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16th European Congress of Endocrinology

Poster Presentations

Thyroid Cancer

ea0035p1083 | Thyroid Cancer | ECE2014

Langerhans cell histiocytosis and papillary thyroid carcinoma

Biagetti Betina , Diego Estrella , Dalama Belen , Iglesias Carmela , Gonzalez Oscar , Mesa Jordi

Introduction: Thyroid gland involvement by Langerhans Cell Histiocytosis (LCH) is a very rare condition. It occurs by thyroid infiltration that may result in hypothyroidism. LCH may be also related to neoplastic processes such as leukemias or lymphomas. However, the association with papillary thyroid carcinoma (PTC) is exceptional. We introduce a case and review the reported cases of this association.Case report: We describe a 33 year old patient diagnos...

ea0035p1084 | Thyroid Cancer | ECE2014

Thyroid carcinoma in cases with end stage renal disease

Stoian Dana , Pantea Stelian , Schiller Oana , Craciunescu Mihaela , Schiller Adalbert

Premilinary: The incidence of thyroid disease in cases operated for hyperparathyroidism is 2.5–17.6%. The coexistence of thyroid and parathyroid nodules makes FNAB difficult in technique but also in cytology diagnosis. Scintigraphy, unless performed with Tc SESTA MIBI, might give unclear informations.Material: From series of 36 operaed cases with renal secondary and tertiary hyperparathiroidism, we identified four cases with concomitant thyroid papi...

ea0035p1085 | Thyroid Cancer | ECE2014

The deleterious effect of levothyroxine (T4) withdrawal on the degree of lipid profile change during follow-up of patients with differentiated thyroid cancer (DTC)

Jin Heung Yong , Park Tae Sun , Baek Hong Sun , Ae Lee Kyung , Kim Sun Hee

Introduction: The degree of dyslipidemia caused by iatrogenic hypothyroidism is not clear in DTC. Therefore, we investigated the average of lipid profile change caused by LT4 withdrawal in the follow-up of DTC.Method: We enrolled 84 DTC patients who underwent high-dose RAI therapy for the treatment of recurred or remnant DTC and we measured serum levels of total cholesterol, triglyceride, LDL, and HDL and then analyzed changes in them accordin...

ea0035p1086 | Thyroid Cancer | ECE2014

Symptomatic hypercalcemia due to primary hyperparathyroidism by parathyroid carcinoma

Cornejo-Pareja Isabel , Gomez-Perez Ana , Maraver-Selfa Silvia , Munoz-Garach Araceli , Molina-Vega Maria , Mancha-Doblas Isabel , Tinahones-Madueno Francisco

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. Clinical suspicion is determined by the severity of hyperparathyroidism associated or not with palpable cervical tumor and local invasion when surgery.Case report: A 45-year-old woman without any previous history of kidney stones or fractures. Admitted to hospital because of high hypercalcemia (calcium 15.1 mg/dl), fatigue and generalized arthralgia. Physical examination revealed right...

ea0035p1087 | Thyroid Cancer | ECE2014

Incidence of thyroid microcarcinoma in relation to gender and age in non-toxic thyroid diseases treated with total thyroidectomy

Askitis Dimitrios , Efremidou Eleni I , Karanikas Michael , Esempidis Agis , Tripsianis Grigorios , Polychronidis Alexandros , Lyratzopoulos Nikolaos

Aim: Thyroid cancer comprises the most common endocrine malignancy and a variety of studies have examined the incidence of microcarcinomas in benign thyroid disorders. Objective of the present retrospective study was the assessment of the possible influence of age and gender parameters in the presence of thyroid microcarcinoma in a patient cohort with non-autonomous thyroid disorders and without cytological establishment of cancer who underwent total thyroidectomy.<p class...

ea0035p1088 | Thyroid Cancer | ECE2014

Estimated 10-year risk of bone fracture in women with diffentiated thyroid cancer on TSH-suppressive levo-thyroxine therapy

Vera Lara , Gay Stefano , Campomenosi Claudia , Mortara Lorenzo , Pera Giorgia , Monti Eleonora , Minuto Francesco , Giusti Massimo

After thyroidectomy (Tx) and RAI therapy, patients with diffentiated thyroid cancer are treated with levo-thyroxine to suppress TSH levels. Whether hyperthyroxinemia causes osteoporosis is debated. The aim of this study was to evaluate bone mineral density (BMD) and the fracture risk assessment tool (FRAX) in DTC women. FRAX calculates the 10-year probability of hip fracture (HF) and major osteoporotic fracture (MOF) in subjects aged >40. 46 women with DTC diagnosed and tr...

ea0035p1089 | Thyroid Cancer | ECE2014

Prognosis and outcome analysis of thyroid cancer: experience from a tertiary care centre in Pakistan

Furqan Saira , Ahmed Asma , Bhutta Zain Ali , Majid Uzma , Awan Safia , Islam Najmul

Material and methods: Retrospective review of patients with thyroid cancer at our hospital from 1999 to 2011 was done.Results: Mean age at presentation was 44±17 years with female to male ratio of 2.1:1. Patients were followed for mean of 6.45 and median of 6 years. Out of 206 patients, 158 had differentiated thyroid carcinoma. Most common variant was papillary (n=130, 63.10%) followed by follicular carcinoma (n=22, 8.73%). 6 (2.91...

ea0035p1090 | Thyroid Cancer | ECE2014

Sentinel lymph node biopsy in thyroid papillary and medullary microcarcinomas

Dzodic Radan , Oruci Merima , Besic Nikola , Santrac Nada , Markovic Ivan , Pupic Gordana , Milic Natasa

Introduction: The aim of this study was to determine whether sentinel lymph node (SLN) biopsy of jugulo-carotid chain (JCC) in thyroid microcarcinomas (TMC) is an accurate technique to select patients with true positive, but clinically and ultrasonically N0 LNs, for modified radical neck dissection (MRND).Materials and methods: In total 199 patients with TMC underwent total thyroidectomy, central neck dissection and SLN mapping with 0.2 ml of 1% methylen...

ea0035p1091 | Thyroid Cancer | ECE2014

Surgical treatment of papillary thyroid carcinoma in children and adolescents

Dzodic Radan , Buta Marko , Besic Nikola , Markovic Ivan , Djurisic Igor , Oruci Merima , Santrac Nada , Pupic Gordana

Background: Papillary thyroid carcinoma in children and adolescents is rare but it shows aggressive behavior. Gross lymph node metastases and distant metastases are common on first clinical presentation.Patients and methods: Forty-eight children and adolescents were operated due to PTC. Mean age was 16.6 years (range 7–21). At the time of diagnosis 13% had lung metastases. Total thyroidectomy or completion of thyroidectomy was performed in all cases...

