Endocrine Abstracts

Background and aim

Major depressive disorder (MDD) is one of the common mental disorder that affect more than 350 million subjects. MDD has been reported to be associated with systemic inflammation and obesity. However, there are no data that relate adipose tissue (AT) inflammation to MDD. The analysis of inflammatory markers in AT could pave the way to clarify the potential association between MDD and obesity. For this reason, the aim of our study was to analyze the expression of inflammatory adipokines in human and mice AT in relation with obesity and MDD.

Materials and methods

IL-6, IL-1b, ADIPOQ, TNF-a, MCP-1, ITGAM and PLAUR expression levels were measured by real-time qPCR from subcutaneous (SAT) and visceral (VAT) adipose tissue of depressive and no depressive normoweight subjects (n = 10) and depressive and no depressive morbid obese (n = 10) and from male obese mice fed a high fat diet (HFD, n = 7) and male lean mice fed a standard diet (S.D., n = 7).

Results

in this study, we observed that in both SAT and VAT the expression levels of IL-6, IL-1b, TNF-a, MCP-1, ITGAM and PLAUR increased significantly in no depressive normoweight and no depressive obese compared with no depressive normoweight, while ADIPOQ expression was lower in these groups compared with no depressive normoweight. Additionally, in obese subjects, the expression levels of IL-6 were higher in depressive subjects compared with no depressive subjects whereas ADIPOQ expression was lower in depressive subjects compared with no depressive in SAT and VAT. The expression levels of Il-6, il-1b, Tnf-a, Mcp-1, Itgam and Plaur increased significantly from obese mice HFD compared with lean mice S.D. in VAT and SAT while, Adipoq expression decreased with obesity.

Conclusion

Our results suggest the potential involvement of VAT and SAT inflammation in MDD, inducing complex mechanisms which are strongly linked with obesity. This work was supported by grants from the Spanish Ministry of Health (FIS), PI18/00785 and Miguel Servet II” [CPII13/00041], and co-funded by Fondo Europeo de Desarrollo Regional–FEDER, and from the Consejería de Innovación and co-funded by Fondo Europeo de Desarrollo Regional–FEDER (CTS-7895) S.L. was a recipient of a post-doctoral grant Plan Andaluz de Investigación, Desarollo e Inovación (DOC-01138) from Consejería de Economía, Conocimiento, Empresas y Universidad.