Endocrine Abstracts

Background: Prolactinoma is the most common functioning pituitary adenoma. Subclinical atherosclerosis and cardiovascular risk in patients with prolactinoma were reported but have not been clarified yet.Aim: Our study aims to compare prolactinoma patients with a control group in terms of lipid profile, body fat distribution, and subclinical atherosclerosis markers.Methods: This single-center, prospective study included 32 patients ...

Chromosome 17q12 deletion is rare. It results from the deletion of a piece of chromosome 17 in each cell. The most recognised phenotype of this mutation is a combination of kidney cysts and Maturity Onset Diabetes of the Young (MODY), which is also known as Renal Cysts and Diabetes syndrome (RCAD). RCAD is caused by a mutation in the gene encoding hepatocyte-nuclear-factor-1-beta (HNF1B) which is part of chromosome 17q12.Introduction: In 1997 while study...

Introduction and objective: Platelets play an important role in the development of thrombotic events. Increase of mean platelet volume (MPV) may indicate pre-thrombotic conditions as a new cardiovascular marker. Larger platelets have been reported to be metabolically more active than smaller ones. Our aim of present study is to evaluate MPV levels in patients with papillary thyroid cancer.Materials and methods: Forty-seven patients with newly diagnosis m...

Introduction: Abnormal uterine bleeding (AUB) refers to uterine bleeding that is excessive or occurs outside of normal cyclic menstruation. The most common cause of AUB in adolescents is anovulatory cycles due to immature hypothalamic-pituitary-ovarian axis. Additionally, endocrinological problems (hypothyroidism, hyperprolacitenemia, etc.) and bleeding disorders may cause AUB. The management of AUB begins with an assessment of whether or not the patient is hemodynamically sta...

Background: Vessel hemostasis during thyroidectomy is the mainstay of reducing the risk of post-operative hypocalcaemia, which can be achieved by using several techniques. The aim of this study was to compare the occurrence of hypocalcaemia 24–48 hours following total thyroidectomy by using FOCUS harmonic scalpel (HS) vs the conventional suture ligation (CSL).Patients and methods: A prospective, single-blind, randomized trial in which 76 patients wi...

Background: Differential thyroid cancer (DTC) is classified into papillary, follicular and papillary micro thyroid cancer. Also, mean platelet volume (MPV) is an independent risk factor for cardiovascular disease. The aim of the present study was to investigate MPV values in DTC patients.Materials and methods: The levels of MPV were assessed in 183 patients with DTC 44 papillary thyroid cancer (mean age 43.±13.9) 34 papillary micro thyroid cancer (m...

Introduction: Accumulating evidence indicate that high PTH resulting from primary or secondary hyperparathyroidism, is associated with hypertension, insulin resistance, dyslipidaemia, obesity, and cardiovascular mortality. Here, we aimed to show whether high PTH levels in obese population contribute the metabolic complications of obesity.Methods/design: The medical records of all subjects attending the obesity outpatient clinic of Kartal Dr Lutfi Kirdar ...

Introduction: Dexamethasone Suppression Test (DST) is a useful approach in diagnosis and differential diagnosis of Cushing Syndrome (CS) despite its limitations. One of the major limitations is the difficulty to provide standard suppression dose depending on the variability of gastrointestinal absorption. One solution is for this testing serum Dexamethasone levels or test it with intravenous (iv) Dexamethasone In this case, we examined 3 patients to whom we applied intravenous...

Although the existence of the interaction between sex steroids and immune system is well known, the mechanisms of this interaction are still unclear. Recently a second form of GnRH (GnRH-II) has been described in human, which is significantly expressed in immune tissues suggesting a potential function. In a recent in-vitro study it has been demonstrated that GnRH-II decreases local expression of IL-2R in peripheral lymphocytes (1). However in-vivo interactions of...

Introduction: In obesity, MPV is found higher compared to healthy controls. It was found that the level of NLR was predictive of the development of type 2 diabetes with high sensitivity and specificity in morbid obese patients. PLR is a new biological indicator that can assess the presence and severity of inflammation. However, in obese patients PLR was not found to associate with degree of of obesity or ratio of weight loss. Regarding the platelet count (PC) in obesity, confl...