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16th European Congress of Endocrinology

Poster Presentations

Thyroid (non-cancer)

ea0035p958 | Thyroid (non-cancer) | ECE2014

A case of primary hypothyroidism: Lingual thyroid

Ozturk Yasin , Arikan Senay , Kibar Yunus Ilyas , Tay Ahmet , Ayhan Mehmet Emin

Lingual thyroid is an abnormal formation appearing as the result of a deficient descent during embryological development of the thyroid gland through the thyroglossal duct to its normal pretracheal location, and it is a rare embryological aberration. A 19 years old woman was admitted to with foreign-body-feeling, dysphonia, hoarseness, constipation. Examination showed a spherical, red fleshy and smooth contoured mass rat back of the tongue. Thyroid scan with technetium 99 m re...

ea0035p959 | Thyroid (non-cancer) | ECE2014

Urinary iodine excretion in Egyptian females with nodular goiter

Aziz Rokaya Abd El , Heshmat Tarek , Salam Randa

Introduction: Iodine is needed for the production of thyroid hormone. The prediction of iodine intake is difficult. The standard measure of iodine nutrition in a community is the median urinary iodine excretion, expressed in micrograms per liter. According to the WHO, a median urinary iodine excretion of 100–199 μg/l indicates that the iodine intake is adequate.The aim of this work is to measure the iodine excretion in patients with thyroid nod...

ea0035p960 | Thyroid (non-cancer) | ECE2014

The FRAX score in postmenopausal women with subclinical hyperthyroidism

Polovina Snezana , Popovic-Brkic Vera , Micic Dragan , Milic Natasa , Sumarac-Dumanovic Mirjana , Zoric Svetlana , Stamenkovic-Pejkovic Danica , Cvijovic Goran , Micic Dusan , Jeremic Danka , Gligic Ana

Introduction: FRAX score is the ten-year estimated risk calculation tool for bone fracture which includes clinical data and hip bone mineral density measured by x-ray densitometry (DXA). The aim of the study was to elucidate the ability of the FRAX score in discriminating between bone fracture positive and negative postmenopausal women with subclinical hyperthyroidism.Material and methods: FRAX score calculation were performed in 27 postmenopausal women ...

ea0035p961 | Thyroid (non-cancer) | ECE2014

Graves' disease presented with renal infarction

Jin Heung Yong , Park Tae Sun , Baek Hong Sun , Lee Kyung Ae , Kim Sun Hee

Introduction: There are few cases about arterial thrombosis combined with thyrotoxicosis independent of atrial arrhythmias. Herein, we report a case of Graves’ disease presented with renal artery infarction withiout atrial fibrillation.Case: A 54-year-old man visited the emergency department due to the sudden onset of left flank pain for 30 min. The left flank pain was accompanied by sole dysuria without other symptoms of pyelonephritis. Physical ex...

ea0035p962 | Thyroid (non-cancer) | ECE2014

Female cardiothyrosis

Chentli Farida , Haddad Meriem , Yaker Amal Fetta , Zellagui Hadjer , Daffeur Katia

Introduction: Cardiothyreosis is a severe and most frequent heart complication due to hyperthyroidism. It includes severe arrhythmias, heart insufficiency or heart coronary insufficiency ± atrial ventricular block, or pulmonary hypertension.Our aim was to study cardiothyreosis frequency in females, its incidence, its causes, and its response to radical treatment.Subjects and methods: It is a retro-and prospective study which a...

ea0035p963 | Thyroid (non-cancer) | ECE2014

Male cardiothyrosis

Chentli Farida , Daffeur Katia

Cardiothyreosis (CT) is defined as an association of hyperthyroidism (HT) with severe heart complications such as rhythmic troubles, heart and/or coronary insufficiency. Recently ventricle-auricular block and arterial pulmonary hypertension (APHT) was added to the definition. CT is the most frequent and one of the most dangerous complications of hyperthyroidism (HT) in emerging countries compared to developed countries where this abnormality is deemed to be very rare. Our aim ...

ea0035p964 | Thyroid (non-cancer) | ECE2014

Abstract withdrawn....

ea0035p965 | Thyroid (non-cancer) | ECE2014

Quality of life is impaired in patients with euthyroid nodular goiter

Ozturk Duygu , Atmaca Aysegul

Description: Quality of life (QoL) is impaired in patients with thyroid dysfunction but has never been evaluated in patients with euthyroid nodular goiter (ENG). The aim of this study was to evaluate QoL in patients with ENG and compare the results with a healthy control group.Methods: Thirty patients with ENG (mean age 38.0 years, male/female=3/27) and 30 healthy, age and gender-matched euthyroid subjects without thyroid nodule (mean age 38.9 years, mal...

ea0035p966 | Thyroid (non-cancer) | ECE2014

Thyrotoxic periodic paralysis as the first manifestation of hyperthyroidism

Silva-Fernandez Julia , Gomez-Alfonso Francisco , Garcia-Ruiz Rafael , Garcia-Manzanares Alvaro , Lopez-Iglesias Maria , Lopez-Gallardo Gema , Gomez-Garcia Inez

Introduction: Thyrotoxic periodic paralysis (TPP) is a complication of hyperthyroidism characterized by muscle paralysis and hypokalemia. It mainly affects male patients of Asian descent. Many patients do not have obvious symptoms and signs of hyperthyroidism, which makes its diagnosis difficult.Case report: A 47-year-old Asian man presented with all four limbs rapidly progressive muscular weakness that caused him inability to walk. He referred a previou...

ea0035p967 | Thyroid (non-cancer) | ECE2014

Usefulness of color-flow doppler ultrasonography in the differential diagnosis of thyrotoxicosis in outpatients

Merchante Agustin Angel , Fabra Amparo , Garcia Lourdes , Tolosa Mercedes , Ferrer Juan Carlos , Sanchez Carlos

Objective: To evaluate the role of thyroid blod flow assessment by color-flow Doppler ultrasonography in the differential diagnosis of thyrotoxicosis in an outpatient endocrinology clinic.Material and methods: Consecutive patients with thyrotoxicosis presenting to our center between January–December 2013 were included in the study. Clinical date were collected and measurements of TSH, serum free thyroxine and TSH receptor antibodies were performed. ...

ea0035p968 | Thyroid (non-cancer) | ECE2014

Evaluation of epicardial adipose tissue thickness in patients with overt hyperthyroidism

Binnetoglu Emine , Asik Mehmet , Altun Burak , Gunes Fahri , Sen Hacer , Gazi Emine , Erbag Gokhan , Bilen Yildiz Garip , Akbal Erdem , Temiz Ahmet , Barutcu Ahmet , Bekler Adem , Ukinc Kubilay

Objective: Thyroid diseases are among the most common endocrine disease and with a prevalence of 1.2%. Thyroid hormones have several effects on cardiovascular system. Many studies showed the association between hyperthyroidism and acute ischemic heart disease with conflicting results. Epicardial adipose tissue (EAT) thickness is a marker of atherosclerosis and independent predictor of coronary artery disease. In this study, we aimed to evaluate the EAT thickness in patients wi...

ea0035p969 | Thyroid (non-cancer) | ECE2014

Evolution of thyroid function in Hashimoto's thyroiditis and related disorders–January 2014

Poiana Catalina , Carsote Mara , Staicu Cristina Daniela , Clodeanu Alexandrina , Peretianu Dan

Aim: Analyzing the evolution of thyroid function in thyroiditis and related disease between 1–20 years.Material and method: i). Diagnostic: Hashimoto thyroiditis (HT): 1. antithyroperoxydase antibodies (ATPO), cut-off 34 ui/ml. 2. if ATPO=normal, thyroiditis was considered if high antithyroglobuline antibodies (T-ATG); 3. idiopathic mixedema (IM): hypothyroidism with no ATPO, no A...

ea0035p970 | Thyroid (non-cancer) | ECE2014

Immune associations in chronic thyroiditis – January 2014

Carsote Mara , Poiana Catalina , Staicu Cristina Daniela , Clodeanu Alexandrina , Peretianu Dan

Material and method: i). Patients: A. ‘Classical’ Hashimoto thyroiditis (hyper-ATPO-emia, HT) =1293, B. thyroiditis with isolated hyper-ATG-emia, with normal ATPO (T-ATG) =92, C. thyroiditis ‘sero-negative’ (normal ATPO and ATG, pathology diagnosis) =11, D. idiopathic myxedema (hypothyroidism, no A,B,C) =86; E. control=1219. 2. Statistical analysis: X2 test, z test.Results:...

ea0035p971 | Thyroid (non-cancer) | ECE2014

Relationships between antithyroperoxydase antibody and antithyroglobulin antibody levels with thyroid function in chronic thyroiditis – January 2014

Carsote Mara , Poiana Catalina , Daniela S Cristina , Clodeanu Alexandrina , Peretianu Dan

Aim and Objectives: Is Hashimoto thyroiditis (HT) different from thyroiditis with only antithyroglobulin antibodies (T-ATG)?Material and method: i). Diagnosis: ATPO >34 ui/ml = HT; ATPO normal with high ATG (>34 ui/ml) =T-ATG. ii). Thyroid function: TSH. iii). Patients: HT=1293, T-ATG=92. iv). Statistical analysis: Student tα, linear correlation tests....

ea0035p972 | Thyroid (non-cancer) | ECE2014

Efficacy of different models for explaining the endocrine surgery operative procedure

Mayilvaganan Sabaretnam , Cheenabassappa Shivaprasad

The acceptance of any operative or interventional procedures depends on the capability of the surgeon to explain the procedure in detail and also associated complications without undue fear to the patient. The aim of this prospective randomised study is to establish an ideal model for the surgeon to explain. We used three models for explaining the procedure of hemithyroidectomy (removal of diseased lobe plus the isthumus and a cuff of contralateral lobe and pyramidal lobe if p...

ea0035p973 | Thyroid (non-cancer) | ECE2014

Hyperprolactinaemia in patients with hypothyroidism

Themeli Yllka , Mustafaraj Kozeta , Barbullushi Myftar , Gjokutaj Aqif

Aim: To determine the prevalence of hyperprolactinaemia in patients with newly diagnosed subclinical and overt hypothyroidism, and to investigate the change in PRL levels during and after the treatment.Methods: In this study were enrolled 100 patients, which have been diagnosed with hypothyroidism during a 2 year period, in ‘IKEDA’ hospital, DC ‘’ and DC ‘La vita’, and 100 healthy persons as controls. Lactating and pre...

ea0035p974 | Thyroid (non-cancer) | ECE2014

Management of hypothyroidism in pregnancy

Bohacikova Andrea , Bullimore David , Pereira Olivia

Until 12th week of gestation foetus is entirely dependent on maternal thyroxine. Inadequate thyroxine replacement may lead to lower IQ of offspring and also an increased miscarriage rate.We audited 68 hypothyroid pregnant females to assess whether management of their thyroid status had met current standards. In the first trimester TSH is not an optimal monitoring marker as it is supressed by rising HCG level. According to established clinical guidelines ...

