General Endocrinology

IntroductionGynecomastia is characterized by the abnormal enlargement of one or both male breasts due to proliferation of the glandular tissue, with many possible underlying causes. A documented rare cause of gynecomastia is chest trauma.Case reportWe present a case of a 53-year-old male patient, with a personal history of arterial hypertension and depressive disorder, medicated with fluoxetine, perindopril, ...

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ea0073aep407 | General Endocrinology | ECE2021

Arrhythmias and cardiac conduction disorders in patients with acromegaly

Przhiyalkovskaya Elena , Melkozerov Konstantin , Almaskhanova Alina , Tarbaeva Natalya , Kuklina Maria , Alferova Polina , Gomova Irina , Belousov Leonid , Belaya Zhanna , Vorontsov Alexander , Kalashnikov Victor

Cardiovascular complications including arrhythmias and cardiac conduction disorders (ACCDs) are leading risk factors for high mortality rate in acromegaly. ACCDs are the main cause of sudden cardiac death in patients with acromegaly. These disorders are detected in up to 40% of patients. Different pathogenetic mechanisms contribute to the development of concentric biventricular myocardium hypertrophy which leads to electrophysiological myocardium feature changes. The goal of t...

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ea0073aep408 | General Endocrinology | ECE2021

A new cause of endogenous hyperinsulinism?

Caballero Manuel J , José Ignacio Fernández Peña , Eyvee Arturo Cuellar Lloclla

We present the case of a patient who started having repeated episodes of symptomatic hypoglycemia at the age of 50.Medical historyFather had type 2 diabetes. Former smoker, moderate alcohol consumption. Chronic otitis media with cholesteatoma, surgically removed. Congenital cataract operated at the age of 3.Clinical courseAt around the age of 50, the patient started having sporadic epis...

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ea0073aep409 | General Endocrinology | ECE2021

Characterization of neuroinflammatory makers and related-genetic variants in athletes from a long duration ultramarathon mountain cycling race and endurance exercises

Matos Andreia , Matinho Miguel , Fontes Miguel , Santos Ana Carolina , Ângela Gil , Cardoso Carlos , Bicho Manuel , Alonso Isanete

IntroductionExercise induces changes in the inflammatory profile that can comprehend changes during and immediately after exercise with long-term effects. This inflammatory profile could impact the cognitive function and so, the performance.ObjectivesCompare the inflammatory status from long duration and endurance exercises and correlate it with an immune and neuroendocrine genetic profile.<p class="abste...

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ea0073aep410 | General Endocrinology | ECE2021

Successful treatment of nesidioblastosis during the time of pandemic: A case report

Sándor Halmi , Berta Eszter , Lengyel Inez , Toth Judit , Kanyari Zsolt , Hutkai David , Nagy V Endre , Bodor Miklos

IntroductionIn the background of persistent hyperinsulinemic hypoglycemia the insulinomas of the pancreatic beta cells may be present, but in some rare cases we fail to identify a well-defined lesion and the insulin hypersecretion is caused by nesidioblastosis, a diffuse proliferation of the pancreatic islet cells. However, the localization of the lesion is necessary for proper treatment, in certain cases finding the insulinoma is difficult and can only ...

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ea0073aep411 | General Endocrinology | ECE2021

Post-menopausal virilizing tumor of the ovary

Nádia Mourinho Bala , Raposo Nuno , José Maria Aragüés , Sílvia Guerra , Brito Delfina , Valadas Cristina

IntroductionLeydig cell tumors are rare entities, representing less 0.1% of all ovarian tumors. Generally these tumors are benign and unilateral. Most originate from the hilus cells and, less frequently, from the ovarian cortical stroma. Leydig cell tumors are functioning tumors, frequently associated with virilization symptoms in post-menopausal women.Case reportWe report the case of a 77 year-old female pat...

