Endocrine Abstracts

Glucocorticoids (GC) are catabolic in skeletal muscle to provide nutrients during fasting or other stressors, including inhibiting insulin-mediated glucose uptake, protein synthesis, and mitochondrial function, while stimulating proteosomal breakdown of proteins. Published work in cultured myotubes required μM GC dosing to see these effects. We found GCs to show low nM activity in myotubes by using a more physiologically relevant setting, including nutrient deprivation an...

W Arlt, School of Clinical and Experimental Medicine, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK AbstractProf. Wiebke Arlt received her undergraduate medical training at the University of Cologne in Germany. She obtained her MD degree in 1993 with distinction and trained in General Medicine and Endocrinology and Diabetes at the University Hospital Würzburg under th...

W Wiersinga, University of Amsterdam, Amsterdam, The Netherlands AbstractWilmar M Wiersinga obtained his MD in Amsterdam in 1969 and his Board Certification in Internal Medicine in 1976. He obtained his PhD cum laude in 1979 at the University of Amsterdam on the thesis ‘The peripheral conversion of T4 into T3 and reverse T3’. Thereafter he spent two years as a research fellow at the UCLA with professors David...

We present the case of a girl with rapidly progressing central precocious puberty, CPP. The young girl presented with consonant rapidly progressive puberty and onset of menarche. She had onset of breast budding at 7 years 11months, menarche at 8 years 2 months, with significant growth spurt. Periods continued every 3 weeks. A Brain MRI demonstrated a dysplastic lesion of her tectal plate. She underwent treatment with Gonadotropin releasing hormone analogues to suppress puberty...

Maturity-onset diabetes of young 5 (MODY5) is a type of monogenic diabetes involving multiple organs including pancreas and kidneys. This is caused by mutation/deletion of the hepatocyte nuclear factor-1β (HNF-1β) gene located in the chromosome region 17q12.We report a 10-year-old, non-obese girl who was diagnosed with diabetes with features of insulin resistance. She was found to have a heterozygous whole gene deletion of HNF-1&#9...

Bert W O’MalleyBert W O’Malley, MD is the Tom Thompson Distinguished Service Professor of Molecular and Cellular Biology at Baylor College of Medicine. A native of Pittsburgh, he has a bachelor’s degree from the University of Pittsburgh (1959) and an MD from their School of Medicine (1963). He completed his residency at Duke University and spent four years at the National Institute of Health followed by four years serving as the Luscious B...

W F Young Jr, Mayo Clinic, Rochester, Minnesota, USA AbstractProf. William Young is Professor of Medicine at the Mayo Clinic College of Medicine and Vice-Chair of the Division of Endocrinology, Diabetes, Metabolism, and Nutrition. He received his MD degree from Michigan State University. Prof. Young trained in endocrinology and metabolism at Mayo Clinic, Rochester, Minnesota. He has been a member of the staff at Mayo ...

Introduction: One third of children in the UK are overweight or obese. The Obesity Services for Children and Adolescents (OSCA) group have agreed upon a guideline for paediatricians on the assessment and management of obese children.Audit aim: To evaluate and improve the care of obese and overweight children.Method: Obese patients seen in secondary care were retrospectively audited from 2008 to 2014.Results: ...

Introduction: Non-syndromic autosomal recessively inherited non-goitrous congenital hypothyroidism (CHNG) can be caused by mutations in TSHR, PAX8, TSHB, and NKX2-5. We aimed to investigate mutational frequencies of these genes and genotype/phenotype correlations in consanguineous families with CHNG.Design: Since consanguinity in individuals with a presumptive genetic condition is often an indicator of an autosomal recessive inherita...

Introduction: Many endocrinopathies such as acromegaly, Cushing’s syndrome (CS), pheomochromocytom and lipodystrophia can be associated with insülin resistance and unregulated diabetes mellitus (DM).Case report: A 37 –year- and 2 months pregnant women admitted to our out patient clinic for regulation of hyperglycemia. On physical examination; Blood Pressure: 140/95 mmHg, Body Mass Index: 31 kg/m2, central obesity, acanthosis nig...