ea0035p975 | Thyroid (non-cancer) | ECE2014

Pregnancy outcomes in women with subclinical hypothyroidism

Themeli Yllka , Mustafaraj Kozeta , Habibaj Julian

Aim: To evaluate pregnancy outcomes, such as spontaneous abortion, preterm delivery, and antepartum or postpartum hemorrhage, in relation to thyroid peroxidase antibody (TPOAb) level during thyroxine replacement for subclinical hypothyroidism.Materials and methods: This study included 50 pregnant women with subclinical hypothyroidism, which were followed from the beginning to the end of their pregnancy. Levothyroxine was supplemented to maintain TSH betw...

ea0035p976 | Thyroid (non-cancer) | ECE2014

Serum C-reactive protein level is a better indicator than erythrocyte sedimentation rate in assessing the severity of inflammation before initiation of glucocorticoid therapy in the sub acute thyroiditis patients

Baruah Manash , Bhattacharya Bhaskar

Background: Serum C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are useful indicators of inflammation in patients with sub-acute thyroiditis. Despite the widespread use of several diagnostic tests, the purpose of this study was to compare the usefulness serum CRP and ESR in deciding which patient requires of glucocorticoid therapy.Methods: A total of 28 patients with sub-acute thyroiditis, included in this study. Serum CRP and ESR mea...

ea0035p977 | Thyroid (non-cancer) | ECE2014

Body mass analysis in patients with Hashimoto thyroiditis

Poplawska-Kita Anna , Telejko Beata , Siewko Katarzyna , Kosciuszko-Zdrodowska Maria , Wawrusewicz-Kurylonek Natalia , Kretowski Adam , Hryiewicka Justyna , Dzieciol Janusz , Bauer Witold , Szelachowska Malgorzata , Gorska Maria

Aim: In Hashimoto thyroiditis (HT) thyroid cells show abnormalities in the intracellular iodine metabolism, associated with the changes in the expression of key proteins involved in the biosynthesis of: thyroid peroxidase (TPO), thyroglobulin (Tg), sodium iodide symporter (NIS) and pendrin. The aim of the present study was to compare the expression of thyroid-specific genes, such as NIS and Tg, as well as pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF&#9...

ea0035p978 | Thyroid (non-cancer) | ECE2014

Body mass analysis in patients with Hashimoto thyroiditis

Poplawska-Kita Anna , Siewko Katarzyna , Telejko Beata , Kosciuszko-Zdrodowska Maria , Hryniewicka Justyna , Szelachowska Malgorzata , Milewski Robert , Gorska Maria

Introduction: Thyroid hormones deficiency in the course of subclinical and overt hypothyroidism is frequently related to the increased body mass, reduced thermogenesis and metabolic rate however the pathogenesis of improper body mass in Hashimoto thyroiditis (HT) patients is still an open question. Therefore, in the present study we compared body mass and body composition between the patients with Hashimoto thyroiditis who were in clinical and hormonal euthyreosis and healthy ...

ea0035p979 | Thyroid (non-cancer) | ECE2014

Ultrasound-guided thyroid fine needle aspiration with rapid on-site evaluation of adequacy: data from the clinic of endocrinology of a Greek tertiary general hospital in 2013

Fountoulakis Stelios , Papanastasiou Labrini , Koutmos Spiros , Charalambous Pinelopi , Stratigaki Aimilia , Panagouli Pelagia , Lazari Paraskevi , Asimis Eleptherios , Vlahou Melpomeni , Piaditis George

Introduction: Ultrasound-guided fine needle aspiration biopsy (US-FNAB) enables selective sampling of thyroid follicular cells while minimizing potential complications. Inadequate specimen sampling can lead to FNAB repeat. Our aim was to evaluate the morphological and cytological characteristics of thyroid nodules with US and rapid on-site evaluation of adequacy (ROSE).Methods: Two independent endocrinologists evaluated nodule characteristics of 171 US-F...

ea0035p980 | Thyroid (non-cancer) | ECE2014

An ectopic thyroid tissue presenting as anterior mediastinal mass in a breast cancer patient

Onal Eda Demir , Aydin Cevdet , Sacikara Muhammed , Ozdemir Elif , Ersoy Reyhan , Cakir Bekir

Introduction: Ectopic thyroid tissue is the result of abnormal gland migration from the foramen caecum to its normal pretracheal position. An ectopic thyroid can be lingual (at the base of the tongue), sub-lingual (below the tongue), prelaryngeal (in front of the larynx), or can be found at other rare sites. The most frequent noncervical location for ectopic thyroid tissue is the thoracic cavity. Here we discuss about a rare case of mediastinal ectopic thyroid tissue presentin...

ea0035p981 | Thyroid (non-cancer) | ECE2014

Hyperthyroidism in a pregnant woman who had hypothroidism due to Hashimoto disease before

Onal Eda Demir , Isik Serhat , Saglam Fatma , Ersoy Reyhan , Cakir Bekir

Introduction: Pregnant women with known hypothyroidism must have monthly follow up with thyroid function tests. Appropriate L-thyroxin replacement dose can be given due to trimester specific thyroid stimulating hormone (TSH) levels. We will discuss about a hyperthyroid pregnant woman who was taking L-thyroxin replacement before and during the first trimester of pregnancy for hypothyroidism.Case: A 24-year old woman came to o...

ea0035p982 | Thyroid (non-cancer) | ECE2014

Treatment of severe thyroid function disorders and observed changes in body composition

Stangierski Adam , Guzik Przemyslaw , Ruchala Marek

Hyper- and hypothyroidism are accompanied by significant changes in basic metabolic rate, balance of catabolic and anabolic processes, thermogenesis and ultimately in body weight. The aim of this pilot study was to estimate changes in body composition during certain stages of treatment in patients with severe hypo- and hyperthyroidism; current relation between observed hormonal status and body composition and ultimately the relation between changes in body composition and chan...

ea0035p983 | Thyroid (non-cancer) | ECE2014

Role of conventional ultrasonography and shear wave elastography in selection lesions for fine needle aspiration biopsy in multinodular goiter - preliminary study

Stangierski Adam , Wolinski Kosma , Szczepanek-Parulska Ewelina , Gurgul Edyta , Ruchala Marek

Introduction: According to a high prevalence and relatively low occurrence of malignancies in thyroid nodular disease (TND), the selection of suspicious lesions for fine – needle aspiration biopsy (FNAB) seem to be a vital problem in the daily endocrinological practice. Beside deciding if the FNAB is necessary, frequently the second problem occurs – which nodule or nodules should be chosen in case of multinodular goiter (MNG), when the number of potential lesions for...

ea0035p984 | Thyroid (non-cancer) | ECE2014

Does iodine status have an impact on thyroid parameters in healthy pregnant women during the first trimester?

Amani Mohammed El Amine , Chentli Farida

Introduction: Iodine deficiency has serious consequences for both the mother and the offspring, it is a real public health problem. Our aim was to study the iodine status impact on thyroid parameters during the first trimester of pregnancy in women free of any current or previous thyroid disease.Patients and methods: Prospective study, on 145 pregnant women (mean age of 29.4±0.5 years) at 10.4±0.2 weeks of gestation. Women with disrupted thyroi...

ea0035p985 | Thyroid (non-cancer) | ECE2014

This is why we recommend the screening for hypothyroidism in pregnant women

Amani Mohammed El Amine , Chentli Farida

Introduction: Hypothyroidism is known for its adverse effects for both the pregnant woman and her offspring. Our aim is to highlight the benefits of screening for hypothyroidism in all pregnant women with and without risk factors.Patients and methods: Prospective study, on 270 pregnant women. Women with disrupted thyroid balance, who smoke (active smoking confessed) and those followed for thyroid disease or taking medications that interfere with the thyr...

ea0035p986 | Thyroid (non-cancer) | ECE2014

Polymorphisms within genes encoding co-stimulatory molecules modulate the susceptibility to Graves' disease and orbitopathy

Daroszewski Jacek , Pawlak-Adamska Edyta , Przemyslaw Janusz , Frydecka Irena , Karabon Lidia , Jonkisz Anna , Tomkiewicz Anna , Partyka Anna , Lebioda Arleta , Bolanowski Marek

The clinical presentation of Graves’ disease (GD) depends on the combination of environmental and genetic factors. The CTLA-4 and CD28, ICOS genes encoding negative and positive regulator of the T-lymphocyte immune response, are candidate genes for conferring susceptibility to thyroid autoimmunity.Polymorphisms in genes: CTLA-4: g.319C>T (rs5742909), c.49A>G (rs231775), g.*642AT(8_33), CT60 (g.*6230G>A, rs3087243), Jo31...

ea0035p987 | Thyroid (non-cancer) | ECE2014

Comparison of aspiration vs with-out aspiration fine-needle biopsy of thyroid nodules for adequacy of cellularity according to Bethesda system

Aydin Cevdet , Sacikara Muhammed , Onal Eda Demir , Dirikoc Ahmet , Yazgan Aylin Kilic , Ersoy Reyhan , Cakir Bekir

Introduction: Fine-needle aspiration (FNA) is a simple, the most cost-effective, less invasive and a commonly used diagnostic tool for evaluating thyroid nodules. Recent times a tech-nique called fine-needle sampling non-aspiration (FNNA) or fine-needle capillary thyroid biopsies (FNC) has been more preferred. This technique prevents the use of suction so there is no aspiration crush and there-fore nondiagnostic outcomes are reduced. The aim of this prospective study was to co...

ea0035p988 | Thyroid (non-cancer) | ECE2014

Long-term efficacy of ultrasound-guided laser ablation for solid thyroid nodules. A three-year multicenter prospective randomized trial

Papini Enrico , Rago Teresa , Gambelunghe Giovanni , Valcavi Roberto , Bizzarri Giancarlo , Vitti Paolo , De feo Pierpaolo , Misischi Irene , Di Stasio Enrico , Pacella Claudio Maurizio

Background: Thermal ablation techniques are reported to significantly decrease thyroid nodule volume in several single-center short-term series. The present trial on ultrasound (US)-guided laser ablation (LAT) of solid thyroid nodules is addressed to assess long-term clinical efficacy, side-effects and variability of outcomes in different centers operating with the same LAT procedure.Patients: Two hundred and one consecutive patients were randomly assign...

ea0035p989 | Thyroid (non-cancer) | ECE2014

Radio frequency ablation (RFA) and percutaneous laser ablation (PLA) in the treatment of thyroid nodules under ultrasound (US) guidance: Preliminary evaluation

Camerieri Laura , Turtulici Giovanni , Corazza Angelo , Schiaffino Simone , Sartoris Riccardo , Silvestri Enzo