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ea0073aep412 | General Endocrinology | ECE2021

Psychological Impact of COVID-19 national lockdown meAsures on tRansgenDer people in Italy: The PICARD study

Ferrigno Rosario , Fattoruso Mariagrazia , Veneri Alessandra Delli , Cuccurullo Alessia , Falanga Daniela Lourdes , Amodeo Anna Lisa , Angelis Cristina De , Garifalos Francesco , Menafra Davide , Zarrilli Stefano , Iasevoli Felice , Vitelli Roberto , Colao Annamaria , Pivonello Rosario

During 2020 spring, national lockdown was adopted in Italy to prevent COVID-19 pandemic spread. Restrictive measures, including lockdowns, were associated with impaired psychological outcome, mainly increased perceived stress and anxiety, in general population. As transgender people (T*) are associated with higher prevalence of perceived stress, anxiety, and depression, higher psychological vulnerability during lockdowns cannot be excluded. The aim of the PICARD study was the ...

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ea0073aep413 | General Endocrinology | ECE2021

Evaluation of serum levels of chemerin and resistin in patients with rheumatoid arthritis. Two adipokines at the crossroad between rheumatology and endocrinology

Vasileva Emanuela , Stankova Teodora , Batalov Anastas , Nonchev Boyan , Karalilova Rositsa , Bivolarska Anelia , Staynova Radiana

Introduction Adipose tissue is already considered as a metabolic active endocrine organ secreting numerous substances called adipokines. A growing body of evidence links two of these adipokines- chemerin and resistin, to the pathogenesis of rheumatoid arthritis (RA) based on their effect on vascular function and creating an environment of low grade inflammation. Nevertheless, the exact mechanism of how these molecules act on the target cells of joint ele...

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ea0073aep414 | General Endocrinology | ECE2021

Menopausal hormone therapy and women’s health: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials and observational epidemiological studies

Guo-Qiang Zhang , Jin-Liang Chen , Luo Ying , Mathur Maya B. , Anagnostis Panagiotis , Nurmatov Ulugbek , Talibov Madar , Zhang Jing , Hawrylowicz Catherine M. , Lumsden Mary Ann , Critchley Hilary , Sheikh Aziz , Bo Lundbäck , Cecilia Lässer , Kankaanranta Hannu , Lee Siew Hwa , Nwaru Bright I.

ImportanceThere remains uncertainty about the impact of menopausal hormone therapy (MHT) on womens health. A systematic, comprehensive assessment of the effects on multiple outcomes is lacking.ObjectiveTo comprehensively summarize evidence on the benefits and harms of MHT across diverse health outcomes in women.Data sourcesMEDLINE, EMBASE and 10 other databa...

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ea0073aep415 | General Endocrinology | ECE2021

Cushing’s syndrome: Do Cushing’s patients have similar diagnostic and treatment journeys and outcomes to mine?

McBride Margaret

BackgroundHaving experienced Cushings syndrome and disease, this author is now a Doctor of Philosophy student studying these medical conditions with the main aim of finding out if others diagnosed with these illnesses have experienced similar diagnostic and treatment journeys with similar outcomes.MethodAn online 2020 survey was conducted on 86 Cushings members of the Pituitary Foundation, (Female...

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ea0073aep416 | General Endocrinology | ECE2021

A single-center observational study of patients with ectopic ACTH syndrome

Golounina Olga , Rozhinskaya Liudmila , Arapova Svetlana , Pikunov Michael , Khandaeva Patimat , Dzeranova Larisa , Marova Evgenia , Belaya Zhanna

BackgroundEctopic ACTH syndrome (EAS) is a rare cause of endogenous hypercortisolism.ObjectiveTo analyze clinical, biochemical features and treatment outcomes of patients with EAS.Materials and methodsRetrospective, observational study on 129 patients (79 women, 50 men) with EAS diagnosed between 1990 and 2020. Plasma levels of ACTH (reference range: morning 7.2&#...

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ea0073aep417 | General Endocrinology | ECE2021

Design of an online platform to support young diabetics transitioning to adult care: an experiment at the endocrinology service of casablanca university hospital

Sekkat Kenza , Haraj Nassim Essabah , Aziz Siham El , Chadli Asmaa

IntroductionThe quality of the transition process from pediatric care to adult care represents an important factor in ensuring uninterrupted follow-up of care for T1D adolescents. By avoiding the risks of poor adaptation, better organization of care would facilitate this transfer. New technologies, notably websites and mobile applications, have been adopted throughout the world to support young patients transitioning to adult care, and their families.</p...

