Endocrine Abstracts

Acromegaly is associated with various skeletal deformities and in some cases with bone deterioration. The aim of the study was to assess the skeletal status using quantitative ultrasound (QUS) in patients suffering from acromegaly. A group of 38 patients with acromegaly (27 women and 11 men) in mean age of 57.21±9.85 y in various gonadal status was compared with a control group matched for sex, age and body mass. QUS measurements at hand phalanges were performed with DBM ...

Acromegaly causes various cardiovascular dysfunctions, and cardiovascular complications are the main cause of increased mortality in non-cured acromegalic patients. The aim of the study was assessment of flow mediated dilatation (FMD) and the concentration of soluble vascular cell adhesive molecule (sVCAM) as the selected markers of endothelial dysfunction in patients suffering from acromegaly. The study was carried out in 40 patients with acromegaly in various stages of the d...

Hemoglobin A1c (HbA1c) is used for the long-term management of patients with diabetes mellitus (DM). Hemoglobin variants other than HbA1c and e-N-lysine-glycated HbA0 may cause analytical interference in determinations of HbA1c. Hemoglobin J is an abnormal hemoglobin, an alpha globin gene variant and present in various geographic locations. Hemoglobin J (depending on its type) has different characteristics and functions. For example hemoglobin J Capetown (α2 92Gln β2...

Objective: To investigate the results of J – 131 treatments in patients (pts) with autonomous thyroid adenomas in long period of follow up.Material and Methods: We enrolled 68 consecutive pts with Plummer’s disease (50 females, 18 males, mean age 54,7 yrs, range 21 – 79 yrs) for period 2000 – 2020 yrs. 87%(59/68) pts had a unifocal nodule, while 13% (9/68) pts had multifocal toxic autonomous nodules. Pts stopped antithyroid drugs for ...

Introduction: Peroxisome proliferatior-activated receptor-γ2 (PPAR-γ2) plays a crucial role in adipogenesis and has been shown to be involved in the control of immunoregulation and inflammation. Orbital fibroblast differentiation to adipocytes is a PPAR-γ dependent process essential for pathogenic tissue remodeling in Graves’ orbitopathy (GO). Genetic variation in PPAR-γ2 gene may modulate expression and/or function of molecule encoded by this gene.</p...

Introduction: Both genetic and environmental factors contribute to clinical manifestation of Graves’ disease including the response to medical therapy. CTLA-4 gene is an important inhibitor of T-cell activation and its polymorphisms may influence the course of the disease.Goal: We investigated the association between CTLA−4 gene polymorphisms: c.49A>G, g.319C>T, g.*642AT(8_33), CT60, and Jo31 and the response to ph...

Introduction: ‘Forgotten goiter’ is defined as a mediastinal thyroid mass discovered after total thyroidectomy. It is a rare clinical finding, usually asymptomatic.Case report: 88-years old woman was admitted to the Endocrinology Department with a suspicion of the retrosternal goiter. In her medical history there was thyroidectomy performed 16 years before because of multinodular goiter and she had recurrent lower respiratory tract infections...

Skeletal muscle constitutes the largest endocrine organ in human body through capability of secreting myokines, which biological activity plays a key role in energy homeostasis. Among the myokines irisin (Ir) is of particular interest, considering it’s broad spectrum of protective influence on obesity and metabolic diseases development, determining therapeutical potential of this molecule. Latest studies indicate close interrelations between Ir and myostatin (Mstn), myok...

J J Kopchick, Ohio University, Athens, Ohio, USA. AbstractDr John J Kopchick is an internationally recognized leader in the growth hormone (GH) field. Since 1987, he has held the Milton and Lawrence H Goll Eminent Scholar Professorship in Molecular and Cellular Biology and directs the Growth/Obesity/Diabetes Section of the Edison Biotechnology Institute at Ohio University in Athens, Ohio. He also is Professor in the B...

Oncogenic activation of MAPK in thyroid cells leads to loss of expression of genes required for thyroid hormone biosynthesis, including the sodium iodide transporter (NIS) and thyroid peroxidase (TPO). Tumors with BRAF mutation have lower expression of NIS, explaining in part why BRAF-mutant PTCs are often resistant to RAI therapy. We developed mouse models of thyroid cancer driven by BRAFV600E, and these tumors also lose the ability to concentrate radioiodine, whic...