ea0035p1092 | Thyroid Cancer | ECE2014

Correlation between biochemical and ultrasound parameters in patients with single parathyroid adenoma

Themeli Yllka , Barbullushi Myftar , Gjokutaj Aqif , Idrizi Alma

Aim: The aim of this study was to determine the relationship of the biochemical parameters serum phosphate, serum calcium, and serum parathyroid hormone levels with respect to parathyroid adenoma weight and volume in primary hyperparathyroidism.Methods: Data were collected retrospectively from patients with primary hyperparathyroidism, who were diagnosed and followed between 2008 and 2013. 26 patients (female/male: 23/3) with a mean age of 51.3±12.7...

ea0035p1093 | Thyroid Cancer | ECE2014

Atorvastatin medullar thyroid cancer over TT cell line impact of apoptosis and calcitonin over gene expression

Baykan Emine Kartal , Avci Cigir Biray , Erdogan Mehmet , Cetinkalp Sevki , Ozgen A Gokhan , Gunduz Cumhur , Saygili L Fusun

Medullar thyroid cancer (MTK) approximately constitutes 5% of thyroid cancer, over the 25% cases it progresses in familial form. In charge of genetic inherited clinical features in RET protooncogene ‘germ-line’ makes up activating mutations. In post RET mutation in association with tyrosine kinase activation oncogenic cell proliferation is increased. In medullary thyroid cancer persistent and recurrence disease management is complicated, because it is unresponsive to...

ea0035p1094 | Thyroid Cancer | ECE2014

Anti-proliferative effects of evodiamine on human thyroid cancer cells

Lee Ying-Ray , Lu Chieh-Hsiang , Chang Yi-Sheng , Liu Yi-Wen

Thyroid cancer is the most prevalent cancer among endocrine malignancies. Surgical resection combined with radioactive iodine therapy has been proved effective in treating differentiated thyroid cancer, including papillary and follicular thyroid cancers (FTC). However, patients with incurable differentiated thyroid cancer (DTC), poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) exhibit worse prognosis. Therefore, a novel and effective treatment is...

ea0035p1095 | Thyroid Cancer | ECE2014

Differential miRNAs expression in papillary thyroid cancer is associated with clinico-pathological features and BRAF mutation

Castelblanco Esmeralda , Rosado Veronica , Martinez Montserrat , Santos Maria Dolores , Mancikova Veronica , Robledo Mercedes , Matias-Guiu Xavier , Maravall Javier , Mauricio Didac

Introduction: MicroRNAs (miRNAs) are short non-coding RNAs that regulate translation or degradation of target mRNAs. Therefore, miRNAs control gene expression in many biological processes, including proliferation, apoptosis, and differentiation. Deregulation of miRNAs expression is an important contributor to tumour development and progression. Even though several genetic and epigenetic lesions have been identified in human thyroid cancer, particularly in the papillary histoty...

ea0035p1096 | Thyroid Cancer | ECE2014

Ultrasound risk factors of thyroid cancer

Muszynska-Oglaza Alicja , Pypkowski Jacek , Guz Anna , Mucha-Zielinska Marta , Junik Roman

Differentiated thyroid cancer (DTC) is a relatively mild disease if detected early.The aim of the study was ultrasound evaluation of thyroid gland, selection of thyroid nodules with high chances of malignancy, and their verification in fine-needle aspiration (FNA), as well as assessment of TSH concentration and antiTPO titre.The study involved 100 patients. DTC was diagnosed in 14 patients and undifferentiated or medullary thyroid ...

ea0035p1097 | Thyroid Cancer | ECE2014

Do the poorly differentiated and undifferentiated thyroid carcinomas could be the next candidates to somatostatin analoques treatment?

Pisarek Hanna , Pawlikowski Marek , Marchlewska Magdalena , Minias Radoslaw , Winczyk Katarzyna

Introduction: The multimodal management of poorly differentiated thyroid carcinomas (PDTC) and anaplastic carcinomas (ATC) include surgical thyroidectomy, radioiodine treatment, and cytotoxic chemotherapy. Patients with distant metastases which do not respond to radiotherapy could be treated with new therapeutic possibilities like tyrosine kinase inhibitors. PPARγ or mutant P53 are also candidates to PDTC and ATC treatment. Somatostatin and its analogs, demonstrate antipr...

ea0035p1098 | Thyroid Cancer | ECE2014

Risk factors of cancer relapse in differentiated thyroid carcinomas

Krajewska Jolanta , Jarzab Michal , Czarniecka Agnieszka , Roskosz Jozef , Kukulska Aleksandra , Handkiewicz-Junak Daria , Puch Zbigniew , Paliczka-Cieslik Ewa , Wygoda Zbigniew , Jarzab Barbara

Introduction: Reliable prognostic factors are crucial to choose the optimal treatment strategy and follow-up for differentiated thyroid carcinomas (DTC) patients. Thus, the aim of the study was a retrospective evaluation of prognostic factors of cancer relapse in patients treated in a single institution.Material: The study group consisted of 510 DTC patients, staged pT1b-T4N0-N1M0, treated with total thyroidectomy followed by complementary 131...

ea0035p1099 | Thyroid Cancer | ECE2014

DNMT1 expression in papillary thyroid carcinoma

Brehar Andreea , Procopiuc Camelia , Paun Diana , Manda Dana , Oros Sabina , Caragheorgheopol Andra , Bulgar Alexandra , Brehar Felix , Dumitrescu Cristina , Gherlan Iuliana , Ghemigian Mircea , Stanescu Bogdan , Brasoveanu Daniel , Terzea Dana , Ioachim Dumitru , Plesa Adriana , Huica Irina , Iancu Iulia , Badiu Corin , Dumitrache Constantin

Introduction: In human cancer cells DNMTs are responsible for both de novo and maintenance methylation of tumor suppressor genes. Many studies have analyzed the relationship between the altered expression of DNMT1 and DNA methylation in cancer.Aim: To analyze DNMT1 expression in thyroid papillary carcinoma.Design: 49 patients aged 10–82 years hospitalized for thyroidectomy were included between January 2013 and July 2...

ea0035p1100 | Thyroid Cancer | ECE2014

Methylation status of HOXB4 gene in papillary thyroid carcinoma

Brehar Andreea , Procopiuc Camelia , Paun Diana , Manda Dana , Oros Sabina , Caragheorgheopol Andra , Bulgar Alexandra , Brehar Felix , Plesa Adriana , Iancu Iulia , Botezatu Anca , Ghemigian Mircea , Stanescu Bogdan , Brasoveanu Daniel , Terzea Dana , Ioachim Dumitru , Dumitrescu Cristina , Gherlan Iuliana , Badiu Corin , Dumitrache Constantin

