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European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

ea0073aep625 | Thyroid | ECE2021

Mycophenolate mofetil in sight threatening Graves’ ophthalmopathy: a case report

Essayeh Sawsen , Ayari Sabrina , Hadj Sliman Chayma , Bchir Najla , Zouaoui Chedia , Ouertani Haroun

IntroductionGraves ophthalmopathy (GO) is an inflammatory autoimmune disorder of the orbit which is associated with autoimmune thyroid disease. The medical treatment of severe and sight threatening GO remains a challenge, it generally implies the use of glucocorticoids with others treatments. Mycophenolate mofetil (MMF) is a prodrug of mycophenolic acid that prevents T-cell and B-cell proliferation and the production of cytotoxic T-cells and antibodies. ...

ea0073aep626 | Thyroid | ECE2021

Inoperable papillary thyroid carcinoma with metastasis pulmonary: therapeutic alternative

Laurinda Pangui Henricia , Essabah Haraj Nassim , El Aziz Siham , Chadli Asmaa

SummaryPapillary thyroid carcinoma is rare in children and adolescents, most often discovered late by lung metastases. It is generally of good prognosis but can present cases difficult to operate requiring a targeted therapeutic approach. We report the case of a 15-year-old patient from a non-consanguineous marriage, with no history of irradiation, followed for Hashimoto’s hypothyroidism since the age of 6 under Levothyrox 25 µg. Admitted for a...

ea0073aep627 | Thyroid | ECE2021

Laser ablation versus radiofrequency ablation for benign non-functioning thyroid nodules: twelve-month results of a randomized, parallel-arm, open-label trial

Cesareo Roberto , Manfrini Silvia , Pasqualini Valerio , Ambrogi Cesare , Sanson Gianfranco , Gallo Andrea , Pozzilli Paolo , Pedone Claudio , Crescenzi Anna , Palermo Andrea

BackgroundRadiofrequency ablation (RFA) seems to achieve a significantly larger nodule volume reduction rate (VRR) than laser ablation (LA) in benign non-functioning thyroid nodules (BNTNs). We compared the efficacy and safety of both thermal ablation treatments at the 12-month follow-up in patients with solid or predominantly solid BNTN.MethodsThis 12-month, single-use, randomized open-label parallel trial c...

ea0073aep628 | Thyroid | ECE2021

Graves’ disease in patients with autoimmune polyendocrine syndrome type 3

Kacem Faten Hadj , Ben Salah Raida , Abir Derbel , Sara Chouaib , Zouhir Bahloul , Mohamed Abid

IntroductionType 3 autoimmune polyendocrine syndrome (APS-3) is defined by the presence of an autoimmune thyroid disease and another autoimmune illness, excluding Addison’s disease; this is a frequent combination. Graves’ disease (GD) is an autoimmune disorder affecting approximately 0.5% of general population. It’s occurrence in autoimmune polyendocrine syndrome (APS) is less common than Hashimoto thyroiditis. The aim of our study was to ...

ea0073aep629 | Thyroid | ECE2021

Long-term outcomes of radioiodine therapy in toxic solitary thyroid nodules

Puga Francisca , Teresa Pereira Maria , Cláudia Freitas , Helena Cardoso Maria

IntroductionThe toxic solitary thyroid nodule is a major cause of hyperthyroidism, especially in iodine-deprived regions. The most widely used therapy is iodine-131, which is effective in achieving normal thyroid function and reducing nodule dimensions, however, it may induce hypothyroidism. The aim of this study was to evaluate the outcomes of radioiodine therapy in patients with toxic solitary nodules and to determine predictive factors for the develop...

ea0073aep630 | Thyroid | ECE2021

Adverse childhood experiences and negative emotional responses : risk factors for thyroid autoimmune diseases?

Ruggeri Rosaria , Liotta Marco , Ferraro Anna , Salvatore Cannavò , Larcan Rosalba , Cuzzocrea Francesca

Stressful condition and negative emotions can contribute to the overproduction of proinflammatory cytokines and promote immune dysregulation, which, in turn, increases the risk of various diseases, including autoimmune disorders. The present study was aimed at evaluating the relationship, if any, between psychological and individual characteristics (stress, coping and emotional intelligence) and thyroid autoimmunity.MethodWe enroll...

ea0073aep631 | Thyroid | ECE2021

Features of Subacute Hhyroiditis in COVID 19

Darashkevich Ina , Mokhort Tatjana V. , Darashkevich Ivan , Martinkevich Olga

The Sars-COV-2 virus is a recognized endocrine disruptor, which determines the possibility of endocrine dysfunctions associated with COVID 19. One of the endocrine diseases associated with COVID 19 is subacute thyroiditis (STh), which develops regardless of the severity of manifestations of the underlying disease. The aim of the study: to evaluate the clinical manifestations, therapy, and outcomes of STh in unvaccinated COVID 19 patients.Materials and me...

ea0073aep632 | Thyroid | ECE2021

The use of Thyroid Uptake scan in non-malignant thyroid disease; a multicentre audit

Sardar Muhammad Shoaib Khan , Larsen Niels , Mola Reyes Laura , Sheikh Riyad , Carlos Mauricio Hernandez Heredia

Thyroid uptake scan is a widely used thyroid investigation that provides valuable information regarding the structure and function of the gland and helps in differentiating some of the common thyroid pathologies. We present a multicentre audit of thyroid uptake scans done for non-malignant thyroid pathologies and try to analyse the usefulness of this investigation in different situations.MethodsThis audit includes thyroid uptake sc...

ea0073aep633 | Thyroid | ECE2021

Efficacy of transcutaneous laryngeal ultrasonography (TLUS) in the diagnosis of vocal cord function in an endocrine surgery referral center.

Offi Chiara , Antonelli Giovanni , Brancaccio Umberto , Edoardo D’Ambrosio , Grazia Esposito Maria , Misso Claudia , Maria Romano Roberto , Spiezia Stefano

IntroductionThyroid diseases affect a large population worldwide and total thyroidectomy (TT) is the most common curative treatment [1]. Recurrent laryngeal nerve (RLN) lesions are the most dangerous complication [1]. The intraoperative neuromonitoring (NIM) is a useful tool in reducing the incidence of nerve injury, but a preoperative examinations of vocal cords function through flexible fiberoptic laryngoscopy (FFL) is recommended [1]. FFL is uncomfort...

ea0073aep634 | Thyroid | ECE2021

Evaluation of fetuin-A levels in patients with autoimmune thyroiditis

Eszter Berta , Sándor Halmi , Inez Mercédesz Lengyel , Mónika Katkó , Harangi Mariann , V Nagy Endre , György Paragh , Miklós Bodor

BackgroundHypothyroidism due to autoimmune thyroiditis (AITD) leads to atherogenic lipid profile and therefore might increase the cardiovascular risk of patients. Fetuin-A is a hepatokine with a role in the regulation of mineralization, metabolism and the cardiovascular system. Fetuin-A levels are known increased in obesity-linked diseases. To date, the role of fetuin-A in autoimmune thyroiditis has not been thoroughly investigated.<p class="abstext"...

ea0073aep635 | Thyroid | ECE2021

Long term outcomes of Graves’ Orbitopathy treatment; a clinic’s experience

Pappa Dimitra , Thoda Pinelopi , Anastasia– Konstantina Sakali , Barmpa Eleftheria , Georgiou Eleni , Gountios Ioannis , Bargiota Alexandra

IntroductionIn this study we present data on the long-term outcomes of treatment of patients with moderate and severe GO.Methods98 patients with GO attending our clinic for the last 13 years and received treatment for moderate to severe GO were evaluated for their long-term response to treatment. Initial decision for treatment was based on activity and severity of the disease, assessed by CAS-score and NOSPEC...

ea0073aep636 | Thyroid | ECE2021

Comparison of metabolic parameters between women with autoimmune thyroiditis on levothyroxine replacement therapy and euthyroid healthy women

Argatska Antoaneta , Nonchev Boyan

IntroductionThe association between thyroid function within the normal range and body weight and related metabolic parameters has been the subject of numerous studies with inconsistent results not only in euthyroid healthy population but also in treated patients with autoimmune hypothyroidism.ObjectiveTo compare body mass index (BMI), blood glucose and serum lipids between women with autoimmune thyroiditis on...

ea0073aep637 | Thyroid | ECE2021

Persistently elevated procalcitonin levels in Covid-19 pneumoniae leading to medullary thyroid cancer diagnosis

Gianotti Laura , Salvatore D’Agnano , Tassone Francesco , Pettiti Giorgio , Lauria Giuseppe , Del Bono Valerio , Borretta Giorgio

ObjectiveWe report a case of acute respiratory syndrome coronavirus 2 (SARSCoV2) pneumonia in which persistently high procalcitonin (PCT) allowed the diagnosis of sporadic medullary thyroid cancer (MTC).MethodsWe describe the history of 43-year-old male with bilateral Sars-Cov-2 pneumoniae, in whom persistent increased PCT despite reduction of C reactive protein lead to investigate other causes of high PCT. S...

ea0073aep638 | Thyroid | ECE2021

Graves’ disease presenting with hypercalcaemia, thymic hyperplasia and lymphadenopathy

Anwar Mehreen , Muhammad Athar Iqbal Khan , Sardar Muhammad Shoaib Khan , thant Yamin , Jones Steve G. , Fernando Devaka

We would like to report an interesting case of Graves’ disease which presented with thymic hyperplasia, bilateral generalised lymphadenopathy and hypercalcaemia, along with other typical manifestations of hyperthyroidism. A 53 year old lady was admitted following an opioid overdose as she was suffering from depression after a recent slipped disc injury which had resulted in poor mobility. She suffered an out of hospital respiratory arrest, underwent cardiopulmonary resusc...

ea0073aep639 | Thyroid | ECE2021

Importance of lymph extranodal extension to therapy outcomes in patients with thyroid follicular epithelial cell-derived carcinoma evaluated at one year

Fernando Hernández Olmeda , Patricia Espinosa De Los Monteros , Xavier Pérez Candel , Lopez Nevado Celia , Raquel Pallarés , Inés Jiménez , Maria Cristina Familiar Casado

IntroductionThe number of lymph node metastasis (NM) and the existence of extranodal extensión (ExEx) are not included among prognosis variables used in the most common staging systems for differentiated thyroid cancer as AJCC and ATA risk systems.ObjectiveIn patients with NM at diagnosis, to analyze the association between the number of NM and the presence of ExEx with response to therapy.<p class="...

ea0073aep640 | Thyroid | ECE2021

Efficacy of multidisciplinary approach in thyroid nodules: analysis of factors used for predicting malignancy

Volkan Kisioglu Savas , Atacan Huseyin , Cakir Emel , Oguz Sukru , Karakullukcu Serdar , Onder Ersoz Halil

BackgroundTo date, numerous molecular tests have been developed for preoperative evaluation of thyroid nodules. Nevertheless, these tests cannot be administered in many centers due to their imprecise diagnoses and high costs. The present study aimed to investigate the effect of making surgical decisions in a council through a multidisciplinary approach after clinical, ultrasonographic, and pathological evaluation of nodules on the accuracy of the decisio...

ea0073aep641 | Thyroid | ECE2021

Percutaneous laser ablation of metastatic lymph nodes, role of minimally invasive thyroid treatment in center of reference of endocrine surgery.

Offi Chiara , Brancaccio Umberto , Antonelli Giovanni , Edoardo D’Ambrosio , Grazia Esposito Maria , Misso Claudia , Spiezia Stefano

BackgroundThe incidence of papillary thyroid cancers is increase in last decades due to easier ultrasound diagnosis. The papillary thyroid cancers metastasize via lymphatics to the lymph nodes of the central and later cervical neck compartment. According to 2015 ATA guidelines, the recurrence rate is less 1–2% [2]. The treatment of choice in lymph node recurrences is surgery, but it is burdened by a higher rate of complications (25% of recurrent lar...

ea0073aep642 | Thyroid | ECE2021

Estimating risk of recurrence of differentiated thyroid cancer patients: a real-world multicenter validation of the american thyroid association initial risk stratification and dynamic re-assessment after 5 years of follow-up.