Purpose: The purpose of our study is to compare the effectiveness of PLA and RFA procedures in the treatment of benign thyroid nodules discussing indications, techniques, complication and outcomes derived from our experience.Method and materials: Thirty-eight patients (26F; 55±14) with benign thyroid nodules were treated, 15 with PLA and 23 with RF. Nodules were classified as thy2 through two consecutive fine-needle-aspiration (FNA) and selected for...

ea0035p990 | Thyroid (non-cancer) | ECE2014

The prevalence of coexistence thyroid carcinoma and thyroid nodules in hyperthyroid patients of San Juan City Hospital

Santiago Monica , Hernan-Martinez Jose , Palermo Coromoto , Figueroa Carlos , Trinidad Rafael , Mangual Michelle , Gutierrez Madeleine , De Lourdes Miranda Maria , Gonzalez Eva

Hyperfunctional nodules of the thyroid are rarely associated with thyroid cancer, for these reason are rarely biopsied. Although multiple theories have being proposed, the relationship is still uncertain. After performing a MEDLINE literature search, we found in multiple retrospectives analysis, that patients with hyperthyroidism with hyperfunctional nodules have an estimated of 0.3–16.3% prevalence of malignancy. In our study forty-eight hyperthyroid cases were prospecti...

ea0035p991 | Thyroid (non-cancer) | ECE2014

Multifocal sclerosing thyroiditis: a case report

Guresci Servet , Dogan Bercem Aycicek , Erkilinc Gamze , Tuna Mazhar Muslum , Kulacoglu Sezer , Guler Serdar

Introduction: Multifocal sclerosing thyroiditis (MST) is a recently proposed histopathological diagnosis for thyroidectomy specimens that have ≥1 radial scar-like foci. Despite the inclusion of the term thyroiditis, MST is not related to other well-known types of thyroiditis and does not have a specific clinical presentation.Case report: A 30-year-old female presented clinic due to thyrotoxicosis. She did not have any symptoms related to thyrotoxic...

ea0035p992 | Thyroid (non-cancer) | ECE2014

Virtually-tracked US-guided radio frequency ablation of benign thyroid nodules: preliminary evaluation

Camerieri Laura , Turtulici Giovanni , Corazza Angelo , Schiaffino Simone , Sartoris Riccardo , Silvestri Enzo

Purpose: Our purpose was to evaluate the safety and effectiveness of a virtual needle tracking system for US-guided percutaneous RFA of benign thyroid nodules (BTN) as compared to standard RFA.Method and materials: A STARmed (Korea) 18G bipolar RF electrode was used to perform the BTN ablation procedures. A US machine (LOGIQ E9, GE Healthcare) with a low magnetic field generator was used; electromagnetic sensors, calculating their mutual position, were s...

ea0035p993 | Thyroid (non-cancer) | ECE2014

Mean platelet volume in euthyroid patients with Hashimoto's thyroiditis

Carliuglu Ayse , Timur Ozge , Durmaz Senay Arikan , Ayhan Mehmet Emin

Aim: Hashimoto’s thyroiditis (HT) is an autoimmune disease in which a breakdown of immune tolerance is caused by interplay of a variety of immunologic, genetic, and environmental factors. Mean platelet volume (MPV) is the measure of platelet size. MPV possibly is a simple way to estimate platelet activity. Activated platelets play an important role in the pathogenesis of vascular disease especially coronary heart diseases. Larger platelets are metabolically and enzymatica...

ea0035p994 | Thyroid (non-cancer) | ECE2014

Frequency of isolated maternal hypothyroxinemia at gestational diabetes mellitus

Oguz Ayten , Gul Kamile , Sahin Murat , Usluogullari Alper Celil , Usluogullari Betul , Tuzun Dilek

Aim: Our aim was to investigate the frequency of isolated maternal hypothyroxinemia (IMH) at gestational diabetes mellitus (GDM)Material and method: Fifty women with GDM aged between 20–41 and 100 healthy pregnant aged between 17–41 were involved to study. Patients that have thyroid disease and low free T4 levels at first trimester were ruled out. Thyroid function tests of patients and healthy controls were assessed at first, second ...

ea0035p995 | Thyroid (non-cancer) | ECE2014

Hyperthyroidism one of the cause of pulmonary hypertension

Dokupilova Adriana , Payer Juraj , Vahala Pavel

Introduction: Hyperthyroidism is a common endocrine disorder that is associated with prominent cardiovascular manifestations. Recent studies also suggest a potential link between hyperthyroidism and pulmonary hypertension (PH). Right-sided heart failure with clinical manifestation is only occasionally seen in patients with Graves’ disease. The prevalence and pathogenic mechanisms of hyperthyroidism-related PHT remain unclear but based on literary data an autoimmune mechan...

ea0035p996 | Thyroid (non-cancer) | ECE2014

Irisin – newly discovered adipo-myokine and its association with thyroid function – preliminary study

Zybek Ariadna , Szczepanek-Parulska Ewelina , Ruchala Marek

Introduction: Irisin is a recently reported adipo-myokine. To date, many researchers underline its significant influence on the body metabolism and thermogenesis. Secreted by muscle and adipose tissue irisin promotes a program of subcutaneous white adipose tissue ‘browning’. As a result, heat production and general energy expenditure raise. Irisin is considered to be a potential mediator of the health-promoting role of physical exercises. Its possible compensatory ro...

ea0035p997 | Thyroid (non-cancer) | ECE2014

Thyroid function during pregnancy

Mladenovic Violeta , Djukic Aleksandar , Macut Djuro

Background: The levels of maternal thyroid hormone concentrations increase from early pregnancy, with a mild increase in free hormones in the first trimester with a corresponding lowering of serum TSH. Thyroid autoantibodies are found in 5–15% of women during childbearing age, and chronic autoimmune thyroiditis is the main cause of hypothyroidism. Thyroid hormone contributes critically to normal fetal brain development. In the first trimester, the ‘normal’ range...

ea0035p998 | Thyroid (non-cancer) | ECE2014

FT3 level is a predictor of mortality in hemodialysis patients in 5 years follow-up

Gasiorek Malgorzata , Marczewski Krzysztof

Introduction: The low FT3 syndrome is known as associated with a high risk of death within a short time. Less is a long-term observations, and only a few concerning patients on chronic dialysis.The aim of the study was to evaluate whether the value of thyroid hormones on hemodialysis are a predictor of risk of death in the follow-up of 5 years.Results: The study included 89 patients (58 men) undergoing dialysis in the period from 0...

ea0035p999 | Thyroid (non-cancer) | ECE2014

Serum leptin levels among women with and without autoimmune thyroid disease in euthyroid state

Drobniak Artur , Radowicki Stanislaw , Kanecki Krzysztof

Introduction: Autoimmune thyroid disease (AITD) with elevated antithyroid peroxidase antibodies (aTPO) levels appear in 12–25% of women and is observed more frequently in patients with polycystic ovary syndrome and endometriosis. Some data showed the interference of elevated thyroid antibodies and infertility and worsening quality of life.Aim: The aim of the study was to determine serum leptin levels among AITD(+) and AITD(−) patients.<p c...

ea0035p1000 | Thyroid (non-cancer) | ECE2014

Delayed puberty and early menopause in women with GH deficiency

Circo Eduard

Introduction: Involvement of growth hormone in the maturation and function of the ovary is proved by a series of clinical observations.Scope: Assessing serum levels of IGF1 as a marker of GH activity correlated to age of onset of menarche and menopause.Method: The study groups consisted of 41 patients (group 1) with GH deficiency diagnosed before the age of 8 years and a group of 18 adult patients with pituitary dwarfism who had ea...

ea0035p1001 | Thyroid (non-cancer) | ECE2014

Amyloid goiter as an unusual presentation of primary systemic amyloidosis: A case report

Nuhoglu Irfan , Civan Nadim , Ucuncu Ozge , Kocak Mustafa , Coskun Hulya , Turgutalp Havva , Ersoz Halil Onder , Erem Cihangir

Introduction: Deposition of amyloid substance within the thyroid gland causing clinically appearent enlargement of the gland is described as amyloid goiter. Although microscopic deposition of amyloid substance in thyroid gland is common in systemic amyloidosis, occurence of amyloid goiter is rare.Case: A 55 years old male patient, who had been diagnosed with multinodular goiter for 10 years, was admitted to our clinic with complaint of increased swelling...

ea0035p1002 | Thyroid (non-cancer) | ECE2014

Thyroid disorders in systemic lupus erythematosus: Influence of hypothyroidism on clinical manifestations and analytical parameters

Blanco Manuel Cayon , Almagro Raul Menor , Mateos Carolina Garcia-Figueras

Introduction: The association of systemic lupus erythematosus (SLE) and dysthyroidism has been reported by several studies in a wide range of variability but studies focused on the influence of hypothyroidism on classic manifestations of SLE are scarce. Our purpose was to evaluate the prevalence of thyroid diseases in a cohort of SLE patients and the relevance of hypothyroidism with clinical and analytical parameters related to lupus.Methods/design: One ...

ea0035p1003 | Thyroid (non-cancer) | ECE2014

Relationship between hypothyroidism and autoimmunity in systemic lupus erythematosus patients: An initial approach

Blanco Manuel Cayon , Almagro Raul Menor , Mateos Carolina Garcia-Figueras , Rodriguez Gutierrez Francisco J

Introduction: Hypothyroidism is the most frequent thyroid disorder in patients with systemic lupus erythematosus (SLE) but the cause of this association is not well established. Moreover, no studies focused on the possible relationship between some specific immunologic patterns of SLE and the development of hypothyroidism have been reported.Methods: In our study, we determined the immunological features and the thyroid status of 103 consecutive patients ...

ea0035p1004 | Thyroid (non-cancer) | ECE2014

Thyroid disorders in adults after oncologic treatment in childhood

Ben-Skowronek Iwona , Sadurska Elzbieta , Zaucha-Prazmo Agnieszka , Brodzisz Agnieszka , Philip Ruby , Patel Sangita

Introduction: The length of patient survival after cancer treatment is increasing and, in some cases, does not differ from the average life span in healthy individuals. The aim of the study is to evaluate thyroid function after oncologic treatment in children.Description of Methods: A group of 158 patients aged 16–25 who underwent oncologic treatment in childhood and the control group – 66 children and young adults were examined. The prospectiv...

ea0035p1005 | Thyroid (non-cancer) | ECE2014

Iodine deficiency in Belarus: state of the problem

Mokhort Tatiana , Kolomiets Natalia , Petrenko Sergey , Mokhort Alena

Introduction: Belarus is included into an iodine deficiency region of Central Europe. Therefore the National program widely was introduced from 1999. This program included salt iodization with KIO3, using of iodizated salt in the food industry and in the field of catering.The purpose of the research is iodine status monitoring in the Republic of Belarus from 1999 to 2012.The investigations included determination of the t...

