Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

Eposter Presentations

Calcium and Bone

ea0073ep22 | Calcium and Bone | ECE2021

Deficiency or insufficiency of vitamin D and the frequency of hypocalcemia episodes and the circadian rhythm of serum calcium level

Kovaleva Elena , Eremkina Anna , Aynetdinova Alina , Mokrysheva Natalia

IntroductionVitamin D deficiency is considered as a major public health concern. Due to vitamin D’s crucial role in the intestinal calcium absorption, its deficiency may result in hypocalcemia and in a spectrum of associated clinical manifestations.AimTo assess the effect of 25(OH) vitamin D level (25(OH)D) on the frequency of hypocalcemia episodes and the daily profile of serum calcium and 24-h urinary ...

ea0073ep23 | Calcium and Bone | ECE2021

Severe hypercalcemia due to vitamin D intoxication in patients with chronic hypoparathyroidism: Five cases report

Asma Kardi , Oueslati Ibtissem , Yazidi Meriem , Chaker Fatma , Chihaoui Melika

IntroductionCurrent standard treatment of primary hypoparathyroidism is based on calcium and activated vitamin D supplementation. Iatrogenic severe hypercalcemia due to vitamin D intoxication is an uncommon complication rarely described in literature. Herein we report 5 cases of severe hypercalcemia secondary to vitamin D intoxication.ObservationsThree men and two women with chronic hypoparathyroidism were in...

ea0073ep24 | Calcium and Bone | ECE2021

Primary Hyperparathyroidism with SVT and hypertensive crises; to proceed or not to proceed with surgery?

Ibrahim Hassan , Albor Christo , Hasnain Solat , Hussain Ayaz , Bashir Jawad

A pituitary hormonal profile and MRI pituitary was requested revealing eupituitary hormonal status with an incidental finding of 4 mm microadenoma. The case was discussed in local MDT and the outcome was to continue conservative management of PHPTH with cinacalcet until pheochromocytoma has been ruled out completely. Both MEN-1 and MEN-2 are associated with PHPTH. If a patient is having episodic adrenergic crises with inconclusive metanephrines analysis then excluding pheochro...

ea0073ep25 | Calcium and Bone | ECE2021

Fahr’s syndrome secondary to hypoparathyroidism revealed by generalized pustulosis (about 2 cases)

Elkhomri Amal , Essabah Haraj Nassim , El Aziz Siham , Hali Fouzia , Chiheb Soumiya , Chadli Asmaa

IntroductionAmicrobial skin pustulosis is one of the exceptional manifestations of hypoparathyroidism. We report 2 observations of a Fahr syndrome secondary to hypoparathyroidism revealed by generalized pustulosis.Observations 124 year old woman, with no history of thyroid surgery, The patient was admitted for generalized covering more than 90% of the body surface. Biology objected to hypocalcemia at 57 mg/l,...

ea0073ep26 | Calcium and Bone | ECE2021

Challenges in diagnosis and treatment of Parathyroid Carcinoma – case report

Reis Guiomar Joana , Moreno Carolina , Melo Miguel , Lúcia Fadiga , Diana Alexandra Festas Silva , Paiva Isabel

IntroductionParathyroid carcinoma (CaPa) is an extremely rare cause of primary hyperparathyroidism. Patients with CaPa usually present severe hypercalcemia with abrupt bone and renal diseases, neurologic manifestations and gastrointestinal symptoms. However, sometimes the presentation is insidious with nonspecific symptoms and mild hypercalcemia. Surgery is the only curative treatment and after surgery close monitoring of calcium levels are necessary due...

ea0073ep27 | Calcium and Bone | ECE2021

Surgical difficulties during parathyroid surgery

Masmoudi Mohamed , Wadii Thabet , Lahmar Rihab , Hasnaoui Mehdi , Khalifa Mighri

IntroductionParathyroid surgery is indicated essentially in primary and secondary hyperparathyroidism. This surgery may present some difficulties even in experienced hands. Our aim is to describe the difficulties that can occur during parathyroid surgery.Material and methodsA retrospective study including 81 cases of hyperparathyroidism, operated between 2001 and 2018.Results<p clas...

ea0073ep28 | Calcium and Bone | ECE2021

Giant maxillary tumor as initial presentation of primary hyperparathyroidism: a case report

Alves Priscilla , Lima Carlos , Leal Angela

CaseMale, 44 y.o., with rigth maxillary tumor of progressive growth for 1 year with local and low back pain. Imaging exams: CT/MRI skull and face: right axial expansive lesion (62×52×46 mm), heterogeneous, multiloculated with bulging of the right orbit inferomedial wall, with a neoplastic aspect. CT pelvis: bone lesions with soft tissue densities in pelvis, heterogeneous L4, with height reduction. Biopsy of the lesion suggesting a brown tumor. ...