Cera Gianluca , Grani Giorgio , Puxeddu Efisio , Arvat Emanuela , Pontecorvi Alfredo , Pio Lombardi Celestino , Torlontano Massimo , Chiara Zatelli Maria , Antonelli Alessandro , Tallini Giovanni , GRAZIA CASTAGNA MARIA , Fugazzola Laura , Filetti Sebastiano , Durante Cosimo

BackgroundMost Differentiated Thyroid Cancer (DTC) cases typically show indolent biological behavior and a low mortality rate. Various prognostic systems are used to assess disease recurrence risk, to tailor treatment and follow-up strategies. The initial Risk Stratification System (RSS) and dynamic Response to Therapy Re-stratification (RTR) system, recommended by the 2015 American Thyroid Association (ATA) Guidelines, are the most employed. Still, they...

ea0073aep643 | Thyroid | ECE2021

Assessment of hearing impairment in adult patients with euthyroid Hashimoto’s thyroiditis

Ömercan Topaloğlu , BayramŞahin

IntroductionHearing loss may be associated with autoimmune diseases, but it was less studied in Hashimoto’s thyroiditis (HT). We aimed to evaluate hearing impairment by audiometric assessments in adults with euthyroid HT.Materials and MethodsAdult patients with euthyroid HT (normal thyroid functions, positive AntiTPO/AntiTg and sonographic findings) were compared with controls. We excluded pregnant or ol...

ea0073aep644 | Thyroid | ECE2021

Assessment of clinical burden and practice patterns in patients with chronic hypoparathyroidism in the united states (us): a claims data analysis using diagnosis-based criteria

Sharma Dolly , L Deering Kathleen , Allas Soraya , Culler Michael D. , Loustau Patrick , Weiss Blandine , Michelle Mitchell Deborah , Astolfi Danette , Mannstadt Michael

ObjectivesThere is a paucity of real-world studies analyzing comorbidities, lab testing and treatment patterns of patients with chronic hypoparathyroidism (cHP). This study describes a large cohort of cHP patients identified using a diagnosis-based approach from a US claims database.MethodsThis retrospective study was conducted using a large (130 million individuals) claims database (HealthVerity Closed Payer...

ea0073aep645 | Thyroid | ECE2021

Phenotypical changes of thyroid disease in a patient with Turner Syndrome

Halloul Imen , Ben Abdelkerim Asma , Ben Othman Wafa , Saad Ghada , Kacem Maha , Maaroufi Amel , Chaieb Molka , Hasni Yosra , Ach Koussay

IntroductionTurner syndrome (TS) is among the most common chromosomal abnormalities in females, resulting from structural or numeric abnormalities in the X chromosome. Autoimmune disorders, especially thyroid diseases have a high prevalence among these patients. Usually Hashimoto’s thyroiditis (HT) is the most frequent one, whilst the association between this syndrome and Graves’ disease (GD) has been less often reported. Here we report a case ...

ea0073aep646 | Thyroid | ECE2021

Hypothyroidism causing acute kidney injury (AKI)

Gohar Marjan , Abdelgader Yagoub , Aarella Vikram

AKI is a potentially a life threatening condition and it is extremely crucial to investigate the root cause it order to manage the patient appropriately.Case reportA 30 years old female presented with complaints of generalized muscle weakness, lethargy and mood changes. She was found to have raised creatinine with significant drop in her GFR to 41. Rest of her electrolytes and full blood count were within normal range. She was comm...

ea0073aep647 | Thyroid | ECE2021

Graves’ disease; relapse or fake news with Biotin

Sakarwadia Rahul , Ibrahim Hassan , Hussain Ayaz , Albor Christo , Hasnain Solat , Bashir Jawad

A 41 year old lady presented to emergency department with tremors and palpitations. Her examination and routine bloods were normal but ECG showed sinus tachycardia (heart rate = 141 bpm). She was treated with propranolol and discharged. She was readmitted in emergency department with ongoing palpitations, lethargy and tremors. On examination, she had a diffuse goitre but no signs of Graves’ eye disease. The blood tests showed overt thyrotoxicosis (TSH<0.01 mU/l, FT4 =...

ea0073aep648 | Thyroid | ECE2021

Case report : A rare case of leucinosis decompensated by hyperthyroidism

Yaker Fetta , Pauline Busiau , Anne-Flore Herrou , yawa Abouleka , Sandrine Gippa , Myriam Dao , Diane Evrard , Ronan Roussel , Louis Potier

Leucinosis also called Maple syrup urine disease (MSUD) is a rare inherited disorder of branched-chain amino acid metabolism classically characterized by poor feeding, lethargy, vomiting and a maple syrup odor in urine with an evolution to encephalopathy and central respiratory failure if untreated. When diagnosed at birth, treatment is based on nutrition therapy aiming at rapidly reducing of toxic metabolites through dietary restriction, shifting towards and preventing or min...

ea0073aep649 | Thyroid | ECE2021

Hyperthyroidism and exophthalmos in a patient with Erdheim–Chester disease

Mitka Kamila , Grzegorz Sokolowski , Pach Dorota , Alicja Hubalewska - Dydejczyk

We present extremely rare case of a female patient with the coincidence of hyperthyroidism, exophthalmos and Erdheim–Chester disease (a rare form of non-Langerhans cell histiocytosis, positive BRAF mutation). The patient was hospitalized due to exacerbations of the primary disease and symptoms of thyroid dysfunction. For about two months, the patient has reported increased feeling of heat, sweating, palpitations, weight loss of about 10 kg for 3 months, significant intens...

ea0073aep650 | Thyroid | ECE2021

Myxedema coma in a COVID-19 patient

Cidade-Rodrigues Catarina , Dalila Martins Marta , Verónica Cardoso , Linhas Rita , Viveiros Filipa , Rogério Ruas , Ferraz Rita , Cunha Filipe

IntroductionMyxedema coma is a rare condition with an estimated incidence of 0.22 per million per year in the western world and a mortality rate around 30–50%. It can occur as the result of severe longstanding hypothyroidism or be precipitated by an acute event, such as infection. We present a rare case of myxedema coma in an elderly woman with SARS-CoV-2 infection.Case reportAn 82-year-old woman, with n...

ea0073aep651 | Thyroid | ECE2021

Evolution of SARS-CoV-2 related atypical thyroiditis

Muller Ilaria , Re Tiziana , Varallo Matteo , Daturi Anita , Cannavaro Daniele , Nadiani Benedetta , Dazzi Davide , Longari Virgilio , Cuzzocrea Marco , Gori Andrea , Mantovani Giovanna , Arosio Maura , Salvi Mario

BackgroundWe provided the first description of thyrotoxicosis due to atypical thyroiditis in patients hospitalised for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic disease (Covid-19), not associated with neck pain, more common in men, correlated with disease severity and coexisting with non-thyroidal illness syndrome. Classic viral subacute thyroiditis is often followed by permanent thyroid dysfunction and autoimmunity, thus we h...

ea0073aep652 | Thyroid | ECE2021

Pre-operative vitamin D deficiency is a risk factor for post-thyroidectomy hypoparathyroidism: a systematic review and meta-analysis of observational studies

Vaitsi Konstantina , Anagnostis Panagiotis , Veneti Stavroula , Papavramidis Theodosios S. , Goulis Dimitrios

ContextWhether pre-operative vitamin D deficiency (VDD) contributes to post-operative hypoparathyroidism (hypoPT) risk is unknown.ObjectiveTo meta-analyze the best available evidence regarding the association between pre-operative vitamin D status and hypoPT risk.Data SourcesA comprehensive literature search was conducted in PubMed, CENTRAL and Scopus databases, u...

ea0073aep653 | Thyroid | ECE2021

Metabolic effects of levothyroxine as a part of multicomponent therapy in patients with a combination of arterial hypertension, type 2 diabetes mellitus and subclinical hypothyroidism

Zlatkina Vira , Nemtzova Valeriya , Ilchenko Iryna

ObjectiveTo establish the association of the dynamic changes in carbohydrate, lipid metabolism parameters and blood pressure (BP) profile in patients with combined course of arterial hypertension (AH), type 2 diabetes mellitus (DM) and subclinical hypothyroidism (SH) and to determine the efficacy of the applied scheme. We examined 106 patients – 45 women and 61 men aged 45–55 years with AH stage II grade 2 and type 2 DM which were divided on SH...

ea0073aep654 | Thyroid | ECE2021

Autoimmune polyendocrine syndrome in patients with thyroid autoimmunity

Kacem Faten Hadj , Abir Derbel , Sara Chouaib , Mohamed Abid , Ben Salah Raida , Zouhir Bahloul

IntroductionAutoimmune Polyendocrine Syndrome (APS) is defined by the presence of 2 or more autoimmune induced endocrine failures in a single patient. There are 4 types of APS: type1 including chronic muco-cutaneous candidiasis, hypoparathyroidism, Addison disease (AD) and ectodermal dystrophy, APS type 2 and 3 containing autoimmune thyroide disease (AITD), type1 diabetes (DT1) with (type2) or without adrenal failure (type3) and type 4 not falling into t...

ea0073aep655 | Thyroid | ECE2021

Vitamin D deficiency is associated with increased thyroid autoimmunity in Georgian adults

Davitadze Meri , Melson Eka , Kobaidze Ann , Tedoradze Nino , Ooi Emma , Kempegowda Punith

IntroductionRecently, apart from its main physiologic role, the active form of vitamin D has also been recognised to have anti-inflammatory and immune-modulating properties. Accumulating evidence suggests that Vitamin D deficiency is associated with increased prevalence of various autoimmune diseases, and in particular, with autoimmune thyroid disease. Despite contradicting evidence, the balance is tipping towards inverse correlation between vitamin D de...

ea0073aep656 | Thyroid | ECE2021

Features of large intestinal microbiota of patients with diffuse toxic goiter

Piddubna Antonina , Pashkovska Nataliia , Abramova Nataliia , Pankiv Ivan , Koval Galina , Marchuk Yulia , Tsaryk Iryna

It is well known that the range of disorders of various organs and systems in thyroid dysfunction is diverse, due to the scale of the impact of thyroid hormones on the body. One of the most characteristic clinical manifestations of thyrotoxicosis is changes in the gastrointestinal tract in the form of dysbiosis. Some studies have found inconsistencies in the association of these filotypes with the presence of thyrotoxicosis. In addition, there is no data in the literature on t...

ea0073aep657 | Thyroid | ECE2021

A case of Grave’s disease following SARS-Cov 2 infection

Bayar Ines , Tahri Soumaya , Hajji Ekram , Ben Amor Bilel , Sayadi Hanene , Héla Marmouch , Inès Khochteli

IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that caused a global pandemic in 2020. The virus has infected more than 100 million people worldwide and the pandemic is still spreading. It can affect practically all organs. Data on the impact of SARSCoV-2 on the thyroid gland are very scarce. Two patients with Graves’ disease (GD) and COVID-19 have been recently published(1). We present a case GD occur...

ea0073aep658 | Thyroid | ECE2021

Neurogenesis pathway-focused gene expression analysis in patients with primary hypothyroidism and autoimmune thyroiditis

Kamyshna Iryna , Kamyshnyi Aleksander

AbstractImportant regulators of metabolism are thyroid hormones. They play an important role in the development and maturation of the central nervous symptom and their failure in the prenatal period leads to irreversible brain damage, however, their effect on the brain of an adult has not been fully studied. On the other hand, Hashimoto encephalopathy is associated with autoimmune thyroiditis. With the discovery of neurogenesis in the adult brain many re...

ea0073aep659 | Thyroid | ECE2021

Outcome of Long Term Antithyroid Therapy in Patients with Graves’ Hyperthyroidism

Găloiu Simona Andreea , Lavinia Popa Maria , Margarit Emma , Baciu Ionela , Alexandru Niculescu Dan , Capatina Cristina , Trifanescu Raluca , Radian Serban , Baculescu Nicoleta , Poiana Catalina

Graves’ disease is an autoimmune thyroid disease which, untreated, carries a significant morbidity risk. Treatment options for Graves’s disease have changed over the decades.AimsTo evaluate the outcome and risk factors for relapses of patients with Graves’s disease treated with antithyroid drugs for at least 2 years.MethodsA retrospective, analytic study on 360 consecutiv...

ea0073aep660 | Thyroid | ECE2021

Factors affecting development of hypothyroidism at patients with subacute thyroiditis

İnan Anaforoglu , Murat Topbaş

IntroductionThe aim of the present study was to determine the possible factors contributing to the development of hypothyrodisim in patients who had a subacute thyroiditis (SAT) attack.MethodsMedical records of patients who were diagnosed with SAT between September 2014 and January 2020 were analyzed retrospectively in one center in Trabzon city of Turkey. The medical records of the patients were searched wit...

ea0073aep661 | Thyroid | ECE2021

Iodine excretion in schoolchildren of Vilnius

Zabuliene Lina , Miglinas Marius , Macioniene Ernesta , Banys Valdas , Bratcikoviene Nomeda , Linkeviciute Ausra , Petronyte Dovile , Urbonas Mykolas , Utkus Algirdas

Iodine deficiency is the main cause of preventable mental retardation in children. Urinary iodine excretion is a marker of recent iodine intake and is used to monitor the iodine status of population. Iodine excretion in Lithuanian schoolchildren was previously investigated in 2001. The main objective of this study was to evaluate iodine excretion in children, ages 6–12, living in Vilnius, Lithuania.MethodsUrine samples were co...

ea0073aep662 | Thyroid | ECE2021

An audit of thyroidectomy in Graves’ Disease, in a large UK tertiary centre

Jones Larissa , Khan Shaila , Tolley Neil , Palazzo Fausto , Cox Jeremy , Agha-Jaffar Rochan , Robinson Stephen

BackgroundThyrotoxicosis with Graves’ Disease is treated with thionamide, radio-iodine treatment and thyroidectomy. Surgery is an important choice, especially when Graves’ Disease is complicated by thyroid orbitopathy. Pre- and post-operative protocols for thyroidectomy are imperative.Aims1) To assess pre-operative preparation of patients, with potassium iodide, vitamin D, beta blockade, and the pre...

ea0073aep663 | Thyroid | ECE2021

Thyroid-receptor antibodies, immunoglubulin E and antinuclear antibodies in patients with Graves’ disease and their association with Graves’ orbitopathy and smoking habits

Stoynova Mariya , Shinkov Alexander , Kirilov Georgi , Kovatcheva Roussanka

IntroductionThyrotropin-receptor antibodies (TRAb) play a key role in the pathogenesis of Graves’ disease (GD) and Graves’ orbitopathy (GO) and are important for the diagnosis of both diseases. Elevated levels of immunoglobulin E (IgE) and antinuclear antibodies (ANA) were also found in GD patients. Smoking is a risk factor for GD and GO development and GO progression. We aimed to assess the associations between TRAb, IgE and ANA, and the prese...

ea0073aep664 | Thyroid | ECE2021

How Does Age Influence Disease Outcome in High Risk Papillary and Follicular Thyroid Cancer Patients?

