isabelle , Graillon Thomas , Amodru Vincent , Cuny Thomas , Dufour Henry , Brue Thierry , Castinetti Frederic

Aim of the studyA relative can be an asset in dealing with chronic illnesses such as acromegaly where quality of life is altered even after remission. However, it has been shown that quality of life of caregivers can also be impacted. Our main objective was to explore the consequences of acromegaly in remission in the patient-relative dyad in a matter of quality of life and self-esteem.MethodsIn this French m...

ea0073aep845 | Late Breaking | ECE2021

Importance of proper diagnosis and treatment challenges in a 16-year-old patient with ectopic posterior pituitary and panhypopituitarism - a rare case report

Stanciu Mihaela , Paula Ristea Ruxandra

BackgroundPosterior pituitary ectopia is a rare congenital condition that consists of the abnormal position of the distinctly hyperintense signal suggestive of the posterior pituitary gland on magnetic resonance imaging. The classical features include the ectopic location of the posterior pituitary gland, pituitary stalk abnormalities and associated clinical manifestations related to isolated growth hormone deficiency. In rare cases, some patients suffer...

ea0073aep846 | Late Breaking | ECE2021

Hemorragic degeneration after covid-19 infection in microprolactinoma

Ince Nurcan , Houssein Mehdi , Bestepe Nagihan , Durmaz Himmet , Ozdemir Didem , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

IntroductionPituitary apoplexy is seen in 1.5–27.7% of pituitary adenomas. Common etiologies include hypertension, diabetes mellitus, radiotherapy, contrast-enhanced MR, surgery, drugs, anticoagulant, antithrombotic, estrogen, head trauma and pregnancy. SARS-CoV-2 had spread rapidly, and caused COVID-19 pandemic. Although it mainly causes respiratory problems, there may also be extrapulmonary involvement. COVID-19 infection is associated with hemorr...

ea0073aep847 | Late Breaking | ECE2021

Two thyrotropin secreting pituitary adenoma cases diagnosed after response to the somatostatin analogue

Karahmetli Gulsum , Houssein Mehdi , Belma Ozlem Tural Balsak , Ogmen Berna , Topaloglu Oya , Ersoy Reyhan , Bekir Cakır

IntroductionPituitary adenomas secreting TSH (TSHoma) are a rare cause of hyperthyroidism. They account for approximately 0.5–3 % of functioning pituitary tumours and much less than 1% of all cases of hyperthyroidism. TSHoma should be considered in all hyperthyroid patients, especially those with diffuse goitre and no extrathyroidal signs of Graves’ disease.Case 1A 30-year-old female applied to the ...

ea0073aep848 | Late Breaking | ECE2021

EGFR (Epidermal Growth Factor Receptor) expression in tumor microenvironment of pituitary adenomas – pathogenic and therapeutic implications

Silvia Corlan Ana , Anca Maria Cimpean , Marius Raica

BackgroundPituitary adenomas are general benign tumors. However, gross invasion at time of operation is observed in up to 35% of pituitary adenomas. The new WHO classification describes pituitary tumor subtypes along with histological markers, such as Ki67 > 3%, that may suggest a potential for aggressive clinical behavior. The expression of EGFR in tumor microenvironment of pituitary adenomas ant its correlation with tumor behavior have been poorly ...

ea0073aep849 | Late Breaking | ECE2021

Pituitary diseases registry study in latvia. Part 2

Rasa Ingvars , Gurevica Maija

IntroductionPituitary diseases result in clinical consequences and increased mortality due to tumors mass effects and also due to pituitary hypersecretion and insufficiency. Pituitary tumors registry enables identification of diagnostic and prognostic markers. The registry improves long-term clinical outcomes, pituitary diseases care and management.The aim of this studyOur registry study is designed to create...

ea0073aep850 | Late Breaking | ECE2021

A case of pituitary xanthogranuloma diagnosed with diabetes insipidus

Turan Kubra , Arifoglu Unzile , Nasiroglu Imga Narin , Tural Balsak Belma , Divanlioglu Denizhan , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

BackgroundPituitary xanthogranulomas are extremely rare tumors of the sellar region. A cystic mass lesion was found in the pituitary MRI of our patient diagnosed with central diabetes insipidus (DI). We aimed to present a case who was operated for a pituitary mass and diagnosed with sellar xanthogranuloma.Case presentation37-year-old female patient was applied to our outpatient clinic with complaints of polyd...

ea0073aep851 | Late Breaking | ECE2021

A man with adenocarcinoma metastasis to the pituitary gland presenting with panhypopituitarism and double vision