ea0073ep29 | Calcium and Bone | ECE2021

Atypical parathyroid adenoma : a case report

Besrour Chayma , Rojbi Imen , Majdoub Marwa , Lakhoua Youssef , Mchirgui Nadia , Ben Nacef Ibtissem , Khiari Karima

IntroductionThe atypical parathyroid adenoma is a histological diagnosis. It is a parathyroid tumor with atypical histological features different from an adenoma and not similar enough to be considered as a carcinoma.It has an uncertain malignant potential.ObservationWe report the case of a 55 year-old woman, referred to us by her rhumatologist after discovering a severe hypercalcemia when exploring her for o...

ea0073ep30 | Calcium and Bone | ECE2021

Sporadic multiple parathyroid gland disease in young woman with primary hyperparathyroidism

Bibik Ekaterina , Eremkina Anna , Mokrysheva Natalya

BackgroundMost cases of primary hyperparathyroidism (PHPT) is caused by a single benign adenoma, multiple parathyroid neoplasms (MPN) occur less often in 10–15%, parathyroid carcinoma accounts for <3%. MPN can be sporadic or develop due to inherited genetic syndromes (most commonly multiple endocrine neoplasia syndrome type 1 (MEN-1) that usually manifest at a young age. The preoperative examination of patients with MPN is important for achievin...

ea0073ep31 | Calcium and Bone | ECE2021

Recurrent and persistent primary hyperparathyroidism due to secondary parathyromatosis

Everardo Josué Díaz-López , Alejandro Ramírez-Izcoa , José Vinicio Velecela Abambari , Adalberto Infante-Amorós

IntroductionParathyromatosis is a potential cause of recurrent hyperparathyroidism, of rare etiology, described as multiple nodules of hyperfunctioning benign parathyroid tissue, it constitutes less than 1% of the cases of recurrent hyperparathyroidism and since its description in 1975, less than 40 cases have been reported Worldwide. The presentation in primary hyperparathyroidism is extremely rare, with around 20 cases reported in the English literatur...

ea0073ep32 | Calcium and Bone | ECE2021

Secondary hyperparathyroidism associated with exostosis in a 10-year-old girl: a case report

Maria Andrei Anca , Mitru Natalia , Vasilescu Sorana , Preda Diana , Mirica Alexandra

BackgroundSecondary hyperparathyroidism is a condition that can occur as a result of low vitamin D level. Parathyroid hormone (PTH) has the role of stimulating bone resorption by two mechanisms: direct activation of osteoblasts and indirect stimulation of osteoclast. Exostosis or bone spur is a benign tumor that consists in overgrowth of a pre-existing bone. Exostoses can affect any bone, however they are most commonly located on the bones of the joints ...

ea0073ep33 | Calcium and Bone | ECE2021

Hyperparathyroidism complicating a pre-existing diagnosis of Familial Hypocalciuric Hypercalcemia (FHH)

Alkundi Alamin , Momoh Rabiu

Familial hypocalciuric hypercalcemia is a rare clinical condition of persistently elevated serum calcium and reduced urinary calcium levels with an autosomal dominance inheritance pattern to the three out of four large types of this condition known. This rare condition goes largely undiagnosed as patients are largely asymptomatic and where symptoms are present, other causes of hypercalcaemia are considered first. Hyperparathyroidism, super-imposing on FHH, is an even rarer occ...

ea0073ep34 | Calcium and Bone | ECE2021

Severe hyperinsulinemia and osteoporosis in a lean patient with Jacobsen syndrome

Boutzios Georgios , Chatzi Sofia , Karampela Athina , Miliou Myrto , Koutsogeorgopoulou Loukia , Koukoulioti Eleni , Psifis Markos , Drakou Androniki

IntroductionJacobsen syndrome (JS) is a rare gene disorder caused by a terminal deletion of the long arm of chromosome 11. The estimated prevalence of Jacobsen syndrome is 1/100.000 births. It is most commonly presented with psychomotor and physical growth retardation, dysmorphic facial features, thrombocytopenia or pancytopenia. It is also characterized by congenital heart defects, and kidney, gastrointestinal tract, genitalia, CNS and skeletal deformit...

ea0073ep35 | Calcium and Bone | ECE2021

Coexistence of multiple cystic parathyroid adenomas and thyroid carcinoma

Boudina Maria , Syndouka Eleni , Fotiadou Aimilia , Stamati Mariana , Zouli Chrysanthi , Argyropoulou Elpiniki , Theodosios S. Papavramidis , Chrisoulidou Alexandra

BackgroundCystic parathyroid adenoma is a rare entity (<0.01% of all cervical masses) that leads to primary hyperparathyroidism in 9% of cases. Parathyroid scintigraphy is essential for the diagnosis although there are pitfalls with false negative results. Parathyroidectomy is the treatment of choice but its success depends on the exact preoperative localization of the parathyroid lesions. 4D-CT is a very helpful diagnostic tool in such cases.<p ...

