Endocrine Abstracts

Introduction: Secretory adrenal tumors sensitive to luteinizing hormone (LH) and/or human chorionic gonadotropin (hCG) are well documented in the literature. LH and hCG share a mutual LH/hCG receptor and a comparable physiological role.Objective: The aim of our study was to evaluate the response of adrenal steroids (cortisol, aldosterone and dehydroepiandrosterone sulphate (DHEAS)) to exogenous hCG stimulation in menopausal patients with adrenal incident...

IntroductionThe connection between obesity and tumorigenesis has been well established.AimThe aim of this study was to elucidate if there are any demographic and functional differences in adrenal incidentalomas (AI) with respect to different body mass index (BMI) categories.Patients and methodsThis was an observational, cross sectional study. The AI cohort consist...

Introduction: After gastric bypass, gastric secretion decreased and resorption of minerals and vitamins may be compromised. Lower resorpion of serum calcium and vitamin D could stimulate PTH secretion after restictive and malabsorptive bariatric procedures.Methods: We have measured serum calcium, D vitamin and PTH in patients (n=50, 17 males and 33 females) 6 and 12 months after R en Y gastric bypass, 38.6±12.6 years of age, with BMI 43&#17...

Thyroid dysfunction has been linked to reduced fertility. It is known that changes in SHBG and sex steroids are a consistent feature associated with hyper- and hypothyroidism. It is also has reported that women with polycystic ovary syndrome (PCOS) are more insulin-resistant than it would be expected on the basis of their age and BMI. The mechanisms underlying this phenomenon are still not clarified. Hyperandrogenaemia may play a role, but also other factors such as thyroid fu...

It has been more than 70 years since the first adrenal incidentalomas (AI) were described. Most of these tumors are non-secreting, and are found in 4–7% of adult population. Patients with subclinical hypercortisolism (or autonomous cortisol secretion) (SH) are observed in 1–29% of patients with AIs. Evidence suggests that this condition may be associated with higher prevalence of diabetes, obesity, hypertension and osteoporosis.Between 1999 and...

It has been more than 70 years since the first adrenal incidentalomas (AI) were described. Most of these tumors are non-secreting, and are found in 4–7% of adult population. Patients with subclinical hypercortisolism (or autonomous cortisol secretion) (SH) are observed in 1–29% of patients with AIs. Evidence suggests that this condition may be associated with higher prevalence of diabetes, obesity, hypertension and osteoporosis.Between 1999 and...

Introduction: Women with polycystic ovary syndrome (PCOS) are at increased risk of developing insulin resistance (IR) and T2DM. In this study, we attempted to detect IR parameters that could be the best predictor T2DM in PCOS comparing to controls.Description of methods/design: In 130 women with PCOS (BMI=29.7±0.66 kg/m2; age: 25.6±0.59 years) and 41 controls (age and BMI matched) (BMI=28.5±1.35 kg/m2; age: 26.5±...

One-hour (1 h) glucose level of the oral glucose tolerance test (OGTT) was proven to be a better predictor of insulin resistance (IR) in nondiabetic population than the two-hour (2 h) postload glucose level. Specifically, the 8.6 mmol/l cut-off was shown to be an early marker of impaired glucose tolerance (IGT). Previous studies have shown that nondiabetic patients with adrenal incidentalomas (AI) have higher IR than healthy control (HC). However, despite the subtle cortisol s...

High prevalence of insulin resistance (IR) has been shown in patients with adrenal incidentalomas (AI) and it has been demonstrated that an increase in IR is related to the adrenal tumor size (ATS). Also, responsive adrenal pathologies are well documented in patients with chronically elevated LH. The aim was to investigate the association between LH and IR and ATS and IR in AI patients. The case-control study was conducted in Clinic for endocrinology, diabetes and metabolic di...

At present there are no unified diagnostic criteria for subclinical hypercortisolism (SH) in patients with adrenal incidentalomas (AI). Recently it has been proposed that an age and gender specific DHEAS ratio (calculated by dividing DHEAS by the lower limit of the respective reference range) has a significant diagnostic value in detection of SH.The aim was to evaluate the value of DHEAS as a diagnostic tool for SH. Retrospectively we evaluated 140 AI pa...