İnan Anaforoglu , Sahin Sevgi , Suleymanlar Erdogan , Ayca Ersen Danyeli&İlhan Elmacı

A 76 year old man known to have coronary heart disease, hypertension and chronic kidney disease due to hypertensive nephropathy admitted to the nephrology clinic with fatigue, nausea and dizziness. His creatinine level was detected to be increased (from 1.5 to 2.5 mg/dl) and was he was hospitalized. The cranial magnetic resonance imaging (MRI) performed after neurology consultation for dizziness showed a pituitary mass. When asked, the patient described bitemporal hemianopsia ...

ea0073aep852 | Late Breaking | ECE2021

Rare hypophysis tumor arising in a case with diabetes incipidus: Granular cell tumor

Ince Nurcan , Serdar Deniz Muzaffer , Keskin Muge , Dirikoc Ahmet , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

IntroductionPituitary gland tumors constitute approximately 10–15% of primary brain tumors, and posterior pituitary tumors are extremely rare. Granular cell tumor (GCT) is a low grade non-neuroendocrine neoplasm. Here, we will present our case who was found to have GCT during follow-up of diabetes insipidus (DI).CaseA 23-year-old male patient applied to our outpatient clinic for routine control. 12 years...

ea0073aep853 | Late Breaking | ECE2021

Giant invasive prolactinoma –a dramatic quick response to medical therapy

Yang Sim Sing , Ma’en Al-Mrayat

Giant prolactinomas are rare tumours, accounting for only 2–3% of all prolactin (PRL)-secreting tumours which can pose therapeutic challenges. It has a higher preponderance in men with a male to female ratio of about 9:1. A 70year old gentleman initially presented to the ophthalmology department with blurred and reduced colour vision. He denied any headache, galactorrhoea or gynaecomastia however he noticed reduced libido and difficulties with erections. His past medical ...

ea0073aep854 | Late Breaking | ECE2021

Examination of pituitary adenomas and non-adenoma lesions

Bülent Vatansever , Soyhan Merve , Ozkan Cigdem

IntroductionPituitary adenomas generate 10–15% of primary brain tumors. Most of these adenomas are benign and orginate from the epithelial cells of the adenohypophysis. Pituitary adenomas can occur in all age groups, but most common in the third and sixth decades. In this study, we are investigated the demographic characteristics of pituitary adenomas and non-adenoma lesions that admission to the Bozyaka Education and Research Hospital Endocrinology...

ea0073aep855 | Late Breaking | ECE2021

An unusual presentation of a metastatic typical bronchial carcinoid

Lavinia Popa Maria , Găloiu Simona Andreea , Adriana Iordan Ingrid , Poiana Catalina

IntroductionLung Neuroendocrine tumors (NETs) range in aggressiveness from low-grade typical carcinoid (TC) and intermediate-grade atypical carcinoid (AC) to the high-grade large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC). TC have excellent prognosis post-surgery and European Neuroendocrine Tumor Society (ENETS) recommands no adjuvant therapy for these well diferentiated tumors.Case report<p clas...

ea0073aep856 | Late Breaking | ECE2021

A rare case of glucagonoma presented with high serum amilase and lipase

Topaloglu Oya , Tayfur Yurekli Oyku , Metindogan Onur , Arda Inan Mehmet , Ali Sendur Mehmet , Ersoy Osman , Ersoy Reyhan , Cakir Bekir

IntroductionGlucagonoma is an extremely rare type of functional pancreatic neuroendocrine tumor that is characterized by distinctive clinical manifestations such as diabetes mellitus, weight loss, deep vein thrombosis, and necrolytic migratory erythema which represents the hallmark clinical sign of glucagonoma syndrome. Here, we report the case of a 53-year-old male patient who presented with high amilase and lipase levels. In further investigation a pan...

ea0073aep857 | Late Breaking | ECE2021

SHBG as a Q1 marker of NAFLD and metabolic impairments in women referred for oligomenorrhea and/or hirsutism and in women with sexual dysfunction

Di Stasi Vincenza , Maseroli Elisa , Rastrelli Giulia , Scavello Irene , Cipriani Sarah , Todisco Tommaso , Marchiani Sara , Sorbi Flavia , Fambrini Massimiliano , Petraglia Felice , Maggi Mario , Vignozzi Linda

PCOS (Polycystic Ovary Syndrome) is one of the most common endocrine disorders and NAFLD (Nonalcoholic Fatty Liver Disease) is one of its most dangerous metabolic consequences. The diagnosis of NAFLD is not a practical task and the condition is at risk of being overlooked. The use of simpler but still reliable surrogate markers is necessary to identify women with a high likelihood of NAFLD. The aim of this study was to evaluate the clinical correlates of NAFLD Liver Fat Score ...