ea0035p1006 | Thyroid (non-cancer) | ECE2014

A case with silent thyroiditis accompanied by repeated deep vein thrombosis

Kumagai Naoko , Honda Kazufumi , Sorimachi Erisa

Case presentation: A 40-year-old woman was admitted to the department of cardiology in our hospital due to iliofemoral deep vein thrombosis (DVT) in August 2010. It seemed that thrombosis was induced by the oral contraceptive (OC) which she had taken. Her serum level of von Willebrand factor was elevated. After the admission, the insertion of a temporary inferior venous cava (IVC) filter and thrombectomy were performed as well as starting of thrombolytic therapy and discontinu...

ea0035p1007 | Thyroid (non-cancer) | ECE2014

The metabolic syndrome, and not obesity, is associated with fasting TSH in euthyroid obese children and adolescents

Martucci Federico , Magni Serena , Rossetti Paola , Manzoni Giuseppina , Di Candia Stefania , Weber Giovanna , Frittitta Lucia , Bonfanti Riccardo , Perseghin Gianluca

Increased serum TSH has been reported in obese children and adolescents and is considered an adaptive mechanism secondary to obesity. This study was undertaken to test the hypothesis that this adaptation is not associated with obesity per se but with its related metabolic alterations. Using a cross-sectional approach, we collected retrospectively fasting serum TSH concentration (if within the normal range), anthropometric parameters and criteria for the diagnosis of t...

ea0035p1008 | Thyroid (non-cancer) | ECE2014

Recurrence of Graves' disease after radioiodine treatment: factors related to treatment failure

Moreno Carolina , Pires Luis , Cardoso Luis , Ruas Luisa , Saraiva Joana , Guelho Daniela , Vicente Nuno , Costa Gracinda , Carrilho Francisco

Introduction: Radioiodine (RAI) therapy is an inexpensive and reliable therapeutic option for Graves’ disease (GD). However, individual characteristics of the disease can influence therapeutic success. The identification of these factors may help to predict outcome and select optimal pre-treatment conditions.Aim: To assess clinical, laboratory and radioactive parameters that may lead to RAI treatment failure in patients with GD....

ea0035p1009 | Thyroid (non-cancer) | ECE2014

Severe side effects of methimazole in the treatment of hyperthyroidism

Moreno Carolina , Alves Marcia , Paiva Isabel , Rodrigues Dircea , Ruas Luisa , Saraiva Joana , Guelho Daniela , Vicente Nuno , Cardoso Luis , Carrilho Francisco

Introduction: Methimazole is the thionamide compound most used in the treatment of hyperthyroidism due to its efficacy, commodity and security. Severe side effects are rare, although potentially fatal: agranulocytosis in 0.1–0.5% and toxic hepatitis in 0.1%Aims: To characterize the patients admitted in the endocrinology ward for the last 10 years for severe complications of methimazole therapy.Material and Methods: Retrospecti...

ea0035p1010 | Thyroid (non-cancer) | ECE2014

Proteomic analysis of thyroid tissue in Graves' disease and toxic multinodular goiter

Karadag Duygu Temiz , Cetinarslan Berrin , Kasap Murat , Canturk Nuh Zafer , Akpinar Gurler , Canturk Zeynep , Tarkun Ilhan , Selek Alev

Introduction: Graves’ disease and toxic multinodular goiter are known to have different etiologies and pathogenesis, which are not fully comprehended today. This study compares the protein profiles of Graves’ disease and toxic multinodular goiter patients’ thyroid samples using proteomics methods and investigates the role of differentiating proteins in the pathogenesis of these diseases.Methods and Design: Difference Gel Electrophoresis (D...

ea0035p1011 | Thyroid (non-cancer) | ECE2014

Hyperglycaemia in hypothyroidism

Azzoug Said , Chentli Farida , Chellali Souad , Boudissa Fatma Zohra , Koceir El Hadj Ahmed

Thyroid hormones disturbances may lead to glucose metabolism abnormalities but little is known about the risk of hyperglycaemia in hypothyroidism.The aim of our study is to determine the frequency and the predisposing factors to hyperglycaemia in hypothyroidism.Subjects and methods: It is a retro and prospective study including 425 hypothyroid subjects (383 F/42 M). We search for hyperglycaemia which means fasting glycaemia ≥...

ea0035p1012 | Thyroid (non-cancer) | ECE2014

May dental extraction trigger subacute thyroiditis?

Onbasi Kevser , Hatipoglu Hasan , Ucgun Serdar , Hatipoglu Mujgan

Introduction: Subacute thyroiditis (SAT) is a self-limiting thyroid disease associated with a triphasic clinical course of hyperthyroidism, hypothyroidism, and return to normal thyroid function. The well-known clinical features of SAT include thyroid pain with symptoms of hyperthyroidism, suppressed level of thyroid-stimulating hormone (TSH), low thyroid uptake of radioactive iodine, and elevated erythrocyte sedimentation rate. Diagnosis is based on clinical and laboratory dat...

ea0035p1013 | Thyroid (non-cancer) | ECE2014

Anti-C1q autoantibodies are linked to autoimmune thyroid disorders in pregnant women.

Vitkova Hana , Jiskra Jan , Springer Drahomira , Limanova Zdenka , Telicka Zdenek , Bartakova Jana , Potlukova Eliska

Introduction: Anti-C1q antibodies have been implicated in the pathogenesis of systemic lupus erythematosus. We have previously shown that anti-C1q antibodies are also linked to autoimmune thyroid disorders (AITD). The aim of this study was to assess the occurrence of anti-C1q antibodies in pregnant women with AITD.Methods: Serum anti-C1q antibodies were measured during the 9–11th gestational weeks in 103 pregnant women screened positive for AITD, an...

ea0035p1014 | Thyroid (non-cancer) | ECE2014

Whether various ways of quality of life answer rank-transformation influence on final score and grouping among hypothyroid patients?

Gluvic Zoran , Mitrovic Bojan , Lackovic Milena , Simovic Nikola , Vujovic Marina , Jevtic Jelena Tica , Popovic-Radinovic Vesna , Rasic-Milutinovic Zorica , Radovic Milica , Popin-Taric Marija , Vasic-Vlasiavljevic Anita , Paunovic Nevena , Milivojevic Esma Isenovic

Quality of life (QoL) of hypothyroid patients can be estimated by use of numerous instruments (GHQ12 and TQ20). By rank transformation of obtained answers, calculated QoL score further determined groups, named as no distress (0–15 patients.), minor distress (16–24 patients.) and major distress (≥25 patients.). Rank transformation can be performed through Likert 0–3 as well modified 0–4 model. To groups with distress, levo-thyroxine (L-T...

ea0035p1015 | Thyroid (non-cancer) | ECE2014

Differences in genetic predisposition to Graves' disease and Graves' orbitopathy between young and elderly patients

Jurecka-Lubieniecka Beata , Ploski Rafal , Kula Dorota , Stechly Tomasz , Krol Aleksandra , Bednarczuk Tomasz , Tukiendorf Andrzej , Kolosza Zofia , Jarzab Barbara

Background: Graves’ disease (GD) is a complex disease in which genetic predisposition is modified by environmental factors. The pathogenesis of GD and Graves’ orbitopathy (GO) might have a different genetic background – in some patients GO is observed before or late after diagnosis of GD hyperthyroidism. The aim of the study was to assess genetic predisposition to GD and GO in young patients (age of diagnosis ≤30 years of age), in which the time of environ...

ea0035p1016 | Thyroid (non-cancer) | ECE2014

Different therapeutic outcomes in two cases with active moderate-to-severe Graves'orbitopathy treated with intravenous steroid therapy-case presentation

Zosin Ioana , Vlad Mihaela , Balas Melania , Bolintineanu Carmen

Background: Graves’ orbitopathy (GO) comprises mild, moderate-to-severe and severe forms. The treatment is complex, depending on the activity and severity of the disease. Patients with active moderate-to-severe GO benefit by correction of thyrotoxicosis and glucocorticoids (GC), as first-line agents. Approximately 20-40% of cases are not responsive to GC therapy.Case presentations: There are presented two cases with active moderate-to-severe GO trea...

ea0035p1017 | Thyroid (non-cancer) | ECE2014

Adipokines and cardiovascular risk factors in patients with autoimmune thyroiditis and subclinical hypothyroidism

Neves Celestino , Esteves Cesar , Sokhatska Oksana , Palmares Carmo , Carvalho Davide , Delgado Luis , Medina Jose Luis

Aim: To evaluate the serum levels of resistin and adiponectin, and the potential relationship between these adipokines, thyroid function, lipid profile, C-reactive protein (CRP) and homocysteine levels in patients with autoimmune thyroiditis (AIT) and subclinical hypothyroidism (SCH).Methods: patients with AIT (58 females; 47.7±16.7 years) were studied; 33 of them had also SCH. These patients were diagnosed by a positive result in an anti-peroxidase...

ea0035p1018 | Thyroid (non-cancer) | ECE2014

Oxidative stress in patients with Basedow–Graves' disease

Petrulea Mirela

Basedow–Graves’ disease is an autoimmune disorder and the most frequent cause of hyperthyroidism.Increased thyroid hormone concentrations change cellular oxidative metabolism, determining the formation of reactive oxygen species.Objectives: To study oxidant–antioxidant status and the effect of antithyroid drugs on oxidative stress parameters in Basedow–Graves’ disease patients.Materials and methods: The stu...

ea0035p1019 | Thyroid (non-cancer) | ECE2014

Oral solution of levothyroxine vs tablets in subclinical hypothyroidism: evaluation of outcomes

Pastore Renato , Mentuccia Daniela , Ylli Dorina , Ilaria Giordani , Simona Frontoni

Introduction: Oral levothyroxine (LT4) is the standard treatment for hypothyroidism and serum TSH represents the best marker for assessing the proper LT4 dose. The absorption and bioequivalence of different commercial LT4 preparations might be variable. The aim of this study is to compare the efficacy of levothyroxine oral solution vs tablets.Methods: Fifty-eight patients (six males, 52 females; average age, 46.9±12....

ea0035p1020 | Thyroid (non-cancer) | ECE2014

Hematological disorders in hypothyroidism: about a series of 100 cases

Haddam Ali el Mahdi , Fedala Soumeya , Meskine Djamila , Chentli Farida , Fedala Naziha

Introduction: Various hematologic disorders have been reported in hypothyroidism. They are resulting from the effect of thyroid hormones regulating the hematopoiesis.Population and methodology: 100 patients with primary hypothyroidism unsubstituted received a thyroid balance (FT4, TSH us, and Ac anti-TPO cevicale ultrasound) and hematologic exploration (FNS determination of serum ferritin, TIBC). The blood test was completed according to the r...

ea0035p1021 | Thyroid (non-cancer) | ECE2014

Vitamin D levels in autoimmune thyroiditis and a control group among the Polish population

Maciejewski Adam , Wojcicka Marlena , Roszak Magdalena , Losy Jacek , Lacka Katarzyna

Introduction: Vitamin D, primarily known for its role in calcium–phosphorus homeostasis, is also a significant immunomodulatory factor. Vitamin D deficiency has been reported in some autoimmune disorders. Recently, vitamin D level in autoimmune thyroiditis (Hashimoto’s thyroiditis (HT)) has become the subject of researchers’ interest.Objectives: This study aims to assess vitamin 25-OH-D3 levels in HT patients in comparison to a control gro...

ea0035p1022 | Thyroid (non-cancer) | ECE2014

Abstract withdrawn....

ea0035p1023 | Thyroid (non-cancer) | ECE2014

Is Clinical Activity Score (CAS) a sufficient indicator of the response to therapy with i.v. methylprednisolone (MP) and external radiotherapy (RT) for Graves orbitopathy?