Van Velsen Evert , Peeters Robin , Stegenga Merel , van Kemenade Folkert , van Ginhoven Tessa , Verburg Frederik , W. Edward Visser

BackgroundThe 2015 American Thyroid Association (ATA) Risk Stratification System for differentiated thyroid cancer (DTC) is designed to predict response to therapy and recurring disease. Although age is not incorporated as a risk factor, recent research suggests that the addition of age can improve this system. However, these studies comprised low number of patients with ATA High Risk, low numbers of patients with follicular thyroid cancer (FTC), and did...

ea0073aep665 | Thyroid | ECE2021

Could ultrasound characteristics guide us on the presence of malignancy in thyroid nodules with Bethesda III cytology?

Suset Dueñas Disotuar , Ana R. Romero LLuch , Navarro Elena

BackgroundThyroid nodules with indeterminate cytology represent a therapeutic challenge. The probability of malignancy had been established between 5 and 15%, but it varies among the published data. Nowadays we have molecular tests to help in therapeutic decisions, but they are not available at all centers leaving uncertainty regarding appropriate management.Objectives– To know the percentage of malignan...

ea0073aep666 | Thyroid | ECE2021

Increased gene expression of TIMP1 and CHI3L1 in fine-needle aspiration biopsy washouts from papillary thyroid cancer

Dimitrova Inna , Shinkov Alexander , Dodova Rumyana , Ivanova Radina , Kaneva Radka , Kovatcheva Roussanka

AimTo assess the relative expression of tissue inhibitor of metalloproteinase-1 gene (TIMP1) and chitinase-3-like protein 1 gene (CHI3L1) in fine-needle aspiration biopsy (FNAB) washouts and the serum levels of their protein products (TIMP-1 and chitinase-3-like protein 1 also known as YKL-40) in patients with histologically confirmed papillary thyroid cancer (PTC) and with benign nodules. Further, we evaluated the correlation between the gene expression...

ea0073aep667 | Thyroid | ECE2021

Molecular landscape of the multiple endocrine neoplasia type 2 syndrome in the Belarusian population

Dydyshka Yuliya , Shepelkevich Alla , Chakhovich Tatsiana , Shloma Alina , Smirnov Sergey , Ruksha Kseniya , Subach Alena , Portyanko Anna , Kondratovich Victor , Leonova Tatiana , Sosedkova Alexandra

BackgroundThe multiple endocrine neoplasia syndrome type 2 (MEN-2) is characterized by medullary thyroid cancer (MTC) as a permanent feature; the combination with pheochromocytoma and parathyroidism is referred as MEN-2a syndrome. The reason for hereditary forms of MTC is mutations in the proto-oncogene RET (RE-arranged during Transfection).The aim of the study was to establish the molecular determinants frequency of MEN-2 syndrome...

ea0073aep668 | Thyroid | ECE2021

Characteristics of medullary thyroid cancer in the Republic of Belarus and prognosis factors

Kondratovich Victor , Leonova Tatiana , Shepelkevich Alla , Dydyshka Yuliya , Sosedkova Alexandra , Chakhovich Tatsiana , Shloma Alina , Smirnov Sergey , Ruksha Kseniya , Subach Alena , Portyanko Anna

BackgroundMedullary thyroid cancer (MTC) is a calcitonin-producing C-cell tumor and accounts about 5% in the structure of thyroid malignancies. There are sporadic and hereditary variant of MTC, which is a mandatory component of endocrine neoplasia syndrome type 2. The aim of the study was to determine the relationship between the aggressiveness of the clinical course of MTC and demographic characteristics.Materials and methods<...

ea0073aep669 | Thyroid | ECE2021

Clinical and laboratory features of patients with medullary thyroid cancer in the Republic of Belarus

Shepelkevich Alla , Kondratovich Victor , Leonova Tatiana , Dydyshka Yuliya , Sosedkova Alexandra , Chakhovich Tatsiana , Shloma Alina , Smirnov Sergey , Ruksha Kseniya , Subach Alena , Portyanko Anna

BackgroundThe management of patients with medullary thyroid cancer (MTC) has an important endocrinological aspect, because MTC can be a manifestation of multiple endocrine neoplasia syndrome (MEN), a genetically determined pathology with an autosomal dominant inheritance. MEN-2 syndrome is characterized by of MTC as a permanent feature, the combination with pheochromocytoma and/or adenoma of the parathyroid glands. The aim of the study was to determine t...

ea0073aep670 | Thyroid | ECE2021

Primitive thyroid Lymphoma: about two cases

Khouchaf Hajar , Essabah Haraj Nassim , El Aziz Siham , Chadli Asmaa

IntroductionPrimary thyroid lymphomas (LTP) are a rare entity, characterized by their histological and clinical heterogeneity. They represent 5% of thyroid tumors and 2% of extra-ganglionic lymphomas. We report two observations of LTP by specifying the epidemiological, diagnostic and therapeutic features.ObservationsObservation 170-year-old patient, followed in internal medicine for Sd ...

ea0073aep671 | Thyroid | ECE2021

Case report of multifocal papillary thyroid cancer in thyroglossal duct cyst.

Bilal Jajah Mohammad , Aljoied Eidhah

Papillary thyroid carcinoma is one of the important but rare differential diagnosis of midline neck masses in adults. Other causes include thyroglossal duct cyst (TGDC) which is the commonest, ectopic thyroid gland, lymph node enlargement, and dermoid cyst. We report a rare case of unusual presentation of papillary thyroid cancer in a TGDC.Case reportA 40-years-old female patient presented with a midline mass in the upper part of t...

ea0073aep672 | Thyroid | ECE2021

Side-effects of calcitonin stimulation tests with calcium gluconate

Baetu Mara , Olariu Cristina , Nitu Ileana , Moldoveanu Gabriel , Corneci Cristina , Badiu Corin

IntroductionOver time, different substances and protocols have been used and tested for stimulating calcitonin (CT). Some of them proved to be useful in diagnosing medullary thyroid carcinoma (MTC). However, these are associated with side-effects, with various duration, intensity and severity.ObjectiveTo report the side-effects observed during CT stimulation test with calcium (Ca) gluconate.<p class="abst...

ea0073aep673 | Thyroid | ECE2021

Graves’ disease with spontaneous resolution following ocrelizumab in primary progressive multiple sclerosis

Borges Duarte Diana , da Silva Ana Martins , Freitas Claudia , Cardoso1 Maria Helena

Introduction Immune reconstitution therapies (IRT), which include antibody-based cell-depleting therapies targeting CD52+ (alemtuzumab) or CD20+ (rituximab, ocrelizumab) leukocytes, are approved for the treatment of multiple sclerosis. Thyroid autoimmunity is a common adverse effect of alemtuzumab treatment, Graves' disease being the most prevalent manifestation. To date, thyroid autoimmunity events have not been reported with CD20 targeting monoclonal a...

ea0073aep674 | Thyroid | ECE2021

A case of thyrotoxic periodic paralysis induced by super-stimulation of na–k–atpase in a competitive bodybuilder with thyrotoxicosis factitia.

Bonnar Clare , Brazil John , Finucane Francis

Thyrotoxic periodic paralysis (TPP) is a rare endocrine emergency where early diagnosis of both hypokalaemia and thyrotoxicosis are vital to allow prompt treatment to prevent life-threatening complications and prevent recurrences. We present the first reported case of TPP in which four known stimulants of Na–K–ATPase acted simultaneously to produce profound hypokalaemia. A 32 year-old competitive body-builder took thyroxine supplements & a long-acting β2 ago...

ea0073aep675 | Thyroid | ECE2021

Multiple endocrine neoplasia type 2a (men 2a) case with bilateral medullary thyroid carcinoma and papillary thyroid carcinoma presentation

Suat Demir Ahmet , Tufekci Damla , Emur Gunay Yasemin , Coskun Hulya , Ucuncu Ozge , Cuneyt Bilginer Muhammet , Nuhoglu Irfan , Kocak Mustafa

IntroductionMEN 2A is an autosomal dominant disease, a familial syndrome with a mutation at RET proto-oncogene. %25 of medullary thyroid carcinoma (MTC) is a part of MEN 2A. Herein, we presented a patient with MEN 2A who was found to be heterozygos for RET mutation cause of the association of MTC and papillary thyroid carcinoma (PTC) is very rare.Case63 year old patient was admitted to the endocrinology clini...

ea0073aep676 | Thyroid | ECE2021

Rare association of two primary carcinomas: papillary and pulmonary thyroid, due to a BRAF mutation

Khamal doghri Sohaib , Echchad Lamya , Rifai Kaoutar , Iraqi Hind , Gharbi Mohamed el Hassan

IntroductionThe coexistence of pulmonary adenocarcinoma and papillary carcinoma of the thyroid is a rare event. The relationship between these two cancers is still unclear; Far from being a coincidence, it’s most often attributed to a genetic mutation (of which that of BRAF’s the most common). The management must focus on the most aggressive carcinoma. In this case, it’s pulmonary adenocarcinoma since the latter carcinoma is known for its ...

ea0073aep677 | Thyroid | ECE2021

Importance in monitoring and treatment of thyroid cancer with new third-generation thyroglobulin assays

Lopez-Martos Aurora , Miguel-Angel Ruiz-Gines , Elena De-Rafael-Gonzalez , Fuentes-Bullejos Patricia , Fernando Sanchez-Escribano-Del-Palacio , Elena Valera-Nuñez , Maria-Carmen Lorenzo-Lozano , Agudo-Macazaga Mercedes

IntroductionUp by 30% of patients have recurrence in the first years after treatment of differentiated thyroid cancer (DTC) so it is necessary to have highly sensitive assays that allow adequate long-term follow-up. Nowadays, the measurement of serum thyroglobulin (Tg) is used as a tumor marker to monitoring DTC and must be determined along with levels of antithyroglobulin antibodies, since they can interfere in Tg immunoassays. Therefore, it is recommen...

ea0073aep678 | Thyroid | ECE2021

COVID-19: a new trigger of subacute thyroiditis in pregnant women?

Kostitska Iryna , Basyuga Iryna , Piddubna Antonina , Zhurakivska Olga , Zhurakivskiy Viktor

IntroductionRecently, there has been an increasing number of reports about subacute thyroiditis (SAT) developing after COVID-19. SAT and transient gestational thyrotoxicosis constitute the majority of emerging thyrotoxicosis during pregnancy.Case reportA 27-year-old, 34-week pregnant women complained of pain in a very small area on the anterior side of her neck and fatigue. Thyroid function tests performed fo...

ea0073aep679 | Thyroid | ECE2021

Subacute thyroiditis cases increasing in pandemic: 2 cases of covid-19 associated subacute thyroiditis

Derya Sema Yaman Kalender , Gonca Oruk Guzide , Karakus Dilek

ObjectiveSubacute thyroiditis (SAT) was first described by Fritz De Quervain in 1904 and is generally a self-limiting disease causing pain, fever and temporary hyperthyroidism. It generally develops as a result of postviral inflammatory response following viral upper respiratory tract infections, and it has increased since the covid-19 pandemic in March 2020. We aim to present 2 SAT cases associated with COVID-19.Case Summary<p...

ea0073aep680 | Thyroid | ECE2021

Benign and malignant thyroid pathology in Albanians living in the Genoa district, Italy: a comparison with data from the Tirana district, Albania

Teliti Marsida , Akshija Ilir , Osmani Migena , Ferone DIego , Giusti Massimo

BackgroundIn Liguria, a region of north-western Italy, the Albanian population is currently estimated to be around 20 000, constituting 15% of foreign citizens living in this area; approximately 50% of these Albanians reside in the Genoa district.MethodsWe retrospectively reviewed the medical records of all the outpatients of the Endocrine Unit of San Martino Polyclinic Hospital from 2002 to 2019. Data on sub...

ea0073aep681 | Thyroid | ECE2021

Thyroid function in adults with Prader-Willi syndrome.

