Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2008) 16 P226

Diabetes and cardiovascular diseases

Serum adiponectin concentration is not dependent on inflammatory process of periodontium in patients with primary hypertension: preliminary results

Edward Franek1, Klamczynska Ewa3, Ganowicz Ewa4, Blach Anna2 & Gorska Renata4

1Department of Endocrinol, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland; 2Department of Endocrinol and Diabetol, Central Clinical Hospital MSWiA, Warsaw, Poland; 3Department of Cardiology, Central Clinical Hospital MSWiA, Warsaw, Poland; 4Department of Periodontologyi, Medical University of Warsaw, Warsaw, Poland.

Introduction: Patient with chronic periodontitis (CP), especially those with its advanced forms, have higher cardiovascular risk compared to those with healthy periodontium. They are also characterized by higher hs-CRP levels, greater left ventricular mass, greater intima-media thickness. Adiponectin, a hormone excreted by fat tissue, is involved in insulin sensitivity regulation and in atherosclerotic processes. The aim of the study was to assess a relationship between chronic periodontitis and serum adiponectin concentration in patients with primary hypertension.

Material and methods: Two groups of patients were included into the study: 28 patients with no or only moderate CP (Community Periodontal Index of Treatment Risk–CPITN – score =0–2, mean age 49.6±5.9 years, BMI 30.6±5.2 kg/m2), and 25 patients with advanced CP (CPITN score 3–4, mean age 50.9±4.5 years, BMI 28.6±3.1 kg/m2). In both groups other than periodontium potential sources of infection were carefully excluded. Serum adiponectin concentration was assessed by EIA (Alpco Diagnostics). Mann–Whitney test was used for between groups comparison, and Spearman rank test for correlation assessment.

Results: Serum adiponectin concentration did not differ between CPITN 0–2 and CPITN 3–4 groups (12.4±5.0 μg/ml vs 12.2±3.9 μg/ml), the same was true for serum hsCRP level (2.99±3.89 mg/ml vs 2.14±2.33 mg/ml, respectively). No significant correlation between adiponectin concentration and mean or maximal CPITN score was shown. There was also no correlation between adiponectin and hsCRP levels.

Conclusion: From those preliminary results one can conclude that there is no relationship between serum adiponectin concentration and inflammatory process of periodontal tissue. However, a small number of included patient and no difference between hs-CRP level between the groups limit power of the study.

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