ea0073aep858 | Late Breaking | ECE2021

Abstract withdrawn...

ea0073aep859 | Late Breaking | ECE2021

Infertility revealing a classical form of congenital adrenal hyperplasia in a 39 years old man

Alassane Ilboudo , Yempabou Sagnan , Mathilde Guigui , Sophie Dubreuil , Antonin Lamaziere , Bachelot Anne , Touraine Philippe , Carine Courtillot

Classical forms of congenital adrenal hyperplasia (CAH) are generally diagnosed in neonates (salt wasting form) or in early childhood (pure virilizing form). Here, we report the case of a 39 years old man from Sri Lanka in whom a classical CAH has been diagnosed during the exploration of infertility with azoospermia, along with extremely low gonadotropins contrasting with a normal level of testosterone. Hormonal tests revealed high serum 17-hydroxyprogesterone levels (255 ng/m...

ea0073aep860 | Late Breaking | ECE2021

Superoxide dismutase activity of testicular organs after intervention with fermented soy milk on hyperlipidemic rats

Luthfi Adnan Muhammad , Islamiana Dini , Ardian Sudarto Hilmi , Dewi Pramaningtyas Miranti

BackgroundOxidative stress in hyperlipidemic conditions can affect superoxide dismutase (SOD), a natural antioxidant in the body. One of the organs affected by increased oxidative stress due to hyperlipidemic conditions is the testicular organ. Increased oxidative stress in the testicular organ can damage to sperm cell and increase the risk of infertility. Soy milk is a beverage product made from soybeans which are widely consumed as an alternative to co...

ea0073aep861 | Late Breaking | ECE2021

Insight on the intracrinology of menopause: androgen production within the human vagina

Cipriani Sarah , Cellai Ilaria , Di Stasi Vincenza , Comeglio Paolo , Maseroli Elisa , Todisco Tommaso , Corno Chiara , Filippi Sandra , Sorbi Flavia , Fambrini Massimiliano , Petraglia Felice , Scavello Irene , Rastrelli Giulia , Acciai Gabriele , Villanelli Fabio , Danza Giovanna , Sarchielli Erica , Guarnieri Giulia , Morelli Annamaria , Maggi Mario , Vignozzi Linda

In this study, we investigated steroidogenic gene mRNA expression in human vagina and verified the ability of human vagina smooth muscle cells (hvSMCs) to synthesize androgens from upstream precursor dehydroepiandrosterone (DHEA). As a readout for androgen receptor (AR) activation, we evaluated the mRNA expression of various androgen-dependent markers. hvSMCs were isolated from vagina tissues of women undergoing surgery for benign gynecological diseases. In these cells, we eva...

ea0073aep862 | Late Breaking | ECE2021

Disorders of steroid metabolism in women of reproductive age with polycystic ovary syndrome

Glavnova Olga , Velikanova Ludmila , Vorokhobina Natalia , Galakhova raviliy , Malevanania Ekaterina , Matezius Irina

Background of studyPCOS is a heterogeneous disease characterized by endocrine, metabolic and reproductive disorders. PCOS plays an essential role among the causes of chronic anovulation, menstrual irregularities, hirsutism and anovulatory infertility. Diagnostic problems appear to be extremely urgent due to the wide range of clinical and laboratory manifestations. The study of urine steroid profile by gas chromatography-mass spectrometry will improve the...

ea0073aep863 | Late Breaking | ECE2021

Predictive factors of final height in children with congenital growth hormone deficiency in Tunisian children

Dorraelguiche Dorra , Jemel Manel , Grassa Anis , Gharbi Radhouane , Kandara Hajer , Kammoun Ines

IntroductionGrowth hormone deficiency (GHD) is a rare cause of statural retardation in children. The diagnosis is evoked in front of a bundle of anamnestic, clinical and radiological arguments. Treatment consists of substitution by recombinant GH with the aim of restoring normal size. There is interindividual variability in the response to treatment. We therefore proposed to study the response to treatment as well as the predictive factors of this respon...

ea0073aep864 | Late Breaking | ECE2021

Are there a gender difference in growth hormone (GH)-deficiency in Tunisian Children?

