Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

Audio Eposter Presentations

Reproductive and Developmental Endocrinology

ea0073aep570 | Reproductive and Developmental Endocrinology | ECE2021

Flow medicated dilation is associated with matrix metalloproteinase-2 in healthy postmenopausal women

Armeni Eleni , Georgiopoulos Georgios , Delialis Dimitrios , Augoulea Areti , Paschou Stavroula , Mili Nikoletta , Chondrou Asimina , Kouerinis Efthymios , Chatzivasileiou Panagiota , Kaparos Georgios , Eleftheriadis Makarios , Stamatelopoulos Kimon , Lambrinoudaki Irene

IntroductionMenopausal transition has been associated with an increase in cardiovascular risk, which is possibly linked with the hormonal imbalance following ovarian senescence. Both insulin levels and circulating androgens (FAI) have been associated with endothelial dysfunction, through studies evaluating flow mediated dilation (FMD). We aimed to investigate whether the link between these hormones and FMD might be explained by markers of oxidative stres...

ea0073aep571 | Reproductive and Developmental Endocrinology | ECE2021

Relationship between vitamin D and thyroid status in women of reproductive age with subclinical hypothyroidism and TPO-Ab +

Kulchinska Veronika

BackgroundToday thyroid diseases occupy the first place among all endocrine pathologies and remain one of the most difficult problems. The prevalence of subclinical hypothyroidism, according to various data, is 4–15%. The category of women of reproductive age deserves special attention, as thyroid dysfunction affects a woman’s fertility and pregnancy. Vitamin D deficiency in the population remains a global problem. The purpose of the study is t...

ea0073aep572 | Reproductive and Developmental Endocrinology | ECE2021

Relationship between KLK3 and the immune system of young women living in two areas with different environmental impact during a menstrual cycle. Preliminary data. (ECOFOODFERTILITY Project)

Gentile Mariacira , Esposito Giusy , Raimondo Salvatore , Gentile Tommaso , Cuomo Felice , De Filippo Stefania , Montano Luigi

IntroductionKallikreins are a subgroup of serine proteases which in women are produced by Skene’s glands. It evaluated the variation of concentrations in KLK3 and immunoglobulins IgA, IgM, IgG and IgE in the menstrual cycle (follicular (FP), ovulatory (OP) and luteal (LF) in young women living in two areas with different environmental impact.Materials and methods82 women aged between 22 and 34, normo-men...

ea0073aep573 | Reproductive and Developmental Endocrinology | ECE2021

Spontaneous thelarche and menarche in children with turner syndrome

Peskavaya Nadzeya , Solntsava Anzhalika , Akulevich Natallia

IntroductionTurner syndrome (TS) is usually accompanied by hyperhonadotroic hypogonadism and primary amenorrhea due to gonadal disgenesis. One-third of girls with TS have spontaneous thelarhe (ST). Regular menstrual cycles occur in at most 6% of this patients.ObjectivesTo analyze the characteristics of pubertal development in children with different karyotype variants of TS.Methods<...

ea0073aep574 | Reproductive and Developmental Endocrinology | ECE2021

Decline in AMH concentrations following radioactive iodine treatment in women with differentiated thyroid cancer: A systematic review and meta-analysis

Anagnostis Panagiotis , Florou Panagiotia , Bosdou Julia , Grimbizis Grigorios , Iakovou Ioannis , Kolibianakis Efstratios , Goulis Dimitrios

PurposeRadioactive iodine (RAI) is frequently used as adjuvant therapy in patients with differentiated thyroid cancer (DTC). However, its effect on ovarian reserve has not been fully elucidated, with studies yielding inconsistent results. The aim of this study was to systematically review and meta-analyze the best available evidence regarding the effect of RAI on ovarian reserve in premenopausal women with DTC.Methods<p class="...

ea0073aep575 | Reproductive and Developmental Endocrinology | ECE2021

Erectile dysfunction as a marker of newly diagnosed endocrine and metabolic disorders

Mazzilli Rossella , Zamponi Virginia , Olana Soraya , bollanti lucilla , Mikovic Nevena , Napoli Angela , Conti Francesco , Pugliese Giuseppe , Faggiano Antongiulio

AimThe aim of this study was to evaluate: a) the prevalence of a previously unknown endocrine / metabolic dysfunction, namely hypogonadism, thyroid dysfunction, hyperprolactinemia, and diabetes or prediabetes, in a population of patients affected by Erectile Dysfunction (ED); b) the differences in ED severity according to the presence/absence of specific endocrine / metabolic dysfunctions.Material and Methods...

ea0073aep576 | Reproductive and Developmental Endocrinology | ECE2021

A rare case of ovotesticular DSD by 46XX /46XY genetic chimerism

Ghervan Cristina , Varro-Bodoczi Eniko , Muntean Valentin , Ghervan Liviu , Miclea Diana