Introduction: HOXB4 functions as a transcription factor involved in cell differentiation during embryogenesis and plays a role in apoptosis.Aim: This study analyzed HOXB4 methylation status in thyroid papillary carcinoma.Method: 54 patients aged 10–82 years hospitalized for thyroidectomy were included between January 2013 and July 2013. The inclusion criterion was patients with thyroid nodules with indication for surgery and t...

ea0035p1101 | Thyroid Cancer | ECE2014

The influence of polymorphisms in tumor suppressor genes in thyroid carcinomas

Dvorakova Sarka , Halkova Tereza , Sykorova Vlasta , Vaclavikova Eliska , Vlcek Petr , Kodetova Daniela , Betka Jan , Vcelak Josef , Bendlova Bela

Introduction: Thyroid carcinomas are the most often endocrine malignancy and their incidence is still growing. Thus, the finding of genetic predispositions to the thyroid cancer is desired. One of the genetic causes can be risk variants of tumor suppressor genes in patients. Our goal was to determine the influence of polymorphisms Val109Gly (T/G) in gene CDKN1B encoding protein p27/Kip1 and Arg72Pro (C/G) in gene TP53 encoding protein p53 on the development of thyroid cancer. ...

ea0035p1102 | Thyroid Cancer | ECE2014

Familial medullary thyroid carcinomas: RET mutation in exon 8 is associated with better prognosis but increased risk for other malignancies

Saltiki Katerina , Rentziou Gianna , Angelopoulou Anastasia , Apostolakis Michael , Papathoma Alexandra , Alevizaki Maria

Objectives: In familial MTC there is genotype-phenotype correlation. The phenotype and clinical outcome in exon8 (G533C) carriers has not been well established.Methods: 95 patients operated for familial MTC (27.2% males) were followed for 0.9–30 years (mean 8.0, median 5.5 years). 45.3% (n=43) were exon8 carriers (exon8MTC) and the remaning were non-exon8MTCs (n=52, exons 10, 11, 13, 14, and 16). Pre-, postoperative calcitonin, ext...

ea0035p1103 | Thyroid Cancer | ECE2014

Single nucleotide polymorphisms associated with papillary thyroid cancer

Kula Dorota , Michal Kalemba , Daria Handkiewicz-Junak , Zbigniew Puch , Malgorzata Kowalska , Monika Kowal , Tomasz Tyszkiewicz , Renata Cyplinska , Joanna Polanska , Barbara Jarzab

Papillary thyroid cancer (PTC) is well known family occurring cancer disease. It is estimated, that ~5% of differentiated thyroid cancers (where PTC is the most frequent) are hereditary. Susceptibility genes are poorly known, however, recently some SNPs located on chromosome 9 in FOXE1 locus (rs965513) and on chromosome 14 (rs944289) close to NKX2-1 locus have been confirmed to be associated with PTC in different populations.The aim of our study was to a...

ea0035p1104 | Thyroid Cancer | ECE2014

A retrospective gender-comparative evaluation of differentiated thyroid cancers

Demirpence M Mustafa , Bahceci Mitat , Tutuncuoglu Aliye Pelin , Salgur Fusun , Gorgel Ahmet , Dolek Devrim , Yilmaz Husnu

Background and aim: Differentiated thyroid cancers are the most common endocrine cancer types. They are more common in women, but the prognosis tends to be poorer with men. We aimed to evaluate male and female patients with differentiated thyroid cancer.Subjects and methods: This retrospective study was performed in last 5 yearly hospital records of our hospital. All data about the patients’ conditions were obtained from hospital information system ...

ea0035p1105 | Thyroid Cancer | ECE2014

Nonincidentally and incidentally discovered thyroid cancer

Ferreira Rute , Serra Filipa , Moniz Catarina , Fonseca Ricardo , Simoes Helder , Limbert Clotilde , Oliveira Manuela , Saraiva Antonio

Introduction: Increasing incidence of thyroid cancer might be a consequence of an increase detection of subclinical disease. The aim of this study was to compare the clinical and pathologic characteristics of nonincidentally discovered (NID) thyroid cancer with incidentally discovered (ID) on postoperative pathology.Methods: A retrospective medical record review of 104 patients with thyroid cancer was performed. A group I of 69 patients with NID thyroid ...

ea0035p1106 | Thyroid Cancer | ECE2014

The role of DNA repair proteins in the assessment of thyroid nodules

Evren Bahri , Karadag Nese , Yilmaz Sami , Sertkaya Ayse Cikim

Aims: Bening and malignant thyroid nodules are the most common lesions of endocrine glands. Some molecular markers; Mut-S homolog-2 (MSH2) and Mut-L-homolog-1 (MLH1) are the two of DNA repair proteins and metil guanin–DNA-metil transferase (MGMT) is the DNA repair enzymes have been studied. In this study, our aim is to evaluate MSH2, MLH1, and MGMT levels in papillary thyroid cancer (PTC), multinodular colloidal goitre (MNG), and chronic lymphocytic thyroiditis (CLT) and ...

ea0035p1107 | Thyroid Cancer | ECE2014

Effects of zoledronic acid monohydrate on cytotoxicity and apoptosis in BCPAP human papillary thyroid carcinoma cell line

Simsir Ilgin Yildirim , Kocabas Gokcen Unal , Yurekli Banu Pinar Sarer , Avci Cigir Biray , Saygili Lutfiye Fusun

Thyroid cancer in Turkey is the most common endocrine neoplasm with an incidence of 3.7%. Papillary thyroid carcinoma is the most common thyroid malignancy in a similar manner. Papillary thyroid carcinoma creates 50–90% of differentiated thyroid carcinomas. There is available in subgroups with poor prognosis. Case-specific mortality of 2% at 5, 10, and 20 years, only 4 and 5%.Mutations and re-arrangements in genes encoding proteins of the MAPK pathw...

ea0035p1108 | Thyroid Cancer | ECE2014

Morphology of recurrent papillary thyroid carcinoma

Abrosimov Alexander Yu , Ryzhenkova Mariya I

Background: Papillary thyroid carcinoma (PTC) is a well differentiated malignant tumour that usually has a good prognosis in vast majority of patients after thyroidectomy, suppressive hormonal, and radioiodine treatment. However 5–10% of PTC cases can develop local relapse and distant metastases.Purpose of study: To make a comparative morphological analysis of PTC in two groups of patients: i) with and ii) without local relapse (regional metastases)...

ea0035p1109 | Thyroid Cancer | ECE2014

Ca 19-9: is there a role for potential new biomarker for medullary thyroid cancer?