Dorraelguiche Dorra , Jemel Manel , Anis Grassa , Gharbi Radhouane , Kandara Hajer , Kammoun Ines

IntroductionCongenital GH deficiency is more common in boys than in girls. Several differences have been noted between the 2 genders. We proposed to study these differences for epidemiological, auxological and anthropometric characteristics.MethodsThis is a retrospective study including 75 patients followed for congenital GH deficiency in the endocrinology department at the National Institute of Nutrition in ...

ea0073aep865 | Late Breaking | ECE2021

Steroid Cell Tumor of the Ovary - A case presenting with hirsutismus

Sacikara Muhammed , Solmaz Kubra , Karaahmetli Gulsum , Baser Husniye , Cevdet Aydın , Ayhan Sevgi , Dincer Nazmiye , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

IntroductionSteroid cell tumors (SCTs) are a rare subgroup of sex-cord tumors of the ovary that account for less than 0.1% of all ovarian tumors. They are classified into three categories based on the cell origin: stromal luteoma, Leydig-cell tumor, and not otherwise specified (NOS). NOS tumors are the most common subtype and comprise the largest proportion of cases (60%).The clinical presentations are not specific, including abdominal pain, distention a...

ea0073aep866 | Late Breaking | ECE2021

Effectiveness of iodine supplementation during pregnancy in western Poland – a single center study

Filipowicz Dorota , Ada Mikulska Aniceta , Marta Karaźniewicz-Łada , Ewelina Szczepanek-Parulska , Franciszek Glówka , Ruchala Marek

IntroductionTwenty-four years after implementing the national salt iodization programme in Poland in 1997, the country is considered as adequate iodine supply. However, most reports do not take into consideration pregnant or lactating females. Additional intake of 150–200 µg KI per day, independently on levothyroxine (LT4) treatment, is a recommended dose for pregnancy and lactation due to Polish endocrinological guidelines. The study aim was t...

ea0073aep867 | Late Breaking | ECE2021

17-β Hydroxysteroid Dehydrogenase Type 3 Deficiency with Novel Mutation in Iranian Family

Saffari Fatemeh , Homaei Ali

IntroductionDeficiency of 17- beta hydroxysteroid dehydrogenase 3 (17-HSD 3) is a rare autosomal recessive disorder which causes sexual ambiguity in fetuses with 46XY karyotype. Pathogenic mutations in the 17βHSD-3 gene (MIM# 264300) are associated with impaired sexual development of the 46, XY fetus. Here, we describe the clinical and genetic findings of a large family with several 46xy cases with a new mutation in 17-β-HSD3 gene in Qazvtn, Ir...

ea0073aep868 | Late Breaking | ECE2021

Case report of complete androgen insensibility syndrome in an adult female

Daniela-Georgiana Amzar , Melania Balas , Ioana Golu , Mihaela Vlad , Dana Stoian , Cotoi Laura

IntroductionComplete androgen insensibility syndrome (CAIS) is an androgen receptor defect disorder associated with vaginal and uterine agenesis in women with a 46, XY karyotype. The syndrome affects sexual development before birth and during puberty. The major clinical issues surrounding this syndrome include timing of gonadectomy, hormone replacement, vaginal dilation, and attention to psychological issues.Case presentation<p...

ea0073aep869 | Late Breaking | ECE2021

Frequency of euthyroid sick syndrome before and after renal transplantation in patients with end stage renal disease and its association with oxidative stress

Akman Tugce , Topaloglu Oya , Altunoglu Alparslan , Neselioglu Salim , Erel Ozcan , Cakir Bekir , Ersoy Osman

AimEuthyroid Sick Syndrome (ESS) is a thyroid disease appeared in critical and noncritical illnesses. ESS can be seen in patients with end stage renal disease (ESRD). In this study, we aimed to evaluate the frequency of ESS before and after renal transplantation in patients with ESRD, and its association with oxidative stress by evaluating thiol-disulphide levels.Material and MethodIn this study, free triiodo...

ea0073aep870 | Late Breaking | ECE2021

Comparative analysis of five different ultrasonographical risk-stratification systems in the preoperative diagnosis of malignant and benign thyroid nodules

Dilek Dellal Fatma , Ali Tam Abbas , Şefika Burçak Polat , Omer Yazicioglu Mustafa , aydin cevdet , Ozdemir Didem , Alkan Afra , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

BackgroundOur aim was to compare the effectiveness of five different risk-stratification systems using the ultrasonographical features of thyroid nodules in determining malignant histopathology.MethodsThe preoperative ultrasonography (US) features of 6925 nodules of 3030 patients who underwent thyroidectomy between 2007 and 2014 were analyzed retrospectively. The nodules were classified according to Kwak-TIRA...

ea0073aep871 | Late Breaking | ECE2021

Relapsed Differentiated Thyroid Cancer, clinical presentation, treatment, and prognostic factors (ERUDIT Study)