IntroductionWe present the very rare case of a patient with ovotesticular disturbance of sexual development (DSD) by 46 XX/46 XY genetic chimerism.Case reportA 47-year-old patient with male appearance consulted for gynecomastia developed in the last 3 - 4 years. Clinical examination showed genital organs ambiguity with a small scrotum, no palpable testis, a clitoris instead of penis. Painful bilateral gyn...

ea0073aep577 | Reproductive and Developmental Endocrinology | ECE2021

A novel heterozygous mutation in CYP19A1 Gene c.456_462del p.(Ser153Profs*24) in a girl with aromatase deficiency

Isabel Inácio , Mafalda Simões , Leitão Martins Vânia , Geraldes Fernanda , Cardoso Rita , Serra-Caetano Joana , Dinis Isabel , Mirante Alice

BackgroundAromatase deficiency is an extremely rare autosomal recessive condition due to mutations on CYP19A1 gene. Despite the size and complexity of this gene, only about 40 cases with aromatase deficiency have been reported.Case reportThe patient was born at term from non-consanguineous parents. Maternal signs of virilization were verified during third trimester (deep voice, acne on arms and face ...

ea0073aep578 | Reproductive and Developmental Endocrinology | ECE2021

Turner Syndrome–An unusual presentation of normal stature and incomplete puberty

Dias Daniela , Serra FIlipa , Neves Carolina , Real Mendes Leonor , Nogueira Filomena , Sapinho Inês

IntroductionTurner syndrome(TS) is characterized by complete/partial monosomy or by a structural defect in one of X chromosomes. Despite clinical hallmarks of short stature(SS) and gonadal dysgenesis(GD), phenotype is variable and related to underlying chromosomal pattern. Loss of the distal segment of the short arm of x-chromosome(Xp-), including haploinsufficiency of short stature homeobox-containing (SHOX) gene, is thought to be the main factor for gr...

ea0073aep579 | Reproductive and Developmental Endocrinology | ECE2021

Congenital GH deficiency in children: What are the differences between isolated and combined/total and partial somatotropic GH deficiency?

Dorraelguiche Dorra , Jemel Manel , Anis Grassa , Gharbi Radhouane , Kandara Hajer , Kammoun Ines

Introduction Growth hormone (GH ) deficiency is a rare but not exceptional cause of statural delay in children. The results of GH stimulation tests and the exploration of other pituitary axes allow us to conclude on the nature of the deficiency: total or partial and its possible association with other pituitary deficits.MethodsThis is a retrospective descriptive study including 75 patients followed for congen...

ea0073aep580 | Reproductive and Developmental Endocrinology | ECE2021

Adverse effects of gender affirming hormonal therapy in transgender persons: assessing reports in the French pharmacovigilance database

Yelehe Melissa , Klein Marc , Gillet Pierre , Maurier Anais , Feigerlova Eva

BackgroundOnly limited data are available regarding adverse effects of gender affirming hormonal treatment (HT) mainly due to the lack of population-based studies with adequate controls, thus making spontaneous reporting systems a valuable tool to detect potential side reactions.ObjectiveIn this nationwide retrospective study, we aimed to analyse adverse drug reactions (ADRs) in relation to gender affirming H...

ea0073aep581 | Reproductive and Developmental Endocrinology | ECE2021

Analysis of insulin like peptide 5 (INSL5) levels and their association between hormonal and metabolic parameters in polycystic ovary syndrome patients

Cengiz Deniz , Ademoglu Dilekci Esra Nur , Albayrak Omur , Yis Ozgur Mehmet

ObjectivesPolycystic ovary syndrome (PCOS) is the most common reproductive disorder that onsets peripubertally and increases morbidity by affecting quality of life. Insulin like peptide 5 (INSL5) is a relaxine/insulin family member gut-peptide hormone that is expressed by various tissues including the hypothalamus, pituitary and ovary. In the present study, we aimed to characterize serum INSL5 levels in PCOS women and determine association of circulating...

ea0073aep582 | Reproductive and Developmental Endocrinology | ECE2021

Hyperandrogenism and portosystemic shunt - report of two cases

Manique Inês , Rego Teresa , Fonseca Fernando , Agapito Ana , José Silva-Nunes

IntroductionSevere hyperandrogenism is a warning sign in young women. Differential diagnosis includes neoplastic, non-neoplastic and iatrogenic causes. The association of hyperandrogenism and congenital or acquired portosystemic shunt (PSS) has been rarely described, with its pathophysiology being unclear.Case 1A 22 year-old woman with diagnosis of autoimmune hepatitis, portal hypertension and PSS since 15 ye...

ea0073aep583 | Reproductive and Developmental Endocrinology | ECE2021

Low intelligent quotient (IQ) in patients with Klinefelter Syndrome are associated with impaired quality of life: A systematic review with meta-analysis

