Introduction: Health-related Quality of Life (HR-QoL) is usually impaired in patients with thyroid diseases compared to the general population. Thyroidectomy is largely performed in case of benign thyroid disease, and can be associated with severe long-term complications: vocal cord palsy (VCP), hypoparathyroidism. Our goal was to report the long-term HR-QoL outcomes after thyroidectomy using the MOS 36-item short form health survey (SF-36) self-questionnaire.
Methods: The prospective ThyrQoL multicenter trial (NCT02167529) included 800 patients who underwent total thyroidectomy in seven French referral hospitals between 2014 and 2017. Exclusion criteria were extensive malignant disease, age <18 years, preoperative voice disorders with confirmed VCP. HR-QoL was assessed using the SF-36 self-questionnaire with a 6 months follow-up.
Results: We observed a significant improvement of HR-QoL 6 months after surgery (P<0.0001). Postoperative complications were associated with a non-significant impairment of HR-QoL. In multivariate analysis, Graves disease was associated with a significant improvement of HR-QoL (OR =2.39 [1.49; 3.84]) and thyroid malignant disease with an impairment of HR-QoL (OR =1.44 [0.99; 2.08]) after total thyroidectomy. Compared to general population, HR-QoL was significantly impaired in patient with thyroid disease (P<0.0001); despite significant postoperative improvement, HR-QoL remained significantly impaired (P<0.0001) after thyroid surgery compared to general population.
Conclusions: We observed a significant improvement of HR-QoL 6 months after total thyroid surgery for benign and non-extensive malignant thyroid disease. Our results may help provide better information to both patients and physicians/surgeons, in order to choose the most appropriate treatment.
18 - 21 May 2019
European Society of Endocrinology