Endocrine Abstracts

The pregnancies conceived after chemotherapy for trophoblastic neoplasia should be followed with clinical surveillance due to higher rates of some pregnancy complications especially when associated with diabetes mellitus. We report the case of a 30-year-old nulliparous woman, obese, had been diagnosed with type 2 diabetes mellitus for 10 years, without micro or macrovascular complications, treated by conventional insulin therapy, with a history of low-risk gestational chorioca...

IntroductionMobile health technology has been highly beneficial for people with diabetes, offering a plethora of educational patterns especially during COVID-19 pandemic. Diabetes self-management education through telehealth technologies is important in promoting health practices and in reducing the risk of complications. Nevertheless, the challenge is to elaborate a digital application in light of sociocultural background and economic status.<p clas...

IntroductionInsulin therapy can lead to obesity which can affect the comorbidities of the type 2 diabetes. Should we consider the body mass index (BMI) before prescribing it?MethodsOur study is prospective, randomized and comparative.We recruited patients with type 2 diabetes hospitalized for a switching to insulin in the C department of diabetology and nutrition at the National Nutrition Institute in Tunis, ...

IntroductionThe emergence of the concept of the expert patient has changed the paternalistic doctor–patient relationship. The ’knowing’ patient is an active actor, his level of knowledge acquired during therapeutic education programs (ETP), allows him a certain autonomy in the management of his pathology. We focus through a case report of ketoacidosis on the useless intervention of an ’expert’ patient to prevent it.<p class="...

IntroductionThe objective of our study was to compare the glycemic control between patients on human insulin and those on insulin analogues.MethodsWe conducted a prospective, randomized and comparative study. By recruiting patients with diabetes hospitalized in the day hospital departement at the National Nutrition Institute in Tunis during 8 months. The glycemic control of patients on human insulin and those...

BackgroundLow serum vitamin D concentrations have been associated with autoimmune thyroiditis. Obesity is characterized by lower vitamin D levels and higher risk to develop autoimmune diseases. The aim of the study was to investigate the possible relation of serum vitamin D concentrations to visceral fat thickness (VFT), insulin resistance (IR), inflammation (serum monocyte chemoattractant protein-1 – MCP-1) and thyroid parameters in obese patients....

IntroductionInternet searches mirror – to a degree – real-life behaviors and are influenced by chronic situations or abrupt events. From 2019 onwards the advent of the COVID-19 pandemic has changed profoundly daily habits, particularly during periods of protracted lockdown and following stay-at-home orders.AimIn this study we aimed to assess Google Trends internet searches for diet and obesity over ...

IntroductionMetabolic syndromeis the association in the same individual of a number of cardiovascular risk factors, namely abdominal obesity, dyslipidemia, high blood pressure and glucose intolerance. The objective of this study is to analyze the clinical and paraclinic characteristics of obese and overweight children in order to look for the elements of metabolic syndrome in these childrenMethodsWe carried o...

Since 2006 at our hospital, lifestyle modification, such as diet and exercise, for obese patients has been provided through a team approach with a physician, dietician, nurse, physical therapist and psychologist. From 2016, a surgeon and anesthesiologist were added to the team for metabolic/bariatric surgery. The aims of this study are to clarify the effectiveness and problems of lifestyle modification for short-term intensive management (for 3 months) and long-term management...

Background and aimMajor depressive disorder (MDD) is one of the common mental disorder that affect more than 350 million subjects. MDD has been reported to be associated with systemic inflammation and obesity. However, there are no data that relate adipose tissue (AT) inflammation to MDD. The analysis of inflammatory markers in AT could pave the way to clarify the potential association between MDD and obesity. For this reason, the aim of our study was to...

AimLockdown order during COVID-19 pandemic caused a sedentary life-style and disruptions in eating and sleeps patterns of obese patients. In this study, it is planned to evaluate the clinical and metabolic effects of this period on obese patients.MethodsThis study included 44 obese patients who were followed up in Endocrinology and Metabolic Diseases Clinic of Karadeniz Technical University. In this study, me...

BackgroundStructured lifestyle modification programmes are offered as first line treatment to patients referred to bariatric specialist services. We sought to describe changes in anthropometric and metabolic characteristics in a cohort of bariatric patients following completion of an eight-week, multidisciplinary group-based lifestyle intervention focussed on diet and physical activity.MethodsWe conducted a p...