Mehmet Brien , Llahana Sofia

ObjectiveThis was a systematic review with meta-analysis aiming to identify if patients with Klinefelter syndrome (KS) had a reduced full scale intelligent quotient (IQ) when compared to controls. Reduced IQ is shown to have a negative multifaceted effect on individuals’ Quality of Life (QoL), having been shown as a predictor of future success, increased criminal behaviour, post-traumatic stress disorder (PTSD), lower academic achievements and i...

ea0073aep584 | Reproductive and Developmental Endocrinology | ECE2021

Primary ovarian failure: descriptive study of 50 cases

Safi Wajdi , Elleuch Mouna , BenSalah Dhouha , Frikha Hamdi , Charfi Nadia , Rekik Nabila , Mnif Fatma , Mnif Feki Mouna , Hadj Kacem Faten , Abid Mohamed

IntroductionPrimary ovarian failure currently represents an increasingly frequent cause for consultation in endocrinology, from 4 to 18 % of the causes of primary amenorrhea and 10 to 28 % of the causes of secondary amenorrhea.ObjectivesIn this context, we report a retrospective study of 50 patients followed between 2000 and 2020 for early menopause, in order to assess the etiologies and risk factors favourin...

ea0073aep585 | Reproductive and Developmental Endocrinology | ECE2021

Long-term psychosocial effects of gender affirming hormone therapy on transgender men

Durcan Emre , Bircan Basak Ecem , Yaylamaz Selver , Taze Sabriye Sibel , Ozkaya Hande Mefkure , Turan Senol , Kadioglu Pinar

Background/AimsGender affirming hormone therapy (GAHT) has been reported to have positive psychosocial effects on transgender people. In present study, we aimed to investigate longitudinally the short-term and long-term impacts on social adaptation, body image, features of alexithymia and aggression changes in transgender men after GAHT administration.MethodsThe single center, longitudinally follow-up study i...

ea0073aep586 | Reproductive and Developmental Endocrinology | ECE2021

Changes in androgen profile in transgender women with or without gonadectomy

Collet Sarah , Defreyne Justine , Kiyar Meltem , De Meijer Delphine , Nobels Sarah , den Heijer Martin , Guy T’Sjoen

ObjectivesThe European Network for Investigation of Gender Incongruence (ENIGI) is a multicenter prospective cohort study. All participants receive a standardized gender affirming treatment (GAHT) protocol including regular follow-up. The current study compared changes in androgens upon starting GAHT and during follow-up in transgender women (TW) with or without gonadectomy by investigating serum total testosterone (TT), calculated free testosterone (cFT...

ea0073aep587 | Reproductive and Developmental Endocrinology | ECE2021

Endocrine features in Noonan syndrome

Inês Vieira , Bastos Margarida , Ruas Luísa , Rodrigues Dírcea , Gomes Leonor , Paiva Isabel

IntroductionNoonan syndrome can result from different mutations, the most frequent being in PTPN11. The diagnosis is often made by the clinical picture of short stature, facial dysmorphisms and heart defects. From an endocrine point of view, growth retardation, hypogonadism and a higher frequency of thyroid autoimmunity are highlighted.ObjectivesTo analyse endocrine features in patients with Noonan syndrome (...

ea0073aep588 | Reproductive and Developmental Endocrinology | ECE2021

Establishment of an assay for the effects of neurodevelopmental toxicity using Sox1-GFP cells

Jeong Sunhwa , Park Seon Mi , Go Seon Myeong , Nam Tran Dinh , Lee Jimin , Eui-Bae Jeung

Developmental toxicity tests have been made by embryonic stem cell tests at the European Centre for the Validation of Alternative Methods or by embryonic body test in our laboratory. However, no neuronal-specific developmental toxicity test has been made yet. Therefore, this study was carried out using a 46C cell line, mouse embryonic stem cells with an endogenous Sox1-GFP reporter, to exploit the developmental neurotoxicity test. The expression of Sox1, a marker for neural pr...

ea0073aep589 | Reproductive and Developmental Endocrinology | ECE2021

Growth retardation in hypothyroidism and growth hormone deficieny : A case report

Laamouri Rihab , Rojbi Imen , Besrour Chayma , Majdoub Marwa , Lakhoua Youssef , Mchirgui Nadia , Ben Nacef Ibtissem , Khiari Karima

IntroductionGrowth retardation is a multifactorial process involving genetic, nutritional and hormonal factors. It has a significant psychological impact. The etiologies are multiple. This case illustrates a growth retardation related to more than one etiology.Case presentationA 22 year-old patient consulted in orthopedics for a right lameness. Diagnosis of primary hip osteochondritis had been suspected on st...