Katalinic Darko , Santek Fedor , Juretic Antonio , Stern-Padovan Ranka , Nikolac Nora , Grah Josip Joachim , Plestina Stjepko

In the recent years, knowledge about cancer biomarkers has increased tremendously providing great opportunities for improving the diagnosis, prognosis and treatment of cancer patients. In clinical practice, the levels of serum calcitonin, and carcinoembryonic antigen (CEA) are important during follow-up for patients with medullary thyroid cancer (MTC). Carbohydrate antigen 19-9 (CA 19-9), routinely used in the monitoring of pancreatic, hepatobiliary, and colon carcinoma, also ...

ea0035p1110 | Thyroid Cancer | ECE2014

Metastatic thyroid papillary microcarcinomas

Bahadir Cigdem Tura , Kan Elif Kilic , Gokosmanoglu Feyzi , Ecemis Gulcin Cengiz , Atmaca Hulusi

Aim: Thyroid papillary carcinomas smaller than 1 cm are called papillary microcarcinomas (PMC). They rarely metastasize to lymph node (LN) and distant areas. The presence of palpable lymphadenopathy at the time of diagnosis shows high risk of recurrence regardless of primary tumor size. We aimed to investigate histopathologic characteristics and recurrence frequency of thyroid PMCs with LN metastasis (LNM).Materials and methods: Thyroid PMC cases with LN...

ea0035p1111 | Thyroid Cancer | ECE2014

Prognostic implications of stage pT3 in well differentiated thyroid cancer

Moreno Carolina , Melo Miguel , Pires Luis , Cardoso Luis , Ribeiro Cristina , Ruas Luisa , Saraiva Joana , Guelho Daniela , Vicente Nuno , Costa Gracinda , Carrilho Francisco

Introduction: The TNM staging system for well differentiated thyroid cancer (WDTC) considers tumours over 4 cm diameter limited to the thyroid or tumours with minimal extra-thyroid extension to be classified as pT3. This stage can be considered quite heterogeneous, as different clinical and pathologic characteristics seem to have distinct prognosis value.Aims: To determine prognostic factors amongst clinical, laboratorial, histologic and radiologic chara...

ea0035p1112 | Thyroid Cancer | ECE2014

The utility of ultrasonographic features on the accuracy of diagnosing individual types of thyroid malignancies

Leung Kelvin , Madhaven Anantha , Elsaify Wael

Introduction: Recent studies have shown that different ultrasound features of a thyroid nodule are associated with high probability of different types of malignancy. The purpose of this study is to evaluate the sensitivities of each of the identified ultrasound features and to determine their corresponding carcinoma types that they are sensitive to.Methods: Retrospective data from January 2010 to October 2013 were collected in a regional thyroid unit in ...

ea0035p1113 | Thyroid Cancer | ECE2014

Prognosis of papillary and follicular thyroid cancers with serum thyroglobulin antibody at 1 year after total thyroidectomy

Kuo Sheng-Fong , Lin Jen-Der

Objective: To investigate the influence of serum TgAb on the therapeutic outcome in papillary and follicular thyroid cancer patients.Methods: In 1378 papillary and follicular thyroid cancer patients (women, 1055 and men, 323; mean age, 42.5 years) with T2 and higher, or N1, or M1 classifications in TNM staging who had undergone total thyroidectomy, we recorded the serum TgAb data (on thyroxin therapy) 1 year (±3 months) after thyroidectomy. The pati...

ea0035p1114 | Thyroid Cancer | ECE2014

Increased mean platelet volume in papillary thyroid cancer

Carlioglu Ayse , Simsek Eda , Durmaz Senay Arikan , Ozmen Hilal Kiziltunc

Introduction and objective: Platelets play an important role in the development of thrombotic events. Increase of mean platelet volume (MPV) may indicate pre-thrombotic conditions as a new cardiovascular marker. Larger platelets have been reported to be metabolically more active than smaller ones. Our aim of present study is to evaluate MPV levels in patients with papillary thyroid cancer.Materials and methods: Forty-seven patients with newly diagnosis m...

ea0035p1115 | Thyroid Cancer | ECE2014

Preoperative TSH value, does it predict the surgical findings in papillary thyroid cancer?

Paja Miguel , Ciriza Maite Perez de , Calles Laura , Etxeberria Eider , Oleaga Amelia , Lizarraga Aitzol

TSH level has been proposed as a thyroid malignancy predictor in nodular thyroid disease. In addition, several clinical studies have reported that higher preoperative serum TSH levels were associated with more advanced stages of differentiated thyroid cancer (DTC) at the time of diagnosis.Methods: We collected retrospectively preoperative serum TSH from patients diagnosed of papillary thyroid cancer (PTC) who had undergone total thyroidectomy during the ...

ea0035p1116 | Thyroid Cancer | ECE2014

Thyroglobulin measurements in fine-needle aspiration cytology of lymph nodes in patients after thyroidectomy because of differentiated thyroid cancer

Musial Emilia , Galczynski Jacek , Bakula-Zalewska Elwira , Dedecjus Marek

Introduction: Approximately 5–20% patients treated for differentiated thyroid carcinoma (DTC) develop metastases to the neck lymph nodes. Ultrasound-guided fine-needle aspiration biopsy (FNAB) is a routinely used method in the examination of suspicious lymph nodes. The measurement of thyroglobulin (Tg) levels in needle washout fluids (FNAB-Tg) has been reported to increase the diagnostic accuracy of FNAB.Description of methods/designs: A total of 10...

ea0035p1117 | Thyroid Cancer | ECE2014

Prediction of lymph node metastasis in papillary thyroid cancer by preoperative BRAF analysis, is it useful?

