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21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

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18-21 May 2019, Lyon, France

ea0063p337 | Thyroid 1 | ECE2019

The serum thyroglobulin level after discontinuation of two weeks of thyroid hormone in patients with differentiated thyroid cancer can be used to determine the therapeutic dose of radioiodine

Song Heesung , Lee Ji Young

Purpose: This retrospective study is intended to determine the dose of radioactive iodine using thyroglobulin levels measured after two weeks of thyroid hormone withdrawal in patients with differentiated thyroid cancer. Methods : Patients who were diagnosed as differentiated thyroid cancer and treated with radioiodine after total thyroidectomy were enrolled. Serum thyroglobulin test (preTG; ng/dl) was performed 1 week before radioiodine treatment and 2 w...

ea0063p338 | Thyroid 1 | ECE2019

Thyroid-associated orbitopathy and quality of life: correlation of GO-QoL with clinical activity score and severity in 101 patients

Borel Marine , Grunenwald Solange , Imbert Philippe , Dekeister Celine , Caron Philippe

Thyroid-associated orbitopathy (TAO) is a classic and sometimes severe complication of autoimmune process associated with thyroid diseases, more common in Graves’ disease. Due to its functional impairment and disfiguring clinical presentation, TAO affects the quality of life of patients. Few studies have examined the importance of this impact in these patients. The main objective of this retrospective study is to determine if there is a correlation between the deteriorati...

ea0063p339 | Thyroid 1 | ECE2019

The influence of thyroid gland subclinical form on hypercholesterolemia patients in Latvia

Jursevics Kirils , Krasilnikova Jelena , Fizdels Igors , Sirotin Igor

Introduction: It is a well-known fact that in Baltic Sea region there is low level of ecological selenium and iodine in soil and water, which can lead to subclinical hypo-activity of thyroid gland. By epidemiological data of that region, chronic stress and low insolation favour the decrease of metabolic rate, hypercholesterolemia and obesity in 30% of population.Method: In Dietological Centre of Jurmala, Latvia, 87 obese patients, in the age group of 25&...

ea0063p340 | Thyroid 1 | ECE2019

Endocrinopathies post Immune check point inhibitors

Hamza Malak , Van Heeswijk Isabelle , Yahia Seif , Fernando Devaka , Abdulla Haitham , Muraleedharan Vakkat

Introduction: Immune adverse related events are commonly recognized complications of immune check point inhibitors. Here we identify multiple endocrinopathies occurring concurrently in the same patient. In addition to highlighting the common immune adverse effects seen in other cases.Case 1: 33F Refractory Hodgkins Lymphoma tried on several therapies. She was started on Nivolumab (PD-1) with remarkable response. She developed symptoms of Amenorrhea, gala...

ea0063p341 | Thyroid 1 | ECE2019

Hashimotos encephalopathy in Graves’ disease

Al Salam Randa Abd , El Hadad Hemmet , Radwan Mona , El Meligy Amr , Galal Mai , Salam Randa

Introduction: Hashimoto’s encephalopathy is a neurological disorder of unknown cause associated with thyroid autoimmunity. It is easy to misdiagnose or overlook and the symptoms frequently lead to mistaken neurological diagnoses. The disease may present in two types – a sudden vasculitic type or a progressive subacute type associated to cognitive dysfunction, confusion and memory loss.Case report: A 34 year old male presented to our emergency d...

ea0063p342 | Thyroid 1 | ECE2019

Role of lipid peroxidation in the progression of autoimmune thyroiditis

Mirza-Akhmedova Istora , Azizova Pokiza , Najmutdinova DIlbar , Mirmaksudov Mirakhmadjon

Introduction: The issue of autoimmune thyroiditis (AIT) today is topical for modern endocrinology both due to the relatively high incidence among the population and the large number of organs and systems involved in the pathological process as a result of loss of the thyroid gland hormone-producing function and a decrease in thyroid hormone levels in the blood.Aim: The aim of the research is to study the state of the processes of lipid peroxidation and e...