ea0073aep590 | Reproductive and Developmental Endocrinology | ECE2021

Turner syndrome with isochromosome Xq (about two observations)

Outtaleb Fatima Zahra , Nora Imelloul , Hind Dehbi

IntroductionTurner syndrome is a chromosomal abnormality linked to the total or partial absence of the X chromosome. Its prevalence is 1/2500 female newborns. It constantly associates a stature delay and ovarian failure, with an increased risk of various malformations. The objectives of this study are to show the importance of the cytogenetic study in the management of patients with delayed height and / or primary amenorrhea, and to search for a possible...

ea0073aep591 | Reproductive and Developmental Endocrinology | ECE2021

Hypogonadotropic hypogonadism revealing a classic form of 21 hydroxylase deficiency in a 39 year old man

Alassane Ilboudo , Carine Courtillot , Yempabou Sagnan , Sophie Dubreuil , Touraine Philippe

Classical forms of 21 hydroxylase defisciency are generally observed during bith life and present as loss of salt or rapid puberty in young boy. We report a rare case of classical 21 hydroxylase defisciency presented as low gonadotrophines contrasted with normal level of testosterone. This was related to a 39 years old patient consulted for male infertility. Clinical exam was normal, including a normal level of blood tension. Liquid chromatography–tandem mass spectrometry...

ea0073aep592 | Reproductive and Developmental Endocrinology | ECE2021

Spuriously high testosterone concentrations testosterone gel users: A marker for detection

Schaper Sophie , Wiepjes Chantal , den Heijer Martin , Beukhof Carolien , Heijboer Annemieke C

ContextContamination of collected blood samples by application of testosterone gel near the venipuncture site can cause spuriously elevated serum testosterone concentrations. Often this will be detected only in case of extreme discrepancies between lab result and clinical effects. Because in vitro testosterone cannot be metabolized as the testosterone in vivo we hypothesized that measuring estradiol, as a metabolite of testosterone after aromati...

ea0073aep593 | Reproductive and Developmental Endocrinology | ECE2021

49, XXXXY syndrome associated with diabetes mellitus with insulin resistance, delayed neurocognitive behaviour, abnormal stature, and osseous deformity- a rare case

Behera Kishore , Jena Ranjan , Naik Suprava , Mishra Shree

Back ground49, XXXXY syndrome is a rare defect of sex chromosomes frequently considered as a variant of Klinefelter syndrome. It is often associated with more severe dysmorphic features, hypogonadism, mental retardation, musculoskeletal abnormality, and rarely with diabetes mellitus due to insulin resistance.The goal: To describe clinical, biochemical, hormonal, radiological and developmental status of the patient with 49, XXXXY ka...

ea0073aep594 | Reproductive and Developmental Endocrinology | ECE2021

C173R and R273W mutations but not P108L in growth hormone secretagogue receptor 1a (GHSR1a) gene may cause short stature in Pakistani children

Kausar Nighat , Akram Maleeha , Shahid Gulbin , Naseem Afzaal Ahmed , Qayyum Mazhar , Tahir Fahim , Jahan Sarwat , Afshan Kiran , Rizvi Syed Shakeel Raza

The combined physiological effects of somatotropic and gonadal axes have been demonstrated to cause acceleration in linear growth at puberty. In synergy, growth hormone (GH) and gonadal steroids (testosterone [T] and estradiol [E2]) stimulate longitudinal bone growth through direct stimulation of chondrocytes and osteoblasts. Amongst others, the secretion of GH is stimulated by ghrelin through its receptor called GH secretagogue receptor 1a (GHSR1a). Ghrelin is a peptide secre...

ea0073aep595 | Reproductive and Developmental Endocrinology | ECE2021

Long-term reproductive and behavioral effects of low dose bisphenol A introduction to rats during late gestation on F1 offspring

Faliush Oksana , Sachynska Olga , Lymareva Anna , Reznikov Alexander

One of the most common environmental endocrine disruptor is bisphenol A (BPA), which mimics estrogen effects. Even at low expositional dose, BPA is capable of transferring across the human placenta in active unconjugated form. The purpose of this work was to investigate the long-term effects of low dose BPA introduction to rats during the critical period of sexual differentiation of the brain on the reproductive system and the behavior of F1 offspring. Wistar dams were exposed...

ea0073aep596 | Reproductive and Developmental Endocrinology | ECE2021

Novel Mutations in Human Luteinizing Hormone Beta Subunit Related to Polycystic Ovary Syndrome among Sudanese Women

Essa Nidal , Rashid Abdalla Rashid Abdalla , Salaheldein Elzaki Salaheldein Elzaki

IntroductionPolycystic ovary syndrome (PCOS) is a common disorder that is not fully understood. Multiple hormonal and metabolic factors impact on disease pathophysiology resulting in various phenotypic characteristics among the PCOS population. Luteinizing hormone beta subunit (LHβ) (protein ID P01229) is mapped on (chr19p13.3) and consists of three exons. It is specific beta (β) subunit giving to LH from the anterior pituitary its specific fun...