BackgroundThe prevalence of type 2 diabetes has been increasing all over the world. Various risk factors have been identified for the generation of type 2 diabetes include; ageing, family history of diabetes, general obesity, central obesity, physical inactivity, and sedentary lifestyle. Obesity, particularly central obesity is associated with insulin resistance (IR), ’beta-cell’ dysfunction, partly through increased free fatty acids (FFAs) and...

IntroductionSelf-esteem is widely viewed as a person’s overall evaluation about self-worth or personal value and is considered an essential indicator for positive mental health and psychological well-being. This study sought to explore the level of self-esteem and identify the factors associated with low self-esteem in this population.MethodsIt was a cross-sectional study conducted in Sfax, Southern Tuni...

IntroductionAn increasing number of type 1 diabetics (T1DM) are being identified as having characteristics of metabolic syndrome and obesity. The aim of our work is to assess the prevalence of overweight and degenerative complications in a population with type 1 diabetes.Material and methodsThis is a descriptive and retrospective study concerning 377 type 1 diabetics hospitalized in the endocrinology-diabetol...

IntroductionOver the past decades, the prevalence of overweight, especially obesity, has steadily increased. This global scourge has affected all populations including that of medical students. The objective of our work was to determine the prevalence of this pathology in the population of future physicians and to study the factors associated with it.MethodsThis is a cross-sectional study including 120 medica...

BackgroundCurrently, the overweight and obesity influence on human organs and systems is being studied all over the world, which are based on the violation of metabolic processes of fat and carbon metabolism, hyperglycemia with glucose toxicity, insulin resistance, obesity and metabolic syndrome. NAFLD progresses not only from steatosis to steatohepatitis (NASH), but is accompanied by liver fibrosis with transformation into cirrhosis and hepatocellular c...

IntroductionThe prevalence and mortality of the new type of coronavirus (SARS Cov-2) are high in patients with metabolic disease, especially in diabetes circumstances. Therefore, this study aims to present the changes in the clinical and biochemical parameters of a patient with Type 1 diabetes who died due to Covid-19.Case Table 1. Laborat...

IntroductionThe diabetic foot represents a public health problem with very important direct and indirect expenses. Multidisciplinary care and monitoring is essential. The aim of this Study was to describe the management of the diabetic foot in the endocrinology department.Materials and methodsIt was a retrospective study carried out in the Endocrinology and Diabetology department of the Hédi Chaker unive...

IntroductionNon alcoholic steato-hepatitis (NASH) is the most common chronic liver disease in developed countries rare in type 1 diabetes it is associated with an increased risk of complications in patients with type 1 diabetes mellitus (T1DM). The aim of this study is to clarify the characteristics of NASH in patients with T1DM.Materials and methodswe conducted a retrospective descriptive study in non-alcoho...

IntroductionThe aim of our study was to search the causes of pain in diabetics followed for a lower limb amputation in physical medicine and rehabilitation (PMR) department.Patients and methodsA retrospective study carried out between 2018 and 2020 on diabetic patients referred to PMR department for lower limb amputation.ResultsForty-two patients were included in ...

BackgroundDiabetic nephropathy complicated by albuminuria along with low estimated glomerular filtrate rate (eGFR) are a typical feature of Type 2 Diabetes (T2D) and it’s related to a significant increase in mortality and chronic complications in diabetic patients However, data from the literature are still not conclusive regarding the direct association between albuminuria and risk of amputation for ischemic limb vascular disease, in diabetic patie...

BackgroundCeliac disease (CD) occurs in patients with type1 diabetes (T1DM) ranging the prevalence of 4.4–11.1% versus 0.5% of the general population. The mechanism of association of these two diseases involves a shared genetic background.AimTo investigate whether in type1 diabetes (T1DM) patients the concomitance of treated celiac disease (CD) impacts glycemic control and the prevalence of microvascular...

IntroductionPancreatitis is an inflammatory condition of the pancreas, which has known an increased incidence over the last years. Gallstones and alcohol abuse are the most common causes. But many risk factors are associated with pancreatitis, including Type 2 diabetes who has an estimated risk of pancreatitis at nearly three times the risk of non-diabetics. The aim of our work is to study the relationship between these two entities.<p class="abstext...

