Introduction and objective: Platelets play an important role in the development of thrombotic events. Increase of mean platelet volume (MPV) may indicate pre-thrombotic conditions as a new cardiovascular marker. Larger platelets have been reported to be metabolically more active than smaller ones. Our aim of present study is to evaluate MPV levels in patients with papillary thyroid cancer.
Materials and methods: Forty-seven patients with newly diagnosis more advanced papillary cancer, 47 micropapillary cancer who referred our Endocrinology Department and 62 age- and BMI-matched healthy subjects were included in the study. All the study subjects were evaluated by biochemical and platelet parameters. All complete blood count (CBC) analysis was performed with the automatic hematology analyzer Beckman Coulter LH 750 (Beckman Coulter, USA) in euthyroid state and preoperative period. All hormonal analyses were done by chemiluminesance assay. All statistical analysis was performed retrospectively.
Results: Mean age were 43.53±10.94 years in micropapillary cancer; 43.26±13.24 years in more advanced papillary cancer; 37.64±15.07 years in control subjects. Mean BMI were 27.84±5.3 kg/m2 in micropapillary cancer; 28.32±4.32 kg/m2 in more advanced papillary cancer; and 25.16±6.32 kg/m2 in control subjects. Tumor diameters at the time of diagnosis were 0.4±0.27 cm in micropapillary cancer and 2.54±1.27 cm in more advanced papillary cancer. Serum MPV levels in both of papillary cancer groups were significantly different from control subjects (8.75±1.13 fl in micropapillary cancer; 8.75±1.13 fl in more advanced papillary cancer; 7.88±0.8 fl in control (P=0.000, P=0.000, and P=0.000 respectively). To assess the correlation with MPV, a Pearsons correlation analysis was performed on each variable. MPV had a positive correlation between serum thyroglobuline levels (r=0.24, P=0.04), tumor diameters (r=0.265, P=0.03) and age (r=0.213, P=0.015). The multiple regression analysis of MPV and other risk factors was performed. Age, gender, and BMI were independent predictive factors of MPV.
Conclusions: The high MPV levels in papillary thyroid cancer may increase cardiovascular risk or thrombotic events. There is a need for further prospective study which was clarifiedrelationship between papillary thyroid cancer and prognostic value of high MPV levels.