Endocrine Abstracts

Introduction: Pheochromocytomas(PCC) and paragangliomas(PGGLs) are rare neuroendocrine tumors. Management is very complex, this is why physicians involved in the management of these patients need to take into account not only clinical aspects but also genetics of these tumors. We present a group of patients diagnosed of metastatic PGG or PCC, their characteristics and long term follow-up.Methods and design: Descriptive and unicentric study that includes ...

Background: Obesity has been associated with low levels of 25-hydroxyvitamin D (25(OH)D). This could be explained by a low dietary intake, reduced sun exposure or less biodisponibility because of its arrest in the fat mass. The main objective is to study the prevalence of 25(OH)D deficiency in premenopausal obese women.Methods: Aleatory sample of 100 morbidly obese patients. Selection criteria were: women, premenopausal, Caucasian. Patient with diabetes ...

Objective: To report a rare case of papillary thyroid carcinoma (PTC) in a thyroglossal duct cyst (TGDC).Case report: A 34-year-old peruvian male came to our hospital with a complaint of a swelling cervical mass in the anterior central side of the neck, which was growing since 6 months earlier. The patient had no significant past medical, surgical history and was completely asymptomatic. He denied any family history of thyroid disease or history of head ...

Non alcoholic steatohepatitis (EHNA) is diagnosed by hepatic biopsy. Its etiology is uncertain but obesity is present in 69–100% of all cases and type 2 diabetes mellitus (DM) in about 34–75%.Objectives: To study the prevalence of EHNA in morbidly obese patients and determine if there is a difference between the prevalence in patients with and without carbohydrate metabolism disorders.Patients and methods: Prospective stu...

Introduction: POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome is a rare multisystemic disease. Diagnosis requires two major criteria and at least one minor criterion. Major criteria include polineuropathy and a monoclonal plasma proliferative disorder (almost always lambda). Minor criteria include osteosclerotic bone lesions, Castleman disease, organomegaly (including lymphadenopathy), oedema, pleural effusion or ascites, e...

Introduction: Ectopic Cushing’s syndrome is a rare disease, with a reported incidence of 0.1/million per year. This disorder accounts for approximately 12–17% of patients with ACTH-dependent Cushing’s syndrome. Small cell lung carcinoma is responsible for about 20% of cases, although ectopic ACTH hypersecretion occurs in only 0.5–2% of these tumours. Hypercortisolaemia is usually severe and of rapid onset. Optimal treatment is surgical excision of the tumou...

Objective: SGLT2 inhibitors, have been shown to improve glycaemic control, stabilize insulin dosing and mitigate insulin-associated weight gain in patients whose type 2 diabetes mellitus (T2DM) was inadequately controlled. The objective is to evaluate the real-world efficacy and safety of adding iSGLT-2 therapy in inadequately controlled patients with oral antidiabetic drugs and with or without insulin therapy.Materials and methods: This observational st...

Primary hyperparathyroidism (PHPT) is a common condition. The prevalence since the introduction of multichannel analysers is approximately 1:1000, with the older female being the typical patient. PHPT is predominantly a sporadic disorder. Surgery remains the only curative approach to most primary hyperparathyroidism (PHPT), medical treatment with cinacalcet has been proven to be an alternative for patients with hyperparathyroidism.Objective: Analyze trea...

Background: Permanent hypoparathyroidism can result from immune-mediated destruction of the parathyroid glands. Alternatively it may result from activating antibodies to the calcium sensing receptor that decrease parathyroid hormone (PTH) secretion. Autoimmune hypoparathyroidism is a common feature of poliglandular autoimmune syndrome type I. Other causes, all very rare, include irradiation and storage of infiltrative diseases of the parathyroid glands. Neurological signs of h...

Introduction: Anorchia or vanishing testis syndrome is defined as the absence of testicular tissue in genetic and phenotypic males. To establish this diagnosis certain criteria must be present, namely non palpable testis during examination under anaesthesia and blind ending spermatic vessels visualized within the retroperitoneu, or the spermatic vessels and vas deferens exiting a closed internal inguinal ring. Bilateral congenital anorchia affects one in 20 000 males.<p cl...