A 20-year-old woman, with type 1 diabetes, presented to Emergency Department complaining of abdominal pain and vomiting for 3 days. She reported intermittent non-compliance with insulin therapy. Physical examination revealed epigastric tenderness. Blood glucose was 34.6 mmol/l, blood ketones 7.8 mmol/l, creatinine 131 µmol/l and CRP 31.47 mg/l (< 10). Despite clinical and initial laboratory features suggesting diabetic ketoacidosis, pH was 7.52 (7.32–7.43), pCO<s...

AimsTo describe the epidemiological and clinical characteristics of temporal-osteomyelitis mandibular complicating necrotizing otitis externa and discuss how to take it in load.Materials and methodsThis is an 18-year retrospective study [2010–2017], conducted in our ENT department, collecting 74 hospitalized patients for management of necrotizing otitis externa.Results<p class=...

IntroductionDiabetes is a chronic disease and a public health problem. Insulin Injection is used as a treatment for type 1 diabetes and insulin-requiring type 2 diabetes. A well-made injection is the key to a good glycemic balance. However, many studies showed that diabetic patients did not master the injection technique, reflecting an empirical random or non-existent therapeutic patient education(TPE). Our objectives were to assess our patients’ kn...

IntroductionPrediabetes and type 2 diabetes prevalence in children and teenagers has been rising lately, according to obesity increase in this population. Diabetes is the first cause of kidney failure in this individuals. These clinical entities are associated with hypertension and dyslipidemia, leading to an increased risk for cardiovascular disease. In this case, as a result of the presence of a diabetic complication, the differential diagnosis of the ...

BackgroundFaced with the increase in the number of diabetic patients in Tunisia, an inventory of their needs as well as their expectations is necessary to help the medical staff deliver appropriate means of therapeutic education of the patient.AimWe aim to assess Tunisian diabetic patients’ understanding of the disease, evaluate its impact on several aspects of their life, and classify their needs and ex...

IntroductionInsulin remains the cornerstone of therapy in a substantial number of patients with type 2 diabetes mellitus (T2DM). Inadequate knowledge regarding insulin pen usage is likely to influence its acceptance and adherence, and outcome of therapy, underscoring need to teach proper injection pen technique to T2DM patientsMethodsIn 2019–2020 we conducted survey of 328 respondents (male: 202, female:...

IntroductionMucopolysaccharidosis type 4A (Morquio 4A) is an autosomal recessive lysosomal storage disease caused by a mutation in the gene encoding galactosamine 6 sulphatase (GALNS). It’s main clinical features include short stature, skeletal dysplasia, cloudy cornea, hearing loss and dental anomalies. Herein, a case of Morquio 4A, a rare cause of short stature is presented.Case reportA 41 year old fem...

IntroductionDifferentiated thyroid cancer (DTC) is the most common thyroid cancer with a relatively high survival rate. Distant metastasis (DM) is not a frequent event in DTC but has an adverse impact on mortality of patients.PurposeThe aim of this study was to determine the most frequent metastases and their prognosis after adequate treatment.MethodsA retrospecti...

IntroductionThe association of type 1 diabetes with other autoimmune diseases is well known due to a common genetic terrain of varied clinical expressions. However, the occurrence of systemic diseases in diabetic patient, whatever the type of diabetes, is poorly studied. The objective of this study is to describe autoimmune and inflammatory diseases associated with diabetes.Materials and methodsIt ’ s a ...

IntroductionDiabetes mellitus (DM) due to cirrhosis is described as hepatogenous diabetes (HD). Despite being frequently described in the literature, it is not recognized as an entity by the ADA/EASD.Case reportWoman, 70 years old, previous history of autoimmune hepatitis with Child-Turcotte-Pugh A cirrhosis (CTP-A) since 2018, arterial hypertension and overweight (BMI 29.1 kg/m2). No personal or f...

Little is known on the impact of acute COVID-19 infection on causation of diabetes. We report on a 36 years old man from Nigeria who presented with diabetic ketoacidosis (DKA) with typical osmotic symptoms of polyuria and polydipsia, fatigue and weight loss over 2 weeks. He tested positive for SARS-COV2 by PCR. The initial laboratory results: Random glucose 30.6 mmol/l, capillary blood ketones 7.4 mmol/l, pH 7.22, bicarbonate 7.5 mmol/l. Despite insulinopaenic state, at presen...

IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has generate a pandemic disease around the world. It has been documented that diabetes mellitus (DM) acts as a risk factor among people hospitalized with coronavirus disease (COVID-19). The objective of this study is to test if DM may unfavorably influence the outcome of COVID-19.MethodsData from Hospital Universitario Central ...

IntroductionThe SARS-Coronavirus-2 pandemic affects 248 469 people with 28 341 deaths in Spain as of June 28, 2020. Severe infection is more prevalent in patients with advanced ages, cardiovascular risk factors (CVRF) and chronic diseases (diabetes mellitus, cardiovascular disease and asthma). Having diabetes implies vulnerability to serious complications and death from coronavirus; although, not all diabetics have the same level of risk. The oldest is p...

IntroductionHyponatremia secondary to the syndrome of inappropriate anti diuretic hormone (SIADH) secretion is one of the most frequently observed electrolyte abnormalities in coronavirus disease -2019 (COVID-19). Herein, we report a new case of SIADH in a type 2 diabetic patient with COVID-19 pneumonia.ObservationA 79-year-old man with type 2 diabetes mellitus was admitted for a poor general condition. On ph...

IntroductionCOVID-19 can precipitate hyperglycaemic emergencies like Hyperosmolar Hyperglycaemic State (HHS) in patients with or without DM. It is currently hypothesized that COVID-19 may have a diabetogenic effect in addition to the stress-related response of glucose metabolism in severe illness. Dexamethasone reduces mortality in people with COVID-19 who require ventilation or oxygen therapy but can impair glucose metabolism. We present a case with HHS...

IntroductionAfter the emergence of the COVID 19 pandemic, many publications have interested in type 2 diabetes mellitus with a dearth of papers regarding type 1 diabetes mellitus (T1DM), especially new-onset type 1 diabetes which entails a special concern. We report herein the experience of a single tertiary care Center.MethodsA retrospective observational study including New-onset T1D patients between March ...

Metabolic syndrome (MS) is one of the most pressing problems of modern medicine. MS is a symptom complex of impaired carbohydrate metabolism, abdominal obesity, dyslipidemia, hypertension with an increased risk of developing cardiovascular diseases and type 2 diabetes mellitus. The main reasons for the increase in the incidence of MS are a decrease in physical activity and a high-calorie diet. The prevalence of MS in different countries is 25–30% and varies depending on t...

The prevalence of MS in different countries is 25–30% and varies depending on the diagnostic criteria used. The severity of the clinical manifestations of MS affects the quality of life (QL) of patients, while the indicators of physical and mental health decrease. The problem of QL of patients suffering from overweight and obesity is relevant and socially significant. Obesity leads to anxiety-depressive disorders, neurosis-like conditions, which contributes to a worsening...

BackgroundOver the last years obesity has become an important medical and social problem in almost all countries of the world. The social significance of the problem is determined by the disability threat of patients and reduction of overall life expectancy due to the frequent comorbidities development. According to scientific data and modern ideas, there are a number of factors that affect not only the course of toxic hepatitis, but also the therapy eff...

IntroductionObesity is a chronic disease that is associated with several comorbidities, decreased quality of life, and increased mortality rate. Bariatric surgery is the most effective therapy for obese patients with class III and class II with metabolic diseases. Its effectiveness is not only related to the weight reduction, but also to the improvement of the metabolic profile. The aim of this study is to characterize the effects of gastroplasty with Ro...

IntroductionIn Tunisia, obesity is a public health problem. In fact, it has been considered as a complex disease including alteration of the nutritional, somatic and psychological functioning of the individual. Various psychological disorders have been associated with it such as social phobia (SP). In this context, our study was conducted to determine the psychological profile in terms of SP in obese adults.Methods<p class="abs...

Sex hormone-binding globulin (SHBG) is a circulating plasma glycoprotein produced by the liver, which in the blood binds estrogens and androgens with high affinity and regulates its bioavailability. Low plasma SHBG levels are associated with obesity, metabolic syndrome and non-alcoholic fatty liver disease. Importantly, epidemiological studies have demonstrated that low plasma SHBG levels is a risk factor for developing type 2 diabetes and cardiovascular disease. In the last y...

IntroductionObesity is a social scourge. Masked arterial hypertension (HTAM) is a relatively recently described entity that poses a diagnostic problem and places the patient with it at an increased risk of cardiovascular events. In this context we report a prospective study of 50 patients to determine the prevalence and predictive factors of HTAM.MethodsDescriptive study of obese patients treated in the Endoc...

