Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

Eposter Presentations

Pituitary and Neuroendocrinology

ea0073ep143 | Pituitary and Neuroendocrinology | ECE2021

Pituitary stalk interruption syndrome: a clinical case report

Mirica Alexandra , Luiza Vitan , Monica Preda Diana , Loreta Paun Diana

IntroductionPituitary stalk interruption syndrome (PSIS) is a rare entity characterized by a triad of thin or interrupted pituitary stalk, aplasia or hypoplasia of the anterior pituitary and absent or ectopic posterior pituitary seen on magnetic resonance imaging (MRI). We are presenting the clinical case of a child who presented for short stature.Case presentationWe present the case of a 4 year and 8 months ...

ea0073ep144 | Pituitary and Neuroendocrinology | ECE2021

Co-existing microprolactinoma and meningioma – a rare case

Mahmood Ifrah , Singh Ankita , Omer Tahir

IntroductionMeningiomas and pituitary tumours are two most prevalent benign tumours of the CNS but neither are common and without a history of radiotherapy their concomitant existence is extremely rare. Meningiomas comprise 15–25% of all intracranial neoplasms while prevalence of benign pituitary adenomas is 10–23%. We report a rare case of co-existing Brain tumours.Case51 year old lady presented wi...

ea0073ep145 | Pituitary and Neuroendocrinology | ECE2021

A case of Cushing syndrome misdiagnosed as treatment with antiepileptic drug

Mehmet Sözen , BerrinÇetinarslan , Zeynep Cantürk , Selek Alev , Gezer Emre , Damla Köksalan

IntroductionThe most common causes of pseudo Cushing syndrome are alcoholism, chronic kidney disease, neuropsychiatric diseases, pregnancy, uncontrolled diabetes, and drugs. We present a patient who was operated on suspected Cushing syndrome based on abnormal results in overnight dexamethasone suppression tests.Case presentationA 49-year-old female patient was referred to our clinic for reoperation due to per...

ea0073ep146 | Pituitary and Neuroendocrinology | ECE2021

A case of primary amenorrhea revealing a macroprolactinoma

Khelifi Dayssem , Rojbi Imen , Ben Nacef Ibtissem , Lakhoua Youssef , Mchirgui Nadia , Khiari Karima

IntroductionPrimary amenorrhea should be considered in any patient who has not experienced periodic menstruation by 16 years regardless of the presence of normal growth and development of secondary sexual characteristics.Observation17-year-old patient, who exhibited normal secondary sexual characteristics, normal auxiliary and pubic hairs, normal breast development since the age of 12 with the non-appearance ...

ea0073ep147 | Pituitary and Neuroendocrinology | ECE2021

A challenging case of Cushing’s disease complicated with diverticular rupture and multiple thrombotic phenomena following trans-sphenoidal surgery

Wijewickrama Piyumi , P Somasundaram Noel , Sumanatilleke Manilka , Ambawatte Sathyajith

BackgroundCushing’s syndrome (CS) occurs due to cortisol overproduction. Endogenous hypercortisolemia can be secondary to Adrenocorticotropic hormone (ACTH) dependent as well as independent causes (1). Early identification and prompt definitive management is crucial to minimize mortality. Successful management of CS becomes extremely challenging due to multiple associated complications, especially the thrombotic events which are even more prominent ...

ea0073ep148 | Pituitary and Neuroendocrinology | ECE2021

Double localization of a cerebral germinoma, a case study

Khadidja Bessaid

IntroductionGerm cell tumour are embryonic tumour localized mainly at the gonads level, their cerebral localization is rare with less than 1% of intracranial neoplasia.ObservationWe have reported a 20 years old girl case without pathological history who had progressive diabetes insipidus for one year associated with spaniomenorrhea, the MRI revealed an aspect suggesting a pineal stem germinoma (12 mm of major...

ea0073ep149 | Pituitary and Neuroendocrinology | ECE2021

Apparently non secreting adenoma: a new challenge

Diana-Georgiana Lazar , Elena Oros Sabina , Dumitrascu Anda , Alexandrescu Daniela , Raluca Petria Andreea , Stoica Sergiu