Luque Alessandra , Sastre Julia , Val Florentino del , Cortes Claudia , Luque Ines , Maqueda Esther , Vicente Almudena , Pena Virginia , Castro Enrique , Morlan Miguel Angel , Campos-Martin Yolanda , Lopez Jose

Introduction and objective: Prophylactic central lymph node dissection (CLND) in patients with suspected papillary thyroid cancer (PTC) without evident lymph node metastasis (LNM), remains debatable. We propose to evaluate whether BRAF V600E mutation presence, could help to identify patients at risk for LMN.Methods: Retrospective study of patients with diagnosis of PTC, who underwent total thyroidectomy during 2002 and 2013 (n: 256) in our hospi...

ea0035p1118 | Thyroid Cancer | ECE2014

Clinical and biochemical characteristics of papillary thyroid cancer according to the presence of BRAF (V600E) mutation

Oleaga Amelia , Goni Fernando , Ciriza Miguel Paja1, Maite Perez de , Etxeberria Eider , Calles Laura , Ugarte Estibaliz , Ugalde Aitziber , Elorza J Ramon

Introduction: BRAF (V600E) mutation is the most frequent detected genetic change in papillary thyroid cancer (PTC). Its presence has been related to aggressive clinical and pathological features. Therefore, BRAF mutation has drawn considerable interest as a potential prognostic factor for PTC. The presence of the mutation confers the tumour a disability to uptake RAI, diminishing the therapeutic tools. However if this feature is related to some kind of tumour dedifferentiation...

ea0035p1119 | Thyroid Cancer | ECE2014

Survivin splice variants expression in thyroid malignancy

Waligorska-Stachura Joanna , Sawicka-Gutaj Nadia , Andrusiewicz Miroslaw , Biczysko Maciej , Jankowska Anna , Ruchala Marek

Introduction: Thyroid cancer incidence has increased significantly during the past decades and is the most common type of endocrine malignancy. Suitable criteria for detecting malignant thyroid tumors are still missing. Therefore, the discovery of molecular markers linked to thyroid carcinogenesis will be helpful in the diagnosis of malignant tumors and managing their appropriate treatment.Aim: The objective of the study was to evaluate survivin expressi...

ea0035p1120 | Thyroid Cancer | ECE2014

Diffuse sclerosing variant of papillary thyroid carcinoma is a rare variant

Aydemir Mustafa , Acibucu Fettah , Turesin Ahmet Kerim , Kilicli Mehmet Fatih , Dokmetas Hatice Sebila

Diffuse sclerosing variant of papillary thyroid carcinoma is a rare variant. It is usually seen in children and young adults.The thyroid gland is diffusely involved. It is characterized by scattered microscopic tumor islands, diffuse fibrosis, calcification, abundant lymphocytic infiltration and psammom body when compared with conventional papillary thyroid carcinoma. Usually the lesion does not cause mass but rather a dominant nodule in one lobe is present in 50% of cases. Ly...

ea0035p1121 | Thyroid Cancer | ECE2014

The role of microRNAs in regulation of RARβ and its function in development of papillary thyroid carcinoma

Czajka Agnieszka , Wojcicka Anna , Stachlewska Elzbieta , Wiechno Wieslaw , Niewinski Grzegorz , Jazdzewski Krystian

Objectives: Papillary thyroid carcinoma (PTC) exhibits aberrant expression of retinoic acid receptor β (RARβ), a retinoic acid-inducible transcription factor, essential for cellular growth and development. The mechanisms leading to decreased RARβ expression in tumors are unknown. We hypothesized that changes in expression of RARB, a gene encoding for RARβ, result from aberrant expression of microRNAs. We elucidated the miRNome of normal thyroid and...

ea0035p1122 | Thyroid Cancer | ECE2014

Rising serum thyroglobulin in the follow-up of patients with differentiated thyroid carcinoma: the role of FDG PET–CT

Godlewska Paulina , Bruszewska Elzbieta , Lapinska Grazyna , Fijolek-Warszewska Agnieszka , Dedecjus Marek

Rising thyroglobulin (Tg) serum concentration in patients after total thyroidectomy due to differentiated thyroid cancer (DTC) with no pathological radioiodine uptake on posttherapeutic whole-body scan (WBS) constitutes a challenge for physicians dealing with DTC management.The FDG PET–CT is regarded as a gold diagnostic standard in such cases.Our aim was to find factors which may help predicting positive PET–CT result, a...

ea0035p1123 | Thyroid Cancer | ECE2014

Sodium–iodide symporter and its microRNA-dependent deregulation in papillary thyroid carcinoma.

Kotlarek Marta , Gierlikowski Wojciech , Kubiak Anna , Maciag Monika , Jazdzewski Krystian , Wojcicka Anna

Objectives: The sodium/iodide symporter (NIS) is a glycoprotein with unique ability of transporting iodine into the thyroid follicle. Apart from the importance in thyroid hormone synthesis, this function of NIS allows the use of radioactive iodine to target residual and metastatic thyroid cancer after thyroidectomy. However, 20–30% of thyroid tumors exhibit lowered expression of NIS, resulting in decreased uptake of radioiodine and inefficient post-surgical therapy. Mecha...

ea0035p1124 | Thyroid Cancer | ECE2014

Functional analysis of newly discovered microRNA deregulated in papillary thyroid carcinoma

Maciag Monika , Kubiak Anna , Swierniak Michal , Dymecka Kinga , Kolanowska Monika , Koperski Lukasz , Gornicka Barbara , Stachlewska Elzbieta , Jazdzewski Krystian

Introduction: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy where alterations in the RET/PTC–RAS–BRAF signaling pathway and deregulation of microRNA (miRNA) expression are suggested to be major mechanism of pathogenesis. MicroRNAs are small non-coding RNA molecules that recognize specific sequences in 3′UTR of target gene and prevent from its translation. Our recent deep sequencing studies of thyroid tissue transcriptome revealed a put...

ea0035p1125 | Thyroid Cancer | ECE2014

Apical iodide transporter and its microRNA-induced silencing in thyroid malignancies

Gierlikowski Wojciech , Kotlarek Marta , Bakula-Zalewska Elwira , Jazdzewski Krystian , Wojcicka Anna

Objectives: Apical iodide transporter (AIT) is essential for thyroid homeostasis, functioning both as iodide transporter and a potent tumor suppressor. Its decreased levels observed in thyroid cancer underlie its progression and inefficiency of radioactive iodine treatment, used for ablation of post-operative and metastatic thyroid cancer cells. Mechanisms of AIT downregulation in cancer are largely unknown, but recent data on overexpression of microRNAs in thyroid cancer sugg...

ea0035p1126 | Thyroid Cancer | ECE2014

TERT promoter mutations correlate with a more advanced stage at diagnosis and with a poorer prognosis in differentiated thyroid cancer

Colombo Carla , Muzza Marina , Rossi Stefania , Cirello Valentina , Perrino Michela , Tosi Delfina , Vigo Beatrice , Leo Simone De , Bulfamante Gaetano , Magnani Elisa , Pignatti Elisa , Simoni Manuela , Vicentini Leonardo , Fugazzola Laura

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends and plays a role in cellular senescence, being repressed in postnatal somatic cells. Mutations C228T and C250T of the telomerase reverse transcriptase (TERT) were recently reported in human cancers. In thyroid cancer, TERT mutations are more frequent in aggressive histotypes, but very few data are available about the potential correlations with clinical features in papillary and follicular thyroid cancer...