Sambo Marcel , Elena Navarro González , Aller Pardo Javier , Guadalix Iglesias Sonsoles , Carles Zafón Llopis , Cintia González Blanco , Javier Santamaría Sandi , Marcelino Gómez Balaguer , Puig Domingo Manel , Juan C. Galofré Ferrater , Iñaki Argüelles Jiménez , Santos Rita , Marta Llanos Muñoz , Juan Antonio Vallejo Casas , Virginia Pubul Núñez , Crespo Herrero Guillermo , Ángel Segura Huerta , Miguel Navarro Martín , Gajate Borau Pablo , Valdivia Bautista Javier , Beatriz Castelo Fernández , Carlos López López , María J. Villanueva Silva , Orcajo Lorenzo , Julio Rodríguez-Villanueva García

Advanced differentiated thyroid carcinoma (aDTC), herein defined as locally unresectable and/or metastatic, is one of the most common late-stage endocrine neoplasias. However, available data about its natural history are limited. ERUDIT is a multicenter, observational, retrospective study of patients diagnosed with aDTC in Spain and Portugal. The study describes its natural history from the initial diagnosis until the advanced stages, focusing on specific characteristics of th...

ea0073aep872 | Late Breaking | ECE2021

A rare cause of malignant pleural effusion: Poorly differentiated thyroid carcinoma

Helvaci Burcak , Karaahmetli Gulsum , Sacikara Muhammet , Cuhaci Seyrek Neslihan , İrem Serifoglu , Aydin Cevdet , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

PurposePoorly differentiated thyroid carcinoma (PDTC); is a rare type of thyroid cancer with a high risk of recurrence, metastasis, and death. Pleural effusion due to thyroid cancer has seldom been reported. In this report, we present a case with PDTC related malignant pleural effusion.CaseA 66-year-old male patient presented with neck swelling and shortness of breath. At another center, thyroid ultrasonograp...

ea0073aep873 | Late Breaking | ECE2021

Changes in thyroid hormones and free triiodothyronine-to-free thyroxine ratio in euthyroid patients with obesity in terms of different glucose metabolism statuses

Hepsen Sema , Akhanli Pinar , Erkam Sencar Muhammed , Duger Hakan , Bostan Hayri , Kizilgul Muhammed , Emre Arslan Ismail , Cakal Erman

PurposeThyroid hormones are known to have an essential role in the regulation of energy homeostasis and glucose metabolism. Considering to literature data, variations of thyroid hormones within normal ranges change in obesity and type 2 diabetes mellitus (T2DM) in opposite ways. This study aims to evaluate thyroid hormone levels and fT3/fT4 ratio in different glucose metabolism statuses of euthyroid patients with obesity.Methods</p...

ea0073aep874 | Late Breaking | ECE2021

Nodular goiter (NOD) observed pre- and post-nuclear powerplant accident (NPP) – Experience in a single institution close to the NPP site

Kunori Takao , Yoshida Hiroshi

BackgroundAn increase of pediatric thyroid cancer has been reported in Fukushima area. While there is no adult survey to date except NPP workers. Our institute is located 40 km from the NPP and has been playing a major medical role in this area (population 340, 000). We analyzed patients with NOD whether there is any difference in cytological findings between pre- and post-NPP accident. Patients and methods:1, 065 new patients (2005–2020) with NOD w...

ea0073aep875 | Late Breaking | ECE2021

Management of thyrotoxicosis induced by PD1 or PD-L1 blockade

Brancatella Alessandro , Lupi Isabella , Viola Nicola , Daniele Sgrò , Montanelli Lucia , Sardella Chiara , Molinaro Eleonora , Piaggi Paolo , Elisei Rossella , Marcocci Claudio , Santini Ferruccio , Latrofa Francesco

BackgroundThyrotoxicosis is a common immune-related adverse event in patients treated with PD1 or PD-L1 blockade. A detailed endocrinological assessment, including thyroid ultrasound and scintigraphy is missing, as are data on response to treatment and follow-up. Aim of the study was to better characterize the thyrotoxicosis secondary to immune checkpoint inhibitors, gaining insights into pathogenesis and informing management.Metho...

ea0073aep876 | Late Breaking | ECE2021

Influence of bitter taste gene TAS2R38 on endocrinometabolic and anthropometric parameters in a sample with thyroid disease

Mendes Costa Marta , Carolina Santos Ana , Ferreira Joana , Mário Rui Mascarenhas , Bicho Manuel , Paula Barbosa Ana , Alda Pereira da Silva

Background and objectivesTAS2R38 is a bitter taste gene that can influence food consumption depending on its single nucleotide polymorphisms (SNPs) leading to aminoacid substitutions in the receptor protein P49A (proline/alanine), A262V (alanine/valine) e V296I (valine/isoleucine). Subjects with at least one PAV (proline-alanine-valine) copy are bitter tasters, while AVI homozygotes are non-tasters. Other variants have intermediate bitter tasting: AAV&#6...

