High prevalence of insulin resistance (IR) has been shown in patients with adrenal incidentalomas (AI) and it has been demonstrated that an increase in IR is related to the adrenal tumor size (ATS). Also, responsive adrenal pathologies are well documented in patients with chronically elevated LH. The aim was to investigate the association between LH and IR and ATS and IR in AI patients. The case-control study was conducted in Clinic for endocrinology, diabetes and metabolic diseases, Belgrade, Serbia. The total studied group consisted of 105 menopausal women: 75 AI patients (mean age 60.13±7.28 years, mean BMI 27.60±4.66 kg/m2, mean menopause duration 10.86±7.79 years, mean LH 31.82±14.17 IU/l and mean ATS 31.25±10.72 mm) and 30 age, BMI, menopause duration and LH matched healthy control (HC) women. Based on level of cortisol after 1 mg-dexamethasone suppression test AI patients were divided in two groups: <50 nmol/L, 27 with nonfunctional AI (NAI) and >50 mmol/l, 48 with (possible) autonomous cortisol secretion ((P)ACS). To estimate IR we used homeostasis model assessment (HOMA-IR). There was no significant difference between AI subgroups in terms of age, BMI, menopause duration, LH and HOMA-IR. HC subjects had significantly lower HOMA-IR when compared to NAI (P=0.017). There was a significant positive correlation between LH and HOMA-IR in AI group (r=0.230; P=0.047) and in (P)ACS subgroup (r=0.353; P=0.017), but not in patients with NAI (r=−0.097, P=0.623). The correlation of ATS and HOMA-IR was significant in AI group (r=0.341; P=0.003) and both NAI (P=0.018, r=0.445) and (P)ACS (P=0.012, r=0.362). After adjusting for age and BMI both LH and ATS were significant predictors of HOMA-IR, (r2=0.196, P=0.004). There was no significant correlation between LH and HOMA-IR in HC. Our data suggest that not only insulin, but also the interplay between LH and insulin may contribute to the adrenal tumorigenesis.
20 May 2017 - 23 May 2017