IntroductionSilent corticotroph adenoma represent an uncommon subtype of nonfunctioning adenoma, immunoreactive for ACTH, without clinical or biochemical evidence of hypercortisolism and unclear pathogenesis. Usually, they present with local mass effect (visual deterioration being the most common) and endocrine dysfunctions. They carry a more aggressive behavior, particularly upon earlier recurrence.Case presentation<p class="a...

ea0073ep150 | Pituitary and Neuroendocrinology | ECE2021

A rare etiology of hypopituitarism in adulthood

Wiem Madhi , Kammoun Ines , Kaabar Malek , Gharbi Radhouane , Sonia Neji , Allah Chatti Hiba , Kandara Hajer , Jemel Manel

IntroductionRathke Cleft Cysts (RCC) are common benign cystic lesions in the sellar region. These cysts are often small, intrapituitary and asymptomatic. Voluminous forms are rare and can be symptomatic by compressing the adjacent structures. We report the case of pituitary insufficiency related to RCC.ObservationA male patient aged 49 years old, diagnosed with type 2 diabetes since 8 years treated with metfo...

ea0073ep151 | Pituitary and Neuroendocrinology | ECE2021

Fasting glucose and other metabolic features of 17 Brazilian women with microprolactinomas

Botelho Mariana , Sousa Rafaela , João Nascimento , Lamounier Filho Adilson , Naliato Erika , Violante Alice

IntroductionAmong other organic functions, Prolactin (PRL) can influence metabolism.AimTo evaluate basal glucose metabolism in women with prolactinoma, according to menstrual cycle, presence of hyperprolactinemia, and dopamine agonist (DA) treatment.Material and methodsCross-sectional study of 17 women with microprolactinoma and 11 healthy controls. Variables eval...

ea0073ep152 | Pituitary and Neuroendocrinology | ECE2021

Management of malignant insulina

Nerea Egaña Zunzunegui , Elias Ortega Cristina , Venegas Nebreda Inmaculada , Bilbao Garay Ismene , Aramburu Calafell Maite , Cristina García Delgado , Rojo Alvaro Jorge , Maite Perez de Ciriza Cordeu , Yoldi Arrieta Alfredo , Miguel Maria Goena Iglesias

IntroductionMalignant insulinoma is a rare pancreatic neuroendocrine tumor that accounts for only 10% of all cases of insulinoma. The clinical picture is characterized by the presence of severe hyperinsulinemic hypoglycaemic syndrome in a patient with pancreatic tumor with locoregional and/or distant metastases. Therapeutic management is challenging due to the need to control both hypoglycemic syndrome and tumor growth. Curative surgery is rarely applica...

ea0073ep154 | Pituitary and Neuroendocrinology | ECE2021

Hydrocephalus associating Hakim-Adams syndrome as unusual manifestation of pituitary adenoma

Begoña Pla Peris , Pablo Abellán Galiana , Blanco Jacobo , Mayet Roxana Padilla Segura , Margarita González Boillos , Maravall Javier , Susana Pérez Naranjo , AgustínÁngel Merchante Alfaro

IntroductionNon-functioning secretory pituitary adenomas are usually characterized by the lack of associated hormone overproduction. The absence of symptoms of excess hormone production results in a delayed diagnosis: sometimes as an incidental diagnosis, sometimes due to compressive symptoms with visual involvement or neurological symptoms as headache. Howewer, hydrocephalus associating Hakim-Adams Syndrome caused by foramen of Monro obstruction seconda...

ea0073ep155 | Pituitary and Neuroendocrinology | ECE2021

Coexistence of papillary thyroid carcinoma and primary hyperparathyroidism in a patient with acromegaly.

Kamoun Elyes , Oueslati Ibtissem , Chaker Fatma , Yazidi Meriem , Chihaoui Melika

IntroductionAcromegaly is an endocrine disorder resulting from an excess of growth hormone (GH). The cause is almost always a pituitary adenoma, and it affects through the insulin-like Growth Factor 1 (IGF-1) the cellular proliferation, increasing therefore the risk of malignancy. Herein, we describe a case of coexistence of papillary thyroid carcinoma and primary hyperparathyroidism in a patient with acromegaly.Case report<p c...

ea0073ep156 | Pituitary and Neuroendocrinology | ECE2021

Functional pituitary gonadotroph adenoma in male patients: a case study

Ram Nanik , Ali Khan Sajjad , Das Bhagwan , Islam Najmul

BackgroundPituitary gonadotroph adenomas are common but very rarely do they secrete biologically active luteinizing hormone (LH) and follicle-stimulating hormone (FSH). There have been case studies reporting high sex hormones (testosterone/estrogen) in the presence of high or normal LH and FSH.Case presentationHere we report two cases who presented with visual disturbance and headache at a tertiary care hospi...

ea0073ep157 | Pituitary and Neuroendocrinology | ECE2021

Psychological effects of cabergoline in a patient with a giant prolactinoma.

