Endocrine Abstracts

Our hospital has a referent population of 50 000 people in a rural area. We have made a retrospective study about ambulatory outpatients who had been diagnosed with subclinical hyperthyroidism.Objectives: To describe and analyze the characteristics of these patients, the treatment they received, the relationship beween TSH and goiter, complementary image tests and evolution.Material and methods: This is a descriptive study about pa...

Aims: To evaluate the prevalence of depression and anxiety in adult outpatients with diabetes and identify the correlation with diabetes management behaviours and clinical outcomes.Methods: Cross-sectional analyses were performed on 142 diabetic patients (type 1 diabetes n=67, type 2 diabetes n=60) attending outpatient clinic. Depression and anxiety were evaluated using the Patient Health Questionnaire (PHQ-2) and the General Anxiety Di...

Introduction: HNF-1β maturity-onset diabetes of the young (MODY5) is uncommon, nevertheless accurate diagnosis guides individualized management and informs prognosis in probands and relatives.Objective: To emphasize the importance of the appropriate use of clinical, biochemical and genetic investigations for the correct classification of diabetes etiology.Case-report: A 35-year-old overweight Latin-American male was diagnosed ...

Background: The Short Synacthen Test (SST) is the most popular test of adrenal insufficiency (AI) worldwide. The current SST protocol at Sheffield Children’s Hospital (SCH) recommends measurement of serum cortisol at baseline, then 30- and 60-minutes post stimulation. A peak cortisol of >429nmol/l constitutes a pass. Our practise has evolved to consider results between 350 and 429nmol/l as “borderline” and these patients may be treated with stress dosing ste...

Introduction: Most (89%) UK units offer some form of free patient choice for new paediatric patients commencing GH therapy. Initial data indicates that patient choice improves adherence, resulting in improved growth (height velocity) short-term.Objective: To compare outcome measures between patients offered free choice and/or hospital supply (including home services and adherence tracking assessed using ampoule counting) with GH therapy with those who di...

Background: Numerous observational studies suggested that variation in thyroid function parameters even within the normal range associates with adverse, in particular non-thyroidal, health outcomes, but causality for most remains to be established.Methods: We combined individual level and summary level genetic prediction methods, i.e., polygenic scores and Mendelian randomization (MR), to systematically test for an association between liability to variat...

Introduction: Duchenne Muscular Dystrophy (DMD) is an X-linked recessive neuromuscular disorder causing progressive muscular degeneration and weakness. The survival of patients with DMD has improved with multi-disciplinary team input. Sub-specialties have moved towards anticipatory diagnostic and therapeutic strategies which focus on prevention and treatment of modifiable disease complications. Endocrine complications of DMD include impaired growth, delayed pu...

The liver produces and secretes sex hormone–binding globulin (SHBG), which transports sex steroids and regulates their access to tissues. Body mass index is a major determinant SHBG concentration in the blood of men and women. Low plasma SHBG levels are associated with obesity and predict the development of type 2 diabetes and cardiovascular disease. The reason why obese individuals have low circulating SHBG has been attributed to hyperinsulinemia, but no mechanistic evi...

Introduction: Currently self-glycemic control by the patient is essential to achieve a right metabolic control of diabetes. Nowadays, there are different systems that have proved useful for this aim.Objectives: Valuing any possible differences between systems and the relation with glycemia identified in our laboratory.Material and methods: We took blood samples by vein-puncture to 41 patients, and simultaneously we measured capilla...

The ‘Multiple Endocrine Neoplasia’ predominantly affect the pituitary gland, parathyroids, thyroids, adrenal glands and pancreas. We present the case of a patient with three different functioning endocrine gland tumours, but who cannot be included in any of these groups.Case report: Sixty-five-years-old female with recurrent episodes of nephritic colic and hypertension for 2 years; non-specific gastrointestinal complaints, hirsutism, hyp...