Pellikaan Karlijn , Snijders Fleur , Rosenberg Anna , Sjoerd van den Berg , Aart Jan Van der Lely , De Graaff Laura

IntroductionPrader-Willi syndrome (PWS) is a complex genetic syndrome in which hypothalamic dysfunction leads to hyperphagia and pituitary hormone deficiencies (PHD), among others. The majority of patients have intellectual disability (ID) and use of psychotropic drugs is frequent. Due to hypotonia and the low muscle mass associated with the syndrome, adults with PWS have a low basal metabolic rate (BMR). Combined with hyperphagia, this results in high r...

ea0073aep682 | Thyroid | ECE2021

Relationship between vitamin D status and metabolic parameters in premenopausal women with autoimmune hypothyroidism

Chukur Oksana

BackgroundVitamin D deficiency is a global health problem. Nowadays is intensively studied the influence of vitamin D on the course of autoimmune diseases of the thyroid gland.ObjectiveTo study the relationship between vitamin D status and metabolic parameters in premenopausal women with autoimmune hypothyroidism.Methods146 premenopausal women with autoimmune hypo...

ea0073aep683 | Thyroid | ECE2021


ea0073aep684 | Thyroid | ECE2021

Prevalence of thyroid dysfunction in untreated chronic hepatitis C

Mazur Lyudmyla

In Ukraine, in 2017, an estimated 53000 people were living with chronic hepatitis C virus (HCV) infection, and its prevalence rate was 123.7 patients per 100000 citizens. Symptoms of at least one extra hepatic manifestations appear in more than 50% of HCV-positive patients, and thyroid abnormalities are rather common. The purpose of the study was to determine the prevalence of thyroid function tests and anti-thyroid autoantibodies abnormalities in the untreated patients with c...

ea0073aep685 | Thyroid | ECE2021

Iodized salt is sufficient to obtain an adequate nutritional status of iodine in pregnant woman

Silvia González Martínez , Ana Isabel Escudero Gomis , Delgado Elias , Edelmiro Luis Menendez Torre

IntroductionIodine is an essential micronutrient used by the thyroid gland to produce thyroid hormones. Iodine deficiency during pregnancy is related to impaired neurocognitive development of fetus and neonate. The WHO recommends iodization of salt as main measure to prevent iodine deficiency disorders. In pregnant population other international organizations recommend the use of iodine supplements to guarantee adequate nutritional status of iodine (medi...

ea0073aep686 | Thyroid | ECE2021

Comparison of body composition and insulin sensitivity changes in patients with Graves disease after radioiodine or antithyroid drugs treatment

Ewa Szczepanska , Glinicki Piotr , Wojciech Zgliczynski , Helena Jastrzębska , Jadwiga Slowinska-Srzednicka , Renata Kapuścinska , Stefan Zgliczynski , Malgorzata Gietka-Czernel

Thyroid hormones (TH) are key regulators of basal metabolic rate and body weight. They increase resting energy expenditure by increased synthesis of uncoupling protein-1 (UCP-1) in brown adipocytes which stimulates energy dissipation as a heat. TH also increase appetite by central adrenergic stimulation. Body weight change is a key symptom of thyroid dysfunction especially the weight gain observed in patients treated for hyperthyroidism AIM: To compare the influence of differe...

ea0073aep687 | Thyroid | ECE2021

Interconnection between obesity, thyroid function, insulin resistance, and cardiovascular risk factors in patients with subclinical hypothyroidism

Yevstratieva Yuliia

Background and aimThe epidemic of overweight and obesity presents a major challenge to chronic disease prevention and health across the life course around the world. The putative relationships between thyroid hormones, body weight, and adipose tissue homeostasis have been the focus of several studies in recent years, but the causal relationships between these parameters have not been well established. Aim of the study: to investigate the relations...

ea0073aep688 | Thyroid | ECE2021

Acoustic radiation force impulse elastography findings of achilles tendon in patients with hypothyroidism

Hale Turnaoğlu , Feride Pınar Altay , Feride Kural Rahatlı , Bozkus Yusuf , Iyidir Ozlem , Murat Haberal Kemal

IntroductionThere are very limited number of clinical studies and data on the effect of thyroid dysfunction in hypothyroidism on connective tissue. Tendinitis can be the first complaint in hypothyroidism and symptomatic relief can be provided with the appropriate treatment of primary thyroid deficiency. There are studies, showed softening in Achilles tendon with age, in patients with intermittent claudication, diabetes patients, and chronic kidney failur...

ea0073aep689 | Thyroid | ECE2021

The SARS-CoV-2 infection and thyroid disorders: review on the literature

Dabrowska Anna , Dudka Jaroslaw

IntroductionCoronavirus disease (COVID-19) caused by SARS-CoV-2 infection, resulted in serious respiratory and other systemic complications, has spread worldwide since December 2019. In patients with the infection, many organ systems can be involved with potentially fatal results due to robust and disorganized systematic immune activation.The state of the artSince the outbreak of the SARS-CoV-2 pandemic, many...

ea0073aep690 | Thyroid | ECE2021

LOW calcium level and thyroid diseases

Tare Rajmonda

BackgroundThe thyroid gland helps regulate the calcium levels in the body. It produces the hormone calcitonin that works by decreasing the available amount calcium in the bloodstream. When the thyroid gland is disrupted, calcium concentrations in the body can be affected as well. It is important that those with thyroid disorders be treated to prevent the effects of hipocalcemia.AimThe objective of this study ...

ea0073aep691 | Thyroid | ECE2021

Hypocalcemia post total thyroidectomy : incidence and management

Abir Meherzi , Mallat Amany , Belaid Takwa , Wassim Kermani , Bellakhdhar Mouna , Mohamed Abdelkefi

GoalsThe most common complication of thyroidectomy is hypocalcaemia. The aim of this work is to determine the epidemiological, ethiopathogenic and therapeutic characteristics of hypocalcemia after total thyroidectomy.Material and methodsThis is a retrospective study of 27 cases of patients operated on for a total thyroidectomy complicated by hypocalcemia, over a period of 9 years (2009–2017) collected by...

ea0073aep692 | Thyroid | ECE2021

Amiodarone-induced thyrotoxicosis in children: a clinical case

Ivannikova Tatiana , Kalinin Alexey , Strebkova Natalia , Kareva Maria , Bezlepkina Olga

IntroductionAmiodarone is a drug commonly used for the treatment of refractory atrial or ventricular arrhythmias. In 20% of patients, amiodarone may cause subclinical or clinically overt hypothyroidism or hyperthyroidism. The high iodine exposure caused by amiodarone treatment interferes with thyroid autoregulation. Two underlying mechanisms are considered to be involved in the pathogenesis of amiodarone-induced thyrotoxicosis (AIT). AIT1 is more common ...

ea0073aep693 | Thyroid | ECE2021

The value of serum thyroglobuline alteration after ultrasonography-guided fine-needle biopsy of suspicous cervical lymph nodes in the diagnosis of metastasis in patients with differentiated thyroid cancer

Dilek Dellal Fatma , Aydin Cevdet , Ali Tam Abbas , Faki Sevgul , Alkan Afra , Şefika Burçak Polat , Dirikoc Ahmet , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

AimIt is known that serum thyroglobulin (TG) can increase after fine-needle biopsy of thyroid nodules. We aimed to determine whether TG is increased after ultrasonography guided fine needle capillary biopsy (FNC) of suspicious cervical LNs in thyroidectomized patients and investigate the possible association between change in TG and cytology results.Material and methodsData of 188 patients who underwent FNC o...

ea0073aep694 | Thyroid | ECE2021

Predictive factors of thyroid differentiated cancers

Masmoudi Mohamed , Wadii Thabet , Guizani Rihab , Hasnaoui Mehdi , Khalifa Mighri

IntroductionThyroid nodules are common. They are mostly benign nodules. Thyroid cancer is rare: 1 % of all cancer sites. Thyroid differentiated cancers are the most common histologic types. There are several factors that can predict the malignancy in patients with thyroid nodule. The purpose of this study is to identify the predictive factors of thyroid differentiated cancers.Material and methodsThis retrospe...

ea0073aep695 | Thyroid | ECE2021

-Systemic erdheim-chester disease associated with braf-positive papillary thyroid carcinoma

Ilie Iuliana , Francois Emile Jean , Chereau Natalie , Haroche Julien , Buffet Camille , Deniziaut Gabrielle , Constantin Teodor , Bercu Bogdan , Oprea Luciana , Banica Andreea , Musat Madalina

Erdheim-Chester disease (ECD) is a rare histiocytic neoplasm with distinctive clinical and immunophenotypic features, involving somatic mutations of BRAF and activation of MAPK pathway. Other BRAF mutated neoplasms such as papillary thyroid carcinoma (PTC), may also occur synchronous with EDC. There are several reports in the literature of concurrent Langerhans Cell Histiocytosis (LCH) and PTC which suggests that the association is not random, howeve...

ea0073aep696 | Thyroid | ECE2021

Multiple etiology pericardial effusion in a young woman

Alexandra Pirga Iulia , Lucian Popescu Marius

ContextSevere hypothyroidism and Systemic Lupus Erythematosus can both be causes for the development of pericarditis with concomitant pericardial effusion.Case illustrationWe report the case of a 23 year-old woman admitted in the ER for progressive dyspnoea, increasing fatigue and peripheral edema, associated with hepatosplenomegaly and polyadenopathy. Transthoracic echocardiogram confirmed sever...

ea0073aep697 | Thyroid | ECE2021

Pembrolizumab as definitive treatment for persistence of Graves’s disease: a case report

Tsiberkin Alexandr , Kravchuk Olga

BackgroundThe usage of Immune checkpoint inhibitors such as pembrolizumab grows over time due to their positive effect on survival and quality of life in patients with advanced cancer. The frequency of immune-related adverse events (IRAEs) associated with this drugs grows over time accordingly. Several endocrine-IRAEs of pembrolizumab are described in the literature and the thyroid disfunction is the most common.Case description</p...

ea0073aep698 | Thyroid | ECE2021

Central hypothyroidism under Bexarotene: a significant side effect.

El Hadadi Farah , Mhamdi Zineb , Benzekri Laila , Senouci Karima

IntroductionRetinoids are a class of molecules, structurally related to Vitamin A, used in various disorders of keratinization (acne, psoriasis, ichthyosis, etc.). these molecules bind two families of Retinoid Nuclear Receptors (RNR): the RA receptors (RAR), which natural ligand is retinoic acid, and the Retinoid X Receptors (RXR), which natural ligand is 9-cis-retinoic acid. Among synthetic retinoids, isotretinoin, acitretin, tazarotene and ada...

ea0073aep699 | Thyroid | ECE2021

Pembrolizumab induced Thyrotoxicosis in patient with bladder cancer

Heard Francesca , Abdelgader Yagoub , Aarella Vikram G.

BackgroundPembolizumab is a highly specific, monoclonal antibody directed against the programmed cell death receptor, PD-1 and its ligand PD-L1. It is licenced as an immunotherapy for use in locally advanced or metastatic urothelial cell carcinoma, amongst other malignancies. Whilst rare, endocrinopathies, including thyroid dysfunction, are recognised side effects of immunotherapy such as Pembroluzimab. However, hyperthyroidism is much less common than h...

ea0073aep700 | Thyroid | ECE2021

Factitious thyrotoxicosis, a diagnostic challenge

José Abuín Fernández , Viyey Kishore Doulatram Gamgaram , Pineda Cantero Araceli , Ignacio Ruíz García , Olveira Fuster Gabriel

IntroductionThe term factitious thyrotoxicosis is defined as an excess of thyroid hormone in the body caused by the ingestion of exogenous thyroid hormone. It can be intentional, usually in patients with psychiatric disorders, or accidentally. Another possible cause is the inappropriate use of thyroid hormone for the treatment of obesity, depression or infertility.Case reportWe present the case of a 32-year-o...

ea0073aep701 | Thyroid | ECE2021

Grave’s disease in a patient with thyroid hemiagenesis

Jane Pang Eleanor , Aminath Aifa Aboobakuru1 , Sardar Muhammad Shoaib Khan1 , Larsen Niels

IntroductionWe present the case of a 50-year-old lady who was referred to the endocrine clinic with a clinical and biochemical picture suggestive of severe thyrotoxicosis. CT scan of thorax, abdomen and pelvis (CT TAP) was performed to rule out malignancy, which showed left lobe agenesis.Case50-year-old lady presented to the GP with hyperhidrosis and unintentional weight loss. She also reported symptoms of le...

ea0073aep702 | Thyroid | ECE2021

Management of Graves’s disease during pregnancy in Covid-19 pandemic conditions - case presentation

Hassan Mervat , Golu Ioana , Vlad Mihaela

IntroductionThe global pandemic caused by the SarsCov2 virus has brought great challenges to the medical system, the management of some cases, especially for those belonging to risk categories, such as pregnant women, being often difficult in this context. Telemedicine has been used frequently during this period, facilitating reducing patient’s risk for exposure to COVID-19, providing continuous support, and coordinating the necessary services to pr...

ea0073aep703 | Thyroid | ECE2021

Collision tumor of the thyroid: follicular thyroid carcinoma plus metastatic renal cell carcinoma