ea0035p1127 | Thyroid Cancer | ECE2014

Puca Entela , Koza Kadir Burak , Puca Edmond , Ylli Agron

Hashimoto’s thyroiditis (HT) is found in a high proportion of resected thyroid specimens. There has been considerable controversy as to whether having HT predisposes a patient to papillary thyroid cancer (PTC) and conflicting data have been reported with regard to HT and risk of malignancy. The aim of this study was to evaluate coexistence of PTC with HT.Materials and methods: This is a retrospective study done at American Hospital 2 from April 2011...

ea0035p1128 | Thyroid Cancer | ECE2014

Next-generation sequencing reveals a novel thyroglobulin-embedded microRNA gene deregulated in papillary thyroid carcinoma

Kolanowska Monika , Wojcicka Anna , Kubiak Anna , Swierniak Michal , Maciag Monika , Wiechno Wieslaw , Jazdzewski Krystian

Introduction: Papillary Thyroid Carcinoma (PTC) exhibits activation of MAPK (Mitogen-activated protein kinases) pathway, leading to uncontrolled cellular division and growth. Concomitantly, thyroid tumors exhibit aberrant expression of numerous microRNAs, which are non-coding RNAs that inhibit expression of protein-coding genes. Employing next-generation sequencing (NGS), we revealed comprehensive miRNA profiles of normal thyroid and PTC, and identified putative novel microRNA...

ea0035p1129 | Thyroid Cancer | ECE2014

The role of ATM–CHEK2–BRCA1 axis in determination of genetic predisposition and clinical presentation of papillary thyroid carcinoma

Wojcicka Anna , Czetwertynska Malgorzata , Swierniak Michal , Dlugosinska Joanna , Maciag Monika , Czajka Agnieszka , Dymecka Kinga , Kot Adam , Ploski Rafal , Jazdzewski Krystian

Background: Risk of developing papillary thyroid carcinoma (PTC), the most frequent thyroid malignancy, is elevated up to 8.6-fold in the first-degree relatives of PTC patients, what could be explained by polygenic action of low-penetrance alleles. Since the DNA-damaging exposure to ionizing radiation is a known risk factor for thyroid cancer, polymorphisms in DNA repair genes are likely to affect this risk. Among the DNA repair proteins, the ATM–CHEK2–BRCA1 axis see...

ea0035p1130 | Thyroid Cancer | ECE2014

Evaluation of factors predict the efficacy of thyroid remnant ablation in patients with differentiated thyroid carcinoma

Imga Narin Nasiroglu , Isik Serhat , Basaran Mehtap Navdar , Dogan Bercem Aycicek , Tuna Mazhar Muslum , Unal Mustafa , Berker Dilek , Guler Serdar

Introduction: Differentiated thyroid cancers (DTC) are the most frequently occuring endocrine malignancies. The factors determine the recurrences and metastases are whole body scanning (WBS) and either suppressed or stimulated thyroglobulin (sTg) levels. The aim of this study to evaluate the preablative factors predict of radioiodine remnant ablation (RRA) therapy success.Patients and methods: One hundred consecutive patients with DTC (94 papillary and s...

ea0035p1131 | Thyroid Cancer | ECE2014

The role of the transcription factor: Prospero homeobox 1: in the biology of differentiated thyroid cancer

Rudzinska Magdalena , Gawel Damian , Karpinska Kamila , Kierdrowski Miroslaw , Stepien Tomasz , Marchlewska Magdalena , Domek Hanna , Czarnocka Barbara

One of the pathways of DTC dissemination is the lymphatic system, however the molecular basis of this process is still unknown. One of the key regulators of lymphangiogesis is Prospero homeobox 1 (Prox1) specifically expressed in LEC and in some human cancers. The present study investigates the expression and function Prox1 in biology of differentiated cancer cells.Studies were performed in a series of thyroid cancer FTC and PTC cell lines. Protein and t...

ea0035p1132 | Thyroid Cancer | ECE2014

Treatment outcomes and prognosis of medullary thyroid carcinoma in a tertiary endocrinology center

Dobrescu Ruxandra , Stanescu Bogdan , Badiu Corin

A rare and aggressive form of thyroid malignancy, medullary thyroid carcinoma (MTC) is virtually incurable except by complete surgical resection. Due to its insidious onset and extensive spread at diagnosis, its prognosis is often poor.Aim: To evaluate treatment outcome and prognosis in patients diagnosed with MTC admitted to our department between 2004 and 2013.Patients and methods: We identified 21 patients (eight men and 13 wome...

ea0035p1133 | Thyroid Cancer | ECE2014

The presence of BRAFV600E mutation in patients diagnosed of papillary thyroid carcinoma in holycross cancer centre in Kielce, Poland

Walczyk Agnieszka , Kowalska Aldona , Kowalik Artur , Kopczynski Janusz , Wypiorkiewicz Elzbieta , Chodurska Renata , Pieciak Liliana , Gozdz Stanislaw

Background: The activating somatic point mutation, BRAFV600E, is the most common genetic alteration observed in papillary thyroid carcinoma (PTC) but its oncogenic role in PTC has been extensively investigated. Numerous studies reported that BRAFV600E correlates with poor clinical outcome, whereas others have found no such association. It is estimated that BRAFV600E occurs in ~ 45–50% of PTC cases, but recent studies showed the more freque...

ea0035p1134 | Thyroid Cancer | ECE2014

Papillary thyroid microcarcinoma: focus on prevalence, characterization and follow-up during a 10 years time period

Pereira Maria Teresa , Carvalho Andre , Garrido Susana , Caldas Ana Rita , Freitas Claudia , Teixeira Sofia , Valente Vitor , Canha Antonio , Costa Moreira , Bateira Paulo , Borges Fatima

Introduction: Recent studies point to an ever increasing papillary thyroid microcarcinoma (PTMC) prevalence, with a percentage range between 20 and 43% of all differentiated thyroid carcinomas. It is many times considered an ‘incidental’ finding and its clinical behaviour is uncertain.Aims: To characterize a cohort of patients with PTMC, with reference to clinical and pathological variables and outcome.Methods: Data from ...

ea0035p1135 | Thyroid Cancer | ECE2014

The role of podoplanin in the biology of differentiated thyroid cancers

Karpinska Kamila , Rudzinska Magdalena , Gawel Damian , Kiedrowski Miroslaw , Stepien Tomasz , Marchlewska Magdalena , Hanna Domek , Czarnocka Barbara

