Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

Audio Eposter Presentations

Pituitary and Neuroendocrinology

ea0073aep457 | Pituitary and Neuroendocrinology | ECE2021

A rare case of pituitary apoplexy likely combined to hypophysitis in an old man with SARS-CoV-2 pneumoniae

Gianotti Laura , Racca Giulia , Fasano Nicoletta , Giamello Jacopo , Martini Gianpiero

IntroductionNeurological complications related to COVID-19 are described. The pituitary expresses ACE which is known as the entrance for Sarscov2 through binding to viral S-protein. Pituitary apoplexy (PA) is due to the sudden hemorrhagic infarction of pre-existing pituitary tumors or the gland itself and its symptoms and radiological findings can be similar to acute hypophysitis (AH) caused by viral infections.Subjects and methods...

ea0073aep458 | Pituitary and Neuroendocrinology | ECE2021

Pituitary apoplexy lead to disappearance of adenoma; two case reports

Djerroumi Imane , Boulgheraief Aicha , Iraten Yasmine , Foudil Dalila , Mimouni Safia

IntroductionPituitary apoplexy is a rare endocrine and neurosurgical emergency. It corresponds to the occurrence of an hemorrhage or infarction in the pituitary gland, or most often within a pituitary adenoma. The usual presentation associates sudden headaches, visual disturbances, altered consciousness and endocrine disorders wich are dominated by corticotropic insufficiency. We present two cases of pituitary apoplexy, the first one complicating an unde...

ea0073aep459 | Pituitary and Neuroendocrinology | ECE2021

Cushing’s disease presenting as pituitary apoplexy: Challenges of diagnosis and treatment

Juskiene Rasa , Romena Laukienė , Ieva Laukytė

BackgroundPituitary apoplexy (PA) is a rare clinical syndrome, usually occurring in the pituitary adenoma due to a sudden bleeding and/or infarction. PA is usually seen in nonfunctional pituitary adenomas, but it can also be seen in ACTH secreting macroadenomas. The most common symptoms PA, which complicates 2 to 12% of pituitary adenomas, are severe and sudden headache, visual disturbances, or eye paralysis, and endocrinological abnormalities. PA is dia...

ea0073aep460 | Pituitary and Neuroendocrinology | ECE2021

Pituitary tuberculosis: A clinical challenge

Chatti Hiba Allah , Kammoun Ines , Gharbi Radhouane , Ibrahim Arbaoui , Sonia Nagi , Kandara Hajer , Jemel Manel

IntroductionCerebral tuberculomas are a rare form of tuberculosis due to the hematogenous spread of Mycobacterium Tuberculosis (MT). Pituitary localization is exceptionally uncommon with total reported cases in the literature fewer than a hundred. Symptoms and radiologic features are nonspecific, leading sometimes to misdiagnosis. We report the rare case of a patient diagnosed with a primary pituitary stalk tuberculosis.Observation...

ea0073aep461 | Pituitary and Neuroendocrinology | ECE2021

A rare case of acromegaly developed in a patient with multicentric Castleman disease and complete disappearance of lymphadenopathies after treatment with Lanreotide Autogel

Aggul Hunkar , Bilen Ogun , Arslan Aysegul Isal , Zuhur Sayid

IntroductionMulticentric Castleman disease (MCD) is characterized by highly vascularized multiple lymph node enlargements throughout the body. MCD is generally treated with systemic cytotoxic chemotherapy, with its attendant risk for toxicity. Studies suggest the presence of growth hormone receptors (GHR) in lymphatic tissues of patients with Castleman disease. However, the effect of somatostatin analogs for the treatment of MCD is not reported so far. H...

ea0073aep462 | Pituitary and Neuroendocrinology | ECE2021

Cardiac remodeling in patients with childhood-onset craniopharyngioma – Results of HIT-Endo and Kraniopharyngeom 2000/2007

Sowithayasakul Panjarat , Boekhoff Svenja , Buschmann Leona Katharin , Hermann Müller

Hypothalamic obesity caused by childhood–onset craniopharyngioma results in long–term cardiovascular morbidity. Knowledge about clinical markers and risk factors for cardiovascular morbidity is scarce. A cross–sectional study on transthoracic echocardiographic parameters was performed to determine the associations with clinical and anthropometric parameters in 36 craniopharyngioma patients. BMI correlated with the thickness of interventricular septum in diastole...

ea0073aep463 | Pituitary and Neuroendocrinology | ECE2021

Epidemiology of acromegaly in south-eastern Norway

Falch Camilla Maria , Olarescu Cristina , Bollerslev Jens , Dekkers Olaf M. , Heck Ansgar

ObjectiveIn order to improve therapeutic outcomes for patients with acromegaly, new treatment algorithms have been developed over the last decades. Valid epidemiological data of acromegaly in Norway is lacking. The overall aim of this study was to investigate incidence, prevalence and mortality of acromegaly in South-Eastern Norway, and to investigate effects of new treatment algorithms.Design and methodPatie...

ea0073aep464 | Pituitary and Neuroendocrinology | ECE2021

The duration of postoperative steroid replacement therapy may not have a predictive role for recurrence risk of Cushing’s disease

Gülnar Zeynalova , Ozturk Feyza Yener , Aslı Büyükkuşcu , Erol Selvinaz , sen Esra Cil , M.Masum Canat , Altuntas Yuksel

ObjectiveIn patients with Cushing’s disease (CD), normal pituitary corticotrophs are suppressed by excessive and persistent cortisol secretion in responce to autonomous ACTH secretion by tumour. Therefore, patients exhibit signs and symptoms of ACTH deficiency shortly after resection of tumour and need steroid replacement therapy (SRT) until hypotalamo-pituitary-adrenal (HPA) axis recovery. We aimed to evaluate whether duration of SRT can serve as a...

ea0073aep465 | Pituitary and Neuroendocrinology | ECE2021

Hypothalamic-pituitary-adrenal axis activity in patients with primary polydipsia and healthy volunteers

Kuehne Jill , Sailer Clara , Ismael da Conceição , Refardt Julie , Christ-Crain Mirjam , Winzeler Bettina

BackgroundThe pathophysiology of primary polydipsia, a disorder with increased fluid intake, is poorly understood. A dysregulation in the hypothalamic-pituitary-adrenal axis (HPA) is speculated and arises mainly from research in patients witch a schizophrenia spectrum disorder but data is contradictory. The aim of this study was to investigate markers of HPA axis activity in patients with primary polydipsia compared to healthy controls.<p class="abst...

ea0073aep466 | Pituitary and Neuroendocrinology | ECE2021

Study of the brain system for motor control in prader willi syndrome

Blanco Laura , Casamitjana Laia , Jesús Pujol , Gerard Martínez-Vilavella , Deus Joan , Olga Giménez-Palop , Assumpta Caixàs

BackgroundPrader Willi syndrome (PWS) is a genetic disorder with a broad clinical expression. Severe hypotonia with feeding difficulties during early infancy and delayed motor development are very characteristic. At older ages, common motor features in the PWS phenotype include decreased muscle strength, deficiencies in motor coordination and sequencing, gait disturbances and dyspraxic manifestations, with no clear pathophysiological mechanism yet identi...

ea0073aep467 | Pituitary and Neuroendocrinology | ECE2021

The GLP-1 receptor agonist dulaglutide reduces fluid intake in primary polydipsia: A randomised controlled trial

Winzeler Bettina , Sailer Clara , David Coynel , Zanchi Davide , Vogt Deborah , Urwyler Sandrine , Refardt Julie , Christ-Crain Mirjam

BackgroundPrimary polydipsia, characterized by excessive fluid intake, carries the risk of water intoxication and hyponatremia, but treatment options are scarce. Glucagon-like peptide-1 (GLP-1) reduces appetite and food intake. In experimental models, they also play a role in thirst and drinking behavior. The aim of this trial was to investigate whether GLP-1 receptor agonists reduce fluid intake in patients with primary polydipsia.<p class="abstext"...

ea0073aep468 | Pituitary and Neuroendocrinology | ECE2021

The diagnostic and predictors of postoperative diabetes insipidus

Mikhaylova Darya , Dzeranova Larisa , Pigarova Ekaterina , Rozhinskaya Liudmila , Marova Evgenia , Grigoriev Andrey , Azizyan Vilen , Ivashenko Oksana

ObjectivesTo assess diagnostic and prognostic markers of permanent and transient postoperative diabetes insipidus.Patients and methodsThe study included 152 patients undergone endoscopic endonasal transsphenoidal surgery aged from 18 to 65 years with median 40 [31; 52] years. Seventy three patients had Cushing disease, 66 – acromegaly, 4 – prolactinoma, 9 – hormonally inactive adenoma, 1 –...

ea0073aep469 | Pituitary and Neuroendocrinology | ECE2021

The usage of aripiprazole as a single agent in the treatment of hyperprolactinemia associated with diogenes syndrome- a novel approach

Birgi Harleen Kaur , Fawzi Waleed , Kapoor Ashutosh

IntroductionHyperprolactinemia is a condition in which a person has higher-than-normal levels of the hormone prolactin in the blood. It is a relatively common condition encountered in the world of endocrinology. It is often seen as a side-effect with usage of anti-psychotics. Treatment options when symptomatic usually constitute dopamine agonist therapy, the common agents being Cabergoline and Bromocriptine. The uniqueness of this case is attributed to t...

ea0073aep470 | Pituitary and Neuroendocrinology | ECE2021

Nonfunctioning pituitary adenomas: What can we do? What we did

Mallea-Gil Susana , Cuccia Mariela , Tubert Gloria , Diez Sabrina , Ballarino Carolina

Nonfunctioning pituitary adenomas (NFAs) have no symptoms of hormonal overproduction and can be asymptomatic or have severe symptoms due to mass effects. The aim of our study was to assess clinical features and therapeutic outcomes in patients with clinically NFAs. We retrospectively collected data of 175 patients from 3 hospitals of Buenos Aires. Mean age: 51 years (r:13–90), 52% women, mean follow-up: 7.37 years. At diagnosis, clinical presentation was: visual field def...