ea0073aep877 | Late Breaking | ECE2021

Papillary thyroid microcarcinomas that metastasize to lymph nodes

Dirikoc Ahmet , Ali Tam Abbas , Ince Nurcan , Ozdemir Didem , Topaloglu Oya , Alkan Afra , Aylin Kılıcyazgan , Ersoy Reyhan , Bekir Cakır

Background We aimed to determine clinicopathological features that can predict lymph node metastasis (LNM) in papillary thyroid microcarcinomas (PTMC).MethodsMedical records of 872 patients with papillary thyroid cancer >1 cm (PTC >1 cm) and 1184 patients with papillary thyroid microcancer (PTMC) (£1 cm) were reviewed retrospectively. Demographical, clinical and histopathological features of (PTC >1 cm) ...

ea0073aep878 | Late Breaking | ECE2021

Serum endocan level and its correlation with clinicopathologic features in patients with Papillary Thyroid Cancer

Kursad Sener Musa , Karakose Mellia , Kocabas Muhammet , Ulutan Kars Taha , Solak Cihad , Fethi Yönet , Emin Gerek Mehmet , Fatma Hümeyra Yerlikaya Aydemir , Kulaksizoglu Mustafa , Karakurt Feridun

BackgroundPapillary thyroid cancer (PTC), has a slow progression and good prognosis and is often treatable, but may show recurrence and metastasis. Age, sex, histopathologic variants of PTC, lymphatic or vascular invasion, lymph node involvement are among the factors affecting the occurrence of metastasis. Endocan is produced in vascular endothelial cells, epithelial cells lining the distal tubules of the kidney, submucosal glands of bronchus and lungs. ...

ea0073aep879 | Late Breaking | ECE2021

Association of thiol/disulfide homeostasis with Bethesda classification of thyroid nodules and thyroid cancer

Cuneyt Bilginer Muhammet , Ali Tam Abbas , FAKI Sevgul , Bağdagül Yüksel Güler , Erel Ozcan , İbrahim Kilinç , Ozdemir Didem , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

BackgroundUltrasonography and fine needle aspiration biopsy are frequently used in the diagnosis of thyroid cancer. However, supportive data might be required in case of diagnostic difficulty. In this study, we investigated whether there is a relationship between thiol/disulfide homeostasis and cytological and histopathological diagnosis of thyroid nodules.Materials and methodsA total of 119 participants were...

ea0073aep880 | Late Breaking | ECE2021

Subacute thyroiditis at the time of SARS-CoV-2 pandemic

Brancatella Alessandro , Viola Nicola , Rutigliano Grazia , Daniele Sgrò , Santini Ferruccio , Latrofa Francesco

BackgroundSubacute thyroiditis (SAT) has been related to acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We evaluated the incidence and the severity of SAT due to SARS-CoV-2.MethodsA cross-sectional, retrospective study was conducted at the Endocrinology Unit of University-Hospital of Pisa, Italy. All patients experiencing SAT arisen within a period of 15 days earlier and yet untreated, assessed from J...

ea0073aep881 | Late Breaking | ECE2021

Follicular thyroid carcinoma in a developing country : A retrospective study of 10 years

Aziz Abdul , Qamar Masood Muhammad , Sattar Saadia , Fatima Saira , Islam Najmul

IntroductionThe most common endocrine tumor is thyroid cancer. Follicular Thyroid Carcinoma (FTC) accounts for 5%–10% of all thyroid cancers. Patients with FTC frequently present with more advanced stage diseases and a higher occurrence of distant metastases because of the propensity of vascular invasion. FTC are mainly treated with surgery while radioactive iodine therapy (RAI) is main adjuvant therapy as per ATA guidelines. In many developing coun...

ea0073aep882 | Late Breaking | ECE2021

Clinical and pathological features of thyroid cancer in adolescents and young adults

Bestepe Nagihan , Dirikoc Ahmet , Baser Husniye , Yazicioglu Omer , Aksoy Altinboga Aysegul , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

IntroductionThyroid cancer is the most common endocrine malignancy and its overall incidence has increased significantly in the last 30 years. Cancer in adolescents and young adults (AYA) is defined by the National Cancer Institute as diagnoses occurring among those aged 15 to 39 years. Thyroid cancer is the second most common cancer in the AYA population. In this study, we aimed to compare clinical, ultrasonographical, cytological and histopathological ...

ea0073aep883 | Late Breaking | ECE2021

Transient thyrotoxicosis induced by bone metastasis from differentiated thyroid cancer : a case report