Podoplanin (PDPN), a mucine type transmembrane glycoprotein specific to lymphatic system is expressed in a variety of human tumors and regarded as a factor promoting tumor progression. In a recent work, we found PDPN expression in tumor cells of 40% of papillary thyroid carcinomas (PTC), however it role remains unclear. The purpose of this study was to elucidate the molecular role of PDPN in the biology of thyroid cancer cells.PDPN gene and prot...

ea0035p1136 | Thyroid Cancer | ECE2014

Prevalence and risk of malignancy of thyroid incidentalomas discovered by 18F-fluorodeoxyglucose positron emission tomography

da Silva Tiago Nunes , Luiz Henrique Vara , Pereira Bernardo Dias , Matos Ana Catarina , Manita Isabel , Carmona Susana , Santos Ana Isabel , Portugal Jorge

The use of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG–PET) has increased the detection of thyroid incidentalomas (TI). These are associated with a risk of malignancy between 25 and 50%. Some studies show an association between SUVmax uptake and malignancy.The objective of this study was to determine the prevalence of malignancy on 18F-FDG–PET positive thyroid nodules and to evaluate the relatio...

ea0035p1137 | Thyroid Cancer | ECE2014

Gardner syndrome; a case of presenting with agressive varyant papillary thyroide cancer

Basaran Mehtap Navdar , Dogan Bercem Aycicek , Tuna Mazhar Muslum , Unal Mustafa , Berker Dilek , Guler Serdar

Introduction: Gardner syndrome (GS) have very different extraintestinal manifestations such as include osteomas and thyroid cancers. Thyroid carcinomas associated with familial adenomatozis polyposis coli (FAP), are typically bilateral and multifocal. Our case presenting that GS included Graves’ disease (GD) and aggressive varyant of PTC.Case report: A 43-year-old men admitted to our out patient clinic for thyrotoxicosis investigation. He was compla...

ea0035p1138 | Thyroid Cancer | ECE2014

Prognostic factors in 213 patients with differentiated thyroid cancer

Librizzi Maria Soledad , Guadalix Sonsoles , Partida Miriam , Ferrero Jorge , Ferrero Eduardo , Perez-Barrios Andres , Martinez Guillermo , Hawkins Federico

Objectives: Prognosis of differentiated thyroid carcinoma (DTC) is usually good, but even so a proportion of the patients develop recurrences and eventually die of the disease. The aim of this study was to analyze the clinical and histopathological features of patients with DTC in our center and to identify prognostic factors in this group of patients.Patients and methods: We reviewed, retrospectively, 213 patients (184 females and 29 males, mean age 48....

ea0035p1139 | Thyroid Cancer | ECE2014

The effect of allelic variants of the thyroid hormone receptor β (THRB) gene on the incidence of papillary thyroid carcinoma

Wojcicka Anna , Roslon Marek , Czetwertynska Malgorzata , Swierniak Michal , Dlugosinska Joanna , Kot Adam , Ploski Rafal , Hromada-Judycka Aneta , Swiech Marta , Jazdzewski Krystian

Objectives: Papillary thyroid carcinoma (PTC) is the most common malignancy of the endocrine system. Its heritability is the highest among common cancers, as evidenced by family-based studies. Thyroid hormone receptor β gene (THRB), a known tumor suppressor, is crucial for the proper thyroid function, therefore its polymorphisms are likely to affect the risk for thyroid cancer.Aim of the study: In order to identify alleles that might modify...

ea0035p1140 | Thyroid Cancer | ECE2014

Thyroglobulin before radio remnant ablation during levothyroxine withdrawal can be considered an accurate parameter of remission of differentiated thyroid cancer

Paragliola Rosa Maria , De Rosa Annapina , Di Donna Vincenzo , Locantore Pietro , Senes Paola , Prete Alessandro , Pontecorvi Alfredo , Corsello Salvatore Maria

Introduction: Differentiated thyroid cancer (DTC) is the most frequent endocrine cancer. After surgery followed, if any, by 131I radio remnant ablation (RRA), follow-up monitoring consists of neck ultrasonography (US) and measurements of thyroglobulin (Tg) levels and anti-Tg antibodies (Ac-Tg) both on levothyroxine (L-T4) therapy and after recombinant TSH (rTSH). The aim of our study is to define a cut-off of Tg before RRA (RRA-Tg) during <...

ea0035p1141 | Thyroid Cancer | ECE2014

The usefulness of thyroid function tests for the estimation of individual sensitivity to levothyroxine therapy in patients with thyroid cancer

Tatiana Mityukova , Natallia Akulevich , Tatiana Leonova , Tamara Platonova , Svetlana Mankovskaya

Introduction: The long-term follow-up of the patients with well-differentiated thyroid cancer (WDTC) includes the monitoring of suppressive levothyroxine therapy. Our study evaluated the peculiarities of thyroid status in WDTC patients on the doses of levothyroxine leading to TSH suppression (lower than 0.5 mI/l).Study design: We have studied 114 patients with WDTC, 24 men and 90 women. The follow-up was a least 10 years after thyroid surgery, mean age a...

ea0035p1142 | Thyroid Cancer | ECE2014

Polymorphic pre-miR-146a and synergistic action of all of its products on NTRK2 gene in papillary thyroid carcinoma

Kubiak Anna , Wojcicka Anna , Wiechno Wieslaw , Niewinski Grzegorz , Jazdzewski Krystian

Objectives: Aberrances in expression and sequence of miR-146a have a well-established role in pathogenesis of papillary thyroid carcinoma (PTC). The G/C heterozygosity in rs2910164 of miR-146a underlies genetic predisposition to PTC and occurs as a somatic mutation in thyroid tumors. Deleterious function of rs2910164 consists in creation of a new variant of microRNA, resulting from the fact that a single microRNA precursor gives rise to −5p and −3p microRNAs. The S...

ea0035p1143 | Thyroid Cancer | ECE2014

Post-ablative thyroglobulin level as a predictor of favourable prognosis in patients with differentiated thyroid cancer

Gadawska-Juszczyk Klaudia , Kowalska Aldona , Palyga Iwona , Mezyk Ryszard , Sluszniak Anna

Introduction: Postoperative thyroglobulin (TgPO) has a well established position as the prognostic factor for the follow-up of patients with differentiated thyroid cancer (DTC) after total thyroidectomy. However, the presence of thyroid remnants after surgery may diminish predictive value of TgPO.The aim of the study is to evaluate prognostic value of stimulated postablative thyroglobulin level (TgPA) measured after 6–9 months after radioacitve iodi...

ea0035p1144 | Thyroid Cancer | ECE2014

Coexistence of mutations in the CHEK2 and BRAFV600E genes and their impact on the course of the papillary thyroid carcinoma (PTC)