Background and objectivesAround 50% of the population is affected with vitamin D insufficiency worldwide. The increasing prevalence is attributed to change in lifestyle, reduced exposure to sunlight and other environment factors. Vitamin D has multiple actions in the body including calcium homeostasis and has impact on several biologic processes with several clinical implications including obesity, diabetes mellitus, and metabolic syndrome, cancer, cardi...

INTRODUCTIONType IV hypertriglyceridemia (HTG IV) or endogenous HTG is a rare inheriteddisorder of the lipoprotein metabolism due to increased hepatic triglyceride synthesis(TG). Although HTGIV is not usually expressed until adulthood, it might be unmasked earlier. We report the case of an early and severe HTGIV complicated with chronic pancreatitis.Case reportA 6-year-old childwith no particular history was ...

IntroductionHypertension is a frequent finding amongst people having either Type1 or Type 2 diabetes. In Type 2 diabetes, hypertension is present in a great number of persons, at the time of diagnosis but it’s occurrence is low with the diagnosis of Type 1 diabetes.Case presentationA 34 years old Saudi male, non-smoker, had been following up at our University Diabetes Center since February, 2020. He had ...

IntroductionGlucocorticoids are among the most widely used treatments for controlling inflammatory or autoimmune diseases. However, their metabolic side effects are not negligible, particularly on carbohydrate metabolism. Corticosteroid-induced diabetes is an identity frequently found in the clinic. Its occurrence during pregnancy can affect the maternal and foetal prognosis. After the illustration of a clinical case, we will discuss the definition, risk...

IntroductionPre-pregnancy diabetes and gestational diabetes are gestational risk situations. The objective of our study is to evaluate the course of these pregnancies in order to improve their management.Patients and methodsDescriptive retrospective study, including 175 patients with diabetic pregnancy followed in the department of gynecology and obstetrics of the Ibn Rochd University Hospital in Casablanca b...

IntroductionThe diabetic is characterized by his vulnerability to infections of the upper limb compared to the general population realizing the tropical diabetic hand. So this is a very serious problem, especially in emerging countries in tropical regions. The aim of this work is to study the clinical, therapeutic and progressive aspects of infections of the upper limb in diabetic patients.Materials and methods<p class="abstext...

BackgroundThe reported HMBS mutations of acute intermittent porphyria(AIP) have been increasing gradually in China. We aim to explore its mutation characteristic in China and improve the understanding of its molecular heterogeneity.Material/methodsWe searched the literature about Chinese AIP patients with HMBS mutation in the PubMed, CNKI, Wanfang and CQVIP database, and 3 AIP patients with HMBS mutation in o...

Diabetes caused by immune checkpoint inhibitors is extremely rare. A 48-year-old male patient with a diagnosis of squamous cell cancer in the external auditory canal and operated on received adjuvant radiotherapy. When relapse was seen, 6 cycles of 5-fluorouracil, carboplatin, and cetuximab were administered. The patient was admitted to the hospital with nausea, vomiting, and abdominal pain 10 days after the second cycle infusion, when pembrolizumab was started when the crania...

Mitochondria play a key role in hormone biosynthesis and involve in renal cell proliferation by producing about 90% of cellular energy and controlling cell apoptosis. Doxorubicin is commonly used for many tumor treatments. However, its clinical utility is limited by the adverse reactions, which are known to be nephrotoxic. The mechanism by which doxorubicin induced kidney damage is still not completely understood, however nephrotoxicity by doxorubicin might be related to mitoc...

IntroductionNon-alcoholic liver fatty disease is one of the metabolic consequences found in patients followed for hyperandrogenia, especially those with polycystic ovary syndrome. Studies have suggested that hyperandrogenia is considered as an additional risk factor in synergy with obesity and insulin resistance in the development of non-alcoholic liver fatty disease. The aim of our work was to study the prevalence of non-alcoholic liver fatty in patient...

IntroductionBardet–Biedl syndrome (BBS) is a rare autosomal recessive ciliopathy characterized by rod-cone dystrophy, learning difficulties, polydactyly, obesity, genital malformations, and renal abnormalities. We report the case of a young patient followed for this syndrome, which is revealed by early obesity.ObservationThis is a 23-year-old patient from a consanguineous marriage with a personal history...

