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Endocrine Abstracts (2022) 81 RC1.7 | DOI: 10.1530/endoabs.81.RC1.7

1Linköping University, Department of Health, Medicine and Caring Sciences, Linköping, Sweden; 2Linköping University Hospital, Department of Endocrinology, Linköping, Sweden; 3National and Kapodistrian University of Athens, 1st Department of Propaedeutic and Internal Medicine, Medical School, Athens, Greece; 4Linköping University, Department of Biomedical and Clinical Sciences, Linköping, Sweden; 5Linköping University, Division of Inflammation and Infection, Linköping, Sweden; 6Örebro University, Faculty of Medical Sciences, Örebro, Sweden


Background and aims: Diabetic neuropathy is a common complication in patients with type 1 diabetes mellitus (T1D). In this study, we explore the importance of circulating chemokines for the development of diabetic neuropathy (DN) in T1D.

Materials and methods: This study was a cross-sectional analysis of patients with childhood onset T1D followed prospectively in a long-term longitudinal cohort study. Fifty-two patients (20 women/32 men; mean age 28 ± 4 yrs.; diabetes duration 19.5 ± 5.5 yrs.), and 19 control subjects (11 women/8 men; mean age 26.5 ± 4.5 yrs.) were included. Plasma levels of Th1- (CXCL9, CXCL10, CXCL11), Th2- (CCL17, CCL22) and Th17-associated (CXCL8, CCL20) chemokines were assessed in all subjects. Clinical examination and electroneurography tests with bilateral measurements of peroneal MCV and CMAP and sural SCV and SNAP were performed in the TID patients.

Results: Patients with diabetic neuropathy had higher levels of CXCL9 (Th1) than patients without DN. Both patients with and without neuropathy had significantly higher CXCL9 levels compared to controls, P=0.002 and P=0.05, respectively. The levels of the other chemokines were similar in patients and controls. In T1D patients with peripheral DN, the CXCL8 (Th17) levels correlated negatively with cold perception threshold (rho -0.645, P= 0.032), while the CXCL10 (Th1) levels were positively correlated with the vibration perception threshold (rho 0.639, P= 0.034).

Conclusions: The Th1 associated chemokine CXCL9 was increased in patients with T1D, both in patients with and without neuropathy. Increased Th1 and Th17 associated chemokines showed possible associations to an impaired peripheral sensory nerve function and nerve conduction tests for the suralis nerve.

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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