ea0073aep597 | Reproductive and Developmental Endocrinology | ECE2021

Triple-X syndrome as a cause of primary ovarian insufficiency

Cidade-Rodrigues Catarina , Chaves Catarina , Martinho Mariana , Cunha Filipe , Almeida Margarida

IntroductionPrimary ovarian insufficiency (POI) occurs in 1% of women between puberty and 40 years old. Despite being idiopathic in 74–90% of the cases, there are other etiologies, such as genetic causes (in up to 16% of cases). Triple-X syndrome (TXS) is a common (estimated incidence of 1/1000 women) but frequently undiagnosed chromosomal abnormality. Most women are phenotypically normal, despite this fact, POI can still develop. We present a case ...

ea0073aep598 | Reproductive and Developmental Endocrinology | ECE2021

Successful twin delivery in a patient with partial 46, XY gonadal dysgenesis

Semeniene Kristina , Navardauskaite Ruta , Tomas Preiksa Romualdas

IntroductionPartial gonadal dysgenesis (PGD) is one of the rare 46, XY disorders of sex development (DSD), associated with variable degrees of impaired testicular development and function. Phenotypic appearance is related to the level of functional testicular hormones. Usually PGD is diagnosed in infancy because of significant genital anomaly at birth, however, spontaneous puberty is seen in up to 57% of all 46, XY PGD cases. Bilateral gonadectomy is per...

ea0073aep599 | Reproductive and Developmental Endocrinology | ECE2021

Polycystic ovary syndrome, subclinical inflammation, DPP4 and the impact of a progestin test

Emmer Lisa , Weber Susanne , Sydorivska Olga , Luppa Peter , Seifert-Klauss Vanadin

IntroductionWomen with PCOS frequently exhibit impaired insulin sensitivity. Low-grade chronic inflammation has been associated with insulin resistance and type 2 diabetes. DPP4, also known as CD26 (T-cell activation antigen CD26) is a prolin-specific serin-exopeptidase. With its binding partner ADA (Adenosine Deaminase complexing Protein) it cleaves numerous chemokines, mitogens, neuropeptides and peptide hormones and thereby influences metabolism, immu...

ea0073aep600 | Reproductive and Developmental Endocrinology | ECE2021

Assisted Reproductive Technology (ART) Success Rate Among Obese And Non-Obese Women, With Infertility Associated With Polycystic Ovary Syndrome (PCOS)

Chaves Carolina , Metello José Luís , Ferreira Pedro , Simões Reis Isabel

IntroductionPrevious studies in women with idiopathic infertility have shown that obesity does not independently contribute to the decrease in the success of assisted reproductive technology (ART) techniques. However, few studies evaluated the success rate of ART between obese and non-obese women in infertility associated with PCOS.ObjectiveTo compare the number of oocytes, mature oocytes, number of embryos a...

ea0073aep601 | Reproductive and Developmental Endocrinology | ECE2021

Hearing abnormalities in Turner patients

Bouichrat Nisrine , Najoua Messaoudi , Karrou Marouan , Mahroug Ikram , Rouf Siham , Latrech Hanane

IntroductionTurner Syndrome is a relatively rare genetic disorder related to the total or partial absence of an X chromosome. Its clinical presentation is very heterogeneous. It can be associated with several organic abnormalities, including hearing disorders. The objective of our work is to study the prevalence of otologic abnormalities in our Turner patients.Material and methodThis is a retrospective descri...

ea0073aep602 | Reproductive and Developmental Endocrinology | ECE2021

Syndromic premature ovarian insufficiency: report of 2 cases with blepharophimosis-ptosis-epicanthus inversus syndrome type 1

Kraoua Lilia , Fredj Hana , Adhoum Cyrine , Achour Ahlem , Maazoul Faouzi , Trabelsi Mediha , Mrad Ridha

IntroductionPremature ovarian insufficiency (POI) is defined by menstrual disturbance (oligomenorrhea or amenorrhea) before 40 years and confirmed by two FSH levels in the menopausal range, obtained at least a month apart. Some POI cases are syndromic such as Turner’s syndrome or Blepharophimosis–Ptosis–Epicanthus inversus Syndrome type 1 (BPES). BPES type 1 (MIM: 110100) is a rare autosomal dominant syndrome caused by mutations in FOX...

ea0073aep603 | Reproductive and Developmental Endocrinology | ECE2021

Swyer Syndrome, 46, XY complete gonadal dysgenesis in a patient with spontaneous menarche

Geru Dana Geru , Dumitru Alina Maria , Taujan Georgiana Taujan , Dragomir Adina Simona

