Endocrine Abstracts

Introduction: Disease control in acromegaly can be achieved by surgery, medical treatment, and radiotherapy either alone or in combination. The acromegaly patients whom tumour shrinkage cannot be provided or growth hormone levels do not decrease under multiple treatment modalities are designated as resistant acromegaly. We aimed in our study to evaluate the clinical features of resistant acromegaly patients and determine their responds to different treatment modalities.<p ...

Objectives: Coexisting thyroid nodules affect the treatment choice for PHPT. We aimed to evaluate the incidence of concomitant thyroid nodules in patients with primary hyperparathyroidism and to investigate the relationship between thyroid nodule volume, thyroid gland volume and thyroid nodules with clinical and laboratory parameters.Materials and methods: This study was carried out at Ankara University Endocrinology and Metabolism Department. 183 patien...

Objectives: We aimed to find if there is any relationship between vitamin D levels and clinical, laboratory parameters and osteoporosis, in primary hyperparathyroidism (PHPT).Material and methods: 128 patients with PHPT and 30 patients as a control group were analysed. Patients with PHPT were grouped due to vitamin D levels and levels low than 20 μg/ml accepted as deficiency.Results: Patients with 25-OH vitamin D <20 &#956...

Background: Transsphenoidal adenomectomy is the first choice of therapy, but about 50% of patients are not cured and require medical treatment and/or radiotherapy. We retrospectively analyzed the data on surgery, sandostatin analog therapy, radiotherapy and the combination of them.Materials-methods: The records of the 96 female and 70 male, totally 166 acromegalic patients who had been followed in Ankara University, Endocrinology and Metabolic Diseases D...

Expression of hormones other than GH may affect the prognosis in acromegalic patients. Generally, Ki-67 is a well-known proliferative index used to predict remission in pituitary adenomas. We aimed to evaluate the relationship of immunohistochemical expression pituitary hormones, ki-67 and remission. Also we evaluated the role of pre, post-operative clinical and laboratory values, pathological characteristics on long-term remission. We included 64 acromegaly patients that were...

Hirsutism, development of terminal body hair in women in unexpected areas, may result from different etiologies; 4.3% being nonclassical congenital adrenal hyperplasia (NCCAH) and acromegaly being one of the rarests. We here present a severe hirsutism case with acromegaly and NCCAH.Case: A 30-year-old woman with headache and visual field abnormalities was consultated by our clinic about her cranial imaging revealing a macroadenoma in pituitary localizati...

Introduction: Subacute thyroiditis is an iflammatory disease of the thyroid gland characterized by pain, tenderness and swelling in the neck. Less frequently, it may present with painless or silent thyroiditis that occurs spontaneously or in the postpartum period. In a few studies in the literature, urinary iodine was reported to be high in patients with postpartum thyroiditis, but it was not evaluated in patients with subacute thyroiditis. We aimed to evaluate urinary iodine ...

Anaemia prevalence is reported between 5 and 31.8% in patients with PHPT. Anaemia in PHPT shows correlations with serum calcium, PTH, alkaline phosphatase levels, severity of the bone disease and PHPT duration. In this study we compared pre-operative and post-operative haemogram parameters of patients with PHPT who received a parathyroidectomy at our department. We determined the prevelance of pre-operative anaemia, thrombocytopenia, neutropenia and observed if any of this par...

Introduction: Neutrophil/lymphocyte ratio (NLR) is an indicative of the acute phase response. It is a significant indicator of the systemic inflammation, and considered as a poor prognosis indicator in various disease. We aimed to evaluate NLR and its determinants in acromegaly patients.Patients and methods: A retrospective chart review of 40 patients with acromegaly and 45 age and sex matched healthy individuals was performed. Patients with active infec...

Introduction: Pituitary involvement has been rarely reported during the course of hematological diseases like thalessemia, Langerhans-cell histiocytosis and lymphoma. We here present a case of chronic myeloid leukemia (CML) with pituitary involvement, in which central diabetes insipidus (DI) was the first sign of progression to accelerated phase.Case report: A 61-year-old man was consultated by our clinic due to polyuria with 6000 ml daily urine output. ...