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ea0073aep418 | General Endocrinology | ECE2021

Designing a chatbot for young diabetics: Unprecedented experiment at the endocrinology service of the casablanca university hospital

Sekkat Kenza , Haraj Nassim Essabah , Aziz Siham El , Chadli Asmaa

IntroductionTechnological progress, the quest for optimization and the evolution of artificial intelligence have given birth to Chatbots. Also called a conversational agent, a chatbot is an artificial intelligence capable of conducting interactive human conversations. The main advantages of Chatbots are their availability 24/7, their accessibility (a Chatbot can take the form of a contact on Facebook Messenger), and the ease of access to information than...

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ea0073aep419 | General Endocrinology | ECE2021

Treatment approach of insulinoma

Kamoun Elyes , Mekni Sabrine , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Nacef Ibtissem Ben , Khiari Karima

IntroductionInsulinoma is the most frequent pancreatic endocrine tumor and is confirmed in case of a hyperinsulinic hypoglycemia with elevated C-peptide and absence of sulfonylureas. Tomodensitometry, MRI, endoscopic ultrasound are the imaging means used to assess localization before surgery as it is not always determined by one mean only, and in a few cases, all means may not determine localization.MethodsTh...

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ea0073aep420 | General Endocrinology | ECE2021

Clinical characteristics of organic hypoglycemia

Kamoun Elyes , Mekni Sabrine , Rojbi Imen , Mchirgui Nadia , Lakhoua Youssef , Nacef Ibtissem Ben , Khiari Karima

IntroductionSpontaneous hypoglycemia in non-diabetic adults represent a challenge in confirming the organic cause, requiring in that case specific medication or surgery, in a setting of a possible life-threatening disease.MethodsWe conducted a retrospective study of patients admitted in our department for spontaneous hypoglycemia. Functional and factitious etiology were excluded. Clinical and biologic feature...

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ea0073aep421 | General Endocrinology | ECE2021

Epidemiological aspects of adrenal insufficiency detected by the Synachten test and insulin hypoglycemia during withdrawal from prolonged corticosteroid therapy

Loukili Mohamed Aymane , Draoui Najat , Jamal Anouar , Rouf Siham , Latrech Hanane

IntroductionAdrenal insufficiency is the most common complication after long-term corticosteroid therapy, to affirm or exclude the diagnosis of adrenal insufficiency several authors suggest basal cortisol testing as first-line, however, others prefer stimulating tests (insulin hypoglycemia (IGH) or synacthen testing). The aim of our work is to Analyze the frequency and determinant of the biological adrenal insufficiency detected by stimulating tests....

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ea0073aep422 | General Endocrinology | ECE2021

The effect of COVİD-19 process on patients with endocrinological disease in a pandemic hospital: What Happened to the others?

Bozkur Evin , Turgut Seda , Pamuk Naim , Piskinpasa Hamide , Metin Duygu , Dural Cem , Sahbaz Nuri Alper , Omur Gunaldı , İlkay Cakir , Mert Meral , Dogansen Sema Ciftci

ObjectiveTo evaluate the effects of the pandemic process on those with an endocrinological disease that will require close follow-up from the last visit before the pandemic.DesignThis was a retrospective study.MethodsPatients of 3903 with thyroid, calcium-bone metabolism, adrenal gland, pituitary diseases, and neuroendocrine tumor (NET) were retrospectively scanne...

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ea0073aep423 | General Endocrinology | ECE2021

COVID-19: Is there an urgent need to further assess how Cushing syndrome patients have reacted to this pandemic and what mechanisms are in place to support them?

McBride Margaret

BackgroundSimilar to other patients with life-threatening medical conditions, the fear of contracting COVID-19 for Cushing Syndrome (CS) patients is a natural reaction which has created a number of urgent questions, requiring answers. These questions include: how my body will react to the virus; will my current comorbidities increase; what will happen if I dont have my regular clinic appointments, surgery and chemotherapy treatments? What do I do i...