Palyga Iwona , Kowalska Aldona , Mysliwiec Janusz , Gajos Grazyna , Palyga Robert , Gasior-Perczak Danuta

Introduction: Treatment of Graves orbitopathy (GO) is one of the most difficult problems in clinical endocrinology. Objective: To establish the efficacy of the regime used in the treatment of GO and to analyze methods used to determine treatment effectiveness.Material: The study involved 30 patients with moderate to severe GO (according to the classification of EUGOGO) being in the active phase of GO.Method: ...

ea0035p1024 | Thyroid (non-cancer) | ECE2014

A case of thyrotoxic hypokalemic periodic paralysis presenting with ‘U’ wave on ECG

Gezer Emre , Yurekli Banu Sarer , Kocabas Gokcen Unal

Introduction: Hypokalemic periodic paralysis (HPP), is a rare neuromuscular disorder caused by dysfunction of the ion channels in red muscle cells which is characterized by painless episodes of muscle weakness generally after strenuous exertion or a high-carbohydrate meal. However, some HPP patients secondary to thyrotoxicosis are also described.Case: A 41-year-old Caucasian man, without any chronic disease, presented to our emergency department with gen...

ea0035p1025 | Thyroid (non-cancer) | ECE2014

Does radioactive iodine ablation treatment in patients with hyperthyroidism effect on glucose metabolism?

Durmaz Senay Arikan , Carlioglu Ayse , Simsek Eda , Demirci Munir , Sevimli Hakan

Aim: Radioactive iodine (RAI) ablation therapy is used as part of the treatment for hyperthyroidism. Recently, low dose applied 131I treatment for hyperthyroidism has decreased the need for thyroidectomy. The aim of this study was to evaluate serum fasting glucose (FG) values in pre and post treatment RAI patients.Materials and Methods: Thirty-two patients with hyperthyroidism (mean age 56.0±14.5 years; range 24–83) treated with a si...

ea0035p1026 | Thyroid (non-cancer) | ECE2014

Nutriciological monitoring of iodine status as a measure of iodine deficiency prevention

Mokhort Tatiana , Kolomiets Natalia , Fedorenko Ekaterina , Mokhort Alena

Implementation strategies for the elimination of iodine deficiency in the last 10 years in Belarus has achieved the WHO evaluation criteria. This was made possible by the universal use of iodized salt in food manufacturing, food service of all types and the availability of its free-trade network salt addition.The aim of this work was to study the iodine daily intake from food, as one of the measures to monitor iodine supply of the population.<p class...

ea0035p1027 | Thyroid (non-cancer) | ECE2014

DHEAS Levels in Obese Patients with Hashimato Thyroiditis

Topsakal Senay , Akin Fulya , Yaylali Guzin F

Introduction: It is well known association between cardiovascular disease and PCOS. Approximately 17–43% of women with PCOS have hyperprolactinemia. Increased levels of prolactin often associated with an increased risk for thromboembolic events, but underline pathophisiological mechanism still unknown. The strong association between hyperprolactinemia and platelet aggregation is well known. Platelets play a key role in the development of atherothrombosis, a major contribu...

ea0035p1028 | Thyroid (non-cancer) | ECE2014

The role of peroxisome proliferator-activated receptors α polymorphisms in Graves' disease and orbitopathy

Janusz Przemyslaw , Pawlak-Adamska Edyta , Bolanowski Marek , Daroszewski Jacek

Understanding the genetic etiology of Graves’ disease (GD) and Graves’ orbitopathy (GO) is recognized as an urgent priority. Since peroxisome proliferator-activated receptors α (PPARα) exhibit anti-inflammatory and immunomodulatory activity, and are required for the control of the adipose inflammation process their role in the GD and GO pathogenesis has been proposed. Abnormal expression and/or function of PPARα could suppress the inflammatory response...

ea0035p1029 | Thyroid (non-cancer) | ECE2014

Mediastinal goiter: a rare cause of dyspnea, chest and back pain

Aydemir Mustafa , Turesin Ahmet Kerim , Ciftel Feyza , Kilicli Mehmet Fatih , Dokmetas Hatice Sebila

Primary mediastinal ectopic goiters are very rare and comprise about 1% of all mediastinal tumors. Blood supply of primary mediastinal goiter comes from local intrathoracic vessels. Compressing symptoms, diagnostic uncertainty, and the risk of malignancy support surgical excision.Case report: The patient is a 40-year-old woman with a 6-month history of progressive dyspnea, chest and back pain. Chest X-ray showed the left superior mediastinal mass was com...

ea0035p1030 | Thyroid (non-cancer) | ECE2014

Infliximab-induced destructive thyroiditis followed by hypothyroidism: a case report

Ozkan Cigdem , Altinova Alev Eroglu , Cerit Ethem Turgay , Yalcin Mehmet Muhittin , Toruner Fusun Balos , Akturk Mujde , Cakir Nuri

Introduction: Infliximab is a tumour necrosis factor (TNF) α inhibitor and used for the treatment of psoriasis. Herein, we report a case of destructive thyroiditis accompanied by transient thyrotoxicosis resulting from the infliximab therapy for the treatment of psoriasis.Case report: A 57-year-old man suffered from psoriasis and was treated with infliximab therapy for 4 years. Thyroid function tests were normal before infliximab therapy. When the p...

ea0035p1031 | Thyroid (non-cancer) | ECE2014

An increase in the circulating concentrations of triiodothyronine appears to be a function of the peripheral conversion of tetraiodothyronine by deiodinases instead of increased stimulation by thyroid stimulating hormone at puberty in normal healthy boys

Rizvi SSR , Asif Hafsa , Saqib Sadia , Perveen Nadia , Shaheen Ghazala , Naseem AA , Tahir Faheem , Qayyum Mazhar

Thyroid stimulating hormone (TSH) causes synthesis of 90% of pro-hormone tetraiodothyronine (T4) and 10% of active triiodothyronine (T3) from thyroid gland. T3 regulates energy metabolism, thermogenesis, body temperature and normal brain development. T3 is produced from deiodination of T4 and circulating levels of T3 are regulated by deiodinases in response to body’s needs. The peripheral conversion of T<su...

ea0035p1032 | Thyroid (non-cancer) | ECE2014

Interplay between ghrelin, obestatin, leptin and triiodothyronine that possibly regulate energy metabolism during the time of puberty in normal healthy boys

Rizvi S S R , Jannat Saba , Mehboob Sana , Afzal Nadia , Shaheen Ghazala , Falak Azka , Naseem A A , kokab Ghazala , Tahir Faheem , Qayyum Mazhar

Ghrelin, a putative signal of insufficient energy stores, increases in fasting states, decreases postprandially, and acts as a potent appetite stimulant increasing food intake. Obestatin affects appetite, food preferences to increase daily caloric intake and weight gain. Leptin regulates body fat mass, food intake and energy expenditure. Triiodothyronine (T3) is a determinant of adiposity, thermogenesis, glucose and lipid metabolism, appetite, food intake, and the o...

ea0035p1033 | Thyroid (non-cancer) | ECE2014

Obesity and metabolic syndrome in patients with primary acquired hypothyroidism undergoing chronic LT4 replacement therapy

Manzoni Giuseppina , Martucci Federico , Oltolini Alice , Villa Simona , Zimbalatti Dario , Lattuada Guido , Orsi Emanuela , Perseghin Gianluca

Hypothyroidism is a risk factor for obesity, central adiposity and ectopic fat accumulation. To assess whether this risk could be detected also in stable patients taking regularly the LT4 replacement therapy we assessed retrospectively the prevalence of metabolic syndrome (ATP III definition) and calculated the fatty liver index (FLI) and the visceral adiposity index (VAI) in patients attending our Outpatient Endocrinology Clinic because of known primary acquired hy...

ea0035p1034 | Thyroid (non-cancer) | ECE2014

A descriptive study on individually titrated levothyroxine in the management of South African hypothyroid patients (DeuTSH)

Oosthuizen Helena , Smuts Phillip , Onia Rudy , Kock Elsabe J E de , Jurgens Jaco C J , Schoeman Hermanus S

Background: Currently little data regarding hypothyroidism in South Africa exists, but it can be seen from international literature that a significant amount of patients, fail to reach target TSH levels.Objectives: This observational study aimed to measure the efficacy of individually titrated doses of levothyroxine to achieve a euthyroid state.Methods: Patients with hypothyroidism, treatment naïve and insufficiently controlle...

ea0035p1035 | Thyroid (non-cancer) | ECE2014

Results of preventive radioiodine therapy in euthyroid patients with history of hyperthyroidism prior to administration of amiodarone with permanent atrial fibrillation (preliminary study)

Czarnywojtek Agata , Wolinski Kosma , Gut Pawel , Czepczynski Rafal , Plazinska Maria Teresa , Kunikowska Jolanta , Kobylecka Malgorzata , Miechowicz Izabela , Krolicki Leszek , Ruchala Marek

Introduction: Radioiodine (RAI) therapy is a standard procedure in therapy of hyperthyroidism. However, the use of RAI in euthyroid patients requiring chronic administration of amiodarone (AM), in a case of lacking efficacy of other antiarrhythmic drugs might be controversial.Objective: The aim of the study was to assess the safety and efficacy of an AM therapy prior to treatment with radioiodine therapy in euthyroid patients with permanent atrial fibril...

ea0035p1036 | Thyroid (non-cancer) | ECE2014

A case with suppurative thyroiditis caused by salmonella infection

Kuzu Fatih , Acar Fatma Zor , Tikanak Sevval Peynir , Cakmak Guldeniz Karadeniz , Celebi Guven , Comert Fusun , Bayraktaroglu Taner