ea0073aep471 | Pituitary and Neuroendocrinology | ECE2021

Association between fibroblast growth factor-21 and carotid intima media thickness in patients with acromegaly

Uygur Meliha Melin , Yavuz Dilek Gogas , Yazici Dilek

İntroductionThe aim of this study was to evaluate the association between fibroblast growth factor-21 (FGF-21) levels and carotid intima media thickness (CIMT) in acromegalic patients in relation to the atherosclerotic complications.Metarials and methodsThe study goroup included 70 acromegalic patients. According to the disease activity, patients cathegorized inti 2 groups: controlled and active acromega...

ea0073aep472 | Pituitary and Neuroendocrinology | ECE2021

Age and sex differences among patients with acromegaly

Anna Boguslawska , Gilis-Januszewska Aleksandra , Godlewska Magdalena , Nowak Andrzej , Starzyk Jerzy , Hubalewska-Dydejczyk Alicja

IntroductionAcromegaly is a chronic, slowly progressing disease caused in most cases by growth hormone (GH)- producing pituitary neuroendocrine tumors (PitNETs). This rare disorder is associated with a spectrum of various clinical manifestations and treatment outcomes differ between patients. The aim of this study was to evaluate the impact of age at the onset of symptoms and sex on clinical features, comorbidities, biochemical status at the diagnosis, a...

ea0073aep473 | Pituitary and Neuroendocrinology | ECE2021

Panhypopituitarism without pituitary ischemia after hantavirus infection

Tufekci Damla , Gunay Yasemin Emur , Demir Ahmet Suat , Guvercin Beyhan , Bilginer Muhammet Cuneyt , Coskun Hulya , Nuhoglu Irfan , Ucuncu Ozge , Kaynar Kubra , Kocak Mustafa

IntroductionHantaviruses are a group of viruses causing hemorrhagic fever with renal failure syndrome (HFRS). HFRS is a disease characterized by bleeding, thrombocytopenia, increased vascular permeability, and acute renal failure. Hypopituitarism associated with HFRS often results from necrosis in the pituitary gland caused by ischemia or infarction. HFRS may be difficult to diagnose due to its unclear clinical features. In this report, we present a pati...

ea0073aep474 | Pituitary and Neuroendocrinology | ECE2021

Pulmonary thromboembolism-caused acute severe euvolemic hyponatremia complicated by COVID-19 infection: A case report

Joksimovic Bojan , Radovic Milica , Mitrovic Bojan , Pancevacki Sasa , Samardzic Vladimir , Lackovic Milena , Obradovic Milan , Isenovic Esma R. , Gluvic Zoran , Djurdjevic Sandra Pekic , Petakov Milan

IntroductionHyponatremia is frequently encountered in clinical practice. Euvolemic hyponatremia (Syndrome of Inadequate Antidiuresis, SIAD) represents diagnostic and management challenge regarding etiology unraveling, its gradual acute substitution, and later causal treatment.Case reportA 68-year-old woman was admitted to the Emergency unit with acute psychosis. On examination, there were no focal neurologica...

ea0073aep475 | Pituitary and Neuroendocrinology | ECE2021

Recovery of reproductive function under indomethacin treatment in a woman with langerhans cell histiocytosis: A case report

Feola Tiziana , Santopietro Michelina , Arosio Maura , Palumbo Giovanna , Giona Fiorina , Marie-Lise Jaffrain-Rea

IntroductionLangherans Cell Histiocytosis (LCH) is a rare disease due to a neoplastic proliferation of Langerhans-type cells. Hypothalamic-pituitary (HP) involvement may occur in 20–40% of the patients, presenting with diabetes insipidus (DI) and/or anterior pituitary dysfunction. Typically, such abnormalities are permanent and unresponsive to systemic treatment of LCH. We report the case of a young woman with pulmonary and HP localizations, and sig...

ea0073aep476 | Pituitary and Neuroendocrinology | ECE2021

Growth Hormone (GH) treatment in adults with Prader-Willi Syndrome (PWS) restores plasma kisspeptin to normal levels

Olga Giménez-Palop , Casamitjana Laia , Corripio Raquel , Rocío Pareja , Oliva Joan Carles , Néstor Albiñana , Neus Gómez Gerique , Rigla Mercedes , Assumpta Caixàs

BackgroundCentral kisspeptin action is well known in reproductive regulation; however, its peripheral action is not well understood. Most studies reveal that kisspeptin signaling influences energy and metabolic status.ObjectiveTo compare serum kisspeptin levels 1) between adult patients with PWS, obese subjects matched for age, sex and BMI and healthy subjects; 2) in adult patients with PWS before and after t...

ea0073aep477 | Pituitary and Neuroendocrinology | ECE2021

Body composition and nuchal skinfold thickness in pediatric brain tumor patients

Peng Junxiang , Boekhoff Svenja , Eveslage Maria , Bison Brigitte , Sowithayasakul Panjarat , Hermann Müller

BackgroundObesity, cardiovascular disease (CVD), and relapse/progression have impact on prognosis in pediatric brain tumor (BT) patients.MethodsIn a cross-sectional study, we analyzed nuchal skinfold thickness (NST) on MRI follow-up monitoring as a parameter for body composition (BC) and CVD in 177 BT patients (40 WHO grade 1–2 BT; 31 grade 3–4 BT; 106 craniopharyngioma (CP)), and 53 healthy control...

ea0073aep478 | Pituitary and Neuroendocrinology | ECE2021

Uncured acromegaly, the dark side of the moon: a cross- sectional study

Porras Mariana Gomes , Alexa Benítez Valderrama , Álvaro Zamarrón Pérez , Carlos Pérez López , Isabel Esteban Rodríguez , Rosa García Moreno , Beatriz Lecumberri Santamaría , Cristina Álvarez Escolá

IntroductionAlthough surgical treatment of acromegaly is the treatment of choice in most patients, a wide therapeutic arsenal is available. Medical treatment can be indicated as primary treatment, complementary and even as pre-operative treatment.ObjectivesTo determine the prevalence of uncured acromegaly and the prevalence of controlled disease within this group. To clinically, biochemically and histological...

ea0073aep479 | Pituitary and Neuroendocrinology | ECE2021

Metabolic profile in patients with prolactinoma before and on dopamine agonist therapy

Giuca Diandra Carmen , Trifanescu Raluca , Vere Cristin Constantin , Baciu Ionela , Baculescu Nicoleta , Capatina Cristina , Dusceac Roxana , Găloiu Simona Andreea , Niculescu Dan Alexandru , Radian Serban , Caragheorgheopol Andra , Schipor Sorina , Poiana Catalina

BackgroundProlactinomas are the most frequent type of hormone-secreting pituitary adenomas. Prolactin(PRL)-receptor mediates intracellular signaling pathways that contribute to weight gain, dyslipidemia, impaired fasting glucose (IFG), type 2 diabetes mellitus (T2DM) and cardiovascular disease, parameters that improve along with PRL level control on dopamine agonist (DA) therapy.AimTo assess metabolic disturb...

ea0073aep480 | Pituitary and Neuroendocrinology | ECE2021

What should be the optimal testosterone level to improve the symptoms of hypogonadism in male macroprolactinomas?

Caklili Ozge Telci , Ayşe Merve Çelik , Istemihan Zulal , Selcukbiricik Ozlem Soyluk , Yarman Sema

ObjectivesMale prolactinoma patients mostly have hypogonadotropic symptoms. While treatment with dopamine agonists (DAs; such as bromocriptine or cabergoline) leads to recovery of sexual glands, it can lead to impulsive control disorders as an undesirable side effect. The aim of this retrospective study is to determine the level of testosterone that eliminates symptoms, provides fertility and does not cause this undesirable side effect regardless of prol...

ea0073aep481 | Pituitary and Neuroendocrinology | ECE2021

Pituitary function after transsphenoidal surgery including measurement of basal morning cortisol as predictor of adrenal insufficiency

Staby Ida , Krogh Jesper , Klose Marianne , Feldt-Rasmussen Ulla , Poulsgaard Lars , Springborg Jacob Bertram , Andreassen Mikkel

IntroductionPatients with pituitary adenomas undergoing transsphenoidal surgery require pre- and post-surgery examination of pituitary hormones. There is currently no consensus on how to evaluate the adrenal axis post-surgery. The aims of this study were to investigate factors that may predict postoperative adrenal insufficiency (AI) and to investigate the overall effect of transsphenoidal surgery on the pituitary function.Methods<...

ea0073aep482 | Pituitary and Neuroendocrinology | ECE2021

Factors that contribute to dopamine agonist resistance of prolactinomas

Berdeli Maria , Trifanescu Raluca , Caragheorgheopol Andra , Anda Dumitraşcu , Poiana Catalina

IntroductionProlactinomas are the most common hormone-secreting pituitary tumours encountered in the clinic. They are usually treated with dopamine agonists (DA): bromocriptine (BRC) and cabergoline (CAB), which are highly effective in the majority of cases. DA resistance is the failure to achieve normal levels of prolactin and, or reduction of the adenoma with at least 50%.Aimto assess the prevalence of the ...

ea0073aep483 | Pituitary and Neuroendocrinology | ECE2021

Electrolyte disturbances in hospitalized patients with COVID-19

Abilov Zaur , Kononykhina Anastasia , Sardaeva Daria , Katamadze Nino , Pigarova Ekaterina , Dzeranova Larisa , Marova Evgenia , Olga Yu. Rebrova , Melnichenko Galina , Mokrysheva Natalia

IntroductionSARS-CoV-2 has caused a global outbreak of coronavirus disease 2019 (COVID-19). It is known that this virus binds angiotensin-converting enzyme 2 (ACE2) of the renin-angiotensin system, which may exert substantial effects on sodium and potassium metabolism. Viral pneumonia and respiratory distress are well known etiologies for hyponatremia due to syndrome of inadequate secretion of antidiuretic hormone, and can worsen clinical course of the d...