ea0063p343 | Thyroid 1 | ECE2019

Clinical evaluation of TSH-receptor antibody measured by a third generation fully automated electrochemiluminescence immunoassay method in Turkish patients with Graves’ disease

Yildirim Ozge Tasgin , Elbuken Gulsah , Topcu Birol , Yildiz Ismail , Zuhur Sayid

Objective: Despite the high sensitivity of TRAb measured by modern assay methods, some patients with Graves’ disease (GD) may still have normal TRAb levels. Therefore, the purpose of this study was to determine the clinical utility of TRAb measured by a third generation assay method, and to determine it’s relationship with clinical and laboratory parameters in Turkish patients with GD.Methods: In this study, 328 consecutive treatment-naive pati...

ea0063p344 | Thyroid 1 | ECE2019

Association between hypothyroidism and venous thromboembolism and the effect of levothyroxine in the adult: a nationwide Cohort study

Wei Wei-Ting

Background: Thyroid hormone plays a potent role in many physiological processes, including the impact on blood coagulation. But, there are some contradictory results on the effect of hypothyroidism on the changes in homeostasis. Venous thromboembolism (VTE), commonly defined as deep vein thrombosis (DVT) or pulmonary embolism (PE), is a major health problem worldwide. Little was known about the association between hypothyroidism and VTE. Our study aimed to evaluate the associa...

ea0063p345 | Thyroid 1 | ECE2019

Should narrower TSH and free thyroid hormone levels be targeted to reduce the cardiovascular risk of euthyroid subjects?

Cetin Zeynep , Kosem Arzu , Catak Merve , Can Bulent , Baser Ozden , Turhan Turan , Berker Dilek , Guler Serdar

Aim: Thyroid hormones have many effects on the cardiovascular system. May studies have showed that apparent or subclinical hypothyroidism increase the risk of hypertension hyperlipidemia and so lead to atherosclerosis susceptibility. This risk can be reduced by treatment. But, studies on the relationship between thyroid function tests and cardiovascular risk in euthyroid subjects are contradictory. This study was designed to investigate the effect of TSH, free T3, f...

ea0063p346 | Thyroid 1 | ECE2019

Thyroid dysfunction in Egyptian HCV patients: prevalence and possible triggering factors

El Haddad Hemmat , Fayed Ahmed , Hussin Mervat

Introduction: The contribution of chronic hepatitis C virus (HCV) infection per se in thyroid autoimmunity and dysfunction remains controversial.Aim: To investigate the prevalence of thyroid disorders and the possible association between thyroid dysfunction and different factors in a cohort of HCV untreated patients.Material and methods: A total 1050 patients with untreated HCV infection were enrolled in this study. Thyroid functio...

ea0063p347 | Thyroid 1 | ECE2019

Management of refractory hypothyroidism with intramuscular levothyroxine: a clinical case

Timon Iciar Martin , Ruiz Inmaculada Moreno , Penalver Juan Jose Marin , Abiega Beatriz Ugalde , Pita Olalla Meizoso , Collantes Cristina Sevillano

Introduction: There are a few hypothyroid patients who are refractory to standard thyroid hormone replacement treatment and require unexpectedly high doses of levothyroxine. In addition to clinical situations where hypothyroid patients are non-compliant (pseudomalbsortion), or where there is the possibility of excipient-induced disease exacerbation, therapeutic failure may be due to impaired absorption of the administered drug. The common approach to managing patients is to es...

ea0063p348 | Thyroid 1 | ECE2019

Thyroid angiosarcoma: in the light of a case

Askaoui Sara , Lmghari Guizlane , Rafi Sana , Ansari Nawal El

Introduction: Angiosarcoma is a highly malignant tumor, very rare and even more so when it comes to a thyroid localization. It is characterized morphologically by its vascular differentiation and cytological polymorphism. The objective of this study is to report a case of this entity with its evolution in the postoperative period.Observation: patient of 54-year-oldm, with no pathological history. Operated (total thyroidectomy) for compressive multihetero...

