Endocrine Abstracts

Introduction: Persistent primary hyperparathyroidism (pHPT) occurs in 2.5 to 15% of cases after parathyroidectomy. Pre-operative localization studies (usually 99mTc-MIBI and cervical ultrasonography (US)) allow focused surgical approach (unilateral neck exploration or minimally invasive parathyroidectomy). Few studies have evaluated the best pre-reoperative approaches in case of persistent sporadic pHPT. The aim of our study is to evaluate the value of a second pre-...

Introduction: Health-related Quality of Life (HR-QoL) is usually impaired in patients with thyroid diseases compared to the general population. Thyroidectomy is largely performed in case of benign thyroid disease, and can be associated with severe long-term complications: vocal cord palsy (VCP), hypoparathyroidism. Our goal was to report the long-term HR-QoL outcomes after thyroidectomy using the MOS 36-item short form health survey (SF-36) self-questionnaire.<p class="abs...

Aims/hypothesis: Obesity and diabetes enhance the risk of developing cardiovascular diseases and heart failure. These metabolic disorders are generally reflected by natriuretic peptides system deficiency. Since brain natriuretic peptide (BNP) is known to influence metabolism and cardioprotection, we investigated the effect of chronic exogenous BNP treatment on adverse myocardial consequences related to obesity and diabetes.Methods: Ten-week-old C57BL/KsJ...

In line with European guidelines, infant formulas in France have been vitamin D-fortified with a vitamin D3 content of ~400 IU/l. New guidelines for the prevention of vitamin D deficiency and rickets have subsequently been published and the vitamin D supplement for formula-fed infants was reduced from 800 to 400 IU per day.To contribute to the evaluation of the need for vitamin D supplementation, a study was conducted to assess vitamin D3 intake (choleca...

Background: Polycystic ovary syndrome (PCOS) is common with a suggested prevalence of 6–7% in Caucasian women of reproductive age. The presence of cardiovascular risk factors of obesity, insulin resistance and dyslipidaemia may predispose women with PCOS to coronary heart disease, although this remains controversial. This study aimed to contrast and compare the changes in lipid profile and hs-CRP following treatment with metformin, orlistat and pioglitazone in women with ...

Background: There are increasing number of reports on immune checkpoint inhibitors induced adverse events including hypophysitis. Hypophysitis tends to occur more with CytotoxicT-lymphocyte-associated protein 4 inhibitors (12-15% of cases) which is a different entity compared to those associated to anti-program death 1 (anti-PD1) inhibitors.Aim: We describe a case of pembrolizumab-associated hypophysitis and conduct a discussion based on a systematic rev...

Background: Medullary thyroid carcinoma (MTC) can result from an inherited predisposition related to variants in the RET gene. The insTTCTdelG variant in codon 666 has been previously associated with MTC in one family, but larger studies are not available. We aim to describe biochemical and clinical characteristics associated with this genetic variant in sixteen Belgian families.Methods: Retrospective study of sixteen families in Belgium, evalua...

Background: chromosome 22q11.2 deletion syndrome has been reported to occur in about 1 per 347 to 992 fetuses.1 Patients present with velocardiofacial syndrome (VCFS) or DiGeorge syndrome (DS). Hypocalcemia has been reported to occur in up to 80.4% of cases.2Case report: a 28-year-old man, known with autism spectrum disorder (ASD), presented at the emergency department (ED) for muscle cramps. Medical history included chronic myeloid leukemia treated with...

Background: Chromosome 22q11.2 deletion syndrome has been reported in about 1 per 347 to 992 living births. Hypocalcemia occurs in up to 80.4% of cases.Case description: A 28-year-old man, known with autism spectrum disorder (ASD), presented at the emergency department (ED) for limbs muscle cramps. Medical history included chronic myeloid leukemia treated with tyrosine kinase inhibitor (TKI) the last 10 years, gastric bypass and recurrent fractures due t...

Thyroid hormone levels are strongly affected by inflammation. In a wide spectrum of diseases, ranging from critical illness in the ICU to ischemic stroke, a decrease in circulating T3 and T4 is observed without the expected increase in TSH. This disruption of the negative feedback system of the hypothalamic–pituitary–thyroid (HPT) axis is accompanied by various changes in thyroid hormone metabolism at the cellular and tissue level. C...