ea0073aep484 | Pituitary and Neuroendocrinology | ECE2021

Spontaneous remission of cushing’s disease – a case report

Curt Ana Maria , Georgescu Carmen Emanuela , Bintintan Adriana , Ioana Rada Popa Ilie

Adrenocorticotropic hormone (ACTH) adenomas causing Cushing’s disease (CD) have been recognized as an aggressive and invasive subtype of pituitary adenomas. Remission of CD without surgical or medical treatment is an extremely rare occurrence. Moreover, a clinically relevant peculiarity of these tumors, though rarely observed, is their ability to modify their clinical expression from a silent form to CD or vice versa, the latter even more unexpected. We describe the case ...

ea0073aep485 | Pituitary and Neuroendocrinology | ECE2021

Hypopituitarism in systemic diseases

Abir Derbel , Mouna Guermazi , Mouna Snoussi , Chebbi Donia , Chifa Dammak , Feten Frikha , Salah Raida Ben , Sameh Marzouk , Zouhir Bahloul

IntroductionHypopituitarism is a rare condition defined by loss of pituitary function due to involvement of hypothalamus and/or pituitary gland by infiltrative diseases mainly sarcoidosis and Langerhans cell histiocytosis (LCH). Central diabetes insipidus is the most frequent manifestation of LCH (10–50%) and rarely in neuro-sarcoidois. Herein, we describe 2cases of hypopituitarism due to neuro-sarcoidosis and LCH.Case 1<p...

ea0073aep486 | Pituitary and Neuroendocrinology | ECE2021

A successful surgical outcome in thyrotropin-secreting pituitary macrodenomas

Boharoon Hessa , Hatfield Emma , Das Gautam , Mendoza Nigel , Meeran Karim

BackgroundTSHomas are a rare cause of hyperthyroidism, and account for 0.5 to 3% of pituitary tumours. Incidence=0.15 per million per year. Prevalence=1 per million. Our limited experience of this condition can result in diagnostic and treatment challenges. Here we describe a case treated surgically lead to successful outcomesCase35 years old female referred to our service with secondary amenorrhea for the la...

ea0073aep487 | Pituitary and Neuroendocrinology | ECE2021

Case report: Girl with short stature with no response to growth hormone treatment

Teodora Gheorghe Elena , Ioana Albu Alice

IntroductionGrowth hormone deficiency (GHD) is a rare disorder and severe forms of GHD may have a genetic basis. Familial isolated growth hormone deficiency (IGHD) is classified into 4 types, type IA being the most severe form. These patients present with severe growth failure with undetectable growth hormone (GH) concentrations and about 50% tend to develop antibodies on GH treatment.(1, 2, 3) The appearance of anti-GH antibodies may not be a regular fi...

ea0073aep488 | Pituitary and Neuroendocrinology | ECE2021

Pituitary surgery in northern ireland: A twenty year retrospective population based analysis

Loughrey Paul Benjamin , Craig Stephanie , Herron Brian , Cooke Stephen , Weir Philip , Bhattacharya Debarata , Sturdy Erin , Salto-Tellez Manuel , Parkes Eileen , McArt Darragh , Korbonits Marta , Hunter Steven , James Jacqueline

In Northern Ireland, the sole tertiary referral centre for pituitary disease which includes neurosurgery and endocrinology for ~1.9 million people, is based in the Royal Victoria Hospital, Belfast. A retrospective study has been commenced to examine clinical, biochemical, histopathological and radiological data for all patients operated on across an approximately 20 year period in Northern Ireland. Ethical approval was obtained from the Northern Ireland Biobank (study num...

ea0073aep489 | Pituitary and Neuroendocrinology | ECE2021

Disease activity is associated with depression and anxiety in cushing’s syndrome during COVID-19 pandemic

Piskinpasa Hamide , Turgut Seda , Karaarslan Ozlem , Bozkur Evin , Ayşe Esen Pazır , Pamuk Naim , Ilkay Çakir , Mert Meral , Dogansen Sema Ciftci

PurposeTo assess the depression and anxiety and their relationship with disease activity in patients with Cushing’s syndrome (CS) in the COVID-19 pandemic.Material and methodsThis is a cross-sectional study including 54 patients with CS (48 female/6 male). Beck Depression Inventory-II (BDI-II), State Trait Anxiety Inventory (STAI)-State, STAI-Trait were used to evaluate, scores and severity of depression...

ea0073aep490 | Pituitary and Neuroendocrinology | ECE2021

Third month MRI predicts macroprolactinoma reduction after cabergoline therapy

Biagetti Betina , Sarria-Estrada Silvana , Ng-Won Karelis , Martinez-Saez Elena , Casteras Anna , Cordero-Asanza Esteban , Irene Hernández-Hernández , Efrain Cordero-Vazquez. , Alba Rojano , Canonge Rafael Simo

BackgroundTranssphenoidal surgery is in general the preferred first-line treatment for patients with macroadenomas except for prolactinomas, which is mainly indicated when the treatment with dopamine agonists (DA) fails. However, in those patients resistant to DA (i.e. volume reduction ObjectiveTo identify predictors of DA resistance in order...

ea0073aep491 | Pituitary and Neuroendocrinology | ECE2021

The role of cannulated prolactin test in females of reproductive age presenting with isolated mild persistent hyperprolactinaemia on random sampling

Gad Hady , Mamoojee Yaasir , James Andy

IntroductionCurrent guidelines recommend a single elevated prolactin measurement drawn without excessive venepuncture stress as sufficient for diagnosing hyperprolactinaemia. However, previous studies have demonstrated that the cannulated prolactin test is more reliable at eliminating stress-induced hyperprolactinaemia, thus avoiding unnecessary additional investigations. We routinely perform morning serial prolactin sampling immediately after brachial v...

ea0073aep492 | Pituitary and Neuroendocrinology | ECE2021

GH and IGF-1 discrepancies in acromegaly patients after pituitary surgery – an observational single-center study

Tomasik Agnieszka , Maria Stelmachowska-Banaś , Wojciech Zgliczynski

IntroductionTreatment of choice in acromegaly is transsphenoidal resection of GH-secreting pituitary adenoma. Its efficacy ranges from 28% to 83% depending on tumor size and location. Random GH < 1 µg/l or nadir GH in OGTT < 0.4 µg/l and normal IGF-1 are found to be the evidence of effective surgery. However, some patients diagnosed with acromegaly remission after surgery present discordant GH and IGF-1 results.Ai...

ea0073aep493 | Pituitary and Neuroendocrinology | ECE2021

Growth hormone treatment for adults with Prader-Willi syndrome: A meta-analysis

Rosenberg Anna , Passone Caroline , Pellikaan Karlijn , Damiani Durval , Aart Jan Van der Lely , Polak Michel , Bernardo Wanderley , Graaff Laura De

BackgroundFeatures of Prader-Willi syndrome (PWS) overlap with features of growth hormone (GH) deficiency, like small hands and feet, short stature, increased body fat and low muscle mass and strength. In children with PWS, GH treatment improves physical health, cognition and quality of life (QoL). GH treatment is standard of care in PWS children, but in adults this is not the case. A systematic review and meta-analysis was conducted to provide a concise...

ea0073aep494 | Pituitary and Neuroendocrinology | ECE2021

Cabergoline treatment for non functioning pituitary macroadenomas

Pappa Dimitra , Thoda Pinelopi , Anastasia – Konstantina Sakali , Barmpa Eleftheria , Georgiou Eleni , Gountios Ioannis , Alexandra Bargiota

IntroductionCabergoline seems to be a promising and effective medical treatment for the more agressive Non Functioning Pituitary Adenomas (NFPAs) by reducing or keeping tumor’s size stable long-term. Here we present the experience of our centerMethodsWe studied 7 patients with NFPAs attending our clinic the last 10 years (median period 42 months, range 12 to 114 months), in whom cabergoline was started d...

ea0073aep495 | Pituitary and Neuroendocrinology | ECE2021

Efficacy and safety of cyberknife stereotactic radiosurgery in acromegaly

Seguna Desiree , Akker Scott A , Ahlquist James , Pal Aparna , Brooke Antonia , Lewis Rachel , Plowman Nick , Evanson Jane , Drake William Martyn

ObjectiveActive acromegaly is associated with increased mortality. While surgery is the mainstay of treatment, it is not always curative. In selected cases, CyberKnife stereotactic radiosurgery (CK SRS) can be used as adjuvant treatment in patients with persistent disease.DesignThis is a retrospective review of the biochemical and imaging characteristics for patients with active acromegaly treated with CK SRS...

ea0073aep496 | Pituitary and Neuroendocrinology | ECE2021

Pituitary apoplexy: Clinical features, management and outcomes-a retrospective study

Czajka-Oraniec Izabella , Stelmachowska-Banas Maria , Szostek Arnika , Wydra Jakub , Zgliczynski Wojciech

IntroductionPituitary apoplexy (PA) is a rare medical emergency caused by acute haemorrhage and/or infarction within a pituitary or usually pituitary tumour. Typically, PA is characterised by severe headache, visual fields defects, decreased visual acuity, cranial nerve palsies and hypopituitarism. However, many patients present with mild or ambiguous signs and symptoms or even PA is an incidental radiological finding.Aim<p cla...

ea0073aep497 | Pituitary and Neuroendocrinology | ECE2021

Kallmann syndrome due to a mutation in ANOS1 gene and monoallelic mutation in GNRHR gene

Cidade-Rodrigues Catarina , Chaves Catarina , Martinho Mariana , Cunha Filipe , Almeida Margarida