ea0073ep36 | Calcium and Bone | ECE2021

Cerebral calcifications revealing familial pseudohypoparathyroidism

Khelifi Dayssem , Debbabi Wided , Kharrat Issam , Samet Slim

IntroductionPseudohypoparathyroidism (PHP) is the first example of hormonal resistance observed in human pathology characterized by a great variability of clinical and genetic expression. We present a case of PHP in a Tunisian family.ObservationThe index case is a 31-year-old man. He was burn out of a consanguineous marriage (distant consanguinity) followed since the age of 15 for convulsive seizures. Three m...

ea0073ep37 | Calcium and Bone | ECE2021

Bisphosphonate-related osteonecrosis of the jaws in persistent primary hyperparathyroidism

Ben Elhaj Wiem , Ben Nacef Ibtissem , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Khiari Karima

BackgroundPrimary hyperparathyroidism (PHPT) results from inappropriate overproduction of parathyroid hormone from one or more of parathyroid glands with consequent hypercalcemia. Medical therapy by bisphosphonates is indicated for patients contraindicated for surgical treatment or those with therapy failure. We report the observation of a patient receiving zoledronic acid for persistent PHPT and who developped bisphosphonate-related osteonecrosis of the...

ea0073ep38 | Calcium and Bone | ECE2021

Vitamin D deficiency and primary hyperparathyroidism

Bouzid Aicha , Malha Azzouz , Meskine Djamila

IntroductionThe association between vitamin D deficiency and primary hyperparathyroidism( PHP) has clear implications. Co-existing vitamin D deficiency may cause the serum calcium level to fall into the normal range, which can lead to diagnostic uncertainty. The objective of this study is to assess the vitamin D status of patients followed for primary hyperparathyroidism.Materials and methodsThis is a retrosp...

ea0073ep39 | Calcium and Bone | ECE2021

Osteoporosis, as a manifestation of multiple myeloma disease in women post menopause

Volkova Natalya , Davidenko Ilya , Dzherieva Irina , Ganenko Lilia , Zibarev Alexander , Sorokina Yulya , Reshetnikov Igor , Degtyareva Yuliya , Merenkova Maria

Osteoporosis is a systemic skeletal disease characterized by a decrease in bone strength and an increased risk of fractures. In the structure of osteoporosis, secondary osteoporosis is 5% in women and 20% in men. Clinicians need to exclude the secondary nature of osteoporosis, since under the ’mask’ of mineral metabolism disorders, more rare and dangerous diseases can arise. A 65-years-old women presents with complaints of three low-traumatic fractures in the last ye...

ea0073ep40 | Calcium and Bone | ECE2021

Shoulder pain, polyuria and lytic lesions: novel presentation of primary hyperparathyroidism or multiple myeloma?

Mulla Kaenat , Giri Ravindran Suganya , Tauni Rahat , Ostberg Julia

Traditionally, patients diagnosed with primary hyperparathyroidism present with mild hypercalcaemia and tend to be asymptomatic. Symptomatic patients tend to have severely high calcium and exhibit the classic ’bones, stones, abdominal moans and psychic groans.’ We present a case of a 92-year-old Caucasian gentleman presenting with recurrent falls, postural hypotension and trauma to head and shoulder. X-ray imaging showed small non-specific lucencies in the cervical a...

ea0073ep41 | Calcium and Bone | ECE2021

Calcium metabolism in Latvian patients with granulomatosis with polyangiitis (GPA) at the time of diagnosis – 2013-2018 data

Ruza Ieva , Plegermane Aiga

Key wordsGPA, granulomatosis, serum, 24 h urine, calcium.IntroductionGranulomatosis with polyangiitis (GPA) is a very rare systemic disease of unknown etiology that is defined by the formation of granulomas in different organ systems. Due to this pathology, there may be an increase in serum and 24 h urine calcium that can have a clinical impact on the course of the disease.Aim<p cla...

ea0073ep42 | Calcium and Bone | ECE2021

Impact Of Vitamin D Supplementation On Phospho-Calcium Metabolism

Ivo Catarina , David Veríssimo , Vitória Duarte , João Silva , Luís Lopes , Passos Dolores , João Jácome de Castro , Marcelino Mafalda

IntroductionIt has been estimated that prevalence of vitamin D deficit (25(OH)D) in the world is between 20 and 100%, depending on age group, ethnicity and region. In European population, the prevalence is around 40%. The Endocrine society guidelines recommend the supplementation of vitamin D when vitamin D deficiency is confirmed. The objective of this work is to evaluate the effect of 25(OH)D supplementation on phospho-calcium metabolites: calcium (Ca)...