Endocrine Abstracts

Background: Gastric neuroendocrine tumors (gNETs) are relatively uncommon. Represent up to 23% of all digestive neuroendocrine neoplasms. The majority are incidentally diagnosed from histology of ‘simple’ gastric polyps identified at endoscopy. There are 3 groups of gNETs: types 1, 2 and 3 with different pathogeneses, biological and clinical behaviors. It is worth mentioning that recent reports suggest a fourth type of gNETs1. Type I represents 75–80%...

Introduction: Several studies have demonstrated a high incidence of vertebral fractures (VF) in acromegaly, not always correlated with bone mineral density (BMD) value adquired by dual X-ray absorptiometry (DEXA). At trabecular level, GH may alter bone microarchitecture (BM) that predisposes to bone fragility. Trabecular Bone Score (TBS), a textural parameter applied to DEXA to evaluate BM, could be useful to predict VF risk in these patients.Materials a...

Introduction: Assessing the effect of GLP 1 receptor agonist on metabolic control and weight loss in obesity and type 2 diabetes patients.Description of methods: A retrospective descriptive study involving type 2 diabetes patients and BMI >30 kg/m2, who started treatment with GLP-1-RAs during the years 2012–2014. Variables analyzed: weight and HbA1c at the begging, 6 months, 1 and 2 years; regimen at baseline and after GLP-1-RAs; inci...

Introduction: Myxoid tumors of the adrenal glands constitute an unusual entity and should be part of the differential diagnosis of atypical adenomas in the study of adrenal incidentaloma.Description of methods: We report the finding of myxoid adrenal adenoma in left adrenal gland in a 38-year-old woman.Case: PMH: Active smoker. Non hypertension, type 2 diabetes or dyslipidemia. No constitutional symptoms.Phys...

Introduction: ‘Atypia of undetermined significance (AUS) or follicular lesion of undetermined significance’ category is established by The Bethesda System for Reporting Thyroid Cytopathology because of the necessity to report those thyroid fine-needle aspiration (FNA) results that are not easily classified into the benign, suspicious or malignant categories. In most cases, a repeated FNA results in a more definitive interpretation. Estimated risk of malignancy for an...

Introduction: Primary hyperparathyroidism is caused by a single adenoma in 85% of cases. This is why bilateral neck exploration seems to be a very aggressive procedure in a large number of cases. Intraoperative parathyroid hormone (IOPTH) monitoring could be a useful tool in primary hyperparathyroidism surgery allowing a less invasive surgical approach. The aim of our study is to evaluate the possible impact of the measurement of IOPTH during surgery.Met...

Introduction: There are new therapies indicated in medullary thyroid cancer (MTC) based on different molecular targets, that appear to be effective in some cases with advanced disease, although many are still under investigation.Material and methods: We retrospectively evaluated five cases of medullar thyroid advanced carcinoma that later were referred to Oncology Department for Chemotherapy treatment.Results: Five patients (mean a...

Introduction: Primary ovarian insufficiency (POI) is commonly defined as amenorrhea or disordered menses for at least 4 months in association with menopausal FSH levels in women who are < 40 years old.Methods: The aim of our study is to describe the etiology, demographic characteristics, therapeutical management and repercussion in reproduction in patiens with POI. We carried out a retrospective observational study including 25 women with a primary o...

Background: The prevalence of unawareness hypoglycaemia in patients with type 1 diabetes mellitus (T1DM) is uncertain. This study aims to determine its prevalence and predictive clinical characteristics with greater precision.Methods: Prospective study. 128 patients were recruited between September 2013 and January 2014. Awareness of hypoglycaemia was assessed using the ‘Clarke’ questionnaire and was classified into two groups, depending on the...

Introduction: Adrenocortical carcinoma (ACC) is a very rare neoplasm with an incidence of about one case per million population. It is an agressive tumor (overall 5-year survival 16–38%) and complete resection is the only curative treatment.Description of methods: We report four cases of ACC. The clinical and biochemical features at diagnosis along with clinical course of the disease are discussed.Results: Four patients (three...