IntroductionHypogonadotropic hypogonadism (HH) is a rare disease. When associated with anosmia/hyposmia, it is called Kallmann syndrome (KS). Several mutations in different genes have been implicated in its pathophysiology, the most frequent being ANOS1/KAL1, FGFR1 and GNRHR genes. This heterogenicity can be explained by the increasing detection of more than one pathogenic variant in the genes responsible for causing the disease (oligogenism). The preval...

ea0073aep498 | Pituitary and Neuroendocrinology | ECE2021

The role of endoscopic ultrasonography for localization of sporadic and men-1 syndrome associated insulinomas: Case series

Bilen Ogun , Altuntas Yuksel , Aggul Hunkar , Zuhur Sayid

IntroductionThe diagnosis of insulinomas is made biochemically. However, proper localization of insulinomas is essential before surgery. Non-invasive methods including magnetic resonance imaging (MRI), computed tomography, ultrasonography, glucagon-like peptide-1 receptor PET/CT, 68Ga-DOTATATE PET/CT, and invasive methods such as endoscopic ultrasonography (EUS) and selective arterial calcium stimulation test are used for preoperative localization. Howev...

ea0073aep499 | Pituitary and Neuroendocrinology | ECE2021

Ectopic cushing’s syndrome: Report of 5 cases from a tertiary care center

Pascual-Corrales Eider , Pinedo Marta Marchan , Maria Fernandez Argüeso , Manuel Luque-Ramírez , Castro Marta Araujo

IntroductionEctopic Cushing’s syndrome (ECS) is a rare entity caused by ACTH secretion by a non-pituitary tumor. The management of these patients is challenging due to its low frequency and limited experienced. The objective of this study was to describe the patients with ECS treated in the Division of Endocrinology at the Ramón y Cajal University Hospital (Madrid, Spain) in the last six years.Methods<p class="abstext...

ea0073aep500 | Pituitary and Neuroendocrinology | ECE2021

Cerebral infarction in childhood-onset craniopharyngioma patients – results of kraniopharyngeom 2007

Boekhoff Svenja , Bison Brigitte , Genzel Daniela , Eveslage Maria , Otte Anna , Friedrich Carsten , Jörg Flitsch , Hermann Müller

BackgroundCerebral infarction (CI) is a known vascular complication following treatment of suprasellar tumors. Risk factors for CI, incidence rate, and long-term prognosis are unknown for patients with childhood-onset craniopharyngioma (CP).MethodsMRI of 244 CP patients, recruited between 2007 and 2019 in KRANIOPHARYNGEOM 2007, were reviewed for CI. Risk factors for CI and outcome after CI were analyzed.<...

ea0073aep501 | Pituitary and Neuroendocrinology | ECE2021

Clinical features, diagnostic criteria and treatment outcomes in 40 patients with thyrotropin-secreting pituitary tumors

Dimitrova Diana , Przhiyalkovskaya Elena , Grigoriev Andrey , Azizyan Vilen , Lapshina Anastasia , Belaya Zhanna , Melnichenko Galina

IntroductionThyrotropin-secreting pituitary adenomas (TSH-omas) are rare. For this reason each case of TSH-secreting pituitary tumor can help expand extensive clinical experience in world practice.Materials and methodsWe included 40 patients with TSH secreting pituitary adenomas. Hormonal profile: TSH (0.25-3.5 mIU/L), FT4 (9-20 pmol/l) FT3 (2.5-5.5 pmol/l) were measured by Architect i2000SR (Abbott Laborator...

ea0073aep502 | Pituitary and Neuroendocrinology | ECE2021

White blood cell count: A potential useful tool for suspected Cushing’s syndrome

Merlo Ignacio , Paja Miguel , Martinez Adela , Monzon Andoni , Rodriguez Josune

BackgroundSuspicion of Cushing´s syndrome (CS) is usually suggested by non-specific clinical data. Chronic hypercortisolism associates changes in white blood cell count (WBC), essentially a higher count with relative lymphopenia. Our purpose is to investigate the prevalence of these findings among a local series of patients with Cushing’s syndrome before and after the hypercortisolism revertion to assess the diagnostic value of these parameters...

ea0073aep503 | Pituitary and Neuroendocrinology | ECE2021

Screening of acromegalia among patients with endocrine and somatic pathology

Nikolaiev Roman , Khyzhnyak Oksana , Mykytyuk Myroslava , Karachentsev Iurii , Gavrish Tatiana

IntroductionThe practice of screening for many chronic diseases, particularly endocrine pathology, is taking place all over the world. The relevance of screening increases significantly when we are talking about diseases with a torpid manifestation and absence of certain clinical symptoms in the debut. Such diseases include pathological conditions caused by pituitary hormone hypersecretion, in particular, acromegaly.The aim<p c...

ea0073aep504 | Pituitary and Neuroendocrinology | ECE2021

Acromegaly: Knowing the enemy in order to win

Porras Mariana Gomes , Alexa Benítez Valderrama , Paola Parra Ramírez , Rosa García Moreno , Rojas Patricia Martin , Gumersindo Fernández Vázquez , Beatriz Lecumberri Santamaría , Cristina Álvarez Escolá

IntroductionAcromegaly is an uncommon chronic disease with an insidious course. Due to the high morbimortality it causes, its early diagnosis and treatment are priority. The three therapeutic pillars are surgery, pharmacological treatment and radiotherapy, alone or in combination.ObjectivesTo clinically, biochemically and histologically characterize patients with acromegaly under follow-up in a tertiary hospi...

ea0073aep505 | Pituitary and Neuroendocrinology | ECE2021

Increased anxiety and perceived stress in active acromegaly during the COVID-19 pandemic

Turgut Seda , Piskinpasa Hamide , Acarer Didem , Karaarslan Ozlem , Bozkur Evin , Pamuk Naim , Cakir Ilkay , Mert Meral , Dogansen Sema Ciftci

AimTo examine and compare the anxiety level and stress perception of acromegaly patients with controlled and active disease in the COVID-19 pandemic.Material and Method49 (23 females/26 males) patients admitted to the outpatient clinic during the first month after the pandemic period were recruited in this cross-sectional study. State-Trait Anxiety Inventory (S-Anxiety for state scale, T-Anxiety for trait sca...

ea0073aep506 | Pituitary and Neuroendocrinology | ECE2021

The association of z-score with early postoperative remission and characteristics of bone mineral density in patients with cushing’s disease: Single center study

gezer emre , Canturk Zeynep , Selek Alev , Cetinarslan Berrin , mehmet sözen , Özlem Elen , İhsan Anık , Savaş Ceylan

IntroductionVarious direct and indirect mechanisms by which glucocorticoid (GC) excess and elevated adrenocorticotropic hormone (ACTH) levels impairs bone metabolism have been described. In the literature, there are different factors described which affect the early outcome of pituitary surgery in patients with CD including preoperative ACTH levels and the clinical severity of the disease. Combining these data, we conducted a retrospective study to inves...

ea0073aep507 | Pituitary and Neuroendocrinology | ECE2021

Treatment regimens affecting glucose metabolism and gastrointestinal hormones in acromegaly: A descriptive study

Nanna Jørgensen , Erichsen Trine , Klose Marianne , Joergensen Morten , Idorn Thomas , Feldt-Rasmussen Bo , Holst Jens J. , Feldt-Rasmussen Ulla

ContextActive acromegaly is associated with impaired glucose metabolism, which improves upon treatment. Treatment options include surgery, medical therapy with somatostatin analogues (SSA) and Pegvisomant (PEG) and in few cases irradiation.ObjectiveTo describe the differential effect of various treatment regimens on the secretion of glucose, insulin, glucagon, glucagon-like peptide-1 (GLP1), and glucose-depen...

ea0073aep508 | Pituitary and Neuroendocrinology | ECE2021

Female central hypogonadism with or without organic pituitary lesions: diagnostic value of LH and FSH basal levels

Loktionova Anna , Ilovayskaya Irena

Central hypogonadism (CH) is a syndrome that can be revealed in women with hypoestrogenic amenorrhea due to the lack of normal response of gonadotropins to the hypoestrogenemia. CH can be caused by organic lesion of the hypothalamo-pituitary region or has idiopathic character – without any structural background. This syndrome is often called ’hypogonadotropic hypogonadism’, but LH and FSH levels within ’normal’ laboratory range does not exclude CH beca...

ea0073aep509 | Pituitary and Neuroendocrinology | ECE2021

Self-administration of long-acting somatostatin analogues in NET patients forced by the COVID-19 pandemic – does it affect the clinical outcome?

Opalinska Marta , Anna Kurzynska , Staszczak Anna Sowa , Joanna Palen-Tytko , Zwinczewska Helena , Karolina Morawiec-Slawek , Hubalewska-Dydejczyk Alicja

BackgroundSomatostatin analogues (SSA) (octreotide and lanreotide) are recommended as a first line treatment of locally advanced or metastatic well-differentiated neuroendocrine tumors (NETs) with a good expression of somatostatin receptor (SSTR). Both of them are usually used in injection repeated every 4 weeks.The study objectiveWas to compare the way of SSA administration (injection performed by profession...

ea0073aep510 | Pituitary and Neuroendocrinology | ECE2021

Is this just vitiligo? Nelson is hiding

Vis Maarten De , Brigitte Velkeniers

A 64-year old man presented to our endocrinology clinic with progressive lumbar pain that had developed two months earlier. He had undergone bilateral adrenalectomy for Cushing disease and two years later transsphenoidal resection for Nelson tumor. On physical examination, the patient had remarkable hyperpigmentation due to ACTH hypersecretion periorbital, peri-auricular and in the lower-neck region. These findings were clearly evident in his case due to the extensive facial v...

ea0073aep511 | Pituitary and Neuroendocrinology | ECE2021

Microprolactinoma and pregnancy. A case report and review of literature

Kermaj Marjeta , Hyka Besa , Shehu Tea , Ylli Agron

IntroductionProlactinomas are the most common pituitary tumors and a common cause of infertility because of gonadal dysfunction, in young women. The treatment of choice is dopamine agonists, which can restore fertility and promote shrinking of the tumor in the majority of cases. Managing prolactinomas during pregnancy may be challenging. Treatment discontinuation is recommended once the pregnancy is confirmed in women with microprolactinoma. For micropro...