Cristina Elías Ortega , Venegas Nebreda Inmaculada , Maria Teresa Aramburu Calafell , Nerea Egaña Zunzunegui , Bilbao Garay Ismene , Garcia Delgado Cristina , Aguirre Echevarria Pablo , Rojo Alvaro Jorge , Yoldi Arrieta Alfredo , Miguel Maria Goena Iglesias

IntroductionThe term collision tumor refers to the coexistence of two histologically distinct malignant neoplasms. The two malignancies can originate from the same organ or occur as metastases from other regions. This type of tumors involving the thyroid gland are especially rare. Reported cases are usually involving papillary thyroid carcinomas in coexistence with other types of tumors like medullary carcinoma, follicular carcinoma or metastasic disease...

ea0073aep704 | Thyroid | ECE2021

Anxiety is more common than depression in indian subjects with recently diagnosed mild subclinical hypothyroidism

Talwa Vipan , Talwar Gourav

BackgroundWith the availability of sensitive and accurate TSH assays, the entity of Mild Subclinical hypothyroidism (SCH) is being diagnosed more frequently in clinical practice. A variety of neuropsychiatric and cognitive complications have been noted in hypothyroid patients but there is a dearth of literature on the psychopathology associated with mild SCH. Objective- This study was undertaken to determine ...

ea0073aep705 | Thyroid | ECE2021

Graves’ disease and isolated langerhans cell histiocytosis, a rare case presentation

Emre Uzun Yusuf , Eroglu Ersan , Kayikci Omur , Ersozlu Ilker , Suheda Hatipoglu Esra

IntroductionLangerhans cell histiocytosis (LCH) is a rare monoclonal disease characterized by abnormal proliferation and accumulation of bone marrow-derived Langerhans cells in various tissues. Heterogeneous collections of Langerhans cells with neutrophils, lymphocytes, eosinophils, histiocytes and Birbeck granules are observed in biopsy materials. Endocrinologic features of LCH are usually due to posterior pituitary involvement. Thyroid infiltration is ...

ea0073aep706 | Thyroid | ECE2021

Awareness of EUGOGO guidelines and attitudes regarding smoking in Graves’ orbithopathy in Croatia

Maja Baretić , Jelena Juri Mandić , Sanja Kusačić Kuna , Gudelj Lara , Marija Radić , Zlatar Mirna

BackgroundIn 2008 EUGOGO (European group on Graves’ orbitopathy) published consensus statement on the management of Graves’ orbitopathy (GO) that was widespread ever since. Having in mind unknown general perception and practical usage of the statement amongst Croatian clinicians, we conducted a survey evaluating the awareness and practical usage of the EUGOGO guidelines among physicians treating Graves’ disease in daily practice. Also, the...

ea0073aep707 | Thyroid | ECE2021

Genetic investigation of thyroid dyshormonogenesis in a Tunisian consanguineous family

Safi Wajdi , Hadj Kacem Faten , Charfi Hana , Mnif Feki Mouna , Abid Mohamed , Bougacha-Elleuch Noura

We aimed to identify causal mutation(s) in 2 patients (P1 and P2) with thyroid dyshormonogenesis (TD) from a consanguineous Tunisian family. Patient P1 developed TD at age 10; while P2 developed it at a late age (30 years) with no goiter. Scintigraphy showed homogeneous uptake of 131I in P1 patient. Genetic analysis was performed using candidate gene approach. Thus, sequencing of the 17 exons of the TPO gene revealed only presence of rs4927611 polymorphism ...

ea0073aep708 | Thyroid | ECE2021

Surgical treatment of Graves’ disease in children and adolescents

Masmoudi Mohamed , Marwa Regaig , Wadii Thabet , Hasnaoui Mehdi , Khalifa Mighri

IntroductionGraves’ disease is the most common cause of hyperthyroidism in children and adolescents. Treatment strategy includes antithyroid drugs, radioactive iodine and thyroidectomy. The optimal treatment of Graves´ disease is still controversial. Our aim is to describe the surgical treatment of Graves’s disease in children and adolescents.Material and methodsWe report the clinical, therapeu...

ea0073aep709 | Thyroid | ECE2021

Antithyroid drugs as treatment of neutropenia in hyperthyroidism

Essayeh Sawsen , Jemel Manel , Chatti Hiba , Madhi Wiem , Gharbi Radhouane , Kandara Hajer , Kammoun Ines

IntroductionHematological abnormalities are frequently observed in hyperthyroidism and are part of complex, multifactorial pathogenetic mechanisms that are still poorly understood, which can affect the three hematopoietic lineages in isolation or in combination. For the endocrinologist, they raise the issue of the risk of their aggravation under the hamatotoxic effect of antithyroid drugs (ATDs).Case presentation<p class="abste...

ea0073aep710 | Thyroid | ECE2021

Thyroglobulin and thyroglobulin antibody measurements in the follow-up of differentiated thyroid cancer: practical implications for laboratories illustrated by means of a new highly sensitive thyroglobulin assay

Schoonen Lise , Neele Marjolein , van Toor Hans , van Kinschot Caroline , van Noord Charlotte , Visser Edward , Sjoerd van den Berg , Snježana Kos

IntroductionMeasurements of thyroglobulin (Tg) and Tg antibodies play a crucial role in the follow-up of treated differentiated thyroid cancer (DTC) patients, for instance to determine the response to therapy and the use of additional investigations and therapies. The aim of this study was to explore, from a laboratory perspective, the practical implications of the substantial clinical role of these measurements being imposed by national and internationa...

ea0073aep711 | Thyroid | ECE2021

Follicular epithelial dysplasia of the thyroid gland on the background of Hashimoto Thyroiditis

Gvianishvili Tamuna , Gogiashvili Liana

Morphologically, the follicular cells of the thyroid gland on the background of chronic lymphocytic (Hashimoto) thyroiditis may exhibit atypical changes in the nucleus, expansion of the nucleus, crowding, irregularities of nuclear membranes, intranuclear grooves and purification of chromatin. Also be observed proliferative foci of thyroid follicular cells with follicular epithelial dysplasia (FED) were as presumed premalignant conditions in chronic lymphocytic thyroiditis. The...

ea0073aep712 | Thyroid | ECE2021

Covid 19 associated with diabetes mellitus tip 2 and hyperthyroidism in one doctor patient

Rrupulli Anila , Xega Viktoria

SARS-CoV2 can induce multiple immunological and endocrinological changes. Diabetes and thyroid disorders tend to coexist in patients. Both conditions involve a dysfunction of the endocrine system. Thyroid disorders can have a major impact on glucose control. On one hand, thyroid hormones contribute to the regulation of carbohydrate metabolism and pancreatic function, and on the other hand, diabetes affects thyroid function tests to variable extents. SARS-CoV-2 uses ACE2 recept...

ea0073aep713 | Thyroid | ECE2021

A male patient with subacute thyroiditis after COVID-19 infection

Carolina Chaves , Carolina Vidal , João Anselmo

IntroductionSubacute thyroiditis is a rare cause of thyrotoxicosis arising in the context or following viral infections. This disorder is more frequent in women than in men (male/female ratio of 1:4). In addition to respiratory symptoms, the SARS-CoV-2 infection (COVID-19) has been associated with extrapulmonary manifestations. Herein we report a male patient with hyperthyroid symptoms starting four-week after a positive test for COVID-19.<p class="a...

ea0073aep714 | Thyroid | ECE2021

Thyroid disease in insulin- treated type 2 diabetes mellitus

Khalaf Rahma , Hadj Ali Zohra , Htira Yosra , Ben Mami Faika

Background and aimAbundant evidence suggests an association between thyroid disease and type 2 diabetes mellitus (T2DM). To determine the interaction between these co-existing pathologies, we analyzed insulin-treated type 2 diabetes patients with diagnosed thyroid disease.Patients and methodsThis retrospective study was performed in 54 type 2 diabetes patients who had been admitted for insulin-treatment and d...

ea0073aep715 | Thyroid | ECE2021

Voluminous primary mediastinal multinodular goiter as a rare cause of hyperthyroidism.

Kardi Asma , Oueslati Ibtissem , Chaker Fatma , Znaidi Nadia , Sadok Boudaya Mohamed , Yazidi Meriem , Chihaoui Melika

IntroductionPrimary mediastinal goiter is an extremely uncommon entity. The majority of primary mediastinal goiters were reported as incidental findings on chest imaging of asymptomatic patients. Symptoms related to compression of adjacent structures and hyperthyroidism were rarely described. Herein we report a case of subclinical hyperthyroidism secondary to a primary mediastinal goiter.ObservationA 50 year-...

ea0073aep716 | Thyroid | ECE2021

Pattern of autoimmune thyroid disease among patients with goitre at a tertiary hospital, lagos nigeria

Diyaolu Funmilayo

IntroductionThyroid disorders are second largest endocrine condition seen in clinics. The most common manifestation of thyroid dysfunction is the appearance of goitre. The elimination of iodine deficiency as a cause of goitres decades ago has demanded a closer look into autoimmune aetiology of thyroid disease in our population. The characteristic features of these autoimmune goitres: Graves’ Disease (GD) were also explored in this study. The finding...

ea0073aep717 | Thyroid | ECE2021

Thyroid carcinoma in cowden syndrome

Khelil Nour El Houda , Sidi Mohammed Meghelli

Cowden’s syndrome (CS), also called multiple hamartoma syndrome is an orphan pathology which associates pathognomonic cutaneous-mucosal manifestations with multiple and disseminated hamartomas (skin, mucous membranes, gastrointestinal tract, thyroid, breasts and genitourinary system) and an increased risk of the development of certain malignant tumors, in particular breast, thyroid and endometrial tumors, which are very serious.Observation<p cla...

ea0073aep718 | Thyroid | ECE2021

Primary diffuse B-cell thyroid lymphoma: A case report

Majdoub Marwa , Rojbi Imen , Adel Meriem , Besrour Chayma , Youssef Lakhoua , Mchirgui Nadia , Ben Nacef Ibtissem , Karima Khiari

IntroductionPrimary thyroid lymphoma (PTL) is a rare affection that represents only 1% to 5% of thyroid malignancies and 1% to 2% of extranodal lymphomas. It involves by definition only the thyroid gland and adjacent neck lymph nodes, at diagnosis.Case presentation:A 65-year-old woman with a controlled Hashimoto’s thyroiditis presented with a 12-month history of painless neck swelling, recently increasin...

ea0073aep719 | Thyroid | ECE2021

Medullary thyroid carcinoma development five years after thyroidectomy for benign non-toxic goiter

Nonchev Boyan , Argatska Antoaneta , Dimov Rosen , Chonov Veselin

Total thyroidectomy is the preferred surgical procedure in patients with high-grade multinodular goiter. The necessity for long-term neck ultrasound (US) surveillance after thyroidectomy for benign diseases remains unclear as the risk of recurrence is very low. However, in a minority of patients a thyroid neoplasm could arise from very small thyroid remnants. We report a case of a 65-year-old female who underwent thyroidectomy for nontoxic multinodular goiter in 2013. Histolog...

ea0073aep720 | Thyroid | ECE2021

Post covid-19 myxedema a case report

Naser Islam , Abushady Manal , Eid Yara , El Halawany Salah , Nesim Mina , Amir Marina , Eldepp Mona , Talaat Amany , Girgis Diana , Mahmoud Riham , Adel Mena

A 65 year old female presented to ER with progressive massive lower limb oedema and dyspnea on mild exertion of insidious onset. The patient started to complain of progressive lower limb oedema shortly after her discharge from Hospital ICU in June 2020 where she was being treated for severe COVID-19. She presented then with acute kidney injury, generalized oedema and was diagnosed with COVID-19 based on clinical, laboratory criteria, PCR, and CT findings. She is a known patien...

ea0073aep721 | Thyroid | ECE2021

A novel DUOXA2 mutation in russian family with thyroid dysgenesis

Shreder Ekaterina , Vadina Tatiana , Bezlepkina Olga

BackgroundDUOXA2 mutations in patients with congenital hypothyroidism (CH) was first described in 2008 as rare cause of CH. mRNA of DUOXA2 is expressed predominantly in thyroid and less in salivary glands. Human DUOXA2 gene is located on 15q21.1 and inherited in an autosomal recessive pattern. In most cases DUOXA2 gene mutations were described in patients with thyroid dishormonogenesis. Last investigations conferred <e...

ea0073aep722 | Thyroid | ECE2021

A prospective study of anesthetic risk and anesthesia particularities under thyroidectomies in thytoxocosis patients

Tarasenko Sergii , Dubrov Sergii , Yefimova Olena , Suslov Gennadii , Rudenko Vasylyna

Objectives.A prospective study to analyze anesthetic risks and anesthesia particularities in thyrotoxicosis syndrome (TTS) patients who were undergone thyroidectomy.Materials.It was analyzed 880 operated the TTS patients. Surgical interventions were performed under general anesthesia with mechanical ventilation by using the inhalation anesthesia (IA) with sevoflurane in 698 (79.3%) patients, by the total intr...

ea0073aep723 | Thyroid | ECE2021

Thyroid morphologic characteristics assessment in a cohort of patients with different glucose tolerance status

