Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2017) 49 EP967 | DOI: 10.1530/endoabs.49.EP967

Ankara University School of Medicine endocrinology and Metabolic Diseases Department, Ankara, Turkey.

Expression of hormones other than GH may affect the prognosis in acromegalic patients. Generally, Ki-67 is a well-known proliferative index used to predict remission in pituitary adenomas. We aimed to evaluate the relationship of immunohistochemical expression pituitary hormones, ki-67 and remission. Also we evaluated the role of pre, post-operative clinical and laboratory values, pathological characteristics on long-term remission. We included 64 acromegaly patients that were treated surgically and followed up in our Endocrinology and Metabolic Diseases Department. Demographic, clinical, laboratory and imaging data were collected. We also re-evaluated the immunohistochemistry of all pituitary hormones and ki-67 marker from paraffin blocks. We followed 64 patients (38 women, 26 Male; mean age 46.7±11.8) for 61.8 (6–192) months. We did not found any relationship between remission and multihormonal expression in our patients. We also did not found a significant relationship between ki-67 expression or sex with remission. Early diagnosis age (P=0.045), greater adenoma diameter (P=0.002), low preoperative LH (P=0.036) and high postoperative IGF1 (P<0.0001) only factors that are significantly related with low rate remission. Preoperative cortisol levels are related to ki-67 index level (P=0.004). Low preoperative LH and high postoperative IGF1 levels and tumor diameter may be predictive for remission and low cortisol levels may be predictive for the high ki-67 index.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.