Endocrine Abstracts

Inflammation is a component of obesity-associated insulin resistance. Significant increases in inflammatory mediators such as IL6, TNFa and IL1b have been detected in the serum of diabetic patients. Herein, we investigated whether pre-diabetic patients also exhibited perturbations in circulating pro-inflammatory cytokines. To this end, we recruited 42 healthy non diabetics and subjected them to 75 g OGTT after an overnight fast. We profiled the cytokines that are present in th...

Introduction: Thyroid cancers are the most common endocrine cancer among children, accounting for 0.5–3% of all childhood malignancies. Thyroid carcinogenesis is well established in Multiple Endocrine Neoplasia syndromes type 2, and may present with medullary thyroid cancer at young age. However, with the advancement of genetics, several other syndromes need to be considered which may lead to non-medullary thyroid cancers including DICER1 tumour predispos...