ea0073aep512 | Pituitary and Neuroendocrinology | ECE2021

When a common symptom leads to a rare diagnosis – prostate metastasis in the pituitary

Makker Tarun , Albor Christo , Ibrahim Hassan , Hussain Ayaz , Bashir Jawad

Common non-specific symptoms like fatigue can occasionally point towards a rare significant pathology. We report a similar case in which investigations for subtle symptoms revealed a serious unexpected diagnosis. A 76 year-old man presented to his GP for new onset mild fatigue. He had an underlying prostate cancer with no known metastases, treated only with hormonal therapy. This was under surveillance with urology team. GP sent off blood tests which showed a very low random s...

ea0073aep513 | Pituitary and Neuroendocrinology | ECE2021

Growth hormone deficiency in hypopituitary male patient with treated Cushing’s disease

Borozan Sanja , Sparavalo Rada , Vrbica Sanja

Impaired growth hormone (GH) secretion occurs in patients with Cushing’s disease (CD) as a result of cortisol excess. After a surgical treatment, eventually accompanied with radiation therapy, recovery of GH secretion is seen in only variable proportion of patients. According to some studies, it is recommended to perform assessment of GH secretion one to two years after surgical cure of CD. We report a case of a 40-years-old male admitted to the hospital because of sudden...

ea0073aep514 | Pituitary and Neuroendocrinology | ECE2021

Control of acromegalo-gigantism with lanreotide: About a case

Bichri Samira , Haraj Nassim Essabah , Aziz Siham El , Chadli Asmaa

IntroductionAcromegalo-gigantism is a rare disease, occurring before the epiphyses weld, it causes a linear acceleration of growth in children and adolescents. Medical treatment with analogues of somatostatin (AS) well established can be used in cases where surgery is impossible or inadequate or in cases of surgical failureObservationThis is a 14-year-old patient, followed for acromegalo-gigantism discovered ...

ea0073aep515 | Pituitary and Neuroendocrinology | ECE2021

Acromegaly revealed by pituitary apoplexy: A case report

Bichri Samira , Haraj Nassim Essabah , Aziz Siham El , Chadli Asmaa

IntroductionApoplexy is a rare, serious and acute complication of pituitary adenomas, revealed by tumor syndrome, visual disturbances and hormonal deficits in 60% of cases. We report a case in which the diagnosis of acromegaly was revealed by pituitary apoplexy.Observation45-year-old patient. The examination found a tumor syndrome made up of headaches, reduced visual acuity and vomiting which had evolved for ...

ea0073aep516 | Pituitary and Neuroendocrinology | ECE2021

Rare case of pituitary apoplexy after SARS-COV-2 infection

Novac Elena Roxana

Pituitary apoplexy is a rare complication of a pituitary adenoma consisting in hemorrhage or infarctation usually in patients with preexisting comorbidities. SARS-COV-2 infection is a ’new’ disease known to determine vascular impairment in some patients, although studies on this particular issue are still rolling. We present the case of a 64 years old woman suffering from mild hypertension (well-controlled under sartans) who in may 2020 got the SARS-COV-2 infection a...

ea0073aep517 | Pituitary and Neuroendocrinology | ECE2021

Septooptic dysplasia -a rare cause of congenital hypopitutarism

Stankovic Valentina Soldat , Pejicic Snjezana Popovic , Malesevic Gabrijela , Grbic Aleksandra , Caric Bojana

Septooptic dysplasia is a clinically heterogeneous disorder characterized by optic nerve hypoplasia, pituitary hormone abnormalities and midline brain defects.clinical diagnosis requires the presence of at least two of the features of the classical triad. Here is male presented on endocrinology consult for the first time at the age of thirthy five. On clinical examination height and weight were normal, face hypogonadal, sparced facial and body hair, testicle hypotrophy, normoc...

ea0073aep518 | Pituitary and Neuroendocrinology | ECE2021

Spontaneous remission in Cushing’s disease: A case report

Radvilė Dobrovolskytė , Birutė Žilaitienė , Knispelis Robertas , Renata Pauliukienė

Spontaneous remission of Cushing disease might be a phase of cyclic disease, but could also be explained by an ACTH-microadenoma infarction or hemorrhage. True remission must be differentiated from cyclic Cushing’s disease with prolonged follow up. 63-years-old female patient was referred to endocrinologist’s and presented with uncontrolled hypertension, type 2 diabetes, central obesity, hirsutism, swelling of the face and legs and a ’buffalo hump’. After a...

ea0073aep519 | Pituitary and Neuroendocrinology | ECE2021

Primary hypothyroidism associated with empty sella turcica and hypopituitarism

Besrour Chayma , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Nacef Ibtissem Ben , Khiari Karima

IntroductionThe empty sella syndrome is a rare disorder characterized by a flattened pituitary gland leaving place to the cerebrospinal fluid to fill in the sella turcica.The diagnosis is radiological and it is often discovered during pituitary disorders. Generally patients suffer from hypopituitarism, and primary hypothyroidism is found to be a rare association.ObservationHerein the case of a young woman who...

ea0073aep520 | Pituitary and Neuroendocrinology | ECE2021

The paradox of growth hormone therapy during the covid-19 pandemics – high serum igf1 and poor growth

Iancu Mirela , Alice Albu1 , Albu Dragos

Affecting multiple aspects of every-day living, Covid-19 could be a stress-promoting event, and short-stature patients could be an at-risk population. The scope of our study is to assess whether the on-going pandemic could affect children’s response to growth hormone therapy. This was a retrospective study that evaluated children on growth hormone treatment who presented for clinical visits between September 2019 and January 2021 at the Pediatric Endocrinology Department ...

ea0073aep521 | Pituitary and Neuroendocrinology | ECE2021

Outcomes and complications of endoscopic pituitary surgery: A single-center study

Taibo Rocio Villar , Alicia Santamaría Nieto , Paula Andújar Plata , Antía Fernández Pombo , María Gemma Rodríguez Carnero , Ignacio Bernabeu Morón

ObjectivesTo present the results of our series of endoscopic surgery of PA, performed in a third level hospital by an experienced team.MethodsRetrospective review of PA undergoing endoscopic surgery between 2011 – 2018 in our institution. Clinical variables and radiological characteristics and outcomes were collected at diagnosis, before surgery and for an average of 4.8 years of postoperative follow-up....

ea0073aep522 | Pituitary and Neuroendocrinology | ECE2021

Nonpituitary neoplastic mass lesions of the sellar region: Hematologic malignancies – A 16-year single-centre experience

Djurdjevic Sandra Pekic , Stojanovic Marko , Gacic Emilija Manojlovic , Antic Darko , Milojevic Toplica , Milicevic Mihailo , Doknic Mirjana , Miljic Dragana , Jemuovic Zvezdana , Djurovic Marina Nikolic , Grujicic Danica , Petakov Milan

IntroductionHematological neoplastic mass lesions of the sellar region are rare.Aim of the studyTo analyze a case series of patients with hematological malignancies affecting sellar region.Patients and methodsA retrospective study of 1166 patients with sellar lesions diagnosed at Department of Neuroendocrinology over the 16-year period (2005-2020).The demographics...

ea0073aep523 | Pituitary and Neuroendocrinology | ECE2021

Biliary ultrasound surveillance in patients with acromegaly treated with somatostatin receptor ligands: A large tertiary centre experience

Panagiotou Grigorios , Mamoojee Yaasir , James Andy

BackgroundSomatostatin receptor ligands (SRL) are commonly used in patients with acromegaly to control insulin growth factor 1 (IGF1) concentrations. Biliary sludge or gallstone formation are well-recognised biliary adverse events (BAE) from SRL therapy. Our current practice is to routinely monitor patients with acromegaly on SRL with ultrasound scanning (USS). Once BAE are detected, ursodeoxycholic acid (UDCA) therapy is initiated.<p class="abstext"...

ea0073aep524 | Pituitary and Neuroendocrinology | ECE2021

Effectiveness of bilataral inferior petrosal sinus sampling in diagnosis of ACTH dependent cushing syndrome

Erol Selvinaz , Yener Ozturk Feyza , cil sen esra , M.Masum Canat , Dogan Cakir Sezin , Sedar Saygili Emre , batman adnan , erem basmaz seda , yildiz duygu , Altuntas Yuksel

PurposeWe aimed to determine the effectiveness of bilateral inferior petrosal sinus sampling (IPSS) in the differential diagnosis of adrenocorticotropic hormone-dependent Cushing Syndrome (ACTH-dependent CS).Method51 patients diagnosed with ACTH-dependent CS between 2010-2019 in the Endocrinology Clinic in Şişli Hamidiye Etfal Health Training and Research Hospital were included in the study. The dia...

ea0073aep525 | Pituitary and Neuroendocrinology | ECE2021

Prognostic factors for remission in Cushing’s disease after pituitary surgery ’bout 100 cases’

Belkacem Samira

IntroductionCushing’s disease described in 1973 by Harvey Cushing is the most frequent cause of endogenous hypercorticism in adults in 80-85% of cases of Cushing’s syndromes, it is secondary to a pituitary microadenoma most often, its treatment is first-line neurosurgical.Aim of the studyTo evaluate the results of the short and medium term therapeutic management of Cushing’s disease and to try ...

ea0073aep526 | Pituitary and Neuroendocrinology | ECE2021

Radiotherapy results non-functional pituitary adenomas about 50 cases

Belkacem Samira

IntroductionNon-functional pituitary adenomas (AHNF) are large tumors expressed primarily by neuro-ophthalmological signs in the foreground and pose a problem of therapeutic management and prognosis.Materials and methodsWe report a retrospective study of 50 files of ’non-functional’ pituitary adenomas collected between 1993 – 2005 with the aim of evaluating the results of surgery and convention...