Gagliardi Irene , Dinatolo Elisa , Franceschetti Paola , Mella Alessandro , Lupo Sabrina , Chiara Zatelli Maria

BackgroundThyroid diseases and diabetes are the two most common endocrinopathies. A relationship between these two conditions is suggested by many studies, as diabetic population seems to present increased thyroid impairment. However, clinical data are still very sparse.AimTo evaluate thyroid morphologic characteristics among patients with different glucose tolerance status.Material and...

ea0073aep724 | Thyroid | ECE2021

Post-operative resistant hypothyroidism of Graves’ disease patient resistant to anti-thyroid treatment

Emur Gunay Yasemin , Tufekci Damla , Ahmet Suat Demır , Cuneyt Bilginer Muhammet , Coskun Hulya , Nuhoglu Irfan , Ucuncu Ozge , Kocak Mustafa

IntroductionGraves’ Disease resistance to anti-thyroid treatment and poor treatment compliance with levothyroxine treatment (pseudomalabsorption) are not common conditions. We presented this case because of the inability to provide euthyroidism with anti-thyroid treatment before the surgery and with levothyroxine after the surgery in the same patient.Case ReportA 24-year-old female patient was admitted w...

ea0073aep725 | Thyroid | ECE2021

Vitamin D deficiency and Hashimoto’s thyroiditis

Roman Gimeno Sergio , Urdaniz Borque Rosana , Elena Pérez Galende , Borja Sanz Martín , Jose Jorge Ortez Toro

IntroductionThe main role of vitamin D is regulating bone metabolism, but over the past years, the importance of vitamin D in non-skeletal actions has been studied. Vitamin D deficiency is very common in our environment. This deficit has been associated with higher risk of many chronic diseases, such as osteoporosis, hypertension, diabetes and even obesity. Recent evidence has demonstrated an association between low vitamin D status and autoimmune thyroi...

ea0073aep726 | Thyroid | ECE2021

Proposal of a predictive scoring system for the accurate diagnosis of Hashimoto’s thyroiditis

Bhargav Panchangam Ramakanth , Mayilvaganan Sabaretnam , Bangariahgari Ramesh , Bangaraiahgari Rajesh , Md Rafi , Reddy Banala Rajkiran

BackgroundThe protean and non-specific nature of diagnostic criteria of Hashimoto’s thyroiditis leads either to overdiagnosis or underdiagnosis. The aim of this study is to propose a comprehensive diagnostic scoring system based on objective clinic-investigative criteria.MethodsA case-control study of patients who underwent surgical thyroidectomy, were compared a with a set of clinical, biochemical, path...

ea0073aep727 | Thyroid | ECE2021

The impact of treatment adherence on the control of the thyroid function in Hashimoto’s thyroiditis patients

Besrour Chayma , Yazidi Meriem , Oueslati Ibtissem , Khessairi Nadia , Grira Wafa , Chaker Fatma , Chihaoui Melika

Hashimoto’s thyroiditis (HT) is a chronic disease that needs a daily substitution by thyroid hormones. The purpose of this study was to assess the level of therapeutic adherence to the hormonal treatment in HT patients and its impact on the thyroid function control.MethodsIt is a cross sectional study including 43 patients treated for hypothyroid Hashimoto’s thyroiditis by levothyroxine (LT4). The patient adherence to tre...

ea0073aep728 | Thyroid | ECE2021

A case of Graves’ disease (GD) associated with HIV disease and late immune reconstitution inflammatory syndrome (IRIS) following initiation of antiretroviral therapy (ART)

Ludgate Stephen , P Connolly Stephen , Fennell David , McQuaid Siobhan

GD following ART occurs rarely, in 3% of HIV-infected women1. It is suggested that CD4 cells increase in a biphasic pattern following ART initiation, with the expansion of naïve CD4 cells following months after the initial redistribution of memory CD4 cells from lymphoid tissue2. A 40-year-old Brazilian lady was diagnosed with HIV in late 2016 following admission with cryptococcal meningitis and salmonellosis, requiring treatment with anti-fungal age...

ea0073aep729 | Thyroid | ECE2021

A case report of ectopic thyroid gland with Hashimoto’s thyroiditis

Bilal Jajah Mohammad , Alharthi Maryam

IntroductionEctopic thyroid gland (ETG) is a rare developmental disorder, and when occurs in the midline of the neck, it mimics the clinical presentation of thyroglossal duct cyst (TGDC). inadvertent surgical removal of ETG simulating TGDC has been reported in the literature in spite of the modern diagnostic methods for this pathology.1, 2. We report a case of a 27-year-old female with Hashimoto’s thyroiditis of ectopic thyroid in whom a ...

ea0073aep730 | Thyroid | ECE2021

Intravenous thyroxine administration in hospitalized patients, a common but unreported practice: A single institution recent experience

Tordjman Karen , Bishouty Nancy , Greenman Yona

BackgroundIntravenous levothyroxine (IVT4) is FDA-approved for the treatment of myxedema coma (ME). We noticed that at our hospital, IVT4 is administered more frequently than expected.Aim of studyTo assess the extent of IVT4 administration, the indications for such a treatment, and its outcome at a tertiary facility.MethodsA retrospective study of IVT4 administere...

ea0073aep731 | Thyroid | ECE2021

Hypothyroidism in the elderly: clinical and therapeutic aspects

Kacem Faten Hadj , AbdelMouhaymen Missaoui , Cherifa Fourati , Hana Charfi , Salah Dhoha Ben , Fatma Mnif , Nadia Charfi , Mouna Mnif , Nabila Mejdoub , Mouna Elleuch , Abid Mohamed

Introduction Hypothyroidism (HT) is widespread in all age groups particularly within the increasing elderly population while its diagnosis is challenging owing to extremely varied and atypical symptoms. The objective of this study is to outline the clinical and biochemical features of HT and determine its main etiologies in a geriatric population. Methods We reviewed the medical charts of 53 patients aged 65 ...

ea0073aep732 | Thyroid | ECE2021

Pulmonary embolism and pulmonary arterial hypertension: Atypical complication of hyperthyroidism

Khouchaf Hajar , Essabah Haraj Nassim , El Aziz Siham , Chadli Asmaa

IntroductionBasedow disease is the most common etiology of hyperthyroidism; the cardiac manifestations seen in hyperthyroidism often affect people over 60 years of age, manifested mainly by sinus tachycardia, atrial rhythm disturbances or increased cardiac output. Pulmonary arterial hypertension and pulmonary embolism are atypical manifestations.Observation39-year-old patient, followed for basedow disease for...

ea0073aep733 | Thyroid | ECE2021

Endocrinologists’ choice of levothyroxine formulation in hypothyroid and euthyroid patients in the republic of belarus

Shepelkevich Alla , Dydyshka Yuliya , Yurenia Alena , Lobashova Veranika , Attanasio Roberto , Laszlo Hegedüs , Nagy Endre , Negro Roberto , Papini Enrico , Perros Petros

Background and aimsIn the Republic of Belarus treatment of hypothyroidism in the adult population is regulated by the order of the Ministry of Health dated 2013. Levothyroxine is available in tablet form (dosage in increments of 25 µg). Liothyronine are not registered in the Republic of Belarus, but patients can purchase them on their own abroad. Thus, the aim was to study of possible endocrinologists’ preferences of choosing the levothyroxine ...

ea0073aep734 | Thyroid | ECE2021

Possible causes of hypothyroidism symptoms in euthyroid patients - an endocrinologist opinion study in the republic of belarus

Dydyshka Yuliya , Shepelkevich Alla , Yurenia Alena , Elena Brutskaya-Stempkovskaya , Attanasio Roberto , Laszlo Hegedüs , Nagy Endre , Negro Roberto , Papini Enrico , Perros Petros

Background and aimsIt has been reported that some patients with hypothyroidism treated with levothyroxine continue to experience persistent symptoms despite normal serum TSH. Thus, the aim was to study of causes of hypothyroidism symptoms in euthyroid patients.Materials and methodsFrom 01.10.2020 to 26.12.2020 there was survey using THESIS questionnaire: Treatment of Hypothyroidism in Europe by Specialists: I...

ea0073aep735 | Thyroid | ECE2021

Block-replace therapy in the management of Graves’ disease

Ana-Maria Stancu , Gheorghiu Monica , Purice Mariana , Alexandrescu Daniela , Badiu Corin

IntroductionAnti-thyroid drugs (ATDs) are the first line treatment in Europe for hyperthyroidism due to Graves’ disease (GD). Adding levothyroxine to ATDs, so called block and replace therapy (BRT) is still controversial.AimTo follow up the outcomes after treating patients with Graves’ disease in a block and replace regimen.Patients & methodsA prospe...

ea0073aep736 | Thyroid | ECE2021

Nutritional status of iodine in the basque country

Alicia Martín Nieto , Isabel Benito Castaño , Urrutia Etxeberria Ines , Mercedes Espada Saenz-Torre , Arana Arri Eunate , Juan Del Olmo Sedano , Aguayo Calcena Anibal , Josep Oriol Casanovas Marsal , Gaztambide Saenz Sonia , Luis Castaño Gonzalez

BackgroundIodine is an essential nutrient necessary for the synthesis of thyroid hormones. Humans need a daily intake of 90–250 µg per day. The WHO criteria on the adequate iodine intake in the general population is: median iodine 100–199 µg/l, levels <100 µg/l in <50% of the population; <50 µg/l in <20% of the population and iodized salt consumption in >90% of households.Objectives...

ea0073aep737 | Thyroid | ECE2021

Thyrotoxic crisis induced by amiodarone therapy

Bystrianska Marianna , Bystriansky Adrian

BackgroundThyrotoxic crisis (TxC) is a medical emergency status needed rapid diagnostic a urgent treatment, presented by failure or multiorgan dysfunction. Amiodarone induced thyrotoxicosis (AIT) is one of the severe complications caused by amiodarone therapy.AimAnalysis of patients suffered from thyrotoxic crisis induced by Amiodarone therapy, with focus on clinical picture, laboratory findings and therapeut...

ea0073aep738 | Thyroid | ECE2021

Hyperparathyroidie primary & pregnancy : A case report

Amina Merrouche , Said Azzoug

IntroductionParathyroid diseases are infrequent during pregnancy, but produce significant perinatal morbidity and maternal mortality if not diagnosed and properly managed. Primary hyperparathyroidism (PHP) is a rare disease in women of childbearing age. The incidence of the disease is unknown, but it is certainly rare, and most of the reported cases have been simple supplemented by a review of the literature.Case presentation<p...

ea0073aep739 | Thyroid | ECE2021

Thyroid cancer detection in routine clinical setting-pilot study

Grimmichova Tereza , Petra Pačesová , Hill Martin , Vaclavikova Eliska , Pekova Barbora , Moravcova Jitka , Vrbikova Jana , Novak Zdenek , Sykorova Vlasta

BackgroundMost thyroid nodules are benign, but therefore it is crucial to correctly stratify the malignancy risk of nodules to avoid unnecessary invasive procedures and/or surgery, but and still identify aggressive tumors. The aim of our study was to address the potential for improvement of malignancy detection in routine clinical setting using clinical examination, risk stratification of thyroid nodules on ultrasound using the American College of Radiol...

ea0073aep740 | Thyroid | ECE2021

Medullar thyroid carcinoma in a patient with Hashimoto’s thyroiditis – A case report

Kermaj Marjeta , Haxhiraj Adela , Hoxha Violeta , Poshi Klodiana , Ylli Dorina , Elezi Edlira , Fureraj Thanas , Ylli Agron

IntroductionHashimoto’s thyroiditis (HT) has been linked to papillary carcinoma of the thyroid, Hurthle cell cancer or even lymphoma. In contrast, there are only a few reports of co-existence of HT with medullary thyroid carcinoma. The link between them is unknown. An overall prevalence of medullary carcinoma of only 0.35% has been reported in HT patients. This prevalence is higher in female rather than male. We present the case of a female patient ...

ea0073aep741 | Thyroid | ECE2021

Cardiovascular outcome in thyroid cancer patients with thyroidectomy: a systematic review and meta-analysis

Lee Eunkyung , Young Ahn Hwa , Jeong Ku Eu , Sang Yoo Won , Kee-Hyun Nam , Jun Chai Young , Yuh-Seog Jung

Thyroid dysfunction is associated with increased risk of cardiovascular disease (CVD) in general population, but it remains controversial whether the treatment of differentiated thyroid cancer (DTC) including thyroidectomy and thyroid stimulating hormone suppression add any risk of CVD compared to general population. We performed a systematic review of observational studies reporting associations between DTC and CVD in MEDLINE, EMBASE, Web of Science and other source (PROSPERO...

ea0073aep742 | Thyroid | ECE2021

Anomalous uptake of 131-iodine in an endometriosis cyst

Rita Elvas Ana , Marques Bernardo , Couto Joana , Raquel G. Martins , Santos Jacinta , Martins Teresa , Oliveira Sofia , Rodrigues Fernando

IntroductionRadioiodine whole-body scintigraphy plays an important role in the follow-up of patients with differentiated thyroid carcinoma (DTC), as it is highly accurate in detecting thyroid residues and recurrent disease. Unusual 131-iodine uptake outside the thyroid bed and areas of physiological uptake is strongly suggestive of distant metastasis. However, uncommon uptake may occur and lead to diagnostic errors.Case report<...

ea0073aep743 | Thyroid | ECE2021

Is there a role of measuring preoperative serum thyroglobulin?