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ea0073aep424 | General Endocrinology | ECE2021

The association of Vitamin D deficiency with COVID-19 severity and mortality

Kazemijahromi Mitra , Samimagham HamidReza , Azad Mehdi Hassani , Arabi Mohsen , Hooshyar Dariush

Background and objectiveThere are few studies showing the association between vitamin D deficiency and COVID-19 severity and mortality. This study designed to investigate the relationship between vitamin D deficiency and the severity and mortality of COVID-19.MethodsThe present cross-sectional study was conducted on 48 COVID-19 patients with positive PCR test results. Patients were divided into three groups a...

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ea0073aep425 | General Endocrinology | ECE2021

Serum 25(OH)D level in patients with COVID-19

Andreeva Alena , Karonova Tatiana , Golovatuk Ksenia , Bykova Ekaterina , Vashukova Maria , Grineva Elena

Recently, vitamin D deficiency has been considered as a risk factor for the morbidity and the severity of acute respiratory infections. The aim of this study was to evaluate the interlinks between serum 25(OH)D level and severity of new coronavirus infection (COVID-19) in hospitalized patients.MethodsWe included 131 patients aged 21 to 93 y.o. (mean age 51.7 ± 13.8 years), 76 (57.1%) men, hospitalized following COVID-19 infect...

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ea0073aep426 | General Endocrinology | ECE2021

Telehealth experience of endocrinology research centre

Gorbacheva Anna , Logvinova Oksana , Mokrysheva Natalia

IntroductionTelemedicine is a useful tool for improving the availability of medical care, especially in the era of COVID-19. It is required to study the needs of the Russian population for telemedicine services for each specific disease.MethodsIn Russian Federation telemedicine consultations (TMC) have been legally allowed since 2018. According to the law, if the patient has not previously attended a face-to-...

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ea0073aep427 | General Endocrinology | ECE2021

A case of severe erosive rheumatoid arthritis developed in an elderly male patient after bilateral adrenalectomy performed for ectopic Cushing’s syndrome

Aggul Hunkar , Baydar Ece , Bilen Ogun , Zuhur Sayid

IntroductionSome, cases of autoimmune diseases were previously reported after surgical remission of CD. In most cases, autoimmune diseases have generally been reported in younger females. However, some cases of Hashimotos thyroiditis, multiple sclerosis, vitiligo, and sarcoidosis in male patients, after the restoration of hypercortisolemia have been reported as well. Nevertheless, an immediate occurrence of severe erosive rheumatoid arthritis (RA) ...

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ea0073aep428 | General Endocrinology | ECE2021

Sonoelastographic characteristics of parathyroid tumors

Aleksandrov Yuriy , Belyakov Ivan

In 20162020, 181 patients (mean age 54.8; range 3177 years) with tumors of parathyroid glands (PG) were operated. All patients had hyperparathyroidism. The diagnosis was confirmed by high levels of ionized calcium and parathyroid hormone (PTH) in the blood. Ultrasound was performed in all patients before surgery. The evaluation of ultrasound images of PG tumors was carried out according to the following parameters: echogenicity, echostructure, shape, clarity...

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ea0073aep429 | General Endocrinology | ECE2021

Case report: The spectrum of autoimmune thyroid disease in association with chromosome 18p deletion syndrome

Vasilescu Sorana , Mitru Natalia Raluca , Massarella Alberto , Andrei Anca , Preda Diana , Mirica Alexandra

IntroductionChromosome 18p deletion syndrome is a rare chromosomal abnormality caused by the complete or partial delation of the short arm of chromosome 18, represented by facial dysmorphic features, hypodontia, microcephaly, short webbed neck, intellectual disability, reproductive system dysplasia, rarely with autoimmune disorders and IgA, IgG or IgM deficiency. A small subset of patients, approximately 910% have cardiac/brain disorders. Circa 150...

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ea0073aep430 | General Endocrinology | ECE2021

Sulfamethoxazole/Trimethoprim associated hypoglycaemia in a patient with renal transplantation history

Lavrador Mariana , Catarino Diana , Cátia Andreia Araújo , Luísa Barros , Paiva Isabel

BackgroundAlthough rare, hypoglycaemia in patients without history of diabetes should be recognized and studied, in order to reduce associated morbidity. Cotrimoxazole (TMP/SMX) is commonly used in clinical practice and hypoglycaemia is a rare side effect associated with its use. Literature advocates that this effect is due to the fact that SMX has the same sulphanilamide structural group of sulfonylurea, mimicking the hypoglycaemic effect by stimulating...

