Endocrine Abstracts

Introduction: Patient with chronic periodontitis (CP), especially those with its advanced forms, have higher cardiovascular risk compared to those with healthy periodontium. They are also characterized by higher hs-CRP levels, greater left ventricular mass, greater intima-media thickness. Adiponectin, a hormone excreted by fat tissue, is involved in insulin sensitivity regulation and in atherosclerotic processes. The aim of the study was to assess a relationship between chroni...

Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants derived from the incomplete combustion of organic materials. In urban and industrial areas, level of pollution with these compounds is high, which leads to numerous negative health effects. Some literature data indicate the involvement of PAHs in the development of obesity, however, there is no data showing the distribution patterns of PAHs in human adipose tissue (AT) and their impact on the process o...

The most common testicular germ cell tumours (TGCT), seminoma or non-seminoma, occur in young adults and are derived from an intratubular precursor, carcinoma in situ testis (CIS). CIS cells display characteristics of developmentally arrested fetal gonocytes which during puberty acquire some features of more mature germ cells. Developing germ cells are under control of their somatic niche (Sertoli- and peri-tubular cells) and androgen-producing Leydig cells. A develop...

Male infertility is a common disorder and a growing health problem. A large proportion of unexplained cases have been summarily categorised as idiopathic infertility. The majority of idiopathic cases, especially those with severely impaired spermatogenesis incl. azoospermia, are presumably caused by genetic defects. Genetics of male infertility has been a largely unexplored area, until quite recently, when new molecular tools unabled discovery of a growing number of genes invo...

TS is a well defined chromosomal disorder that affects 1 in 2500 females. Its characteristic stigmata are short stature and gonadal dysgenesis with skeletal, soft tissue and visceral abnormalities. The range of morbidities has a profound impact on quality of life of patients with TS so multidisciplinary approach to the management is needed in childhood, adolescence and adulthood.The diagnosis is based on a karyotype and may be done prenatally during chor...

Introduction: Although education is widely regarded as one of the pillars of diabetes treatment, it is relatively little work analysing its effectiveness. Therefore we would like to present our prospective observations.Method: In 2003–2004, 500 consecutive patients visiting our diabetes education centre put to the test the knowledge of diabetes as 20 questions which focus on practical skills proceedings in diabetes. We did not have a direct affect t...

The aim of this study was to evaluate whether the coexistence of obesity in children with precocious puberty symptoms influences significantly the diagnostic process.Material and methods: We retrospectively analysed a group of 200 children’s records (F/M 164/36) hospitalised because of precocious puberty suspicion. The analysis evaluated the nutritional status based on BMI percentile level, compatibility between the bone age and the chronological ag...

With the increasing prevalence of obesity in children, there is a growing number of its comorbidities as nonalcoholic fatty liver disease (NAFLD).The aim of this study was to evaluate the prevalence of NAFLD in a group of obese patients and to identify additional risk factors for NAFLD development in the examined population.Materials and methods: We examined 88 obese children (41 boys) mean age 14.4 (±2.6) hospitalized in our ...

Background: Raised blood pressure (BP) in adolescents with type 1 Diabetes Mellitus (T1DM) has been associated with adverse cardiovascular outcomes independently of raised HbA1c. It is therefore of critical importance that these patients are identified early and appropriate treatment instigated. Of concerns, studies have recognised suboptimal management of hypertension in most of these young people, allowing them to succumb to complications of diabetes with hypertension in the...

Tumor growth is limited by its neoangiogenesis, which is dependent on dynamic balance beetween it’s activators and inhibitors. One of the most important antiangiogenic factor is endostatin. Therefore we hypothesized, that serum endostatin concentration would differ between patients with metastatic and non-metastatic thyroid cancer, with multinodular goiter and healthy subjects. We also hypothesized that endogenous TSH stimulation would effect serum endostatin level.<p...