Introduction: Non-typhoid salmonella as the causative agent of acute bacterial thyroiditis is rarely reported. We report a case with suppurative thyroiditis caused by salmonella infection.Case report: Fifty-year old woman had fewer and recurrent pain with swelling in the left region of the neck. Physical examination revealed the weight 78 kg, the height 167 cm, blood pressure 100/70 mmHg, pulse 78/min, the body temperature 37.6 degrees. Thyroid gland was...

ea0035p1037 | Thyroid (non-cancer) | ECE2014

Grave's disease as an adverse effect of ipilimumab: first description of two cases

Coppin Mathilde , Arnault Jean-Philippe , Lameth Ileana De , Flahaut Helene , Desailloud Rachel

Ipilimumab is an immunomodulating agent for the treatment of metastatic melanoma. Ipilimumab is a human mAb which works by inhibiting cytotoxic T-lymphocyte antigen 4 (CTLA-4).CTLA4 typically works to down-regulate the T-cell response and protects self-antigens from recognition by the immune system. Since the T-cells are no longer down-regulated by this antigen, they are allowed to proliferate, thereby helping to prevent melanoma tumor evasion. As a resu...

ea0035p1038 | Thyroid (non-cancer) | ECE2014

Thyroglobulin as a biomarker of iodine deficiency

Bilek Radovan , Cerovska Jarmila , Zamrazil Vaclav

Introduction: We are presenting our results on the relationship between a concentration of urinary iodine (UI) and serum thyroglobulin (Tg) in population studies carried out on a general healthy total population that was randomly selected (individuals aged 6–98 years, 1751 males, 2420 females). 87.2% of the total population was described as the normal population with a simultaneously determined thyrotropin and free thyroxine within reference ranges....

ea0035p1039 | Thyroid (non-cancer) | ECE2014

Abstract withdrawn....

ea0035p1040 | Thyroid (non-cancer) | ECE2014

Quality of life and the psychoemotional status of the patients after radical treatment of Graves' disease

Dreval Alexander , Nechaeva Olga , Mamedova Tamara , Chikh Irina , Shestakova Tatyana , Komerdous Irina , Dreval Oleg

Methods: 157 patients (118 women and 39 men) aged from 30 to 73 years with radical treatment for Graves’ disease were included in this study. Patients were divided into two groups depending on a type of radical treatment: 76 patients have received radioiodine therapy, 81 persons received surgical treatment. Quality of life assessment was made by SF-36 questionnaire which includes eight scales: (physical functioning (PF), role physical functioning (RPF), pain (B), general ...

ea0035p1041 | Thyroid (non-cancer) | ECE2014

The induction of hyperthyroidism in patient with non-toxic goiter after radioiodine therapy: a case report

Abdelrazek Saeid , Mysliwiec Janusz , Szumowski Piotr , Kraszynska Anna

Two female patients aged 44 (PtA) and 68 years old (PtB) with non-toxic nodular goitre for more than 10 years were treated with radioiodine therapy. High resolution ultrasonography show enlarged thyroid glands 50 ml, with two nodules in left and right lobe in PtA and 58 ml with one nodule in the left lobe in PtB. Serum TSH, fT4 and fT3 were in normal ranges. Malignancy was ruled out by ultrasound-guided fine-needle aspiration biopsy. In PtA thyroid radioi...

ea0035p1042 | Thyroid (non-cancer) | ECE2014

Antithyroid drug-induced agranulocytosis: experience of the French centers of Pharmacovigilance with a retrospective study of more than 200 cases

Andres Emmanuel , Weitten Thierry , Alt-Tebacher Martine

Objective: Agranulocytosis to the antithyroid drugs is a rare adverse drug effect exposure to potentially lethal infections. It is a public health problem with hyperthyroidism in nearly 1% of the French population. However, many uncertainties remain in the knowledge, understanding, prevention and management of this drug effect. In this work, we report the French experience through pharmacovigilance data.Materials and methods: This is a retrospective stud...

ea0035p1043 | Thyroid (non-cancer) | ECE2014

Quality of life of patients with hypothyroidism

Nechaeva Olga , Dreval Alexander , Mamedova Tamara , Chikh Irina , Shestakova Tatyana , Komerdous Irina , Dreval Oleg

Materials and methods: 157 patients (118 women and 39 men) aged from 30 to 73 years with radical treatment for Graves’ disease were included in this study. The patients were divided into two groups depending: (76) included patients with low-normal level of TSH (0.4–2.0 mU/ml), the second group (81 patients) with upper-normal level of TSH 2.1–4.0 mU/ml. Quality of life was assessed with the help of the questionnaire Short-Form SF-36.Results...

ea0035p1044 | Thyroid (non-cancer) | ECE2014

ThyPROpl: the polish version of the thyroid-specific quality of life questionnaire ThyPRO

Sawicka-Gutaj Nadia , Watt Torquil , Sowinski Jerzy , Gutaj Pawel , Waligorska-Stachura Joanna , Ruchala Marek

Introduction: Thyroid disorders have significant impact on patients’ quality of life (QoL). ThyPRO is a thyroid-specific QoL questionnaire applicable to patients with benign thyroid disorders. There is substantial evidence for its clinical validity and reliability in patients with benign thyroid disorders. ThyPRO consists of 85 questions summarized in 13 scales, measuring aspects of QoL relevant to thyroid patients. Our aim was to develop a validated Polish version of thi...

ea0035p1045 | Thyroid (non-cancer) | ECE2014

Evaluation of risk of hypothyroidism in pregnant women with overweight and obesity

Senterkiewicz Lilla , Krintus Magdalena , Junik Roman , Malak Marta , Sypniewska Grazyna

Introduction: Thyroid dysfunction affect up to 5% of pregnant women and hypothyroidism complicates up to 3% of pregnancies, of which 0.3–0.5% is diagnosed as overt, 2.0–2.5% as subclinical hypothyroidism. Obesity in pregnant women may further contribute to the development of hypothyroidism and adversely affect the pregnancy. The aim of the study was to assess the risk of hypothyroidism in overweight and obese pregnant women on the basis of concentrations of TSH, free...

ea0035p1046 | Thyroid (non-cancer) | ECE2014

Amiodarone induced thyrotoxicosis, a difficult cases report

Basaran Mehtap Navdar , Imga Narin Nasiroglu , Dogan Bercem Aycicek , Tuna Mazhar Muslum , Karakilic Ersen , Isik Serhat , Tutuncu Yasemin Ates , Berker Dilek , Guler Serdar

Introduction: There are two clinical types of amiodarone induced thyrotoxicosis (AIT). Type I AIT appears with hyperthyroidism and type II with a destructive thyrotoxicosis. Treatment of type I AIT includes antithyroid drugs meanwhile type II needs steroids as the first line therapy. If there is no respond to medical treatment, surgical approach must be considered. Here in we present a type II AIT case who had no respond to combined therapy therefore treated with surgical appr...

ea0035p1047 | Thyroid (non-cancer) | ECE2014

Study of thyroid function during pregnancy in a random population of Northern Greece

Kourtis Anargyros , Xanthopoulou Eleni , Makedou Kali , Slavakis Aristides , Mane Vasileia , Rakintzi Pantelitsa , Delkos Dimitrios , Rousso David

It is well established that overt maternal hypothyroidism and subclinical hypothyroidism may be associated with an adverse outcomes for both the mother and offspring. Therefore, maternal hypothyroidism should be early diagnosed and treated.Aim: The present study was designed in order to investigate thyroid function in the three trimesters of pregnancy, according to the recently updated guidelines.Materials and methods: One hundred ...

ea0035p1048 | Thyroid (non-cancer) | ECE2014

Adherence of levothyroxine treatment in primary hypothyroid patients in Turkey: a multicenter study

Yavuz Dilek Gogas , Keskin Lezzan , Atmaca Aysegul , Dikbas Oguz , Hekimsoy Zeliha , Sahin Ibrahim , Yalin Serap , Yilmaz Murat , Uygur Melin , Yazici Dilek , Sarac Fulden , Sancak Seda , Sekizkardes Sibel , Asmaz Ozlem

Non adherence to medication schedules by patients with chronic illnesses has long been recognized as a problem. The aim of this study is to evaluate levothyroxine (L-T4) compliance, daily dosage and TSH levels under treatment in primary hypothyroid patients.We included 1636 primary hypothyroid patients over 1 year under L-T4 (F/M: 1469/167, 46±13 years of age) included from 11 tertiary health care ...

ea0035p1049 | Thyroid (non-cancer) | ECE2014

Thyroid hormone concentration and ultrasonographic findings in middle-aged lithuanian males and females from general population

Zilaitiene Birute , Sidlauskas Vygandas , Daugintyte-Petrusiene Laura , Ceponis Jonas , Vainikonyte Jelena , Kvedarauskas Kipras , Seibokaite Audrone

Introduction: Thyroid disorders are the most frequently diagnosed endocrinopathies prevalence of which is highly dependent on geographic region and age of study population.Main objective: Evaluation of thyroid function and thyroid ultrasonographic features in 48–50-year-old people from general population in Lithuania.Methods: During a 1 year period 395 randomly selected 48–50-year-aged men (169) and women (226) were enrol...

ea0035p1050 | Thyroid (non-cancer) | ECE2014

Selective embolization thyroid artery as a treatment for Graves' disease

Arzykulov Zhetkergen , Ormanov Baurjan , Shaikhiyev Yerbol , Juraev Shakir , Shokebayev Adil , Aliev Arman , Imammyrzayev Nurmakhan , Tanabaev Janat

Background: Minimally invasive surgery in short time has been widely used in many fields of medicine and endocrinology not an exception. Having a number of advantages, such as small traumatic intervention, as well as cosmetic effect.Materials and methods: Selective embolization thyroid artery (SETA), we used as an independent method of treatment Graves’ disease (GD). Following this procedure the treatment of 17 patients received for the period from ...

ea0035p1051 | Thyroid (non-cancer) | ECE2014

Postoperative monitoring and replacement therapy after resection of the thyroid gland

Tkachuk Nina , Bilookyi Viacheslav

Introduction: The problem of postoperative hypothyroidism has the same long history as thyroid surgery. Levothyroxine monotherapy is the treatment of choice for hypothyroid patients because peripheral T4 to T3 conversion is supposed to account for the overall tissue requirement for thyroid hormones.The aim of this retrospective study conducted in the hospital is to evaluate the effectiveness of levothyroxine monotherapy in patients ...

ea0035p1052 | Thyroid (non-cancer) | ECE2014

Prevalence of thyroid dysfunction and thyroid auto-antibodies among persian pregnant women

Mansouri Masoume , Hassani-Ranjbar Shirin , Mansour Asieh , Shyrzad Noshin , Keshtkar Abasali