Rita Elvas Ana , Marques Bernardo , Couto Joana , Raquel G. Martins , Santos Jacinta , Martins Teresa , Rodrigues Fernando

IntroductionThe measurement of serum thyroglobulin (Tg), a glycoprotein produced exclusively by follicular thyroid cells, is an important tumour marker used in the follow-up of patients with differentiated thyroid carcinoma (DTC) and residual or recurrent disease. However, its role as a screening tool before thyroid surgery is not yet defined, as benign conditions can result in its increase.ObjectiveThe aim o...

ea0073aep744 | Thyroid | ECE2021

Coexistence of primary hypothyroidism and hypopituitarism due to pituitary adenoma – pitfalls during levothyroxine supplementation

Aleksandra Mlodozeniec , Renata Orlowska-Florek , Agnieszka Gala-Bladzinska

95% of all cases of overt hypothyroidism are primary. It is defined as low levels of blood thyroid hormone due to disorder of the thyroid gland causing decreased synthesis and secretion of thyroid hormones. Levothyroxine is recommended as the preparation of choice for the treatment of this disease. The therapy should eliminate the symptoms of hypothyreosis, lead to the normalization of thyroid axis hormones and the avoidance of iatrogenic thyrotoxicosis. Serum TSH is the param...

ea0073aep745 | Thyroid | ECE2021

Secondary intrathyroid localization of bronchial micro- papillary carcinoma

Masmoudi Mohamed , Hasnaoui Mehdi , Lahmar Rihab , Guizani Rihab , Khalifa Mighri

ObjectiveTo highlight the diagnostic difficulties that a pathologist may encounter in identifying intra-thyroid metastasis when the primary cancer is not known.Case reportA 73-year-old woman with no specific pathological history, admitted for the management of a right mean spinal swelling that had appeared two months earlier and is gradually increasing in size. The evolution was marked by the association of d...

ea0073aep746 | Thyroid | ECE2021

Case report: Inaugural diabetic ketosis revealing hyperthyroidism

Bammou Sanaa , Sara Chtioui , Sana Rafi , Mghari Ghizlane El , Ansari Nawal El

IntroductionSecondary diabetes mellitus is seen in 10 to 70% of cases depending on the endocrinopathy involved; it can be indicative of the disease and often associated with other metabolic disorders. We report the case of a patient with inaugural diabetic ketosis revealing hyperthyroidism.Case reportIt’s a 42-year-old patient with a history of gestational diabetes not followed 5 years ago, with diabetic...

ea0073aep747 | Thyroid | ECE2021

Agranulocytosis due to antithyroid drugs : A case report

Besrour Chayma , Rojbi Imen , Kamoun Elyes , Lakhoua Youssef , Mchirgui Nadia , Ben Nacef Ibtissem , Khiar Karima

IntroductionHyperthyroidism is a very common disease due to an overactive thyroid gland. Antithyroid drugs (ATD) represent the first line treatement. Their side effects can be severe and even potentially fatal. Among them, agranulocytosis, defined as an absolute neutrophils count less than 500/µl is the most feared one.ObservationWe report the case of 57 year-old woman with no medical history, recently d...

ea0073aep748 | Thyroid | ECE2021

Paraneoplastic hyperthyroidism in hCG-secreting metastatic testicular cancer

Patera Bohdan , Fazzino Gaia , Lanzo Nicola , Lepanto Silvia , Gallo Daniela , Lai Adriana , Piantanida Eliana , Laura Tanda Maria

IntroductionWe report a case of severe thyrotoxicosis due to a metastatic testicular tumor secreting human chorionic gonadotropin (hCG), known to have a TSH-mimicking effect due to alpha-subunits’ structural similarity.Case reportIn November 2020 a 38-year-old man was referred to our Department for thyrotoxicosis of unknown etiology. He had no family history of thyroid disease and his medical history had...

ea0073aep749 | Thyroid | ECE2021

Warthin-like variant of papillary thyroid carcinoma

Nádia Mourinho Bala , Raposo Nuno , José Maria Aragüés , Sílvia Guerra , Brito Delfina , Valadas Cristina

IntroductionA rarely reported histologic subtype of the papillary thyroid cancer is the Warthin-like variant (WLPTC). This carcinoma resembles the Warthin tumour of the salivary gland by virtue of a papillary pattern of eosinophilic tumour cells associated with a rich lymphoplasmacytic infiltrate in the cores of the papillae. Due to the its rarity, the pathological characteristics and clinical behavior of WLPTC are not well doc...

ea0073aep750 | Thyroid | ECE2021

Increasing levothyroxine requirements in a patient with previously stable hypothyroidism

Batool Maria , Cadogen Sinead , Kyaw Tun Tommy , Sreenan Seamus , Denton Mark , Mcdermott John

A 44 year old woman presented with leg swelling. Past history included hypothyroidism and ulcerative colitis treated with eltroxin (100 mg/day) and azathioprine (100 mg/day) respectively. Clinical examination revealed pitting oedema to knees and a ’puffy face’. Free T4 was 5.8 pmol/l (12–22 pmol/l), TSH 84.61 mU/l (0.27–4.20), serum albumin 24 g/l (40–49 g/l). She reported good compliance with L-thyroxine and no recent gastrointestinal symptoms. L-thyr...

ea0073aep751 | Thyroid | ECE2021

Topiramate Induced Hyperthyroidism –? New emerging evidence.

Farhan Malik Mohammad , Khalid Maha , Kumar Jesse , Sivappriyan Siva , Anandappa Samantha

Case PresentationA 25-year-old lady presented with symptomatic hyperthyroidism. She had a 4–6-week history of unexplained weight loss, pain in her neck and difficulty swallowing. Bloods confirmed mild hyperthyroidism with TSH 0.19 mU/l (reference range 0.27-4.2) with free T4 24.4 pmol/l (reference range 12.0-22.0), and she was commenced on carbimazole. There was no evidence of inflammation with CRP < 1 mg/l. Her mother had a thyroidectom...

ea0073aep752 | Thyroid | ECE2021

Characteristics of differentiated metastatic thyroid cancers: experience at the endocrinology service of chu ibn rochd of casablanca, morocco

Sekkat Kenza , Essabah Haraj Nassim , El Aziz Siham , Chadli Asmaa

IntroductionDifferentiated thyroid cancers DTC are metastatic in 10% of cases. The most frequent sites are the lungs, the bones, the brain and the liver. The presence of a metastasis reduces the life expectancy of patients by 60%. The objective of this work is to describe the characteristics of metastatic DTC in our service.MethodologyDescriptive retrospective study of 740 patient files monitored at the endoc...

ea0073aep753 | Thyroid | ECE2021

Predictive factors of central lymph node involvement in differentiated thyroid cancers

Masmoudi Mohamed , Hasnaoui Mehdi , Wadii Thabet , Njima Marwa Ben , Chaima Zitouni , Khalifa Mighri

IntroductionPapillary and follicular thyroid carcinomas are the most common forms of endocrine carcinomas. Lymph node involvement seems to be a low risk factor for death, but it increases the risk for loco-regional recurrences and distant metastasis. Lymph node involvement is more seen in case of papillary thyroid carcinoma, less reported in vesicular carcinoma. The aim of this work is to determine the clinicopathologic predictive factors of central lymp...

ea0073aep754 | Thyroid | ECE2021

Follicular thyroid carcinoma with lymphatic and macroscopic vascular extension

Teheni Dardouri , Manel Nouira , Lobna Chouchane , Hajer Boudrigua , Abir Ezzine , Hela Charfi , Raja Sfar , Fredj Maha Ben , Mohamed Abdelkefi , Kaouthar Chatti

Introduction and aimsMacroscopic angioinvasion associated to lymph node metastasis from follicular thyroid carcinoma (FTC) is scarce and leads usually to a poor outcome.Subjects and methodsWe report a case of FTC with extensive vascular invasion into the right jugular vein and numerous lymph nodes. We reviewed clinical records of our patient and analysed clinical outcomes and thyroglobulin rate as well as ima...

ea0073aep755 | Thyroid | ECE2021

Is there a link between the levels of vitamin D and differentiated thyroid cancer risk in multinodular goiter patients?

Tudorache Alina , Albu Alice , Scarabnii Tatiana

IntroductionBoth vitamin D insufficiency and multinodular goiter (MNG) are widespread throughout the world, with Romanian population being no exception. However, at this point in time there is insufficient data whether there is a connection between the two or is it just a coincidence. The aim of this study is to evaluate whether there is a relationship between serum level of 25-hydroxyvitamin D (25OHD) and the risk of differentiated thyroid cancer (DTC) ...

ea0073aep756 | Thyroid | ECE2021

Papillary thyroid cancer presenting with splenic infarction

Saraiva Miguel , Magda Garça , Rita Costa Ana , Pinheiro Guiomar , Rita Cruz Ana , Ribeiro Sofia , Cláudia Freitas , André Carvalho

IntroductionThe close relationship between cancer and thrombotic phenomena has been widely recognized and paraneoplastic organ infarctions may occur. Reports of papillary thyroid cancer associated to paraneoplastic phenomena are particularly scarce.Case reportA 39-year-old man with no prior relevant medical history was evaluated for acute onset of fever, malaise and mild pain referred to his left hypochondriu...

ea0073aep757 | Thyroid | ECE2021

Fetal and neonatal thyrotoxicosis after 12 years from thyroid surgical ablation for Graves disease

Bohaltea Roxana , Sucaliuc Alina , Szini Elena , Grigoriu Corina , Badiu Corin

Clinical fetal thyrotoxicosis is a rare disease occurring in 1-5% of pregnancies with Graves disease. Although transplacental passage of maternal TSH receptor stimulating autoantibodies (TRab) to the fetus does occur early in gestation, the fetal concentration is low until the end of second trimester, but reaches maternal levels in the last period of pregnancy. The mortality of fetal thyrotoxicosis is 12–20% mainly due to heart failure. We present a case of fetal and neo...

ea0073aep758 | Thyroid | ECE2021

Prevalence of autoimmune thyroid diseases in patients with prolactinomas and non-functioning pituitary adenomas

Hajizada Aytan , Oruk Gonca

AimProlactinoma, which is the most important cause of hyperprolactinemia, is an adenoma that originates from lactotropic cells of the pituitary and causes excessive prolactin release. Besides various physiological effects, the immunoregulatory effect of prolactin and its role in the development of autoimmune diseases are well known. The thyroid gland is one of the organs most frequently affected by autoimmunity. However, in our country, there are few stu...

ea0073aep759 | Thyroid | ECE2021

The fluctuation the oxygen delivery during thyroidectomy in the thyrotoxicosis syndrome patients

Dubrov Sergii , Suslov Gennadii , Tarasenko Sergii , Maznichenko Vladyslav , Palamarchuk Volodymyr , Voitenko Volodymyr

ObjectivesImpact of inhalation anaesthesia (IA) during thyroidectomy in the thyrotoxicosis syndrome (TTS) patients on the fluctuation the oxygen delivery (DO2).Materials90 TTS patients undergoing thyroidectomy. Depending on the type of anaesthesia, patients were divided into the «balanced analgesia-sevoflurane» group (BA-S) – 44 patients (where bilateral superficial cervical plexus blockade (BS...

ea0073aep760 | Thyroid | ECE2021

Graves’ Disease after COVID-19

Moreno Tirado Antonio , Paloma González Lázaro , Contreras Pascual Cristina , Montalban Mendez Cristina , Maria Zhao Montero Benítez , Florentino Del Val Zaballos

IntroductionGraves’ Disease is an autoimmune syndrome that include hyperthyroidism, goiter, thyroid eye disease, and occasionally, a dermopathy called pretibial or localized myxedema. As each autoinmune ailment to develop in sufferers with genetic susceptibility after a certain environmental exposure (infection, stress…). COVID-19 can cause both pulmonary and systemic inflammation, potentially determining multi-organ dysfunction. Since the out...

ea0073aep761 | Thyroid | ECE2021

Management and outcome of Graves orbitopathy

Hiba-Allah Chatti , Oueslati Ibtissem , Laamouri Rihab , Yazidi Meriem , Chaker Fatma , Chihaoui Melika

IntroductionGraves orbitopathy is the main extra thyroidal manifestation of Graves’ disease, though severe forms are rare (< 5%). Management of Graves orbitopathy is often suboptimal, largely because available treatments do not target pathogenic mechanisms of the disease. The aim of our study was to evaluate different treatment modalities and assess their impact on the outcome of Graves orbitopathy.Patients and methods...

ea0073aep762 | Thyroid | ECE2021

clinical aspects of cardiothyreosis in adult population of southern tunisia

Ben Teber Sawssan , Elleuch Mouna , Kacem Faten Hadj , Ben Salah Dhoha , Charfi Nadia , Mejdoub Nabila , Mnif Mouna , Mnif Fatma , Abid Mohamed