Hiba-Allah Chatti , Oueslati Ibtissem , Chaker Fatma , Yazidi Meriem , Chihaoui Melika

IntroductionPsychological disorders may be expected in patients with hyperprolactinemia. Indeed, they generally have poor quality of life, anxiety, depression and certain personality troubles. Dopamine agonists are the first-line treatment of prolactinoma. Recently, an increasing number of reports emphasized on dopamine agonists psychological side effects. Effectively, some patients develop de novo psychiatric symptoms or have exacerbation of pre-existin...

ea0073ep158 | Pituitary and Neuroendocrinology | ECE2021

Rapid decrease of a pituitary mass with gonadotrophic and thyrotrophic insufficiency – the case for lymphocytic hypophysitis?

Livia Gheorghiu Monica , Irina Andreea Bunea , Sofia Maria Lider Burciulescu , Anda Dumitrascu , Ramona Aldea

BackgroundLymphocytic hypophysitis is an unusual inflammation of the pituitary gland affecting mostly women. Its pathogenesis is still poorly understood and the presentation and clinical course vary largely. Serum prolactin levels may be low, normal, or elevated. Unlike what is observed in clinically nonfunctioning pituitary adenomas, there is not a clear hierarchy of anterior pituitary hormone deficiencies. Hypophysitismay resolve spontaneously, may rel...

ea0073ep159 | Pituitary and Neuroendocrinology | ECE2021

Diabetes insipidus

Kacem Faten Hadj , Asma Gorchene , Ben Salah Dhoha , Mohamed Elmoctar Sidina , Mnif Fatma , Charfi Nadia , Mnif Mouna , Rekik Majdoub Nabila , Elleuch Mouna , Mohamed Abid

BackgroundDiabetes Insipidus is a complex and heterogeneous clinical syndrome affecting water balance, resulting in large volumes of dilute urine. Determining the mechanism and etiology of diabetes insipidus, as well as differentiating it from other pathologies that cause polyuria and polydipsia has always been a challenge since water deprivation test is not always conclusive and antidiuretic hormone can not be reliably measured in the circulation.<p...

ea0073ep160 | Pituitary and Neuroendocrinology | ECE2021

A pituitary TSH and GH co-secreting adenoma presenting with thyrotoxicosis, but no symptoms of acromegaly: a case report

Nagy Rea , Anna Vágvölgyi , Szucs Nikolette , Scheich Balint , Nyari Gergely , Hortobagyi Tibor , Barzo Pal , Valkusz Zsuzsanna

TSH producing pituitary adenomas are a rare cause of thyrotoxicosis. These tumors account for only 1–2% of the pituitary adenomas. Co-secretion occurs in 30% of thyrotropinomas and requires careful investigation and subsequent follow up.A 43-year-old male presented with hand tremor and tachycardia. He was found to have elevated TSH, free T4 (FT4) and free T3 (FT3), but did not get treatment for years. In 2019 he developed atrial fibrillation. TSH wa...

ea0073ep161 | Pituitary and Neuroendocrinology | ECE2021

Predictive factors of macroprolactinoma aggressiveness: case report and review of literature

Asbar Hind , Rafi Sana , EL MGHARI Ghizlane , El Ansari Nawal

IntroductionProlactinomas are the most frequent pituitary tumors. They are usually benign with a good response to conventional medical treatment by dopaminergic agonists (DA). However in some cases, prolactinomas are defined as invasive or aggressive according to clinical, radiological, biological and histopatholgical arguments. The aim of our case report is to discuss potential predictors of aggressiveness in prolactine secreting pituitary tumors.<p...