Introduction: Maternal thyroid deficiency can induce serious adverse events on both mother and fetus during the whole period of pregnancy. The purpose of this study was to determine various epidemiological aspects of thyroid dysfunction among persian pregnant women.Methods: Four hundred-eighty pregnant women with a mean age of 26.9±5 regardless of their gestational age were registered. After recording their medical history, serum samples were collec...

ea0035p1053 | Thyroid (non-cancer) | ECE2014

Thyroid volume in adult β-thalassemic patients is smaller than in controls

Ansaloni Anna , Diazzi Chiara , Santi Daniele , Brigante Giulia , Ferrara Francesca , Pietrangelo Antonello , Rochira Vincenzo

Introduction: Thyroid function is commonly impaired in β-thalassemic patients with an estimated prevalence of hypothyroidism of 9–11%. According to literature, iron overload is the main cause of tissue damage involving both thyroid and pituitary gland, thus leading to primary or secondary hypothyroidism respectively. However, thyroid morphology has been rarely investigated in adults. The aim of this study is to evaluate thyroid volume (TV) and thyroid morphology in &...

ea0035p1054 | Thyroid (non-cancer) | ECE2014

Steroid treatment in patients with active moderate-to-severe Graves orbitopathy

Tsirouki Theodora , Giotaki Zoi , Rizoulis Andreas , Tigas Stelios , Asproudis Ioannis , Tsatsoulis Agathocles , Kapsalaki Eftychia , Tsironi Evaggelia , Koukoulis Georgios N , Bargiota Alexandra

Background: Although IV steroids are the treatment of choice for moderate-to-severe graves orbitopathy (M-S GO), the most efficacious regimen is not yet defined. Cases not responding or relapsing after steroid treatment (STx) are not uncommon and STx can cause serious adverse events. The aim of the present study is to define the steroid regimen which balances between efficacy and damage, using stir-sequence orbital-MRI (SsMRIo) as an additional objective tool for the evaluatio...

ea0035p1055 | Thyroid (non-cancer) | ECE2014

The influence of radioiodine therapy in 1600 patients with subclinical hyperthyroidism

Abdelrazek Saeid , Szumowski Piotr , Mysliewiec Janusz , Kosciuszko Maria , Szelachowska Malgorzata , Gorska Maria

The aim of our study was to assess the influence of radioiodine (131I) therapy on the achievement of euthyroidism, prevention of adverse effects on the cardiovascular and prevent evolvement to overt hyperthyroidism.Materials and methods: We treated 1600 patients refered to our department during the last 8 years, aged 23–77 years; 89% of them were females and 11% males; 520 patients with multinodular goitre (MNG), and 1080 patients with au...

ea0035p1056 | Thyroid (non-cancer) | ECE2014

Hydrolytical activity of autoantibodies to double-stranded DNA in autoimmune thyroiditis

Shipaeva Natalia

Objective: To evaluate the hydrolytical activity of autoantibodies (Ab) to double-stranded DNA using atomic force microscopy in patients with autoimmune thyroiditis.Methods: Ab to double-stranded DNA (dsDNA) IgG class were isolated from the serum of patients with autoimmune thyroiditis by DNA-affinity chromatography. Hydrolytical activity of Ab to dsDNA was confirmed by Polyacrylamide Gel Electrophoresi (PAGE). The images of Ab to dsDNA and results of ds...

ea0035p1057 | Thyroid (non-cancer) | ECE2014

Analysis of chosen polymorphisms in FoxP3 gene in children and adolescents with autoimmune thyroid diseases

Bossowski Artur , Borysewicz-Sanczyk Hanna , Wawrusiewicz-Kurylonek Natalia , Szalecki Mieczyslaw , Wikiera Beata , Barg Ewa , Mysliwiec Malgorzata , Kucharska Anna , Bossowska Anna , Gorska Maria , Kretowski Adam

Forkhead box P3 (Foxp3) is an important regulatory factor for the development and function of T regulatory cells (Tregs). Moreover it has been established that deficiency of the Foxp3 gene in Treg cells suppresses their regulatory function leading to the development of autoimmune thyroid diseases (AITDs). The aim of our study was to estimate the association of three polymorphism of FOXP3 gene with the predisposition to GD and HT in children.<p class="abst...

ea0035p1058 | Thyroid (non-cancer) | ECE2014

The clinical values of IGF1 and IGF-binding protein-3 levels in blood and thyroid nodules

Altas Ayfer , Kuzu Fatih , Haytaoglu Gurkan , Can Murat , Barut Figen , Kokturk Furuzan , Bayraktaroglu Taner

Introduction: Serum and intranodal levels of IGF1 and IGF-binding protein 3 levels (IGFBP3) were determined in patients with nodular thyroid diseases.Materials and methods: Demographic, clinicopathological and laboratorial caracteristics of the subjects were recorded. After performing fine needle aspiration biopsy, IGF1 and IGFBP3 levels were determined in blood and aspiration samples. Clinicopathological and laboratorial findings were analysed.<p cl...

ea0035p1059 | Thyroid (non-cancer) | ECE2014

Voluntary supplementation does not fully correct iodine deficiency among Latvian pregnant women: a national cross-sectional survey

Teterovska Dace , Jekabsone Anna , Tetere Elina , Kalere Ieva , Strele Ieva , Dambrova Maija , Makrecka Marina , Mezhapuke Rudolfs , Veisa Vija , Gavars Didzis , Konrade Ilze

Introduction: Low iodine intake during pregnancy may cause thyroid dysfunction, which might result in an inadequate foetal brain development. Although Latvia has been considered iodine replete, newborn TSH screening data suggest some iodine deficiency. In the absence of universal salt iodization programme we conducted a nation-wide study of pregnant women from all regions of Latvia.Methods: The study enrolled 426 pregnant women. They were asked to fill a...

ea0035p1060 | Thyroid (non-cancer) | ECE2014

THRB expression is affected by miR-26a and miR-496, but age-associated decrease of the expression of this gene in human peripheral blood mononuclear cells is not dependent on these miRNAs

Pawlik-Pachucka Eliza , Budzinska Monika , Domaszewska-Szostek Anna , Owczarz Magdalena , Gewartowska Magdalena , Kurylowicz Alina , Puzianowska-Kuznicka Monika

Introduction: Decreased function of the thyroid axis during aging is associated with a better functional performance and longer survival. This phenomenon can be a result not only of a lower production of thyroid hormones including bioavailable triiodothyronine, but also of age-associated alterations regarding triiodothyronine receptors.Methods: Functional studies regarding interaction between the 3′UTR of TRβ1 mRNA and in silico-ident...

ea0035p1061 | Thyroid (non-cancer) | ECE2014

Hyperthyroidism during pregnancy: the role of measuring maternal TSH receptor antibodies and fetal ultrasound monitoring

Gietka-Czernel Malgorzata , Debska Marzena , Kretowicz Piotr , Zgliczynski Wojciech , Oltarzewski Mariusz

Aim: To evaluate the usefulness of measuring maternal anti-TSH receptor antibodies (TRAbs) and fetal ultrasound (US) monitoring in cases of current or past maternal hyperthyroidism.Materials and methods: A 77 pregnant women with active hyperthyroidism irrespective of its cause or with history of Graves’ hyperthyroidism were observed prospectively. Maternal serum TSH, fT4, fT3, TRAbs, and fetal US were performed at baseline and ...

ea0035p1062 | Thyroid (non-cancer) | ECE2014

High mean platelet volume in hyperthyroid patients after radioactive 131I treatment

Durmaz Senay Arikan , Carlioglu Ayse , Simsek Eda , Demirci Munir , Sevimli Hakan

Introduction and objective: Recently, a lot of studies associated with high mean platelet level (MPV) in patients with hypo- and hyperthyroidism has reported in medical litherature. But it is not clear whether or not radioactive iodine treatment effect on platelet activity. It is well known that elevated platelet size is associated with its high enzymatic and metabolic activity. Aim of our preliminary study is to determine the platelet size via MPV level in hyperthyroid patien...

ea0035p1063 | Thyroid (non-cancer) | ECE2014

Inferior oblique muscle enlargement in a patient with Grave's orbitopathy

Tsirouki Theodora , Vasiliou Agathe , Koukoulis Georgios N , Tsironi Evaggelia , Kapsalaki Eftychia , Bargiota Alexandra

Graves’ orbitopathy (GO) is an auto-immune disorder that targets intra-orbital tissues. It is well proven to involve inflammatory hypertrophy of the rectus EOMs. Superior oblique (SO) muscle has been sporadically reported to be involved in GO. However, there are extremely few reports in the literature that refer to the involvement of the inferior oblique (IO) muscle and here we present such a case.A 33-year-old man with unilateral exophthalmos was r...

ea0035p1064 | Thyroid (non-cancer) | ECE2014

Solitary autonomously functioning thyroid nodule and severe osteoporosis

Stanciu Mihaela

Objective: Thyrotoxicosis have received wide attention from researchers over the last century as it an important cause of secondary osteoporosis. Most of the cases present mild osteoporosis.Design: We present the case of a old women (77 years) with no thyroid disease in medical history, only with stable hypertension and artrosis. She was sent to endocrine exam by the oncologyst because she started to have intense lumbal painand the MRI describe osteoliti...

ea0035p1065 | Thyroid (non-cancer) | ECE2014

Assessment of thyroid function and volume in hypogonadal patients

Arpaci Dilek , Cuhaci Neslihan , Saglam Fatma , Ozdemir Didem , Ersoy Reyhan , Cakir Bekir

Background: Hypogonadism is related to additional endocrine abnormalities. Thyroid abnormalities may be common in hypogonadism patients, although this association is not clear.Objective: In this study, we examined the incidence of thyroid disorders in hypogonadisms.Methods: A case–control study of 68 hypogonadal patients and 74 age-matched healthy controls from the general population was conducted. Thyroid function, thyroid vo...

ea0035p1066 | Thyroid (non-cancer) | ECE2014

MRI evaluation of extraocular muscles in patients with Grave's orbitopathy

Tsirouki Theodora , Valvis Nikolaos , Tsironi Evaggelia , Koukoulis Georgios N , Kapsalaki Eftychia , Bargiota Alexandra

Background: Clinical evaluation of Graves’ orbitopathy (GO) is often insufficient. Frequently it is difficult to decide whether a case of GO is active, or to detect the degree of severity. STIR sequence MRI suppresses signal from fat and thus in the orbits can also detect active inflammation and oedema of extra-ocular muscles (EOMs). The aim of the present study is to examine whether imaging of rectus EOMs with STIR MRI could provide additional information for the activit...

ea0035p1067 | Thyroid (non-cancer) | ECE2014

Successful preoperative treatment of toxic nodular goiter patient with agranulocytosis using plasmapheresis