ea0073aep527 | Pituitary and Neuroendocrinology | ECE2021

Copeptin predicts clinical outcome in schizophrenia spectrum disorder

Sailer Clara , Jennifer Küster , Borgwardt Stefan , Christ-Crain Mirjam

BackgroundVasopressin, the main hormone regulating sodium-water balance, is involved in higher brain functions, e.g., cognition, emotion regulation and social functioning. In patients with an acute psychotic episode, increased vasopressin levels have been described and impaired higher brain functions are associated. Copeptin, the stable surrogate marker of vasopressin, has been shown to predict outcome in somatic diseases, i.e., stroke, myocardial infarc...

ea0073aep528 | Pituitary and Neuroendocrinology | ECE2021

Craniopharyngiomas presenting as incidentalomas – Results of KRANIOPHARYNGEOM 2007

Boekhoff Svenja , Bison Brigitte , Eveslage Maria , Sowithayasakul Panjarat , Hermann Müller

PurposeChildhood-onset craniopharyngiomas (CP) are diagnosed due to clinical symptoms (symCP) or incidentally (incCP). We investigated clinical manifestations and outcome in incCPs and symCPs.MethodsIncCP were discovered in 4 (3m/1f) and symCP in 214 (101m/113f) CP recruited 2007–2014 in KRANIOPHARYNGEOM 2007. Age, sex, height, body mass index (BMI), tumor volume, degree of resection, pre- and postsurgic...

ea0073aep529 | Pituitary and Neuroendocrinology | ECE2021

Severe hyponatremia and syndrome of inappropriate antidiuretic hormone secretion (SIADH) as a primary presentation of neurosarcoidosis

Ali Uzair Akbar , Amin Asad , Nazir Hafiz Irbaz

Introduction/BackgroundSarcoidosis is a multi-system inflammatory disease of unknown etiology, characterized by abnormal collection of inflammatory cells termed as granulomas. This disease usually involves lungs, skin, or lymph nodes, but can less commonly affect the eyes, liver, heart and brain. Neurological involvement is rare and appears in 5-10% of the cases. Neurosarcoidosis most frequently affects the cranial nerves, the hypothalamus and the pituit...

ea0073aep530 | Pituitary and Neuroendocrinology | ECE2021

Case report of family form of multiple endocrine neoplasia syndrome type 1 with a non-classic course

Volkova Natalya , Degtyareva Yuliya , Davidenko Ilya , Dzherieva Irina , Ganenko Lilia , Zibarev Alexander , Sorokina Yulya , Reshetnikov Igor

Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary condition that most often manifests with primary hyperparathyroidism followed by other syndromes, but there are other variations in the clinical presentation, which can increase the risk of medical error and worsen prognosis. A 32-year-old woman presents with complaints of low glucose levels, hunger, weakness, sleep disturbances, which are stopped by taking sweets. At the age of 16, a pituitary macroadenoma, prola...

ea0073aep531 | Pituitary and Neuroendocrinology | ECE2021

Transsphenoidal surgery in acromegaly: Experience in a tertiary hospital

Alexa Pamela Benítez Valderrama , Porras Mariana Gomes , Carlos Pérez López , Álvaro Zamarrón Pérez , Rosa María García Moreno , Lecumberri Beatriz , Marcelino Pérez Álvarez , Cristina Álvarez Escolá

BackgroundAcromegaly is an infrequent chronic multisystemic disease associated with a significant morbidity and mortality rate. The treatment of choice is transsphenoidal surgery (TSS) because of its low risk of mortality and few complications.AimsTo determine the cure prevalence after TSS of growth hormone (GH) secreting pituitary adenomas. To analyze the predictive factors of non-remission after the surgery...

ea0073aep532 | Pituitary and Neuroendocrinology | ECE2021

Gender differences in eating-related behaviour and traits of patients with craniopharyngioma

Sylvère Störmann , Roemmler-Zehrer Josefine , Geigenberger Veronika , Schilbach Katharina , Ising Marcus , Pfister Hildegard , Jung-Sievers Caroline , Günter Stalla , Schopohl Jochen

IntroductionCraniopharyngiomas are rare and benign tumours of the suprasellar region along the craniopharyngeal duct. Their clinical manifestations result from tumour compression or therapy-induced damage of the surrounding tissue, namely visual impairment, pituitary deficiencies and increased intracranial pressure. Hypothalamic damage often leads to central obesity and fatigue. The impact of these changes on quality of life and body perception has been ...

ea0073aep533 | Pituitary and Neuroendocrinology | ECE2021

Improved response to somatostatin analogue (SSA) therapy in acromegaly following treatment pause

Rajan Roby , Bhatt D , Philip S , Graveling AJ , Bashari W , Gurnell M , Abraham P

Background/methodsPatients with uncontrolled acromegaly or receiving high cost medical therapy despite initial treatment, usually transsphenoidal surgery (TSS), were considered for a ¹¹C-methionine PET-CT scan (11C-Met PET-CT). This imaging technique may identify a target for TSS or radiotherapy when MRI appearances are inconclusive1. In preparation, four patients on long-term SSA were taken off treatment 3 months prior to the scan. ...

ea0073aep534 | Pituitary and Neuroendocrinology | ECE2021

Does concomitant prolactin measurement increase the accuracy of inferior petrosal sinus sampling?

Apaydin Tugce , Yasar Mehmet , Baltacioglu Feyyaz , Haklar Goncagul , Yavuz Dilek Gogas

PurposeInferior petrosal sinus sampling (IPSS) is the gold standard test for the differentiation of pituitary Cushing disease from the ectopic ACTH syndrome (EAS). The measurement of prolactin during IPSS can be helpful to improve the accuracy of the procedure. We aimed to evaluate the effect of measuring prolactin levels as a predictor for the accuracy of IPSS procedure and evaluate its’ impact on the lateralization of adenoma.<p class="abstext...

ea0073aep535 | Pituitary and Neuroendocrinology | ECE2021

The alpha-subunit of glucoprotein hormones and anatomopathological aspects of pituitary adenomas

Berrabeh Soumiya , Abdellaoui Wahiba , Assarrar Imane , Elmehraoui Ouafae , Rouf Siham , Latrech Hanane

IntroductionThe pituitary glycoprotein hormones, luteinizing hormone (LH), follicule-stimulating hormone (FSH), thyroid-stimulating hormone (TSH) and human chorionic gonadotropin (hCG) are comprised of two separate noncovalently bound subunits:alpha and beta units. The alpha subunit is identical in all of the hormones, while the β-subunit is unique for each hormone and confers the specific immunologic and functional activity.Hypersecretion of the gl...

ea0073aep536 | Pituitary and Neuroendocrinology | ECE2021

Pituitary apoplexy- a single-center, retrospective study of clinical outcomes

Ghenoiu Sandra , Gheorghe Diana Maria , Ciubotaru Gheorghe Vasile , Anda Dumitraşcu , Capatina Cristina , Poiana Catalina

IntroductionPituitary apoplexy is a rare entity characterized by abrupt hemorrhage and/or ischaemia of the constituents of sella turcica. It usually occurs in a previously unsuspected pituitary tumor. It may have an acute or subclinical presentation and it may represent a neuroendocrinological emergency.AimThis study aims to analyze predisposing or precipitating factors, clinical status, imaging and hormonal ...

ea0073aep537 | Pituitary and Neuroendocrinology | ECE2021

The perspective of patients with pituitary disease on work according to the expanded ICF model: A qualitative study

Merel Van der Meulen , Lobatto Daniel J. , Wouter R. van Furth , Huisman Sasja D. , Heerkens Yvonne F. , Thea P.M. Vliet Vlieland , Biermasz Nienke R. , Andela Cornelie D.

PurposeAs the majority of patients with pituitary disease are of working age, their health situation may negatively impact their functioning at work. However, work participation can also be influenced by contextual (environmental and personal) factors. The aim of this qualitative study was to investigate the perspective of patients with pituitary disease on their functioning at work and on contextual factors contributing to work-related problems, using t...

ea0073aep538 | Pituitary and Neuroendocrinology | ECE2021

Silent somatotroph giant pituitary adenoma with the first manifestation at the age of 15 with a 16-year follow up- case report

Godlewska Magdalena , Gilis-Januszewska Aleksandra , Anna Boguslawska , Przybylik-Mazurek Elwira , Zielinski Grzegorz , Hubalewska-Dydejczyk Alicja , Jurecka-Lubieniecka Beata

BackgroundSilent somatotroph pituitary tumours are very rare, representing only 2-4% of all pituitary tumours in surgical series. Little is known about the course of the disease and efficacy of possible treatment modalities.Presentation of the caseA male, born in 1990, was first admitted to the hospital at the age of 15, due to sudden ptosis of the right eye and headaches, present for 1 year before the diagno...

ea0073aep539 | Pituitary and Neuroendocrinology | ECE2021

Assessing quality of life and cardio-vascular risk in patients with acromegaly: A single tertiary center case series

Morea Alexandru , Lambrinoc Diana , Nitu Ileana , Baciu Ionela Florina , Poiana Catalina

BackgroundAcromegaly is a rare disease, caused by an autonomous excessive secretion of growth hormone (GH). Apart from skeletal alterations, the GH excess leads to metabolic and visceral disease. Thus, one of the most frequent associated complications is the cardio-vascular one represented by hypertension, cardiomyopathy and ischemic heart disease. The presence of multiple complications in patients with acromegaly leads not only to increased morbidity an...

ea0073aep540 | Pituitary and Neuroendocrinology | ECE2021

A micromegaly case: Difficult to determine whether a metabolic state or an acromegaly subset

Uygur Meliha Melin , Yavuz Dilek Gogas

Introduction:Acromegaly is caused by excess levels of growth hormone (GH) and insulin-like growth factor 1 (IGF1), which usually result from a pituitary adenoma. At the presence of classical symptoms, the diagnosis is confirmed by increased serum IGF1 concentrations and high serum levels of GH that are not suppressed in an an oral glucose tolerance test (OGTT). A nadir GH cut-off of 0.4 µg/lwith ultrasensitive assays is considered as diagnostic. How...