46, XY complete gonadal dysgenesis, also known as Swyer Syndrome, is characterized by the presence of normal female external genitalia at birth, late puberty and primary amenorrhea. Spontaneous menses (due to hormone-secreting tumor) and breasts development occur in rare cases. With proper hormonal substitution, patients could carry pregnancies achieved through IVF with donor oocytes.Case presentationFemale patient, aged 22, addres...

ea0073aep604 | Reproductive and Developmental Endocrinology | ECE2021

Hyperthyroidism on molar pregnancy about a case

Bifoume Ndong Charlene Ludwine , Elgharroudi Farah , Ange Dandou , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal , El Adib Ahmed Ghassane

IntroductionHyperthyroidism during pregnancy can be caused by an hydatiform mole in its partial or total form. The biochemical particularities between hcg (human corionic gonadotropin) and Tsh (thyreo-stimulating hormone) in gestational trophoblastic disease can explain the thyrostimulating effect in it. We report a case of hyperthyroidism on molar pregnancy through an observation.ObservationPatient of 27 yea...

ea0073aep605 | Reproductive and Developmental Endocrinology | ECE2021

Primary amenorrhea due to hypogonadotropic hypogonadism

Sparavalo Rada , Borozan Sanja

A diagnosis of primary amenorrhea (PA) is always a clinical challenge. By definition, PA is a failure to reach menarche by age 14 with the absence of secondary sexual characteristics or absence of menses by age 16 years regardless of the development of secondary sexual characteristics. It may result from a number of different conditions and requires comprehensive evaluation to identify a cause, along with a regular patient follow-up. The aim of this case report is to emphasize...

ea0073aep606 | Reproductive and Developmental Endocrinology | ECE2021

Translation of OAT syndrome infertility into normozoospermia after short duration testosteron therapy – case report

Tesic Dragan , Andric Dragica , Tomic Mirjana , Pantelinac Pavle

IntroductionInfertility associated with hypergonadotropism is usually an unpromising condition related to acheiving fertilization. We describe the patient presented as oligoasthenoteratozoospermia (OAT syndrome), with laboratory primary hypergonadotropic hypogonadism but normal male fenotype, including typical male hair dustribution.Case descriptionmale, born 41 year ago, presented when he was 29 year old, as...

ea0073aep607 | Reproductive and Developmental Endocrinology | ECE2021

Analysing by decade, testosterone undecanoat depot injectable does not increases prostate volume. Study during up to 13 years on hypogonadic patients. (January 2021)

Peretianu Dan , Pisoschi Matei , Stanciu Mihaela , Oprisan Bogdan

AimRe-Analysing (starting 2007) the effect of injectable testosterone undecanoat depot (TUD) in hypogonadic patients.Material-methodA. Patients: at onset 333 men with hypogonadism (median: 62 y).B. Distribution: by decade (starting with 20y->90y); no = 6, 18, 35, 80, 104, 67, 21, 2.C. TUD (Neb...

ea0073aep608 | Reproductive and Developmental Endocrinology | ECE2021

After up to 13 years observation, testosterone undecanoat 1000 mg at 3 months did not increased Prostatic Specific Antigen level. Relation with prostatic volume (January 2021)

Pisoschi Matei , Stanciu Mihaela , Peretianu Dan , Oprisan Bogdan

AimWe appreciate the effect of testosterone undecanoat 1000 mg intramuscular injection (NebidoR; Bayer) on both prostatic volume (see Peretianu, this congress) and PSA (this study) in hypogonadic patients after up to 13 years.Material and methodA. PSA (ng/ml) was done in Bucharest accredited laboratories, appreciated at 1 year. B. Prostatic volume (PV): ultrasound,...

ea0073aep609 | Reproductive and Developmental Endocrinology | ECE2021

Premature ovarian insufficiency associated with a small supernumerary marker chromosome 15: a case report

Essayeh Sawsen , Kraoua Lilia , Ayari Sabrina , Chadia Zouaoui , Mrad Ridha , Ouertani Haroun

IntroductionPremature ovarian insufficiency (POI) is characterized by the loss of ovarian activity before the age of 40. It is associated with hypoestrogenism, raised gonadotrophins and oligomenorrhea or amenorrhea. POI is a heterogeneous disease that can result from different etiologies, including genetic, autoimmune, and iatrogenic. Of the genetic causes, single-gene mutations and chromosomal imbalances involving X chromosome or autosomes have been ass...

ea0073aep610 | Reproductive and Developmental Endocrinology | ECE2021

Assessment of glycemic variability using the FreeStyle Libre flash monitoring system in pregnant women with gestational diabetes mellitus

