Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

Eposter Presentations

Endocrine-Related Cancer

ea0073ep125 | Endocrine-Related Cancer | ECE2021

Relationship between phase angle and urinary tract infection in hospitalized cancer patients

Bianca Tabita Muresan Oltean , Ana Jiménez Portilla , Ruiz Berjaga Jessica , Artero Fullana Ana , Mario López Merseguer , Voltas Arribas Beatriz , Martín Núñez Abad , Juan Manuel Mascarós Martínez , Camps Herrero Carlos , Carlos Sánchez Juan

BackgroundBioelectrical impedance analysis (BIA) has been widely used in the evaluation of body composition. Phase angle (PhA) is obtained from the direct measurements of resistive (Rz) and reactive (Xc). Pha and can be interpreted as an indicator of fluid distribution, electric resistance and cellular membrane capacitance of the human body, and is associated with nutritional status. Its screening, and an early intervention in patients with a low PhA, ma...

ea0073ep126 | Endocrine-Related Cancer | ECE2021

Hyperprogression of Merkel cell carcinoma during immunotherapy

Ivana Bozic-Antic , Jovanovic Marko , Petkovic Ana , Micev Marjan , Popovic Bojana , Ognjanovic Sanja , Tatjana Isailovic , Ilic Dusan , Bogavac Tamara , Opalic Milica , Valentina Elezovic-Kovacevic , Macut Djuro

IntroductionMerkel cell carcinoma-MCC) is a rare, aggressive, neuroendocrine skin tumor with a poor prognosis. Chemotherapy (CT) and/or local/locoregional radiotherapy (LRRT) are first-line MCC therapies, but disseminated/locally advanced MCCs often become resistant to this treatment. The use of programmed cell death receptor1/programmed cell death ligand 1 (PD-1/PD-L1) monoclonal antibodies is a new type of therapy for MCC. While PD-1 monoclonal antibod...

ea0073ep127 | Endocrine-Related Cancer | ECE2021

Advanced metastatic disease in a low-grade pulmonary neuroendocrine tumor: a case report with partial response to targeted therapy

Cristiana Calin , Dusceac Roxana , Burcea Iulia-Florentina , Catalina Poiana

BackgroundIt has been well recognized that grade heterogenity exists within well-differentiated neuroendocrine tumors (WD-NETs). Targeted therapy plays an important role in metastatic disease control.Case presentationWe present the case of a 58-year-old male patient who was diagnosed with a pulmonary tumor on computer tomography (CT) and underwent a posterobasal left lobectomy. On immunohistochemical staining...

ea0073ep128 | Endocrine-Related Cancer | ECE2021

A neuroendocrine tumour presenting with double vision

Boharoon Hessa , Wernig Florian

Carcinoid tumours are low grade neoplasms usually arising from neuroendocrine cells of the bronchial and gastrointestinal tracts. Carcinoid tumours metastasise in 50–75% of patients, most commonly to lymph nodes, liver, and bones, but intra-orbital metastases have only rarely been reported. Here, we describe a patient who presented with an intra-orbital neuroendocrine tumour which was successfully treated with surgery and radiotherapy. A 70-year-old female patient present...

ea0073ep129 | Endocrine-Related Cancer | ECE2021

PRPF8 regulates FAK/AKT pathway and cytoskeleton remodeling through modulation of fibronectin 1 splicing in liver pathologies

Natalia Hermán-Sánchez , Juan L. López-Cánovas , Mercedes del Río-Moreno , Antonio C. Fuentes-Fayos , Marina E. Sánchez-Frias , Víctor Amado , Rubén Ciria , Javier Briceño , Manuel de la Mata , Justo P. Castaño , Manuel Rodríguez-Perálvarez , Raúl M. Luque , Manuel D. Gahete

Obesity is emerging as a prevalent cause of chronic liver damage, which can lead to the development of metabolic-associated fatty liver disease (MAFLD), nonalcoholic steatohepatitis (NASH), or even hepatocellular carcinoma (HCC). Increasing evidence suggests a profound dysregulation of the splicing machinery (spliceosome and splicing factors) in these pathologies; however, the role of PRPF8, a pivotal spliceosome element, has not been described in chronic liver pathologies. Th...

ea0073ep130 | Endocrine-Related Cancer | ECE2021

Bilateral pheochromocytoma in MEN 2A

Besrour Chayma , Rojbi Imen , Majdoub Marwa , Lakhoua Youssef , Mchirgui Nadia , Ben Nacef Ibtissem , Khiari Karima

IntroductionPheochromocytoma is rare neuroendocrine tumor arising from the chromaffin cells of the adrenal medulla. It can be even sporadic or take part of inherited syndromes.ObservationWe report the case of a young 32 year-old woman followed by her oncologist for medullary thyroid cancer treated with surgery and radiotherapy. On the examination of the removed tissue, there was a bilateral cancer, measuring ...

ea0073ep131 | Endocrine-Related Cancer | ECE2021

Endocrine monitoring after severe hypercalcemia due to primary hyperparathyroidism. In search of lost…MEN 2A?

Teodoriu Laura , Hogea Maximilian , Scripcariu Viorel , Ioan Bianca , Leustean Letitia , Ungureanu Christina , Stefanescu Cipriana , Preda Cristina

The association between primary hyperparathyroidism and pheochromocytoma is present in multiple endocrine neoplasia type 2A (MEN 2A) along with medullary carcinoma or it can be a simple simultaneousness. The presence of the genetic mutation is mandatory in order to have a positive diagnosis of MEN. We report the case of a female patient 63 years old admitted in our department for a large adrenal incidentaloma (10 cm) with no clinical signs of adrenal dysfunction. An adrenal bi...