Hajji Ekram , Ezzin Abir , Tahri Soumaya , Nouira Manel , Sfar Raja , Chatti Kaouther

IntroductionThyrotoxicosis due to functioning metastases in differentiated thyroid cancer (DTC) is exceedingly rare. The mechanism remains unknown despite several hypotheses. We report on a case of transient thyrotoxicosis due to functioning bone metastasis of follicular thyroid carcinoma.Case reportWe present a case of female patient of 68-years-old diagnosed with follicular thyroid carcinoma revealed by a l...

ea0073aep884 | Late Breaking | ECE2021

A tru-cut biopsy proven rare thyroid neoplasia in a giant nodule with a benign fine needle aspiration cytology

Leyla Akdoğan , Ahmadova Konul , Bestepe Nagihan , Burcak Polat Sefika , Dilek Imdat , Aydin Cevdet , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

IntroductionExtramedullary plasmacytoma (EMP) is a plasma cell neoplasm of extraosseous tissues. Less than 5% of all plasma cell neoplasms develop extramedullary. EMP is most common in the upper respiratory tract and oral cavity. The thyroid gland is one of the extremely rare regions. It is more common in men and the average age at diagnosis is 55. Primary thyroid plasmacytoma is one of the rare thyroid neoplasms. It often manifests as a rapidly growing ...

ea0073aep885 | Late Breaking | ECE2021

Thyro-cutaneous fistula a rare presentation of thyroid lymphoma

Faki Sevgul , Durmaz Himmet , Deniz Serdar , Tural Balsak Belma , Merve Pamukçuoğlu , Oya Topaloğlu , Ersoy Reyhan , BekirÇakir

BackgroundPrimary thyroid lymphoma (PTL) is defined as a lymphoma involving only the thyroid gland or the thyroid gland and adjacent (regional) neck lymph nodes. Primary lymphomas of the thyroid are uncommon tumours, representing approximately 5% of the thyroid neoplasms and 2% of extranodal lymphomas. The most characteristic presentation is that of a rapidly enlarging neck mass often associated with dysphagia [5]. The majority of patients are euthyroid ...

ea0073aep886 | Late Breaking | ECE2021

Hematological changes before and after radioactive iodine therapy

leyla akdoğan , Burcak Polat Sefika , Fatma Neslihan Cuhaci Seyrek , Ali Tam Abbas , Ozdemir Elif , Aydin Cevdet , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

ObjectiveRadioactive iodine (RAI) therapy is widely used in both diagnosis and treatment of benign and malignant thyroid diseases. It is generally a well tolerated therapy. Bone marrow suppression is often a temporary side effect with a decrease in white blood cells and platelets up to 6–10 weeks. In this study, we aimed to examine hematological changes in patients who received RAI treatment for benign or malignant diseases of the thyroid.<p cla...

ea0073aep887 | Late Breaking | ECE2021

Effect of iodine 131 in the treatment of Graves’ disease on thyroid mass and clinical signs of hyperthyroidism

Hajji Ekram , Sfar Raja , Tahri Soumaya , Kamoun Tarek , Nouira Manel , Ayechi Najla , Chatti Kaouther

IntroductionRadioiodine I-131 (RAI) therapy of Graves’ Disease (GD) affects biological thyroid function, clinical signs of hyperthyroidism (SCH), but also the mass of the thyroid (MT). The aim of our study is to assess the effect of RAI on GD and TM according to biological thyroid function after 6 and 12 months.MethodsThis is a prospective study of 86 patients (mean age 43 ± 11, sex ratio 2.07) refe...

ea0073aep888 | Late Breaking | ECE2021

Thyroid diseases and mastopathy in normally cycling women

Vasyhina Irina , Larisa A. Danilova

ObjectiveTo evaluate the combined pathology of the thyroid and mammary glands in normally cycling womenMaterials and MethodsWe have examined normally cycling 265 women aged 18 to 56 years. The modeling was performed using the SPSS 17.0 statistical software package.Resultsthe combined pathology of the thyroid and mammary glands was detected in 149 women (56.2%) of ...

ea0073aep889 | Late Breaking | ECE2021

Emergency total thyroidectomy in a COVID 19 patient with Graves’ disease and pancreatitis induced by methimazole

Balas Melania , Varcus Flore , Daniela-Georgiana Amzar , Golu Ioana , Plotuna Iulia , Borlea Andreea , Silvia Corlan Ana , Vlad Mihaela

IntroductionThe use of antithyroid drugs is associated rarely with severe hepatotoxicity. Recently, due to several cases reported in the literature, acute pancreatitis was added as a severe potential adverse effect induced by methimazole. The physiopathology of methimazole induced pancreatitis is not fully understood (intrinsic toxicity or idiosyncratic drug reaction were proposed as possible mechanisms). If adverse effects occur and no other treatment o...

