Endocrine Abstracts

Background: Adipocyte cells could produce numerous extracellular vesicles and orchestrate the balance of endocrinological system. Polycystic ovary syndrome (PCOS) is a refractory reproductive disease and also a kind of endocrine and metabolic disease. The aim of the study was to explore the effects of adipocyte-derived extracellular vesicles-miR-26b on cumulus cells (CCs) and development of PCOS.Methods: The crosstalk mediated by extracellular vesicle-mi...

Background: Prior small studies have suggested increased risk of infections in patients with hypoparathyroidism (HypoPT). This study using a large managed care cohort evaluated whether chronic HypoPT is associated with increased risk of sepsis, respiratory infections, and kidney or other genitourinary (GU) infections.Methods: A retrospective cohort study using a US commercial claims database (Q1 2007–Q2 2017) was conducted to examine the association...

Background: Diabetes prevalence and mortality are increasing rapidly and glycemic goals (hemoglobin A1c < 7%) are often not achieved in patients with type 2 diabetes in China, The low control rate of diabetes has become a global problem. The management of community diabetes is the most effective choice to prevent and control chronic diseases.Objective: To improve the management of diabetes mellitus in community, we analyze the effect of hospital-comm...

Instruction: Previous studies have been shown that obese individuals have reduced natriuretic peptide levels. But conflicting data exist on the relation of natriuretic peptide levels to other metabolic risk factors. We investigated the relationship between plasma N-terminal pro-B-type natriuretic peptide levels (NT-proBNP) and metabolic syndrome (MetS), metabolic risk factors in 469 patients free of heartfailure.Material and methods: Two hundred and thir...

Background: Obesity, as a worldwide healthcare problem, has been attracting more and more attention. Chronic low-grade inflammation is regarded as an inducer of adipocyte cell death. Pyroptosis,a kind of inflammatory cell death,is involved in various inflammatory diseases.Gasdermin E(GSDME) is a mediator of pyroptosis via the cleavage of caspase-3. However, whether GSDME is involved in the regulation of adipose tissue function remains unknown. In the present study, we aim to i...

Introduction: Early diagnosis is therefore important for patients with asymptomatic diabetes mellitus. The aim of this study is to validate the use of Urine Dipstick in the screening of glycosuria (Gu).Material and methods: Our study involved 30 fresh urine specimens. Urinalysis was performed by dipstick (SPINREAT®). Gu was measured by the hexokinase method (DxC800® Beckman Coulter). The gold standard to diagnose Gu was co...

Placental corticotrophin releasing hormone (CRH) appears to play important physiological roles during pregnancy and labour. In the placenta, CRH appears to regulate diverse actions such as human trophoblast cell grown and invasion, tissue remodeling, direct modulation of the placental prostaglandin generation and bioavailability and control of placental vascular tone through regulation of endothelial NOS (NOSIII) expression and activation1. CRH actions are mediated ...

Objective: Autologous hematopoietic stem cell transplantation (AHSCT) is a promising treatment to reverse type 1 diabetes (T1D) in patients with significantly improved β-cell function. This study was designed to investigate the potential immunological mechanisms involved.Design and methods: 18 newly-diagnosed T1D were divided into two groups, the AHSCT group and the insulin therapy group. Blood mononuclear cells (PBMCs) of the patients at the baseli...

Background: Previous studies have yielded conflicting results on biochemical control with medical therapy in patients with or without prior pituitary surgery. The LANTERN study (NCT02493517) demonstrated that lanreotide autogel (LAN ATG) was non-inferior to lanreotide prolonged release (LAN PR) in Chinese patients with active acromegaly. This post hoc analysis of the LANTERN study aimed to explore the efficacy of LAN ATG in patients with or without prior pituitary surgery....

Background: The LANTERN study (NCT02493517) has demonstrated that lanreotide autogel (LAN ATG) was non-inferior to lanreotide prolonged release (LAN PR) in Chinese patients with active acromegaly. This post hoc analysis of the LANTERN study assessed the impact of tumor size on treatment effect.Design: In the LANTERN study, LAN ATG was started at 90 mg and subsequently titrated according to GH and IGF-1 levels for 32 weeks. Tumor diameters > 10 mm wer...