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ea0073aep431 | General Endocrinology | ECE2021

A giant GIST of the greater omentum in a female transsexual patient, hopefully not a side effect of hormonal therapy

Gonzalez-Diaz Paula , Leon-Durango Ricardo de , Hernandez-Lazaro Alba , Paula Maria Fernandez-Trujillo-Comenge , Kuzior Agnieszka , Acosta-Calero Carmen , Velazquez Yanina Elizabeth , Hernandez-Felipe Esther , Maria del Pino Perez-Garcia , Martinez-Martin Francisco Javier

IntroductionMany transsexual patients are concerned about the risk of cancer associated with hormonal gender-affirming therapy. However, the general risk seems to be very low. We hereby report the case of a strikingly large gastrointestinal stromal tumor (GIST) in a male-to-female transsexual patient, after 25 years of hormonal therapy.MethodsReview of the patients clinical records and the relevant lite...

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ea0073aep432 | General Endocrinology | ECE2021

Endocrine function in centenarians

Heshmati Hassan

IntroductionCentenarians are subjects living 100 years or older. They represent a model of successful aging. In 2020, the number of centenarians in the world was approximately 573.000. Multiple endocrine changes occur with normal aging. Most centenarians have managed to avoid, postpone, or overcome the important age-related and life-threatening diseases. The purpose of this review is to present the endocrine function in centenarians with special emphasis...

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ea0073aep433 | General Endocrinology | ECE2021

Potential endocrine markers of severity and outcomes in critical patients with COVID-19

Isachkina Volha , Danilova Larissa I.

BackgroundThe current COVID-19 pandemic is the worst from world infection outbreaks have occurred frequently in the last two decades, and it has led to significant mortality. Although the respiratory system is the most prominent target of SARS-CoV-2, extrapulmonary involvement are important contributors of its morbidity and mortality. A number of symptoms occur in these patients due to the involvement of various endocrine glands. The nervous, endocrine, ...

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ea0073aep434 | General Endocrinology | ECE2021

Drinking only when thirsty or when eating solids can normalize serum sodium levels in most patients with SIADH and a high fluid intake, regardless of Urine Osmolarity

Pazos Mario , Jorge Gabriel Ruiz Sánchez , Xavier Pérez Candel , Martín Cuesta Hernández , Nevado Celia Lopez , Raquel Pallarés , PATRICIA ESPINOSA DE LOS MONTEROS , Fernando Hernández Olmeda , Calle Alfonso , Runkle Isabel

Introduction Institutional campaigns, and some health care professionals, encourage the elderly to drink large quantities of fluids, regardless of their level of thirst. Furthermore, SIADH-inducing medications can often cause dryness of mouth. Thus, patients when diagnosed with SIADH can have a high fluid intake (FI), drinking in the absence of thirst. However, fluid restriction, considered the first step in therapy of mild/moderate SIADH hyponatremia, h...

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ea0073aep435 | General Endocrinology | ECE2021

Congenital adrenal hyperplasia due to 3 beta hydroxysteroid dehydrogenase deficiency About two cases

Belkacem Samira

Introduction3ßeta Hydroxysteroid Dehydrogenase (3ß HSD) deficiency is a very rare autosomal recessive disorder affecting the synthetic pathways of all active steroids in the adrenals and gonads.ObservationThe 4-year-old child M.A and his 8-year-old sister M.M, from a consanguineous marriage, with a family history of sexual ambiguity. The clinical examination found a sexual ambiguity in the boy: &#15...

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ea0073aep436 | General Endocrinology | ECE2021

Analysis of glycemic variability in patients with diabetes mellitus type 2

Makhlina Elena , Navmenova Yana

ObjectiveTo identify risk factors affecting the severity of glycemic variability indicators in patients with diabetes mellitus type 2.Materials and methodsThe study included 92 patients with diabetes mellitus type 2 and an average age of 62.25 ± 9.52 years. A biochemical blood test was performed on an automated Cobas 6000 system. To assess the glycemic variability, the standard deviation (SD</smal...