Background and aimVitamin D may affect glucose homeostasis, vitamin D levels having been found to be inversely related to glycosylated hemoglobin (HbA1c) levels in type 2 DM. With the scarcity of the regarding data in Ukraine, the aim of this study was to assess the relationship between hypovitaminosis D and glycemic control in type 2 DM women of reproductive age.Material and methodsTo test the hypothesis tha...

IntroductionMetabolic syndrome is the concurrence of the metabolic risk factors for both diabetes and cardiovascular disease, namely, hypertension, hyperglycemia, dyslipidemia and abdominal obesity.Case presentationWe report a case of 59 years old morbidly obese, Saudi lady, who had been following up at our outpatient diabetes clinic, since last many years. She had Type2 diabetes for 34 yrs, hypertension, adv...

IntroductionGastrointestinal adverse effects such as nausea and vomiting are widely described for GLP-1 receptor agonists (arGLP-1). We highlight Semaglutide, a drug that needs to start its administration at a reduced dose, to be able to increase the dose later with better tolerance and adherence of the patient. Not doing it this way can lead the patient to have serious adverse effects such as incoercible vomiting or profuse diarrhea that entails serious...

IntroductionTraditionally, there has been a stepwise introduction of glucose-lowering interventions, with the final ’step’ of insulin therapy being administered 10–15 years after diagnosis. Both patients and physicians are often reluctant to start insulin because of fears of painful injections, hypoglycemia, and weight gain. The aim of our study was to assess the effectiveness of initial basal insulin therapy on glycaemic control in type 2...

IntroductionModerate hypertriglyceridemia is exceedingly common in diabetes, and there is growing evidence that it contributes to residual cardiovascular risk in statin-optimized patients. Added to lipid lowering drugs and lifestyle intervention, an optimal glycemic control is necessary. The aim of our study was to compare triglyceride levels in diabetic patients before and after initiating insulin therapy.Methods<p class="abst...

IntroductionWeight gain represents a considerable challenge in type 2 diabetes mellitus patients with insulin therapy and a frequent cause of delay in initiation of treatment with insulin. The aim of our study was to describe the features of diabetic obese patient when switching to insulin therapy.MethodsIt was a retrospective study which enrolled 61 patients with type 2 diabetes divided in two groups: patien...

IntroductionDiabetic retinopathy is a serious complication of type 2 diabetes, which compromise the visual function and impair the quality of life of these patients. A rapid lowering of blood glucose especially when starting insulin therapy can worsen this retinopathy. We studied the variation of the initial daily insuline dose in the presence of diabetic retionopathy.MethodsOur study is prospective randomize...

Coronavirus disease 2019 (COVID 19) caused by severe acute respiratory syndrome corona virus 2 (SARS – CoV-2) which predominantly affects lungs and leads to COVID 19 pneumonia. India is second worst affected country in the world after U.S having more than 10 Million COVID 19 cases till date. Diabetes is frequently associated with severe COVID-19 infection and with a worse prognosis. This retrospective study aims to evaluate the impact of diabetes mellitus on baseline SpO2...

BackgroundIn type 2 diabetes, abnormalities of lipid metabolism and tissue distribution are common and associated with an increased risk of cardiovascular disease. The aim of this work was to study the relationship between the impedancemetric parameters and the lipid profile in a population of type 2 diabetics followed in the Endocrinology Department MED VI of Marrakech.MethodologyBody fat was assessed using ...

IntroductionIn clinical practice, differentiating between the types of diabetes is not always possible. In recent years, there has been an increase in the cases of Type 2 diabetes triggered by diabetic ketoacidosis in young-adult age individuals, and this condition is known as ketosis-prone diabetes (KPD). In this report, we present a case of autoantibody-positive KPD who had an adequate pancreatic reserve and an atypical phenotype due to having a normal...

IntroductionKetosis-Prone Diabetes (KPD) is a heterogeneous condition that shares clinical characteristics of type 1 and type 2 diabetes. It is usually a challenging diagnosis because patients are prone to develop diabetic ketoacidosis (DKA) without having the classic clinical phenotype of autoimmune type 1 diabetes.Case reportA Caucasian 26-years-old female with known history of renal transplant, morbid obes...

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IntroductionType 2 diabetes is a field of immunosuppression predisposes to infections in all its locations. The mode of revelation by degenerative or infectious complications is frequent. The aim of our work is to study the epidemiological, clinical and therapeutic aspects of infections that reveal type 2 diabetes.Material and methodsThis is a retrospective study, including 35 type 2 diabetic patients, hospit...

