Endocrine Abstracts

Background and aim: Obesity (Ob) is tightly associated with metabolic diseases such as type 2 diabetes (DT2) andinsulin resistance (IR). Furthermore, obesity has been identified as one of the primary causes of mood disorders (MDs) including depression. Several studies have demonstrated the link between Ob, adiposity, neuroinflammation and MDs. The Brain-Derived Neurotrophic Factor (BDNF) and its regulator, the non-coding RNA BDNF antisense RNA (BDNFas), play an import...

Background and aimMajor depressive disorder (MDD) is one of the common mental disorder that affect more than 350 million subjects. MDD has been reported to be associated with systemic inflammation and obesity. However, there are no data that relate adipose tissue (AT) inflammation to MDD. The analysis of inflammatory markers in AT could pave the way to clarify the potential association between MDD and obesity. For this reason, the aim of our study was to...

Introduction: Adrenal vein sampling (AVS) is the gold standard test to distinguish between unilateral adenoma and bilateral hyperplasia in primary hyperaldosteronism. This is a technical complicated procedure with a variable success rate. Our aim was to report our 10-year-success rate and results as regards to this procedure.Material and Methods: Retrospective observational study including data from patients undergoing AVS between 2009 and 2019.<p cl...

IntroductionSemaglutide is a glucagon-like peptide-1 receptor agonist which has shown important benefits in patients with type 2 diabetes mellitus (T2DM) in randomized clinical trials. Its commercialization in Spain began in May of 2019. The main purpose of this study was to analyze the effectiveness of this drug into routine clinical practice in patients with T2DM with a body-mass index above 30 kg/m2.Matherial and meth...

Erectile dysfunction(ED) is a common but under – appreciated complication of diabetes. The current pilot study aims to determine the prevalence of ED and its association with a set of socio-demographic and lifestyle characteristics among type 2 diabetic men in Jos, Nigeria.Consecutive male type 2 diabetic patients attending a diabetic clinic in Jos were interviewed with the aid of a questionnaire on socio-demographic and lifestyle characteristics an...

IntroductionSodium-glucose cotransporter-2 inhibitors (SGLT2i) are a new class of oral antidiabetic drugs used for the treatment of type 2 diabetes mellitus. Recently, the SGLT2i dapagliflozin was approved for use in type 1 diabetes (T1DM) as an add-on to insulin therapy.Material and methodsWe conducted a retrospective observational study which included demographic and clinical-analytical data from 16 patient...

Introduction: Adrenocortical carcinoma (ACC) is a very rare entity with a variable clinical presentation.Objective: To review the casuistry of ACC in our center in the last 15 years and to assess clinical characteristics and evolution in our patients.Material and method: We searched cases of ACC from 2004 to December 2018 registered in the Pathology Department.Results: Fifteen cases were found, 9 women and 6 ...

Introduction: Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of LDL cholesterol (LDL-C) from birth. Treatment with statins and ezetimibe achieves in most cases large reductions in LDL-C. In those patients in whom the reduction in LDL-C is insufficient or who have intolerance to such treatments, the appearance of PCSK9 inhibitors has been an effective and safe alternative to achieve the LDL-C objectives.Materials and...

Introduction: Paraganglioma type 4 is the second most common hereditary paraganglioma syndrome. It is due to a mutation in the succinate dehydrogenase B (SDHB) gene. Associated with high morbimortality for presenting high penetrance (77%) and debut at an early age with a high probability of malignancy (31–71%). In terms of follow-up, annual biochemical monitoring is recommended for mutation carriers. However, the affected gene should be taken into account, for example: t...

Neoplastic thyroid diseases (multinodular goiter (MNG), follicular adenoma, differentiated (DTC) and undifferentiated thyroid carcinoma) have a higher incidence in women than in men. In fact, in the last ten years, DTC is the only cancer increasing the frequency in women, with an incidence similar to ovarian carcinoma or lymphomas.TGFb is a secreted factor important in the normal function of the thyrocyte. It has two independent actions: a fast antiproli...