Endocrine Abstracts

Several lifestyle modification strategies have been suggested to prevent lifestyle-related diseases. However, the situation may be different for health check participants and outpatients. This study aimed to determine suitable lifestyle modification strategies to prevent diabetes in individuals who participated in a medical health check using retrospective cohort study. Individuals who participated in a medical health check in Fukuyama, Japan every year from 2011–2015 wer...

Introduction: Surgery for benign nodular goiter (NOD) is currently limited to cancer or cosmetic deformities. Most patients are, in principle, followed up for years or decades. The long-term outcome, however, is not always clear.Patients and methods: NOD was diagnosed as benign in 1,825 patients (1990–2015). 102 patients (5%) were treated by surgery. 95% returned to home doctors (69%) or continued to visit our clinic (518 patients, 31%). Follow-up e...

Background: Nodular goiter (NOD) is one of the most common disease (69% in our thyroid clinic). Although the nodular growth is generally slow, it may be influenced by thyroid hormones, autoimmunity or other factors. The analysis may contribute to predict the outcomes.Patients and methods: 2,213 Japanese patients (2007–2018; Fukushima coast area) with NOD were enrolled in this study. Mean observation period was 6.4 years with 7 visits (1–50). Th...

Nodular goiter (ND) is increasingly found by image analysis. The long-term course of ND, however, is not necessarily clear and may differ in locality. The present study analyzed the changes of ND in Japanese, taking iodine-rich foods, during follow-up periods.Patients and methods: Patients (n=4,229) were followed up to 28 years (3.4±5.8 years). Volume of nodules (VOL) by ultrasonography (US) and laboratory data, including thyroid hormones (...

Objectives: Secretion of GH, a pituitary and anabolic hormone that reduces visceral fat, is diminished in obese or elderly subjects. The reduced GH may induce visceral fat accumulation and subsequently accelerate metabolic syndrome in these population. In the present study, we sought the effect of chronic GH supplement on visceral fat and glucose metabolism in diet-induced obese (DIO) mice.Methods and results: Male obese mice (C57BL/6, 12 weeks old) unde...

Myocardin-related transcription factor (MRTF)-A is a Rho signaling-responsive co-activator of serum response factor (SRF). In this study we investigated roles of MRTF-A in the process underlying vascular diseases by using two different mouse models of vascular diseases. MRTF-A expression was significantly higher in the wire-injured femoral arteries of wild-type mice and in the atherosclerotic aortic tissues of ApoE−/− mice than in healthy control tissues...

Background: In 1985, Mikati et al., described a new syndrome, which included microcephaly, hypergonadotropic hypogonadism, short stature, mental retardation and minor anomalies in four out of nine siblings of consanguineous parents. No genetic disorder was associated to the disease. No further references to this syndrome have been found in literature. The authors present a new possible case of Mikati-Naijjar and Sahli syndrome (MNJS).Clinical case: Forty...