ea0073aep890 | Late Breaking | ECE2021

Radiofrequency ablation for benign thyroid nodules: 600 patients - five years follow-up single center experience

Solovov Vyacheslav

PurposeThe objective of this study was to evaluate the efficacy and safety of ultrasound (US)-guided radiofrequency ablation (RFA) for treating of benign thyroid nodules of long-term follow-up.Material and methodsThe retrospective analysis included the results of treatment of 600 patients with benign tumors of the thyroid gland in the Samara Oncology Center. 108 (18%) patients had autonomously functioning thy...

ea0073aep891 | Late Breaking | ECE2021

SARS-Cov-2 related subacute thyroiditis in Belarusian patients with the previous autoimmune thyroiditis

Lushchyk Maxim , Larissa I. Danilova , Dudzik Natallia , Bourko Irina , Korolenko Galina , Kuzmenkova Elena , Grigorovich Artur

Introduction & BackgroundA COVID-19 pandemic smashed the world not only by it`s severity, but also by the tremendous amount of comorbidities, many of them having autoimmune basis. Thyrotoxicosis as one of the above - could result either from SARS-CoV-2 directly infecting the thyroid gland, as described in other viral infections, or can develop due to immune overactivation during the severe viral load. Subacute thyroiditis (SAT) is a self-limiting inf...

ea0073aep892 | Late Breaking | ECE2021

Evaluating the role of circulating dendritic cells in methimazole-treated pediatric Graves’ disease patients

Starosz Aleksandra , Karolina Stoɫek , Moniuszko Marcin , Grubczak Kamil , Bossowski Artur

Graves’ disease (GD) is hyperthyroidism associated with organ-specific autoimmune 14 inflammation. GD occurs more frequently in adults than in children, however, pediatric patients are 15 a therapeutic challenge due to cycles of remissions and relapses requiring constant monitoring at 16 every stage of treatment administered. Dendritic cells (DCs) are considered a link between innate 17 and adaptive immunity. DCs as antigen-presenting cells (APCs) are involved in antigen ...

ea0073aep893 | Late Breaking | ECE2021

Two cases of rare thyroid cancer• Hyalinizing trabecular tumor and Warthin like papillary carcinoma.

Psachna Stavroula , Vogiatzi Evangelia , Ioannidis Dimitrios , Lilis Dimitrios , Drakou Maria , Zoumpouli Christina , Goutas Nikolaos , Polymeris Antonis

BackgroundFollowing the 4th edition of WHO classification of thyroid tumors several pathologic entities were reclassified, mainly as a means of de-escalating addressed therapy. We herein present two rare types of thyroid cancer, hyalinizing trabecular tumor (HTT) and Warthin-like papillary carcinoma (WL-PTC).Cases presentationA 64-year-old female patient presented with an ultrasonographic 1.92 × 1.11 cm ...

ea0073aep894 | Late Breaking | ECE2021

Radioactive iodine therapy with recombinant human TSH (rhTSH) for well-differentiated thyroid cancer had no difference in GO outcome; case report

Faki Sevgul , Deniz Serdar , Burçak Cavnar Helvacı , Çağlar Keskin , Burçak Polat , Nilay Yüksel , Şeyda Türkölmez , Oya Topaloğlu , Ersoy Reyhan , BekirÇakir

BackgroundThe risk of cancer is relatively higher in Graves’ patients presenting simultaneously with thyroid nodules. Radioiodine (RAI) therapy recommended in intermediate-high risk differentiated thyroid carcinoma may be associated with worsening of a pre-existing Graves’ orbitopathy (GO) or developing a new onset. The impact of RAI therapy in patients with differentiated thyroid cancer on the course of a pre-exisiting GO has not been specific...

ea0073aep895 | Late Breaking | ECE2021

Are the outcomes that matter most to persons with thyroid dysfunction in Malaysia the same as in other populations in developed countries?

Peng Ooi Cheow , Abdul Hanif Khan Yusof Khan , Abdul Manaf Rosliza , Mohd Nor Sharifah , Sukor Norlela , Mustafa Norlaila , Azmi Kamaruddin Nor

BackgroundThe burden of disease in thyroid dysfunction (TD) is modifiable. Social domain of quality-of-life is a vital aspect of the biopsychosocial approach to management. Treatment decisions are increasingly guided by quality-of-life issues, creating a need to monitor the quality-of-life within clinical practice. Thyroid-specific patients reported outcomes scale/tool (ThyPro) was developed and used predominantly in populations in developed countries. W...