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ea0073aep437 | General Endocrinology | ECE2021

Insulinoma during pregnancy: A case report

Kamoun Elyes , Mekni Sabrine , Besrour Chayma , Rojbi Imen , Mchirgui Nadia , Lakhoua Youssef , Nacef Ibtissem Ben , Haroun Ouertani , Khiari Karima

IntroductionInsulinoma is a rare neuroendocrine tumor with an incidence of 1 to 4 per million person-years. It is the most frequent endocrine tumor of the pancreas and is revealed by a spontaneous hypoglycemia in the absence of insulin or any antidiabetic medication.Only few cases of confirmed insulinoma with pregnancy have been described in the literature. We describe a case of insulinoma discovered early in pregnancy.Case report<...

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ea0073aep438 | General Endocrinology | ECE2021

Insulinoma: a challenge for a diagnosis

Kamoun Elyes , Mekni Sabrine , Besrour Chayma , Rojbi Imen , Mchirgui Nadia , Lakhoua Youssef , Nacef Ibtissem Ben , Khiari Karima

IntroductionInsulinoma is the most frequent endocrine tumor of the pancreas and a diagnosis challenge in all cases of spontaneous hypoglycemia. The confirmation of hypoglycemia is the first step of the diagnosis before initiating the complementary investigations to confirm the insulinoma and determine its localization. The aim of this study was to investigate the diagnosis of insulinoma in a setting of organic hypoglycemia.Methods<...

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ea0073aep439 | General Endocrinology | ECE2021

A case report of cerebral salt wasting incorrectly diagnosed as the syndrome of inappropriate antidiuretic hormone secretion

Qayum Mohammed , Banwaith Tavlene , Nawaz Ghulam , Acharya Jayashekara , Sudarshan Veena

Cerebral salt wasting (CSW) occurs as the result of injury to the central nervous system and is most commonly found among those who have experienced a traumatic brain injury (TBI). Although incidence is varied, it has been reported to be as high as 30% within the patient population presenting to hospital with a TBI. CSW causes hyponatremia with concurrent hypovolemia and increased sodium within urine despite normal renal function. Because of its rare nature, CSW is often misdi...

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ea0073aep440 | General Endocrinology | ECE2021

Myasthenia during multiple autoimmune syndrome: About two observations

Imen Chabchoub , Elleuch Mouna , Salah Dhoha Ben , Charfi Nadia , Mohamed Abid

Introduction Multiple autoimmune syndrome (MASI) is a rare entity, defined by the presence of at least three autoimmune diseases in the same person. We report two specific observations of myasthenia gravis in the context of an SAIM3. Observation 1 A 58-year-old man initially presented bilateral ptosis, difficulty chewing and swallowing, dysphonia and fatigability. Myasthenia gravis was suspected due to the ag...

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ea0073aep441 | General Endocrinology | ECE2021

Association of Hadju Cheney syndrome with adrenal insufficiency in a diabetic patient: A rare association

Lassoued Najoua , Rihab Ajili , Senda Rebai , Sondos Arfa , Baha Zantour , Habib Sfar Mohamed

IntroductionHadju Cheney syndrome (HCS) is a rare progressive and debilitating genetic disorder that is characterized by a high degree of phenotypical pleiotropy. We report the first clinical case of a 44-year-old patient with HCS, diabetes and adrenal insufficiency (AI).ObservationA 44-year-old patient with a history of myocardial infarction at the age of 33 and diabetes for 2 years on oral antidiabetic drug...

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ea0073aep442 | General Endocrinology | ECE2021

Corticosteroids – 70 years of balancing between good and bad

Borozan Sanja , Vujosevic Snezana

When in September 1948 the Compound E was first synthesized and successfully administered as intramuscular injection to a woman with rheumatoid arthritis, hardly that anyone could imagine what profound impact it will have on medical research and practice. In a span of just two years, in 1950, the fascinate drug was renamed to Cortisone and brought from laboratory to broad clinical use. Seventy years later, it is still hard to find a medical field where corticostero...