Ushanova Fatima , Demidova Tatyana , Izmailova Mariyam

Background and aimEarly control of gestational diabetes mellitus (GDM) can reduce the likelihood of adverse maternal and fetal outcomes. Glycemic variability (GV) is a more accurate parameter for assessing the risk of developing diabetic complications than traditional parameters of assessing compensation. In most cases, diet therapy is used to treat GDM, meanwhile the glycemia in pregnant women with GDM should correspond to the glucose level in healthy p...

ea0073aep611 | Reproductive and Developmental Endocrinology | ECE2021

Vitamin D and sex hormones levels in men of different ages

Khyzhnyak Oksana , Bondarenko Vladimir , Sanina Yevheniia , Nikolaiev Roman , Karachentsev Iurii

IntroductionVitamin D (VitD) is thought to be essential for adequate testosterone (T) secretion in men. In the absence of D-hypovitaminosis, their blood T levels and T to estradiol (E2) ratio values are higher relative to those with VitD deficiency. The correlation between VitD levels and androgenization indices in men of different ages has not been practically studied.The aimTo study blood levels of T and th...

ea0073aep612 | Reproductive and Developmental Endocrinology | ECE2021

Central hypothyroidism during pregnancy in a woman with Graves’ disease

Faustine Tanguy , Hamdi Safouane , Karim Chikh , Daniel Glinoer , Caron Philippe

IntroductionDuring pregnancy, women with Graves’ disease are at risk of maternal and fetal hyperthyroidism caused by stimulating TSH receptor antibody. Here we report the unusual case of a woman with recurrent Graves’ disease who developed central hypothyroidism transiently during pregnancy.Case report and resultsA 26-year-old woman was treated by antithyroid drug for a third episode of hyperthyroid...

ea0073aep613 | Reproductive and Developmental Endocrinology | ECE2021

Bone metabolism in PCOS – influence of progestins

Sydorivska Olga , Weber Susanne , Emmer Lisa , Luppa Peter , Seifert-Klauss Vanadin

IntroductionThe polycystic ovary syndrome (PCOS) affects about 6–10% of women of reproductive age and is associated with oligomenorrhoea and anovulation. Recently, a possible impairment of bone accrual in women with PCOS due to the chronic inflammation disposition has been postulated [Kalyan, 2017]. The lack of progesterone due to anovulation may also have effects on bone metabolism [Seifert-Klauss, 2015]. A progestin test is a classic tool for asse...

ea0073aep614 | Reproductive and Developmental Endocrinology | ECE2021

Peculiarities of cytokin levels in women with infertility living in iodine deficiency regions of Bukovina

Koval Halyna , Pashkovska Nataliia , Abramova Nataliia , Pankiv Ivan , Piddubna Antonina , Marchuk Yulia , Tsaryk Iryna

IntroductionThe problem of ecologically caused iodine deficiency is acute in many countries around the world, including Ukraine, where the endemic zone for the development of iodine deficiency is Northern Bukovina. The possible participation of iodine in the induction or manifestation of autoimmune processes in the thyroid gland and their role in reproduction is discussed. Iodine deficiency is significantly higher in infertile women than in women with no...

ea0073aep615 | Reproductive and Developmental Endocrinology | ECE2021

Y chromosome in Turner syndrome: preventive management Case report and review of the literature

El Miski Fatiha , Hanafi Asmaa , Boufettal Houssine , Mahdaoui Sakher , Samouh Naima

IntroductionTurner syndrome (TS) is one of the most common types of aneuploidy; its etiology is associated with total or partial X-chromosome monosomy. In 5–12% of patients, mosaicism for a cell line with Y chromosome is identified. The presence of Y-chromosome increases the risk of gonadal tumors, especially gonadoblastoma and subsequent dysgerminoma. Here we report on the case of a girl with a rare 45X0/46XY mosaic TS exhibiting a primary amenorrh...

ea0073aep616 | Reproductive and Developmental Endocrinology | ECE2021

Phenotypic expression of a defects in androgen synthesis of action

Safi Wajdi , Ben Rhouma Bochra , Abdelhedi Fatma , Kammoun Thouraya , Belghuith Neila , Rekik Nabila , Kammoun Hassen , Mnif Feki Mouna , Abid Mohamed

Sexual differentiation is a sequential process where several genes are involved, therefore a defect at any stage can lead to a divergence between genetic, gonadal and phenotypic sex. The objective of our work is to analyze the clinical and hormonal characteristics of 13 XY patients, explored between 1989 and 2007 and belonging to 10 different families. The average age of our patients was 18.9 years (2–33 years). The reason for consultation was sexual ambiguity in two case...

ea0073aep617 | Reproductive and Developmental Endocrinology | ECE2021

The prevalence of NAFLD in menopause: A systematic review

Ntikoudi Anastasia , Vlachou Eugenia , Evangelou Eleni , Kanakis George , Tsartsalis Athanasios N. , Vaitsi Violetta , Komninos John , Mastorakos George

