Endocrine Abstracts

ObjectiveTo evaluate the frequency of common risk factors for depression development in patients with the diabetes mellitus of the type 2 (DM 2).Materials and methods163 patients with DM 2 at the age of 40–65 years old, period of DM is 11.18 [4.28; 22.33] years. The evaluation of the anxiety and depression level was carried out with the use of the Hospital anxiety and depression scale (HADS); a ...

IntroductionSevere hypertriglyceridemia (sHTG) (plasma triglycerides b 10 g/l) is a rare but pernicious and understudied condition.ObjectiveOur objective was to evaluate the etiology, characteristics, and complications of sHTG.MethodsIt’s a retrospective study including 10 patients with (sHTG) diagnosed between 1998 and 2020, at the department of endocri...

IntroductionAutoimmune polyglandular syndrome (APS) is a rare endocrinopathy, characterized by the coexistence of two or more glandular autoimmune diseases that can appear at different intervals of time.ObservationHerein the case of a young woman descendant of first degree consanguineous marriage, diagnosed since the age of six with celiac disease (CD) where gluten-free diet was not respected due to poor soci...

IntroductionMultiple endocrine neoplasia type 1 (MEN-1) is a hereditary condition with neoplastic lesions in multiple endocrine organs, which most frequently involves pituitary, parathyroid gland, and pancreas.Case reportA 53 y/o male visited endocrine clinic with the chief complaint of foreneck swelling for 1 month. He had history of renal stone for years. He had normal fT4 (1.13 ng/dl, reference 0.93–1...

IntroductionSolriamfetol is a dopamine and norepinephrine reuptake inhibitor, indicated to improve wakefulness in adult patients with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea (OSA). Decrease in the body weight as an adverse effect of < 2% incidence in both the narcolepsy and OSA patients has been reported. We hypothesise that the baseline Body Mass Index (BMI) may be a an independent predictive marker for the...

IntroductionCeliac disease is an autoimmune enteropathy secondary to gluten intolerance developing in genetically predisposed patients. The atypical presentation is the most common form of the disease. The aim of this work is to report the various extradigestive manifestations associated with celiac disease.Patients and methodsThis is a descriptive transversal study carried out over a period of 10 years. All ...

IntroductionAs hypoglycemia is a common symptom, an organic cause is always the first diagnosis looked for as it can be associated with a specific medical or surgical treatment. Diagnosis of functional etiology isn’t as precise, as the whipple triad can be incomplete. We herein report a serie of confirmed etiology for functional hypoglycemia.MethodsThis is a descriptive retrospective study including 20 c...

IntroductionPolycystic ovary syndrome (PCOS) is the most common female endocrine disorder with a prevalence of 8– 13% in women of reproductive age. Accumulating evidence suggests that vitamin D deficiency might have multiple impacts on the disease process ; and is involved in the pathogenesis of metabolic syndrom in PCOS. This notion is carried by the fact that the vitamin D receptor gene regulates about 3% of the human genome. The purpose of this s...

IntroductionThe occurrence of thromboembolic events in celiac disease has been reported in the literature, especially in adults. The objective of our study is to determine the prevalence and clinical characteristics of thrombosis in celiac disease and to clarify the role of thrombophilic factors.Patients and methodsThis is a retrospective series of four observations of thrombosis among a cohort of 41 patients...

IntroductionWerner syndrome (WS) is a rare genetic disorder that displays clinical features suggestive of accelerated aging. Also known as adult progeria, it is caused by mutations in the WRN gene, which encodes a RecQ DNA helicase. Primary characteristics of this syndrome are progeroid changes of hair, bilateral cataract, atrophic skin, soft-tissue calcification, bird-like face, abnormal voice and many others features. Here we report 5 patients...

Calcium signaling plays a regulatory role in the events of cellular proliferation. In immunocytes such as T cells, B cells, mast cells and many other cell types, Ca2+ signals show to control the proliferation, differentiation, and function. Furthermore, Ca2+ has been shown to act as a second messenger to regulate innate immune cell function and activation. Here, we found that loss of Nckx3, a potassium-dependent Na+ /Ca2+</...