IntroductionCardiothyreosis is the most dreadful complication of hyperthyroidism. In Tunisia, cardiothyreosis has rarely been analyzed. The aim of our study was to describe the clinical aspects of this disease in an adult population of southern Tunisia.MethodsRetrospective study (January 1999 to December 2018) including all cases of hyperthyroidism with cardiothyreosis followed in our department.<p class=...

ea0073aep763 | Thyroid | ECE2021

Immune-related adverse effects as predictors of the response to ANTI-PD-1 immunotherapy: a clinical and diagnostic challenge

Maria-Piedad Picazo-Perea , Miguel-Angel Ruiz-Gines , Sastre Julia , David Melguizo-Melguizo

IntroductionCurrent rise in use of monoclonal antibodies to Immune Check Point inhibitors (ICPIs) has led to the appearance of a great variety of immune-related adverse effects (irAEs), mainly affecting gastrointestinal tract, skin, liver and endocrinological system. With a variable prevalence (4–21%), thyroid dysfunction (TD) is the most common immune-mediated endocrinopathy. However, in the literature, it occurs in different patterns and levels of...

ea0073aep764 | Thyroid | ECE2021

Amiodarone-induced hyperthyroidism

Elleuch Mouna , Frikha Hamdi , Ben Salah Dhoha , Ameni Salah , Charfi Nadia , Mnif Fatma , Rekik Majdoub Nabila , Mnif Mouna , Kacem Faten Hadj , Mohamed Abid

BackgroundAmiodarone is a widely-used anti arrhythmic medication. Amiodarone-induced hyperthyroidism (AIH) develops in 3% of amiodarone-treated patients. AIH is classified as type 1 or type 2. Type1 AIH occurs in patients with underlying thyroid condition while Type2 AIH is a result of amiodarone causing a subacute thyroiditis. Appropriate therapy for amiodarone-induced hyperthyroidism requires a careful diagnosis that may be difficult to achieve.<p ...

ea0073aep765 | Thyroid | ECE2021

Graves’ disease and myasthenia gravis: About a rare association

Asbar Hind , Benlafqih Maryame , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

IntroductionGraves’ disease is found in 5% of patients with myasthenia gravis. It’s a described but rare association that addresses pathophysiological, diagnostic and management challenges. We report a case of Graves’ disease revealed by an orbitopathy in a patient with coexisting mysthania gravis.Case reportA 40-year-old woman with established myasthenia gravis presented to the emergency room ...

ea0073aep766 | Thyroid | ECE2021

Thyroidian abscess (about an observation)

Monia Ghammmam , chouchane lobna , Bellakhdhar Mouna , Bel Hadj Miled Heyfa , Wassim Kermani , Mohamed Abdelkefi

AimsStudying the clinical presentation, paraclinical explorations, and therapeutic modalities of thyroid abscess.Materials and methodsWe report the observation of a diabetic patient with multiple thyroidian abscesses, hospitalized in the ENT department.ObservationThe patient is 55 years old, diabetic, treated one month before admission for urinary tract infection....

ea0073aep767 | Thyroid | ECE2021

Thyrotoxicosis and its association with sarcopenia

Marinova Gergana , Siderova Mira

The aim of this study was to assess the physical well-being among women with thyrotoxicosis. It was important to investigate the relationship between thyrotoxicosis and muscle quantity and quality as being components of sarcopenia.Methods36 women over 40 years of age with thyrotoxicosis took part in this cross-sectional study. After excluding factors affecting physical performance and body composition 13 women remained (mean age 64...

ea0073aep768 | Thyroid | ECE2021

Is it necessary to perform a thyroid evaluation on patients who will undergo parathyroidectomy for primary hyperparathyroidism?

Cruz Andrea , Rocío Revuelta , castro Ana , Vicente Almudena , Castro Enrique , Sastre Julia , Mollejo Manuela , Carrasco Miguel

IntroductionThe association of autoimmune, nodular or neoplastic thyroid disease and primary hyperparathyroidism (PHPT) has been reported in 17 to 84% of cases. In the surgical treatment of PHPT, simultaneous thyroidectomy may be necessary to optimize surgical access and / or when there is abnormal thyroid pathology. On the other hand, an incomplete diagnosis in the previous study of PHPT increases the risk of not removing clinically significant thyroid ...

ea0073aep769 | Thyroid | ECE2021

Fluctuations of thyroid autoimmunity pattern in a female patient with excessively elevated TRAb titers- a case report

Askitis Dimitrios , Zissimopoulos Athanasios

IntroductionThyroid autoimmunity comprises a dynamic entity and may manifest with different forms over the course of time at the same patient, thus causing fluctuations in thyroid functionality. Hereby, we present the case of a patient treated for hypothyroidism of autoimmune etiology, who developed hyperthyroidism accompanied by an excess of thyrotropin receptor autoantibodies (TRAb) and was followed by multiple swings in the thyroid state over an 1.5-y...

ea0073aep770 | Thyroid | ECE2021

Thyroid pathologies in acromegaly

Rihab Ajili , Yosra Hasni , Abdelkarim Asma Ben , Ghada Saad , Maha Kacem , Amal Maaroufi , Molka Chaieb , Koussay Ach

IntroductionAcromegaly is a rare disease, but serious in its complications. It is a multisystemic pathology also affecting the thyroid. The aim of our work is to study thyroid involvement in acromegaly.Patients and methodsThis is a retrospective study of acromegalic patients, in the endocrinology department of Sousse over a period of 20 years.ResultThese are 40 ac...

ea0073aep771 | Thyroid | ECE2021

A case of Grave’ s disease complicated with thyrotoxic hepatic failure and thyrotoxic period paralysis.

saafi wiem , Ben Abdelkarim Asma , Ben Abdallah Bouthaina , Saad Ghada , hammami Aya , ben ameur wafa , Maaroufi Amel , Kacem Maha , Chaeib Molka , Jaziri Hanen , Hasni Yosra , Ach Koussay

IntroductionGrave’s disease is an autoimmune thyroid disorder. It is the most frequent cause of hyperthyroidism with variable manifestations. When not recognized in time and not adequately treated, Graves’ disease poses serious risks and can have severe complications.ObservationA 63-year-old female was admitted to the endocrinology department for severe thyrotoxicosis. She was diagnosed in 2011 with...

ea0073aep772 | Thyroid | ECE2021

Hyperthyroidism diagnosed in a patient hospitalized for COVID-19 hypoxaemic pneumonia : Diagnostic and therapeutic challenges

Lassoued Najoua , Senda Rebai , Rihab Ajili , Jihen Chelli , Baha Zantour , Mohamed Habib Sfar

IntroductionPatients who are critically ill can have alterations of thyroid function tests, known as non-thyroidal illness syndrome (NTIS). Moroever thyrotoxicosis can result from SARS-CoV-2 directly infecting the thyroid gland, as described in other viral infections. We report a case of hyperthyroidism diagnosed in a patient hospitalized for COVID-19 severe hypoxemic pneumonia.ObservationA 78-year-old patien...

ea0073aep773 | Thyroid | ECE2021

The lower information...the greater risk of malignancy. A retrospective study of 50 patients underwent thyroid surgery

Iciar Martín Timón , Ugalde Abiega Beatriz , Inmaculada Moreno-Ruiz , Juan Jose Marin-Peñalver , Olalla Meizoso-Pita , Huguet Isabel , Cristina Sevillano-Collantes

ObjectiveThe aim of the study was to evaluate the overall malignancy rate on final histopathology in nodules with Bethesda III or IV surgically excised and review the ultrasound and cytological features givenMaterial and methodsIs a retrospective analysis of patients referred to our outpatient clinical of endocrinology after thyroid surgery with a previous thyroid nodule FNA cytology in Bethesda III or IV cat...

ea0073aep774 | Thyroid | ECE2021

Variables related to Response to Therapy in 340 patients with thyroid follicular epithelial cell-derived carcinoma

Patricia Espinosa De Los Monteros , Fernando Hernández Olmeda , Lopez Nevado Celia , Xavier Pérez Candel , Pazos Mario , Marcuello Foncillas Clara , Maria Cristina Familiar Casado

IntroductionResponse to Therapy, according to ATA’s dynamic classification, provides a description of the clinical situation in patients with thyroid cancer (TC) a year or more after treatment. It gives us more accurate information than the obtained at diagnosis by static staging systems as AJCC and ATA risk system.ObjetivesTo analyse the association between some factors collected at diagnosis and the ty...

ea0073aep775 | Thyroid | ECE2021

Behind seeming sepsis. An outstanding clinical debut of medullary thyroid carcinoma

Andoni Monzón Mendiolea , Paja Fano Miguel , Lizarraga Zufiaurre Aitzol , Oleaga Alday Amelia , Adela Leyre Martínez Martínez , Merlo Pascual Ignacio , Miren Josune Rodríguez Soto , Izquierdo Coca Jon

Procalcitonin (PCT) is a sepsis diagnostic marker and mortality predictor, although its elevation can be related to other diseases such as medullary thyroid carcinoma (MTC). A 72-year-old woman was transferred to the intensive care unit of our institution from another center. One week before, she had been admitted with a clinical picture of progressive malaise, fever, and dyspnea. Weeks before her admission, she had consulted for dyspnea, anorexia, asthenia, and weight loss. I...

ea0073aep776 | Thyroid | ECE2021

Epidemiological, clinic-pathological, evolutionary profile of papillary thyroid microcarcinomas

Khouchaf Hajar , Essabah Haraj Nassim , El aziz Siham , Chadli Asmaa

IntroductionPapillary carcinoma is the most frequent histological form of malignant thyroid tumors, increasingly diagnosed at the microcarcinoma stage. Papillary microcarcinomas, often localized, are classified as very low risk.Objective of the studyTo describe the epidemiological and clinical characteristics, the evolutionary profile as well as to determine the predictive factors of recurrence of papillary m...

ea0073aep777 | Thyroid | ECE2021

Prognostic factors and therapeutic strategy for patients with bone metastases from differentiated thyroid carcinoma

Gherissi Wiem , Hamza Fatma , Charfi Hana , Jardak Issam , Maaloul Mohamed , Kallel Faouzi , Amouri Wissam , Charfeddine Salma , Chtourou Khalil , Guermazi Fadhel

Thyroid differentiated carcinomas are of good prognosis except in case of metastatic dissemination. These distant metastasis, especially the bone one, are a major cause of altered quality of life and death. This study concerns a cohort of 21 patients treated from 1995 to 2011.The aim of our work is to study the characteristics of patients who had bone metastases in association with thyroid cancer to determine their prognostic factors. 18 of our patients were ...

ea0073aep778 | Thyroid | ECE2021

Thyroid nodule classified as Bethesda III: Our clinical experience and management strategy

Borja Sanz Martín , Roman Gimeno Sergio , Elena Pérez Galende , Sota Ochoa Patricia , Carlos Miguel Peteiro Miranda , Jose Jorge Ortez Toro , Urdaniz Borque Rosana

BackgroundThe prevalence of malignancy among Bethesda category III (atypia of undetermined significance) cytologies is variable in different studies.ObjectiveThe aim of this paper is to evaluate the risk of malignancy of thyroid nodules classified as Bethesda III in our hospital.MethodsWe have reviewed the medical records of 146 patients who underwent FNA with Bet...

ea0073aep779 | Thyroid | ECE2021

Management of papillary thyroid carcinoma in children

Masmoudi Mohamed , Guizani Rihab , Lahmar Rihab , Sara Lazid , Hasnaoui Mehdi , Khalifa Mighri

ObjectiveThyroid cancer is a rare disease in children and adolescents; it accounts for only 1.4% of all pediatric malignancies. Papillary carcinoma is the most common histological type. Furthermore, its treatment remains controversial. The aim of our work is to illustrate the clinical, histological and therapeutic features of pediatric papillary thyroid carcinoma.Materials and methodsThis is a retrospective s...

ea0073aep780 | Thyroid | ECE2021

Parathyroidian cysts: About an observation

Monia Ghammmam , Chouchane Lobna , Bellakhdhar Mouna , Teheni Dardouri , Wassim Kermani , Mohamed Abdelkefi

IntroductionThe parathyroid cyst is a benign lesion that develops at the expense of the gland parathyroid. It is rarely revealed by palpable cervical swelling and is often a surgical discovery. The purpose of our work is to report an observation of parathyroid cyst, and specify the methods of pre-operative diagnosis and the different therapeutic possibilities.Materials and methodsWe report an observation of a...

ea0073aep781 | Thyroid | ECE2021

Neuroendocrine carcinoma of the thyroid: About of a case

Ghammem Monia , chouchane lobna , Bellakhdher Mouna , BelHadj Miled Heyfa , Dardouri Tahani , Kermani Wassim , Abdelkefi Mohamed

GoalsThe purpose of this work is to study histological, clinical, and therapeutic features neuroendocrine carcinomas of the thyroid.Materials and methodsWe report a case of neuroendocrine carcinoma of the thyroid colliged in ENT department of sousse.ObservationThe case involved an 83-year-old woman with a history of family dysthyroidism who had significant cervica...