Trybek Tomasz , Kowalska Aldona

Agranulocytosis is an uncommon but very serious complication during treatment with thyrostatic. In case of severe hyperthyroidism removal of circulating thyroid hormones by plasmapheresis may be an effective therapeutic option.We present the therapeutic difficulties and successful treatment with preoperative plasmapheresis in 63-year-old female patient with severe hyperthyroidism in the course of toxic nodular goiter and agranulocytosis, which occurred a...

ea0035p1068 | Thyroid (non-cancer) | ECE2014

The lipid profile in patients with subclinical hypothyroidism and metabolic syndrome

Radinovic Vesna Popovic , Milutinovic Zorica Rasic , Jevtic Jelena Tica , Vujovic Marina , Lackovic Milena , Simovic Nikola , Ilic Maja Stojadinovic

Background: We know that lipid profile is disturbed in both subclinical hypothyroidism (SH) and metabolic syndrome (MetSy). In this study we observed lipid profile in newly diagnosed patients with SH and MetSy.Materials and methods: We chose 70 patients (all females) with newly discovered SH and 20 healthy controls, mean age 51.1 (±6.79). The parameters that we determined are: TSH, FT4, anti-TPO-At, triglycerides, whole, LDL and HDL chole...

ea0035p1069 | Thyroid (non-cancer) | ECE2014

Hypertensive patients with mild hypothyroidism show less frequent spontaneous normalization of thyroid function than normotensive patients

del Pino Alberiche Maria , Sanchez Rosa Maria , Lopez Xabier , Martin Daniel , Garcia Yaiza , Novoa Francisco Javier , Boronat Mauro , Wagner Ana Maria

Introduction: Overt hypothyroidism is associated with diastolic hypertension, but in subclinical hypothyroidism, data are inconclusive. HS tiroxina is a double-blind trial evaluating the effect of levothyroxine on blood pressure in patients with mild SH (TSH 5.0–9.9 mU/l and normal free T4) and moderate-to-high cardiovascular risk.Methods: We analized baseline data of the first 46 patients screened. Confirmatory thyroid function tests wer...

ea0035p1070 | Thyroid (non-cancer) | ECE2014

Ultrasound thyroid imaging, TSH and anti-thyroid peroxidase antibodies concentrations in Warsaw adolescents: the influence of family history of thyroid disease: preliminary results

Kochman Magdalena , Gapys Dorota , Kapuscinska Renata , Jeske Wojciech , Wycisk Aleksandra , Zgliczynski Wojciech

Introduction: Data regarding the thyroid gland evaluation in Polish adolescents are limited.Aim: The aim of the study was to asses TSH and anti-thyroid peroxidase antibodies (anti-TPO) concentrations as well as thyroid morphology on ultrasound in Warsaw adolescents in regard of family history of thyroid disease.Materials and methods: The study was carried out on a group of 480 adolescents (285 girls and 195 boys), aged 17–18 y...

ea0035p1071 | Thyroid (non-cancer) | ECE2014

Prevalence of subclinical hypothyroidism among girls attending the gymnasia in the city of Starogard Gdański

Siek Michal , Breska-Kruszewska Justyna , Cherek Maciej , Sharma Vijay , Rachon Dominik

Introduction: Subclinical hypothyroidism (SCH) can impair concentration and memory skills. If this is a case among adolescents it may impair learning abilities, which in turn may be the cause of poorer performance on various tests and exams. Therefore, the aim of this study was to evaluate the prevalence of SCH in teenage girls attending the gymnasia in the city of Starogard Gdański.Material and methods: In total 487 girls (age range 11.5–14.7 ...

ea0035p1072 | Thyroid (non-cancer) | ECE2014

Antiepileptic drugs and the thyroid hormone axis

Einarsdottir Margret Jona , Olafsson Elias , Sigurjonsdottir Helga Agusta

Introduction: Antiepileptic drugs may cause altered thyroid function in adults according to previous studies. The cllinical impact of this is unclear. The aim of this study was to evaluate thyroid function in patients taking antiepileptic drugs to evaluate a possible clinical impact.Methods: Adult epileptic patients (older than 18 years old) who attended the neurology outpatient clinic at Landspitali University Hospital in Iceland (the only University Ho...

ea0035p1073 | Thyroid (non-cancer) | ECE2014

Hyperthyroidism in a pregnant, previously hypothyroid patient

Lopez Xabier , Sanchez Rosa , Rodriguez Elisa , Sanchez Ana , Garcia Maria , Rodriguez Carlos , Novoa Francisco Javier , Wagner Ana , Alberiche Maria del Pino

Introduction: Graves’ and Hashimoto’s diseases are considered two extremes of the same autoimmune thyroid disease. Spontaneous conversion from hypothyroidism to hyperthyroidism is uncommon. On the other hand, Graves’ disease typically improves during pregnancy and worsens after delivery. We describe a patient with an unusual course of thyroid disease during pregnancy.Case report: An 33-year-old woman, with a two-year history of hypothyroid...

ea0035p1074 | Thyroid (non-cancer) | ECE2014

High-resolution thyroid nodule clinic: analysis of 1674 thyroid nodules

Fernandez-Garcia Jose Carlos , Cortes-Salazar Carmen Maria , Mancha-Doblas Isabel , Tinahones Francisco

Background and objectives: The finding of a thyroid nodule is a very common occurrence in clinical practice. Management of thyroid nodules requires a multidisciplinary approach that may be eased by a high-resolution thyroid nodule clinic. We report our clinical experience and outcomes in a high-resolution thyroid nodule clinic.Materials and methods: We conducted a retrospective analysis of 1674 thyroid nodules evaluated in a high-resolution clinic from a...

ea0035p1075 | Thyroid (non-cancer) | ECE2014

Cardiothyreosis in female with overt hyperthyroidism

Haddad Meriem , Yaker Amel Fetta , Zellagui Hadjer , Daffeur Katia , Chentli Farida

Introduction: Cardiothyreosis (CT) is the most frequent and dangerous complication of hyperthyroidism (HT). It is defined as an association of HT with severe heart abnormalities such: rhythmic troubles, heart and/or coronary insufficiency, atrio-ventricular block, and arterial pulmonary hypertension.Our aim was to study its frequency, in Algerian population, analyze its profile and its response to radical treatment.Materials and me...

ea0035p1076 | Thyroid (non-cancer) | ECE2014

Therapeutic options for Grave's disease and toxic nodular disease: experience of an endocrinology department

Silva Joao , Marcelino Mafalda , Lopes Ana , Lopes Luis , Passos Dolores , Salgado Lucilia , Costa Paulo , Ferreira Bruno , Campos Pedro , Lopes Carlos , Castro Joao Jacome de

The thyroid pathology is an area of special interest in our department. Hyperthyroidism represents 3.4% of the 8144 patients followed.The aim of this study is to characterize the therapeutic approach in patients with Grave’s disease (GD) and toxic nodular disease (TND).Retrospective study of 217 patients diagnosed with GD and TND, evaluated according parameters of therapeutic option, efficacy, relapse rate and associated compl...

ea0035p1077 | Thyroid (non-cancer) | ECE2014

A typical clinical manifestations of Graves' disease

Hegazi Mohamed

Hyperthyroidism is a common medical disorder that is not infrequently overlooked or misdiagnosed. Hyperthyroidism presents with multiple symptoms that vary according to the age of the patient, duration of illness, magnitude of hormone excess, and presence of co-morbid conditions. Over the last few decades, there are increasing numbers of reports of newly recognized manifestations of hyperthyroidism that are related to various body systems and may create a wide range of differe...

ea0035p1078 | Thyroid (non-cancer) | ECE2014

Evaluation of cardiovascular risk factors in adults with primary hypothyroidism

Joucef Hafsa Si , Haddam Ali El Mahdi , Fedala Soumeya , Mansouri Wassila , Meskine Djamila , Chentli Farida

Introduction: Hypothyroidism is a frequent pathology responsible for a significant increase in cholesterol. It is caracterized by myocardial changes, increased risk of cardiovascular disease and more particularly coronary event performance.Aim: Assess cardiovascular risk factors in adults suffering from primary hypothyroidism.Materials and methods: This retrospective study included data from 50 patients (44 women and 6 men) adults ...

ea0035p1079 | Thyroid (non-cancer) | ECE2014

Optical neuropathy and Graves' disease

Youcef Hafsa Si , Haddam Ali El Mahdi , Fedala Soumeya , Meskine Djamila , Chentli Farida

Introduction: Graves’ disease is rare but may be complicated by major eye signs of Graves’ series rarely causing paralysis of the optic nerve.Aim: Report cases of seven patients collected between 1982 and 2013 presenting Graves’ disease complicated by optical neuropathy.Observations: Men patients aged on average 44 years old (35–48), admitted for Graves’ disease complicated by ophthalmopathy with oculomotor...

ea0035p1080 | Thyroid (non-cancer) | ECE2014

Associations of thyroid function and autoantibodies with parameters of oxidative stress in women with Hashimoto's thyroiditis

Giannakou Maria , Saltiki Katerina , Loukari Eleni , Mantzou Emily , Philippou George , Terzidis Konstantinos , Stavrianos Charalampos , Alevizaki Maria

Objectives: Patients with thyroid dysfunction due to AITD have been found to have increased oxidative stress. Possible associations of oxidative stress with thyroid hormone (TH) and thyroid autoantibodies (ThAb) levels in euthyroid patients with autoimmune thyroiditis have not been adequately studied. We examined possible associations of oxidative stress markers with TH levels and with the presence of ThAb in euthyroid women with Hashimoto’s thyroiditis (with or without T...

ea0035p1081 | Thyroid (non-cancer) | ECE2014

Involvement of Lat2 in the transport of 3,3′-T2 across the plasma membrane and first structural insights into transport mechanisms by homology model generation

Kinne Anita , Hinz Katrin , Wittner Melanie , Krause Gerd

Thyroid hormones (THs) are transported into their target cells by diverse transmembrane transporter proteins, e.g. by members of the L-type amino acid transporter (LAT) family. The Lat2 is a sodium independent amino acid exchanger and interacts with CD98 for its efficient cell surface expression. So far the role of Lat2 in TH transport including the transport mechanisms is unclear. It is important to determine TH subtype specificity and to identify amino acids at Lat2 which ar...

ea0035p1082 | Thyroid (non-cancer) | ECE2014

A Sensitive LC/MS/MS Method for the Quantification of Free T3 and Free T4 in Serum, using a Simple Ultrafiltration Sample Preparation

Jarvis Michael , McClure Evelyn

Introduction: The measurement of free thyroxine (FT4) and free 3,3′,5-triiodothyronine (FT3) in serum by equilibrium dialysis immunoassay methods may suffer from a lack of specificity, therefore measurement by LC/MS/MS has the potential to increase the accuracy of the results. Here we present a sensitive method, employing a simple ultrafiltration sample preparation.Description of methods: 400 uL of serum were processed for 90 minutes using a 3kDa c...