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ea0073aep443 | General Endocrinology | ECE2021

Monitoring of patients on high-dose long-term steroids in a rheumatology outpatient service

Cadogan Sinead , Cowley Sharon

IntroductionCorticosteroids play an essential role in the management of many rheumatic diseases. However, corticosteroids are associated with many adverse effects, including hyperglycaemia, dyslipidaemia, and osteoporosis. These adverse effects are dose related and patients on high dose, long term steroids (defined as > 5 mg oral prednisolone and treatment duration > 3 weeks) are at greatest risk. NICE guidelines on corticosteroids recommend moni...

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ea0073aep444 | General Endocrinology | ECE2021

ABSTRACT WITHDRAWN...

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ea0073aep445 | General Endocrinology | ECE2021

Vitamin D deficiency in young adults and the question of the need for early replacement for the primary prevention of osteoporosis

Tatjana Bačun , Ivan Lekić , Jelena Šarić , Barbara Bačun , Željko Debeljak , Dunja Degmečić , Vatroslav Šerić

IntroductionLow concentrations of vitamin D are associated with decreased calcium absorption, negative calcium balance, and compensatory growth of parathyroid hormone, resulting in excessive bone resorption. The first step in preventing osteoporosis is to ensure a proper diet, especially calcium and vitamin D intake.Aim of the studyThe aim of this study was to determine the concentration of 25-hydroxyvitamin ...

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ea0073aep446 | General Endocrinology | ECE2021

An audit of Multiple Endocrine Neoplasia type-1 (MEN-1) surveillance

Sim Sing Yang , Ma’en Al-Mrayat

IntroductionMultiple Endocrine Neoplasia type-1 (MEN-1) is an inherited autosomal dominant condition with a high degree of penetrance characterized by tumour occurrence in the form of pancreatic neuroendocrine (pNET), parathyroid and anterior pituitary gland tumours, among others. Treatment for MEN-1 associated endocrine tumour, particularly pancreatic, is more challenging than in those without MEN-1, given its multicentric nature and aggressive behaviou...

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ea0073aep447 | General Endocrinology | ECE2021

Attitudes of physicians towards the guideline-recommended LDL target levels in diabetic dyslipidemia

Naime Afşar Satiş , Yavuz Dilek Gogas

AımThe aim of this study is to investigate the attitude of physicians, who are specialized in internal medicine, endocrinology, nurology and cardiology, on LDL target levels and antilipidemic treatments in Turkey.MethodsThis study outlines attitudes of physicians towards the guideline-recommended LDL target levels in diabetic dyslipidemia. An invitaiton to fill a questionnaire on demographic and professi...

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ea0073aep448 | General Endocrinology | ECE2021

Biological activity of thrombopoietin receptor agonists: development of in vitro functional and binding assays

Dorotenko Artem , Saparova Valeria , Afanaseva Alina , Makarenko Igor , Drai Roman

IntroductionNowadays thrombopoietin receptor agonists (TPO-RAs) represent a promising approach for the patients with immune thrombocytopenia (ITP). Usage of two licensed TPO-RAs, romiplostim and eltrombopag, provide efficient support of ITP patients´ platelet count and, as a consequence, better control of disease. Both agents have an acceptable toxicity profile, but there are several another disadvantages in terms of usage of these drugs such as cos...

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ea0073aep449 | General Endocrinology | ECE2021

Parameters of successful telephone endocrinology consultation during covid-19 pandemic

Krajnc Mitja , Marija Kovše Krajnc

ObjectiveThe COVID-19 pandemic is an unseen international emergency causing major challenges in medical care delivery. Patients with some chronic endocrine disorders (obesity, type 2 diabetes, probably also hypertension, corticosteroid excess) have higher rates of acute COVID-19 complications and death. Due to the changes in outpatient management there is a clear danger of inadequate clinical support for endocrinology patients. The decision for face-to-f...

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ea0073aep450 | General Endocrinology | ECE2021

Role of estradiol and progesterone in fragmented sleep of castrated rats

Cabeza Marisa , Nayely Carrasco-Núñez , Romano Martha

Sleep is disturbed in both healthy and pathological aging, so it is essential to consider the role of ovarian hormones in both processes. Studies supporting the natural function of E2 (or elevated FSH) in fragmented sleep are inconsistent because when non-human animals have been used, they have mainly been male. Given this background, this study focused on determining the role of different estradiol and progesterone doses in the intermittent arousals of castrated rats maintain...