IntroductionThe prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) varies according to age, gender and nationality. In the general population, the incidence is about 15–25%. Liver disease increases with age and its prevalence is higher in menopausal women suggesting that steroid sex hormone metabolism may play a role in the pathogenesis of NAFLD.AimThe purpose of this systematic review was to invest...

ea0073aep618 | Reproductive and Developmental Endocrinology | ECE2021

Effects of mitochondrial dynamics during myocardial differentiation in 3D model

Jeong Sunhwa , Lee Minsu , Mi Park Seon , Lee Jimin , Eui-Bae Jeung

Mitochondria, which are essential organelles for endocrine health, plays an important role in various physiological functions including hormonal biosynthesis, cell metabolism, proliferation and differentiation. Thus, mitochondrial toxicity can affect a variety of organs, such as liver, heart, muscle, kidney, and central nervous system. Mitochondrial toxicity is recognized as a contributor to drug-induced toxicity of various drugs such as hydroxytamoxifen, valproic acid, acetam...

ea0073aep619 | Reproductive and Developmental Endocrinology | ECE2021

Leydig cell tumor in childhood: a case report

Bouguerra Hadjer , Khellaf Amina , Adimi Amel , Arbouche Zakia

BackgroundIn the pediatric population, the Leydig cell testicular tumor (TCL) is rare. It manifests communally in childhood with isosexual precocity gonadotropin-independent due to excess testosterone production.Case reportWe admitted a case of an 8.5 years old boy with the complaint of sexual precocity dating back to 4 years, which manifested by acne, hyper seborrhea, stature advance, penile enlargement, pub...

ea0073aep620 | Reproductive and Developmental Endocrinology | ECE2021

Selected steroid hormones – their physiological effects and use in diagnostics and research

Duskova Michaela , Kolatorova Lucie , Šimková Markéta , ámková MonikaŠr , Malíková Maria , Horackova lenka , Jana Vítků , Starka Luboslav

The determination of steroid hormones and subsequent interpretation of results is accompanied by a range of difficulties. The amount of information that current technology can provide on the circulating concentrations of more than a hundred various steroid compounds can lead to problems with interpretation. The aim of this study is to help provide orientation in this maze of data on steroid hormones. First, we focus on specific aspects arising from the pre-analytical phase of ...

ea0073aep621 | Reproductive and Developmental Endocrinology | ECE2021

Experience of the transgender care unit

Moreno-Moreno Paloma , Ángel Rebollo-Román , Mª Rosa Alhambra Expósito , MaríaÁngeles Gálvez-Moreno

ObjectiveHealth care for transsexuals has changed in Andalucia since 2014. Our unit of attention to transsexual people began in 2015. The objective of this study is to analyze our experience.Patients and methodsRetrospective study by reviewing the medical records of the transsexuals treated in our unit.Results145 transsexual people. Transsexual man to woman (TMW):...

ea0073aep622 | Reproductive and Developmental Endocrinology | ECE2021

Mayer-Rokitansky-Kuster-Hauser Syndrome type 2 – A case report

Dumitru Teodora , Anisia Miruna , Anca-Georgiana Tudorean-Olteanu , Preda Cristina , Leustean Letitia , Starcea Magdalena , Christina Ungureanu Maria

IntroductionMayer-Rokitansky-Küster-Hauser (MRKH) type 2 or MURCS (Müllerian duct aplasia, unilateral renal agenesis and cervicothoracic somite anomalies) syndrome is a congenital disease with an incidence of 1 in 4000–5000 female live births, with unknown etiology. Several chromosomal abnormalities were associated with the disease, with a normal 46XX karyotype and familial members to share the same associated anomalies as sporadic cases h...

ea0073aep623 | Reproductive and Developmental Endocrinology | ECE2021

Perrault Syndrome, a case study

Khadidja Bessaid

IntroductionPerrault syndrome is a rare recessive autosomal degenerative disease defined by the combination of ovarian dysgenesis 46XX with sensorineural deafness. Other manifestations can expand the clinical picture, particularly a cerebellar degeneration and/or peripheral neuronal sensitivo-motor.ObservationWe have reported a 14 years old patient case, from a 2nd degree consanguineous marriage with percepti...

ea0073aep624 | Reproductive and Developmental Endocrinology | ECE2021

Systematic review and meta-analysis of the observational trials evaluating the functional impact of COVID-19 on sexual health

Jumani Deepak , Jumani Abhishek , Lufti Ismaeel Ghufran , Phatale Hemant , Joshi Shashank

BackgroundNatural disasters resulting in psychosocial stress and endocrine imbalances are implicated for impacting sexual health. We postulate COVID-19 for its longer duration and global lockdown has implications on the sexual healthMethodsWe analysed contemporary protocols of six ongoing trials through WHO International Clinical Trials Registry Platform and trials registry database. Th...