Dunnigan-type familial partial lipodystrophy (FPLD2) is a rare genetic disease associated with loss of subcutaneous adipose tissue and metabolic involvement such as diabetes, hyperlipidemia, and hepatosteatosis. We aimed to present a rare FPLD2 caused by an atypical Lamin A/C gene (LMNA) mutation. We report a case of an Algerian 31 year-old female with a lamin A specific pathogenic variant in exon 11, denoted LMNA (c.5454G b  A; p.R582H), present in the homozygous s...

Risk factors were assessed, including lipid spectrum studies, among young patients. The survey included 225 men and 327 women. All examined patients had no clinical signs of diseases of the cardiovascular system and type 2 diabetes mellitus. The median age was 33.35 (31.15; 35.52) years. Obesity was 1.6 times more common among young men than among women (χ2 = 4.67; P = 0.03). The relative risk of developing (RR) obesity in (men/women) was 1.79 (1.23 ÷ 2.60); P</e...

IntroductionInadequate low serum of 25(OH) vitamin D leads to skeletal effect (rickets, osteoporosis, osteomalacia) and furthermore exhibits nonskeletal effects – increase the risk of cardiovascular diseases, type 2 diabetes, mental illness and many others. Vitamin D deficiency is associated with a severe morbidity burden and low functional performance among elderly patients. A long length-of-stay (LOS) among elderly patients is related to revere mo...

Aimidentify the clinical presentation of retropharyngeal abscesses in adults and the therapeutic management modalities.Materials and methodsWe illustrate two cases of retropharyngeal abscess in two elderly subjects collected in the ENT department of the Farhat Hached hospital in Sousse.Observations1-/It is about a 70-year-old man, diabetic (DNID) who consulted us ...

IntroductionIn Morocco, the Moorish bath is an important social ritual. All categories of society frequent it very regularly. The traditionnel bath can lead in the diabetic, by the means of acute decompensations, serious falls and burns, with heavy functional, social and psychological consequences. Through this observation, we report the risks associated with the Moorish bath, and we underline the value of educating diabetic patients and making them awar...

IntroductionThe only currently available treatment of coeliac disease is a gluten-free diet (GFD). It improves outcomes, and reduces health-care costs. However, adhering to a gluten-free diet is difficult for many people. The aim of this study is to evaluate the diet adherence in real life and his impact on disease evolution.Patients and methodsThis is a descriptive transversal study carried out over a period...

Keywords diabetes, COVID-19, medical careCOVID-19 belongs to the global problem and health systems are faced with severe challenges. Diabetic patients are in the group of risk, especially among elderly people. The aging of the population leads to the comorbidity of diabetic patients with a high risk of death in the case of severe COVID-19 complications. Never doubt it could be fatal for diabetic patients more often than among non-diabetic. Patients with ...

IntroductionType 1 Diabetes (T1D) diagnosed during adulthood is a form of diabetes which is underdiagnosed and underreported. Lower incidence of cardio metabolic risk factors such as atherogenic dyslipidemia, high blood pressure and obesity have been reported in T1D patients compared to type 2 diabetes. In this study, we aimed to determine the prevalence of and predictive factors for macrovascular complications during T1D diagnosed in adulthood.<p cl...

Purpose of researchTo determine the level of insulin content, the content of nitric oxide metabolites, Malondialdehyde, the activity of lipoprotein-associated phospholipase A2 (FLA2), in the blood serum of patients with NFLD with type II D and impaired glucose tolerance.Material and methodsThe study included 74 patients with non-alcoholic fatty liver disease. 30 of them have diabetes of the second type, and 3...

IntroductionCandidate patients for colorectal cancer surgery may present malnutrition due to the tumor pathology itself. This must be corrected preoperatively in order to achieve good surgical results.Methods and objectivesObjectivesDetermine the nutritional status in our population and to know the type of nutritional support necessary.Methods<p class="abstext...

IntroductionUncontrolled patients with oral antidiabetics may require injectable treatment including insulin. We studied the variation of the initial daily insuline dose with the duration of diabetes.MethodsWe conducted a prospective randomized study. We recruited patients with type 2 diabetes hospitalized for a switching to insulin in the C department of diabetology and nutrition at the National Nutrition In...