Endocrine Abstracts

Cadmium (Cd) is a ubiquitously present toxic metal with an established ability to induce endocrine disruption, in literature often referred to as metalloestrogen. Some of the major uncertainties connected with endocrine disrupting chemicals (EDCs) in general, are low-dose exposure and the presence of nonmonotonic dose-response curves. This study aims to elucidate the presence of a dose-response relationship between the measured Cd levels in the tissue (internal dose) and estro...

Thyroid hormones are important regulators of metabolism and development. Iodothyronine selenodeiodinases can both activate and inactivate thyroid hormones (Bianco et al. 2002) thus in vitro assays to quantify deiodinase inhibition are considered to be a valuable tool for studying effects on thyroid hormone metabolism by potential endocrine disruptors. The prohormone thyroxine (T4) is converted to 3, 5, 3’-triiodothyronine (T3) by outer-ring deiodination,...