ea0073ep162 | Pituitary and Neuroendocrinology | ECE2021

Pituitary macroadenoma and Covid-19 infection

Maghakyan Sona , Aghajanova Elena

IntroductionSARS-CoV-2 is a novel coronavirus rapidly spread throughout the world.. As it is already known, several endocrine organs do express ACE2, namely, pancreas, thyroid, testis, ovary, adrenal glands, and pituitary We report a patient diagnosed with pituitary incidentaloma and Covid-19. We would like to introduce our experience in treating patient with pituitary incidentaloma and covid-19.Materials and methods<p class="a...

ea0073ep163 | Pituitary and Neuroendocrinology | ECE2021

Analysis of clinical and biological features of non-functioning pituitary adenomas: A retrospective study

Kacem Faten Hadj , Boujelben Khouloud , Imene Ghariani , Salma Gdoura , Nadia Charfi , Mouna Mnif , Fatma Mnif , Nabila Rekik , Mohamed Abid

IntroductionNon-functioning pituitary adenomas (NFPA) present approximately 15% to 30% of all pituitary adenomas. They are most commonly misdiagnosed, until they are large enough to lead to mass effect and hypopituitrasm. The present study was carried out with the aim of studying the clinical and biological characteristics of patients who are followed for NFA.Patients and methodsThis is a retrospective study ...

ea0073ep164 | Pituitary and Neuroendocrinology | ECE2021

Is hypoprolactinemia also associated with sexual dysfunction?

Can Erdi Zuleyha , Ozkan Cigdem

Our knowledge about sexual dysfunction during the treatment of patients with prolactinoma is limited. The sexual dysfunction may not improve or turn out a different form as in our patient. Delayed ejeculation (DE) is a complex form of male sexual dysfuntion, characterized by a considerable delay in ejaculation or an inability to complete ejaculation. Both organic and psychogenic etiologies can cause DE, however the pathophysiology is indefinite. In this case, we present a male...

ea0073ep165 | Pituitary and Neuroendocrinology | ECE2021

Hypopituitarism in young patients: clinical aspects and diagnosis

Kacem Faten Hadj , Trimeche Oumeyma , Ben Salah Dhoha , Frikha Hamdi , Chaabouni Mahdi , Mnif Fatma , Rekik Majdoub Nabila , Mnif Mouna , Charfi Nadia , Elleuch Mouna , Mohamed Abid

IntroductionHypopituitarism is the partial or complete loss of anterior pituitary function that can result from acquired or congenital causes. Understanding its clinical aspects in children could lead to early diagnosis and therefore better outcome.ObjectiveThe aim of this study is to evaluate the characteristics of presentation, and etiology of Hypopituitarism in children.Methods<p...

ea0073ep166 | Pituitary and Neuroendocrinology | ECE2021

Acromegaly: clinical and para-clinical study by gender

Jemaa Marwa , Khessairi Nadia , Grira Wafa , Mouelhi Yasmine , Yazidi Meriem , Chihaoui Melika

Gender is a factor in clinical presentation, biological and morphological characteristics in certain types of pituitary adenomas. Concerning acromegaly, this influence is not well known. In our retrospective study of 32 patients, 12 women and 20 men, hospitalized in our department from 2002 to 2019, we have realized a comparative clinical, para-clinical, therapeutic and prognosis. The median age of women is 47 years, the same as that of men. The average duration of disease pro...

ea0073ep167 | Pituitary and Neuroendocrinology | ECE2021

Delayed diagnosis of acromegaly: a two-year journey

Asma Bitar De Zayas-Enriquez , Stojanovic Nemanja , Mlawa Gideon

AimsTo present the case of a 69 year-old female patient who was diagnosed with acromegaly two years following the initial onset of facial and acral symptoms, having already developed colonic hyperplastic polyps, one of the complications associated with acromegaly, one year prior to diagnosis.MaterialCase report and literature review.MethodAcromegaly was diagnosed ...

ea0073ep168 | Pituitary and Neuroendocrinology | ECE2021

Acromegaly and discoid lupus: a case report

Bichri Samira , Essabah Haraj Nassim , El Aziz Siham , Chadli Asmaa

IntroductionAcromegaly is an acquired endocrine pathology associated with the overproduction secondary to hypersecretion of growth hormone, by a somatotropic pituitary adenoma in more than 90% of cases, the symptoms of which may concern various organs (eye, heart, colon, etc.). skin….). Occasionally, it can present itself in association with skin changes which in some cases are very rare. We report the observation of a patient followed for acromega...

