Endocrine Abstracts

Introduction: The Warthin-like variant of papillary thyroid cancer (WLPTC) is a rare subtype of papillary thyroid carcinoma (PTC) resembling Warthin tumours of the salivary glands, and more commonly associated with Hashimoto’s thyroiditis than other types of PTCs. The WLPTC is characterized by papillae lined by large oncocytic cells with cores having dense lymphoplasmacytic infiltrate. The prognosis of WLPTC is the same or less aggressive than that of classical PTC, but i...

The hypothalamic paraventricular nucleus (PVN) is a major regulatory centre of energy homeostasis by possessing the unique capability of simultaneously controlling endocrine axes, water balance and autonomic functions. It receives neuronal information form orexigenic and anorexigenic cell groups of the basal hypothalamus that monitor peripheral metabolic signals (leptin, insulin, ghrelin, glucose, glucocorticoids) and also from brainstem centers relaying sensory information fr...

Background: Peripheral clocks are set by different nervous, hormonal and metabolic stimuli and regulate the circadian expression of several genes. It has been demonstrated that circadian oscillation of gene expression can be detected in various cell lines in vitro.Aim: To explore whether a peripheral clock could be induced in human adrenocortical cell line H295R and what are the effects of glucocorticoids on this clock system.<p class="abste...

Currently, there is increasing evidence that various chemicals introduced in the environment have the potential to cause damage to endocrine system, which regulates reproductive processes. Iron has various effects on reproductive endocrinology and it can also cause or contribute to hormonal disruption and to interfere with the key enzymes involved in steroid synthesis. The target of this in vitro study was to determine the effects of iron (FeSO4·7H<sub...

Background and Purpose: Laparoscopic adrenalectomy has become the preferred surgical approach to manage adrenal disorders. Bilateral adrenalectomy is performed for diseases that are unresponsive to medical management and, frequently, for neoplastic disease. The aim of this study was to review our experience with laparoscopic bilateral adrenalectomy and to evaluate its safety, efficacy, and outcomes.Patients and Methods: Between May 1999 and May 2005, fou...

Puberty is the final stage of maturation of the hypothalamo-pituitary-gonadal axis and is characterized by changes in circulating gonadotropins and increased levels of sex steroids. There are both genetic and external factors (e.g. nutrition, stress) which can alter the onset of puberty. The aim of this study was to determine the onset of puberty in genetically homogeneous inbred mouse strains. Five strains were used: 129X1/SvJ, DBA/2J, C57BL/6J, CBA/CaJ and A/J. Various puber...

Keywords: sugar substitute agent exposures, nutritional biology, neuroendocrine system, oxytocinHuman homeostasis is maintained by the complex functioning of the psycho-neuroendocrine-immune system. If a disturbance is generated in this neuroendocrine system for any reason, it can trigger pathogenic processes. One of the factors disturbing homeostasis today may be changes in dietary habits, e.g. through the use of undue sweeteners (e.g. stevia, xylitol e...

The biological organisms are complex systems regulated by the homeostatic back-end network. In these days the growing environmental loads (from industry, household, etc.) contain chemical exposure eg. halogenated hydrocarbons (monuron: MU (C9H11ClN2O), diuron: DU (C9H10Cl2N2O)), which can be endocrine disruptor compounds (EDCs). Synthesis, release of hormones and cell processes of endocrine cells, and...

Introduction: Endocrine disruptor compounds (EDCs) are chemicals that may interfere with the endocrine system and produce adverse developmental, reproductive, neurological and immune effects.These agents can be found in household, in the industry and in our environment.Endocrine disruptors are substances that interfere with the synthesis, secretion, transport, binding, action, or elimination of natural hormones in the body that are responsible for development, behavio...

Introduction: In vitro adipogenesis is a two-step developmental process in which an undifferentiated mesenchymal cell differentiates into a preadipocyte, which then undergoes a secondary differentiation step to become a lipid-filled adipocyte. The triglyceride accumulation is influenced by various endogenous and exogenous factors.Methods: In an attempt to understand the antipsychotics effects on lipid accumulation duri...