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ea0073aep451 | General Endocrinology | ECE2021

The (epi)genetic basis of gender incongruence

Fernandez Rosa , Collet Sarah , Ramirez Karla , Kiyar Meltem , Delgado-Zayas Enrique , Guy T’sjoen , Guillamon Antonio , Mueller Sven C , Eduardo Pásaro

In mammals, the gonads and the brain develop from bipotential organs that will differentiate into female or male organs, during a critical period of development. This process begins with the production of testosterone by the testes, which will be converted into estradiol in the brain, by the aromatase. While the end is defined by the moment when the inhibition of androgens (in males), or treatment with estrogens (in females), stops having an effect on brain dimorphism. But in ...

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ea0073aep452 | General Endocrinology | ECE2021

Growth hormone treatment in turner syndrome: How is the statural growth after one year?

Yamani Nada El , Abdellaoui Wahiba , Yakhlef Salma Ben , Siham Rouf , Hanane Latrach

IntroductionTurner syndrome is a rare condition that affects only females. It results when one of the X chormoses is missing or partially missing. It can cause short height, ovarian failure, heart defects and other complications. It is an indication for growth hormone treatment. The aim of our study is to evaluate the statural growth over one year in turnerian patients treated with growth hormone.Materials and methods<p class="...

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ea0073aep453 | General Endocrinology | ECE2021

The association of angiotensin converting enzyme inhibitors and receptor blockers with COVID-19 severity and mortality

Kazemijahromi Mitra , Samimagham HamidReza , Arabi Mohsen , Hooshyar Dariush , sharifi mohammad

BackgroundThe available data on the effect of Angiotensin Converting Enzyme Inhibitors (ACEIs) and Angiotensin Receptor Blockers (ARBs) use on COVID-19 infection are both insufficient and controversial. The present study was conducted to investigate the effect of a history of ACEI/ARBs use on the severity and mortality of COVID-19 infection.MethodsThis study recruited 147 patients with confirmed COVID-19. The...

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ea0073aep454 | General Endocrinology | ECE2021

Acute pancreatitis in a covid-19 patient

Maria Zhao Montero Benítez , Pascual Cristina Contreras , Mendez Cristina Montalban , Tirado Antonio Moreno , Paloma González Lázaro , Florentino Del Val Zaballos , Julia Silva-Fernández , Meneses Amparo Lomas , Francisco Javier Gómez Alfonso , Inés Gómez García

Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, most commonly caused by gallstones and heavy alcohol consumption. The diagnosis is established with at least 2 of the following criteria: abdominal pain; increased serum lipase/amylase levels greater than 3 times the upper limit of normal value; or characteristic findings on contrast computed tomography (CT). Since the beginning of the severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic, a few...

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ea0073aep455 | General Endocrinology | ECE2021

Profil of vitamin D in patients with idiopathic short stature: About 62 cases

Yamani Nada El , Abdellaoui Wahiba , Yakhlef Salma Ben , Siham Rouf , Hanane Latrach

IntroductionIdiopathic short stature is a condition in which the height of the individual is more than 2 standard deviation below the corresponding mean height for a given age, sex and population, in whom no identifiable disorder is present. The aim of this study is to describe the vitamin D profile of patients followed up for idiopathic short stature in the endocrinology department of Mohamed VI University Hospital Center.Material...

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ea0073aep456 | General Endocrinology | ECE2021

Carney complex – a rare cause of Cushing’s syndrome

Guiomar Joana Reis , Moreno Carolina , Lúcia Fadiga , Diana Alexandra Festas Silva , Paiva Isabel

IntroductionThe Carney Complex (CNC) is a rare, autosomal dominant, multiple endocrine neoplasia. It involves multiple endocrine glands, cardiac and skin myxomas, mammary fibroadenomas and mucocutaneous pigmentation. Cushings syndrome, due to primary pigmented nodular adrenocortical disease (PPNAD), is described in 25% of the cases.Case reportWoman, 21-year-old, was refered for secondary amenorrhea. Med...

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European Congress of Endocrinology 2021

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