ea0073ep169 | Pituitary and Neuroendocrinology | ECE2021

Multiple endocrine neoplasia type 1: clinical features, diagnostics

Burak Andrew

BackgroundIn medical practice, there occurs an increasingly common pathology of various endocrine and not only these organs, which is known as multiple endocrine neoplasia – MEN syndrome, which, depending on the affected organs, is classified as MEN type 1, MEN type 2 and MEN type 3. Multiple endocrine neoplasia type 1 (MEN-1, Wermer syndrome) is a rare hereditary disease with an autosomal dominant type of inheritance characterised by high penetranc...

ea0073ep170 | Pituitary and Neuroendocrinology | ECE2021

Gonadotropic pituitary adenomas

Berrabeh Soumiya , Assarrar Imane , Elmehraoui Ouafae , Abdellaoui Wahiba , Rouf Siham , Latrech Hanane

IntroductionGonadotropin-secreting adenomas occupy nowadays the third or fourth place of all pituitary adenomas (12 to 17% of pituitary adenomas operated on), after prolactinomas, somatotropic adenomas and corticotropic adenomas. They can be either accompanied by hypersecretion of gonadotropins or their dosable subunits in plasma recognized only by immunocytochemistry. Gonadotropic adenomas are not uncommon. They are often misknown because they lack any ...

ea0073ep171 | Pituitary and Neuroendocrinology | ECE2021

Acromegaly in the elderly: about 3 cases

Rihab Ajili , Hasni Yosra , Asma Gorchene , Abdelkarim Asma Ben , Saad Ghada , Kacem Maha , Chadli Chaieb Molka , Maaroufi Amel , El Euch Koussay

IntroductionSomatotropic adenomas in the elderly are rare, and characterized by diagnostic delay and non-specific clinical signs. We report three cases of acromegaly discovered at a late age.ObservationThey are three women aged 66, 68 and 77 respectively. The circumstance of discovery of acromegaly was goiter in the first case (P1), poorly controlled diabetes in the second case (P2) and dysmorphic syndrome in...

ea0073ep172 | Pituitary and Neuroendocrinology | ECE2021

Recurrence of hypercortisolism after long-term post-transsphenoidal surgery remission in a patient with Cushing disease

Lorena Barbuceanu Anca , Cucu Constantin

Selective transsphenoidal resection of the pituitary adenoma is the initial treatment of choice for Cushing disease. Although the achievement of low cortisol levels following transsphenoidal surgery for Cushing disease is associated with surgical success, recurrence can still occur.Case presentationA 38 years old female patient, known with Cushing disease, secondary hypertension, type 2 diabetes and osteopenia, is admitted to our c...

ea0073ep173 | Pituitary and Neuroendocrinology | ECE2021

The psychogenic polydipsia: clinical and biological profiles

Kacem Faten Hadj , Boujelben Khouloud , Ben Salah Dhoha , Hamdi Frikha , Nadia Charfi , Fatma Mnif , Mouna Mnif , Nabila Rekik , Mouna Elleuch , Mohamed Abid

IntroductionPsychogenic polydipsia (PPD), also known as self-induced water intoxication, is mostly seen in psychiatric populations. PPD can lead to life threatening complications and may even be lethal if not diagnosed and treated early. The aim of this study is to determine the clinical and biological features of PPD.Patients and methodsA retrospective study including 11 patients consulting for polydipsia at...

ea0073ep174 | Pituitary and Neuroendocrinology | ECE2021

Acromegaly and cardiovascular risk factors

Madhi Wiem , Khessairi Nadia , Mouelhi Yasmine , Grira Wafa , Yazidi Meriem , Chihaoui Melika

IntroductionAcromegaly is a rare chronic disorder caused by GH hypersecretion. It’s associated with an elevated morbidity and mortality rate. Cardiovascular diseases’ complications are the first cause of mortality in patients. In this study we conducted an assessement of cardivascular risk factors in patients with acromegaly.Patients and methodsA retrospective evaluative study of 32 patients followe...