Endocrine Abstracts

Experimental results have shown that the presence of endocrine disrupting chemicals (EDCs) such as the diphenyl compound DDT and its analogue DDE, allosterically cause the release of the stably bound dihydrotestosterone (DHT) from the steroid binding site of the Androgen Receptor (AR) ligand binding domain. It was hypothesized that EDCs mediate this effect via binding to the Binding Function 3 (BF3) surface binding site. Mutations of three BF 3 amino acids (F673K, F673W, G724R...

The androgen receptor (AR) function is inhibited by endocrine disrupting chemicals (EDCs) such as DDT and DDE leading to problems in embryonic development and negative health outcomes for adults. EDCs may bind in the steroid binding pocket and disrupt AR function by leading to altered receptor conformations. However, this may not be the only way EDCs interfere with the receptor. Estébanez-Perpiñá et al identified binding function 3 (BF3) as a surface bi...

Prostate cancer (PC) is currently the most commonly diagnosed non-cutaneous cancer affecting UK men. Androgen deprivation therapy (ADT) has traditionally been used as the gold standard treatment for advanced PC. Despite the initial response to androgen ablation, tumours relapse and become refractory to clinically approved anti-androgens, resulting in castration-resistant PC (CRPC). In CRPC, androgen receptor (AR) signalling is inappropriately restored by AR splice variants (AR...

Androstenedione and 17OHP are often used as measures of cortisol replacement in congenital adrenal hyperplasia (CAH) rather than cortisol itself. Very little is known of the dose response relationships between cortisol and A4 and 17OHP.We have studied the relationship between 24 h serum cortisol, 17OHP and A4 in 33 (18M) children with CAH due to P450c21 deficiency. 24 h serum cortisol and 17OHP profiles were constructed using 20 min sampling intervals an...

Objectives: The interplay between thyroid function and metabolic state has been studied in many population subgroups. For pregnant women thyroid and metabolic parameters, including glucose homeostasis, are of great importance for a successful outcome. We examined aspects of thyroid function in relation to GDM and BMI in pregnant women referred to our Department.Methods: We studied 520 women during 24th – 32nd gestation week. De...

Aim: Postoperative calcitonin (postCT) is a prognostic factor for disease progression in MTC patients. We evaluated the disease course in patients with persistently elevated post-CT.Methods: Of all MTC patients (n=273) followed-up in our Unit (for 1–37, median 7 years), 140 (39.3% men, 67.1% sporadicMTCs) had persistently elevated postCT (≥2.0 pg/ml). Clinical and biochemical data were recorded. Patients were classified in four groups...

Objective: Impaired linear growth is a common complication of end stage renal failure (ESRF), with recombinant human growth hormone (rhGH) being the suggested treatment until renal transplantation (RTx). Growth improvement post RTx has been reported, however data on the degree of catch up growth post RTx and final height (FH) is limited. We aimed to evaluate the effect of RTx on FH standard deviation score (SDS) and the possible contributing factors.Meth...

Background and aims: Diabetic neuropathy is a common complication in patients with type 1 diabetes mellitus (T1D). In this study, we explore the importance of circulating chemokines for the development of diabetic neuropathy (DN) in T1D.Materials and methods: This study was a cross-sectional analysis of patients with childhood onset T1D followed prospectively in a long-term longitudinal cohort study. Fifty-two patients (20 women/32 men; mean age 28 &#177...

Introduction A few adrenal masses may elude characterization on cross-sectional imaging and remain indeterminate. These include lipid-poor adenomas, adrenal metastases and carcinomas and phaeochromocytomas. It is important to distinguish between them, as phaeochromocytomas can be fatal if operated without preoperative blockade. Their clinical spectrum varies, from dramatic symptoms and signs including paroxysmal headache, flushing, diaphoresis, hyper...

Introduction A few adrenal masses may elude characterization on cross-sectional imaging and remain indeterminate. These include lipid-poor adenomas, adrenal metastases and carcinomas and phaeochromocytomas. It is important to distinguish between them, as phaeochromocytomas can be fatal if operated without preoperative blockade. Their clinical spectrum varies, from dramatic symptoms and signs including paroxysmal headache, flushing, diaphoresis, hyper...