ea0073aep541 | Pituitary and Neuroendocrinology | ECE2021

Successful recovery after COVID-19 infection in a patient with diabetes insipidus and pituitary insufficiency due to a pituitary stalk tumor

Trifanescu Raluca , Schipor Sorina , Vladoiu Suzana , Poiana Catalina

BackgroundFluid balance in patients with diabetes insipidus and COVID-19 is very fragile. The prevalence of hyponatraemia in patients with pneumonia due to COVID-19 seems to be low, but in patients admitted to intensive care units (ICU) is high (up to 20.5%). In contrast, hypernatraemia may also develop in COVID-19 patients in ICU (up to 3.7% of cases), due to insensible water losses from pyrexia, increased respiration rate and use of diuretics. Both hyp...

ea0073aep542 | Pituitary and Neuroendocrinology | ECE2021

Descriptive analysis of patients with Multiple Endocrine Neoplasia type 1. Experience at a tertiary hospital

Rosa María García Moreno , Gomes-Porras Mariana , Lecumberri Beatriz , Cristina Álvarez Escolá

BackgroundMultiple Endocrine Neoplasia type 1 (MEN 1) is a genetic syndrome caused by inactivating mutations of the menin gene, which predisposes to the development of endocrine tumors. The causative mutations, clinical manifestations, and age of tumor development are highly variable. The objective of this study is to describe the characteristics of patients with MEN1 in our hospital.Material and methodsWe pe...

ea0073aep543 | Pituitary and Neuroendocrinology | ECE2021

Pituitary apoplexy secondary to anticoagulation for pulmonary thromboembolism

Inês Ferreira Barros , Ramos Rui , Almeida Rui , Marques Olinda

IntroductionPituitary apoplexy (PA) consists of acute infarction/hemorrhage of the gland, involving mostly a previously unrecognized adenoma. One of its most documented precipitating factors is anticoagulation in the context of acute coronary syndrome treatment. To our knowledge only one report described a PA secondary to anticoagulation for pulmonary thromboembolism.Case reportA 75-year-old men with known hy...

ea0073aep544 | Pituitary and Neuroendocrinology | ECE2021

30-year postoperative course of invasive prolactinoma in a male patient

Vaychulis Irina

Most of prolactin secreting tumors excellently respond to low doses of dopamine agonists (DAs). However, management of giant, invasive prolactinomas, partially or completely resistant to DAs is a challenge. Male patient was referred to endocrinologist in 2008, at the age of 63 years, presented with headaches, pressure sensation behind the left eye, decreased vision and fatigue for the last 2 months. In 1986 (at the age of 40 years) blurred vision had appeared...

ea0073aep545 | Pituitary and Neuroendocrinology | ECE2021

Postoperative central diabetes insipidus after transsphenoidal adenomectomy in patients with Cushing’s disease

Tsoy Uliana , Bolatova Aizanat , Cherebillo Vladislav , Grineva Elena

PurposePostoperative central diabetes insipidus (PCDI) is one of the complications of transsfenoidal adenomectomy (TSA) in patients with Cushing’s disease. Identification of predictors of PCDI development and clinical course could optimize the management of such patients.AimTo study the prevalence of PCDI in patients with Cushing’s disease after transsphenoidal adenomectomy and to find the risk fact...

ea0073aep546 | Pituitary and Neuroendocrinology | ECE2021

A double-blind, randomized, placebo-controlled trial of SPI-62 safety and efficacy for the treatment of Cushing’s syndrome

Fleseriu Maria , Bancos Irina , Katz David

11β-hydroxysteroid dehydrogenase type 1 (HSD-1) controls the intracellular cortisol pool that has access to cytosolic glucocorticoid and mineralocorticoid receptors. HSD-1 activity is elevated in patients with Cushing’s syndrome (CS).1 Patients with CS and constitutionally low HSD-1 activity showed no hypercortisolism-related symptoms despite very high 24-hour urine free cortisol.2, 3 A recent pilot trial of a HSD-1 inhibitor in patients with classical or mild CS sho...

ea0073aep547 | Pituitary and Neuroendocrinology | ECE2021

Long-term survival in a patient with corticotroph pituitary carcinoma and brain metastases

Czajka-Oraniec Izabella , Stelmachowska-Banas Maria , Szostek Arnika , Baranowska-Bik Agnieszka , Zgliczynski Wojciech

BackgroundPituitary carcinoma (PC) is a very rare clinical entity, which is defined as a pituitary tumor that has metastasized to sites distant from the pituitary. It may present as hormone-secreting, invasive and recurrent macroadenoma causing a mass effect.Case presentationWe present a 58-years old male patient with corticotroph pituitary carcinoma and brain metastases who underwent 9 neurosurgical interven...

ea0073aep548 | Pituitary and Neuroendocrinology | ECE2021

Clinical features and pituitary function in primary empty sella syndrome

Faten Hadj Kacem , Zargni Asma , Salah Dhouha Ben , Mohamed Abdellahi Mohamed Ahmed , Mnif Fatma , Charfi Nadia , Mnif Mouna , Majdoub Nabila Rekik , Elleuch Mouna , Mohamed Abid

IntroductionEmpty sella syndrome (ESS) is a rare condition in which the sella turcica is partially or completely filled with cerebrospinal fluid. ESS can be classified as primary or secondary, depending on the identification of underlying etiologies. Whether empty sella has any functional implications in causing pituitary hormonal disturbances needs to be understood. The aim of our study was to assess the incidence of pituitary hormonal disturbances in p...

ea0073aep549 | Pituitary and Neuroendocrinology | ECE2021

Primary lymphocytic hypophysitis diagnosed during pregnancy: Case report

Mezoued Mouna , amine habouchi , malha Azzouz

Primary lymphocytic hypophysitis is an autoimmune endocrinopathy affecting mainly women during pregnancy and psot-partum. We report the observation of a 28 year old patient, G5P2C2 with a progressive pregnancy at 32 SA, with a history of hypertension without any particular familial history. The patient had an ophthalmologic examination as part of the exploration of the repercussions of hypertension, which objectified an abnormal excavation of the left eye at the fundus examina...

ea0073aep550 | Pituitary and Neuroendocrinology | ECE2021

Improvements in quality of life after treatment in three acromegalic patients

Plotuna Iulia-Ştefania , Vlad Mihaela , Balas Melania

Acromegaly is a rare disease. In more than 99% of cases this is due to a benign pituitary growth-hormone secreting adenoma. This leads to changes in appearance, enlargement of the internal organs and, after a long period of time, to multiple comorbidities.ObjectivesTo determine which factors might have contributed to the lower quality of life in three acromegalic patients.Materials and methods<p class="ab...

ea0073aep551 | Pituitary and Neuroendocrinology | ECE2021

MODY 3 and acromegaly: An improbable association treated with bromocriptine

Puga Francisca , Cláudia Amaral , Cláudia Freitas , Cardoso Maria Helena

IntroductionMaturity Onset Diabetes of the Young (MODY) is an autosomal dominant disease, diagnosed mainly in young individuals with a strong family history of diabetes, that results from mutations impairing pancreatic β cell function. The MODY 3 subtype, caused by a HNF1α mutation, with consequent deficit in insulin secretion, is the most frequent and responds more effectively to sulfonylureas, compared to metformin. Acromegaly is a rare condi...

ea0073aep552 | Pituitary and Neuroendocrinology | ECE2021

A complex case of refractory hypercalcaemia, end-stage diabetic nephropathy with pituitary mass and hypopituitarism– is there a unifying diagnosis?

Fennell David , Holland John A , Corkery Laura , Ludgate Stephen , McQuaid Siobhan

A 54-year-old female presented with one week of weakness, fatigue, headache, worsening constipation, and general malaise. Background history included long-standing type 1 diabetes (glutamic acid decarboxylase positive), on continuous subcutaneous insulin infusion, proliferative diabetic retinopathy, end-stage diabetic nephropathy on haemodialysis and subclinical hypothyroidism. Tertiary hyperparathyroidism was diagnosed (adjusted calcium 2.82 mmol/l, phosphate 1.42 mmol/l, par...

ea0073aep553 | Pituitary and Neuroendocrinology | ECE2021

A rare case of panhypopituitarism and diabetes insipidus secondary to sarcoidosis

Kilcoyne Ciara , Hatunic Mensud

IntroductionSarcoidosis is a multisystem disorder, characterised by the presence of non-caseating granulomas. 5–13% of cases involve the nervous system. Neurosarcoidosis carries a poor prognosis and can lead to an infiltrative process in the hypothalamo-hypophyseal region, resulting in panhypopituitarism and central diabetes insipidus (DI). These are rare but serious complications of neurosarcoidosis.Case<p class="abstext"...

ea0073aep554 | Pituitary and Neuroendocrinology | ECE2021

Assessment of a developmental neurotoxicity test using Ki-67 in ReNcell CX cells

Kim Kang Min , Go Seon Myeong , Jeong Sunhwa , Lee Jimin , Jeung Eui Bae

Ki-67 can be solely detected within the cell nucleus, whereas in mitosis, most of the Ki-67 proteins are located on the chromosome surface. Ki-67 is present during all phases of the cell cycle (G1, S, G2, and M), but BrdU is only present in the S phase. This study examined whether it is possible to establish a developmental neurotoxicity test in human neural progenitor cells using Ki-67 instead of BrdU (5-bromo-2’-deoxyuridine). In the present study, Ki-67-expressed ReNce...

ea0073aep555 | Pituitary and Neuroendocrinology | ECE2021

Abberant expression pattern of circadian clock genes in Type 1 gastric neuroendocrine neoplasms compared to ECL hyperplasia