Gasior-Perczak Danuta , Kowalska Aldona , Palyga Iwona , Walczyk Agnieszka , Siolek Monika , Kowalik Artur , Mezyk Ryszard , Gozdz Stanislaw

Introduction: The activating BRAFV600E is the most common genetic alteration in PTC. There is a common belief that it can correlate with a more aggressive clinical course. The mutation of the CHEK2 gene impairs the repair processes of the damaged DNA. It can be expected that the coexistence of both mutations can be related to a worse clinical course.Aim: To assess the prevalence of the coexistence of the CHEK2 and BRAFV600E mutation...

ea0035p1145 | Thyroid Cancer | ECE2014

Impact of different methods on the detection frequency of BRAF mutation in papillary thyroid carcinoma

Kowalik Artur , Kowalska Aldona , Kopczynski Janusz , Walczyk Agnieszka , Nowak Ewelina , Wypiorkiewicz Elzbieta , Chodurska Renata , Pieciak Liliana , Gozdz Stanislaw

Introduction: Still there is a discussion about the importance of diagnostic and prognostic relevance BRAFV600E mutation. The wide range of BRAFV600E mutation frequency (40–80%) doesn’t facilitate this task. Population diversity and genotyping methodology are suspected sources of differences seen in the mutation frequencies detected by different studies. The aim of this study was to assess the prevalence BRAF V600...

ea0035p1146 | Thyroid Cancer | ECE2014

Long-term follow-up of young patients submitted to radiotherapy: analysis of ten thyroid cancer cases

Simoes-Pereira Joana , Silva-Vieira Margarida , Pereira Maria Conceicao

Introduction: The increasing risk of thyroid cancer (TC) in patients who underwent radiotherapy is well documented, especially at early ages. In our center, young patients undergoing cancer treatments are referenced to Endocrine Rehabilitation Clinics (ERC). Their risks are initially identified and monitored regularly. We intended to analyze the characteristics and outcomes of patients who developed post-radiotherapy TC.Methods: Medical records of patien...

ea0035p1147 | Thyroid Cancer | ECE2014

Occurrence other than V600E mutation in the BRAF gene in papillary thyroid carcinoma

Kowalik Artur , Kowalska Aldona , Kopczynski Janusz , Walczyk Agnieszka , Nowak Ewelina , Wypiorkiewicz Elzbieta , Chodurska Renata , Pieciak Liliana , Gozdz Stanislaw

Introduction: BRAFV600E mutation constitutes 98–99% of all detected mutation in thyroid carcinoma. The remaining 2% are BRAF mutations detected in the vicinity of codon V600. Due to the low incidence not much is known about their importance for the development of papillary thyroid carcinoma (PTC). In addition, some of these mutations co-occur with the mutation BRAFV600E.Methods/design: The study prese...

ea0035p1148 | Thyroid Cancer | ECE2014

Does lymphocytic thyroiditis influence the histological characteristics and the course of thyroid carcinoma in children and adolescents?

Iliadou Paschalia , Mandanas Stylianos , Michalakis Konstantinos , Mitsakis Periklis , Patakiouta Frideriki , Pazaitou-Panayiotou Kalliopi

Introduction: The aim of the present study was to evaluate if demographic and histological characteristics as well as the long-term outcome of thyroid cancer was different in children and adolescents with and without autoimmune thyroiditis taking into consideration that information in the literature is scarce.Methods: The medical records of children and adolescents (≤21-year-old) followed up in Theagenio Cancer Hospital due to histologically proven...

ea0035p1149 | Thyroid Cancer | ECE2014

Prognostic significance of TERT promoter mutations in follicular cell-derived thyroid carcinomas

Melo Miguel , da Rocha Adriana Gaspar , Vinagre Joao , Batista Rui , Peixoto Joana , Celestino Ricardo , Salgado Catarina , Eloy Catarina , Lima Jorge , Amaro Teresina , Lobo Claudia , Moura Margarida , Cavaco Branca , Leite Valeriano , Cameselle-Teijeiro Jose Manuel , Carrilho Francisco , Carvalheiro Manuela , Maximo Valdemar , Sobrinho-Simoes Manuel , Soares Paula

Context: Telomerase promoter mutations (TERT) were recently described in follicular cell-derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers.Objectives: We aimed to evaluate the frequency of TERT promoter mutations in thyroid lesions and to investigate the prognostic significance of such mutations in a large cohort of patients with differentiated thyroid carcinomas (DTC).<p class="abstext"...

ea0035p1150 | Thyroid Cancer | ECE2014

BRAF V600E genetic mutation analysis in patients had been diagnosed of unknown malignancy potential thyroid tumors and papillary thyroid microcarcinoma

Sezer Havva , Canturk Zeynep , Ergul Emel , Cetinarslan Berrin

Aim: The purpose of this study was to analysis BRAF V600E mutational status in papillary thyroid microcarcinomas (PTMCs) and unknown malignant potential thyroid tumors (UMP-TTs) and to investigate association of BRAF V600 positivity with clinicopathologic parameters.Material and method: Seventy-two PTMC and 20 UMPTT tissues were included in this study. Genomic DNA was extracted from paraffin-embedded tumor tissue. The paraffin-embedded thyroid tumor samp...

ea0035p1151 | Thyroid Cancer | ECE2014

Prognosis of papillary thyroid cancer with lung metastasis at diagnosis

Tseng Fen-Yu

Introduction: Subjects with papillary thyroid cancer (PTC) usually have a long survival time after diagnosis. However, the prognosis of PTC subjects with lung metastasis noted at the time of initial diagnosis is unknown.Material and methods: From 1998 to 2009, patients with PTC were recruited by medical chart review. Patients with lung metastasis at initial diagnosis (PTC-L) were identified. Their follow-up courses were evaluated and compared to patients...

ea0035p1152 | Thyroid Cancer | ECE2014

Gene expression signature associated with BRAFV600E mutation in human papillary thyroid carcinoma based on transgenic mouse model

Rusinek Dagmara , Swierniak Michal , Chmielik Ewa , Kowal Monika , Kowalska Malgorzata , Czarniecka Agnieszka , Przeorek Cezary , Cyplinska Renata , Jarzab Michal , Widlak Wieslawa , Jarzab Barbara

Objectives: Recent studies on BRAFV600E mutation, known as initiating event in papillary thyroid carcinoma (PTC) and related to more aggressive clinical course of the disease, revealed its significant influence on gene expression profile suggesting that BRAF(+)PTCs represent a molecular subtype of PTC. However, the human material disables distinction of possible molecular causes of cancer from its effects, unlike the mouse model. The main goal of our project was to find genes ...