Karapanagioti Angeliki , Daskalakis Kosmas , Nasiri-Ansari Narjes , Vlachou Erasmia , Kyriakopoulos Georgios , Kassi Evanthia , Kaltsas Gregory

PurposeThere is a continuity of changes ranging from enterochromaffin‐like (ECL) cell hyperplasia to type 1 gastric neuroendocrine neoplasms (GNEN1) with important clinical implications. Although the effect of the circadian clock system on tumorigenesis has been addressed, the role of the peripheral clock system in the transition from ECL-cell hyperplasia to GNEN1 remains to be explored.MethodsSix patie...

ea0073aep556 | Pituitary and Neuroendocrinology | ECE2021

Value of cross- sectional area of the median nerve in acromegalic patients

Ivana Ságová , Dušan Pavai , Daniela Kantárová , Dana Holováčová , Dragula Milan , Payer Juraj , Peter Vaňuga

IntroductionMedian nerve neuropathy is commonly associated with acromegaly.ObjectiveThis study aims to investigate ultrasound examination of median nerve in acromegalic patients and assess the relationship with activity and duration of disease.Patients and methodsWe prospectively examined the cross sectional area (CSA) of median nerve with high-resolution ultrasou...

ea0073aep557 | Pituitary and Neuroendocrinology | ECE2021

Response to treatment with temozolomide in cases with invasive pituitary macroadenomas: A single-center experience

Bilen Ogun , Aggul Hunkar , Elbuken Gulsah , Zuhur Sayid

IntroductıonRecent studies suggest temozolomide as an effective treatment modality in invasive pituitary adenomas that did not respond to conventional treatments. In this case series, we present three cases of invasive pituitary adenomas that did not respond to conventional medical treatments and radiotherapy and were subsequently treated with temozolomide.CasesThe first patient had an invasive prolactin...

ea0073aep558 | Pituitary and Neuroendocrinology | ECE2021

Hypopituitarism secondary to a pituitary metastasis as a first manifestation of an invasive nasopharyngeal carcinoma

Hiba-Allah Chatti , Oueslati Ibtissem , Azaiez Aymen , Yazidi Meriem , Chaker Fatma , Besbes Gazi , Chihaoui Melika

IntroductionNasopharyngeal carcinoma is characterized by distinct geographical distribution and is particularly prevalent in East and Southeast Asia. Environmental factors, genetic structure, and Epstein Barr virus infection are involved in the etiology of the disease. While nasal and otological symptoms are the most common (80%), intracranial extension is prevalent among 8% of cases and pituitary localization is rarely described in the literature. We re...

ea0073aep559 | Pituitary and Neuroendocrinology | ECE2021

A rare case of panhypopituitarism secondary to neurosarcoidosis initially treated as sepsis of unknown origin

Anwar Mehreen , Abdulla Eman , Joseph Vinod

Sarcoidosis is a very rare inflammatory disease and UK prevalence was 8% between 2008 to 2012 of which only 15 % developed neurosarcoidosis. Our patient is a 83 year old gentleman who presented with symptoms of lethargy, low blood pressure and confusion over 2 weeks . He had multiple comorbidities including heart failure, chronic kidney disease, permanent pacemaker, hypertension. His bloods showed normocytic anaemia and raised inflammatory markers, with eosinophilia and he was...

ea0073aep560 | Pituitary and Neuroendocrinology | ECE2021

Treatment patterns, healthcare utilization and related costs of acromegaly in a real-world setting in finland

Ilona Iso-Mustajärvi , Tuurinkoski Anna , Juha Mehtälä , Ylisaukko-oja Tero , Merja Väkeväinen , Pia Jaatinen , Camilla Schalin-Jantti

IntroductionAcromegaly is a chronic disease associated with multiple comorbidities and increased incidence of cancer and mortality. The diagnosis often takes several years after the onset of symptoms. The costs of acromegaly in Finland are not known. This study aimed to characterize the treatment patterns, healthcare resource utilization, and direct costs of acromegaly in Finland.MethodsAll adult (≥18 y...

ea0073aep561 | Pituitary and Neuroendocrinology | ECE2021

A growth retardation revealing a pituitary stalk interruption syndrome: A case report

Laamouri Rihab , Aycha Ghachem , Rojbi Imen , Besrour Chayma , Lakhoua Youssef , Mchirgui Nadia , Ben Nacef Ibtissem , Khiari Karima

IntroductionPituitary stalk interruption syndrome is an entity radiologically defined by the association of an absent or thin pituitary stalk, an ectopic posterior lobe and a hypoplasia or aplasia anterior lobe. It can manifest as a several of hormonal deficiencies. The circumstances of discovery are multiple. This case illustrates a pituitary stalk interruption syndrome revealed by a growth retardation.Case presentation<p clas...

ea0073aep562 | Pituitary and Neuroendocrinology | ECE2021

Cognitive impairment, obesity, and hypopituitarism - several entities or one syndrome?

Juliana Marques-Sá , Joana Santos Maria

IntroductionPrader-Willi syndrome (PWS) is a multisystemic genetic disorder caused by lack of expression of genes on the paternally inherited chromosome 15q11.2-q13 region. Despite PWS present manifestations from birth, affected individuals can remain undiagnosed until adulthood.Clinical caseWoman, 40 years old, with cognitive impairment, referred to endocrinology due to morbid obesity (BMI 44.5 Kg/m2</s...

ea0073aep563 | Pituitary and Neuroendocrinology | ECE2021

Invasive Thyrotropin-secreting pituitary adenoma: A case report

Wiem Madhi , Jemel Manel , Said Wadiaa , Mereghni Syrine , Allah Chatti Hiba , Kandara Hajer , Kammoun Ines

IntroductionThyrotropin-secreting pituitary adenoma is a rare cause of hyperthyroidism which must be differentiated from other etiologies of inappropriate TSH secretion.Observation:We report the case of a 49 years old male patient with no particular pathological history, addressed for thyrotoxicosis (weight loss, irritability, thermophobia, dyspnea and palpitation) with no goiter or ophtalmopathy. Echocardiog...

ea0073aep564 | Pituitary and Neuroendocrinology | ECE2021

Successful pregnancy in a female with a large prolactinoma after pituitary tumor apoplexy

Sara Chtioui , Hind Asbar , Sanaa Rafi , Ghizlane El Ansari , Nawal El Ansari

IntroductionPituitary apoplexy is a rare condition which may cause death of the patient in severe cases and many times leads to hypopituitarism. It results from haemorrhagic infarction of a pre-existing pituitary adenoma or within a physiologically enlarged gland .Case reportOur patient is a 31-year-old female, with a history of macroprolactinoma for approximately 7 years . Who presented to our hospital with ...

ea0073aep565 | Pituitary and Neuroendocrinology | ECE2021

Recurrent hypoglycemia as an initial presentation of Isolated ACTH deficiency

Akbar Ali Uzair , Abdelnour Elsadig , Ghyar Praful

Introduction:Adrenocorticotropic hormone (ACTH) deficiency can occur either due to decreased or absent production of the hormone by the pituitary gland. A decline in the production of ACTH can result in adrenal insufficiency. The exact etiology of ACTH deficiency is unknown. A defect in the hypothalamus or pituitary gland may be the cause. This can also be congenital involving mutations of the TBX19 gene (also referred to as TPIT) on the long arm of chro...

ea0073aep566 | Pituitary and Neuroendocrinology | ECE2021

Functioning gonadotroph adenoma accompanied by erythrocytosis in an elderly man

Mamedova Elizaveta , Buryakina Svetlana , Selivanova Liliya , Azizyan Vilen , Grigoriev Andrey , Belaya Zhanna

IntroductionClinically functioning gonadotroph adenomas (FGA) are rare, especially in men. We present a case of a LH/FSH-secreting functioning gonadotroph macroadenoma in an elderly patient, which manifested with visual impairment and was accompanied by secondary erythrocytosis.Clinical caseA 62-y.o. male was admitted to our hospital with a 9-month history of visual impairment and a 5-year history of plethora...

ea0073aep567 | Pituitary and Neuroendocrinology | ECE2021

Lymphocytic auto immune hypophysitis : A case report

Laamouri Rihab , Rojbi Imen , Besrour Chayma , Kamoun Elyes , Lakhoua Youssef , Mchirgui Nadia , Ben Nacef Ibtissem , Khiari Karima

IntroductionLymphocytic hypophysitis is an autoimmune inflammatory pathology of the pituitary gland responsible for partial or global hypopituitarism. In this context, we report a clinical case illustrating this entity.Clinical caseA 31-year-old woman with a family history of hypothyroidism and a personal history of vitiligo was seen in the 8th month of pregnancy for headaches that have progressed rapidly in ...

ea0073aep568 | Pituitary and Neuroendocrinology | ECE2021

Managing pituitary disease during COVID-19 pandemic: A case report

Dumitriu Roxana , Burcea Iulia Florentina , Dusceac Roxana , Poiana Catalina

IntroductionThe COVID-19 pandemic has significantly affected health systems all over the world, putting on a hold medical care and delaying surgical interventions. Patients with pituitary tumors, especially those who associate hormonal hypersecretion or defficiency and mass effects represent a management challenge even in a non-pandemic time.Case descriptionA 41 years old, non-smoker, overweight, male patient...

ea0073aep569 | Pituitary and Neuroendocrinology | ECE2021

Craniopharyngioma presenting with amenorrhea and a polyuric polydipsic syndrome

Besrour Chayma , Rojbi Imen , Kamoun Elyes , Laamouri Rihab , Lakhoua Youssef , Mchirgui Nadia , Ben Nacef Ibtissem , Khiari Karima

Introduction Craniopharyngioma is a rare type of benign brain neoplasm, arising from the pituitary stalk or gland and found most commonly in children. The clinical presentation is variable and may include endocrine or ophtalmogical disorders, intracranial hypertension syndrome and other neurological symptoms.ObservationWe report the case of a 16 year-old girl with a normal staturo-ponderal development and no ...