ea0063p349 | Thyroid 1 | ECE2019

Collision tumor: A case report of tall cell variant of papillary thyroid carcinoma and laryngeal squamous cell carcinoma

Garcia Maria Laura , Lisdero Ana Paula , Szuman Gabriela , Endelman Marta , Castelletti Natalia

Collision tumors (CT) refers to the coexistence of two histologically distinct malignant tumors within the same mass. CT involving the thyroid gland (TG) and/or the neck are specially uncommon and present a diagnostic and treatment challenge.Case report: A 69-year-old male presented with a one year history of bilateral cervical lymph node growth, a four-month history of progressive dysphagia and a dyspnea associated with a rapidly expanding, painless mas...

ea0063p350 | Thyroid 1 | ECE2019

Outcomes of surgery and radioiodine treatment for neck recurrence in papillary thyroid cancer

Kalaitzidou Styliani , Tampouratzi Dimitra , Papadakis Georgios , Karavasili Chrysi , Triantafillou Eleni , Kanouta Fotini , Sapera Aggeliki , Kotis Michalis , Aravantinou Aggeliki , Roumpidaki Zoi , Dracopoulou Anna , Kaltzidou Victoria , Veniou Irini , Tertipi Athanasia

Background: Persistent/recurrent disease in the neck is frequent in patients with papillary thyroid cancer. The main goal of this study was to evaluate the efficacy of the reoperation and radioiodine (RAI) treatment for persistent/recurrent disease after the initial treatment. Patients and Methods: A total of 30 patients (13 M/17 F) with papillary thyroid cancer were enrolled in this study. Seven cases (23.3%) had an aggressive subtype of papillary carcinoma. All had been subm...

ea0063p351 | Thyroid 1 | ECE2019

Anaplastic thyroid carcinoma or radiation-induced sarcoma: About a case

Amira Bouchenna , Abdelghani Tibouk , Youcef Bakkouche , Samia Ould Kablia

Introduction: Anaplastic thyroid cancer has long been considered as a mesenchymal tumor (sarcoma). To date, it is difficult to differentiate between the two types. Radio-induced sarcomas of the head and neck are a very rare entity. Their annual incidence is 0.06 to 0.17%.Observation: We report the case of a 83-year-old patient, with a history of breast neoplasia treated with radiotherapy 7 years ago. Followed for a year for papillary carcinoma of the thy...

ea0063p352 | Thyroid 1 | ECE2019

The relationship between thyroid receptor antibody and anti mullerian hormone in Graves’ disease

Demir Keziban , Kursat Hakan , Yazici Sevde , Pişkinpaşa Hamide , Bozkir Evin , Esen Ayşe , Akdeniz Yasemin , Doğanşen Sema , Hurşitoğlu Mehmet , Kural Alev , Mert Meral

Introduction and Aim: Thyroid dysfunction is the most common autoimmune endocrine disorder in women of reproductive age. Autoimmune thyroid disease is related to menstrual irregularities, anovulation and infertility. Thyroid dysfunction is thought to disrupt follicular growth and maturation. Autoimmunity may have a negative effect on fertility, independent of age. The relation between TSH (Thyroid Stimulant Hormone), thyroid antibodies and AMH (anti-mullerian hormone) is a top...

ea0063p353 | Thyroid 1 | ECE2019

Infrared thermography in association with indirect calorimetry: a new methodology for diagnosis and follow-up of subclinical hypothyroidism

Massarini Stefano , Natarelli Federica , Ferrulli Anna , Macri Concetta , Luzi Livio

Infrared Thermography (IT) is a non-invasive method and complementary to other diagnostic techniques to identify inhomogeneity of the thermal emission of the skin. We used IT (InfRec R500, Nippon Avionics Co.; 640×480 pixel, spatial resolution 0,87 mrad, sensitivity 0.03°C at 30°C, accuracy ±1°C) to assess the variations of skin temperature of the neck region: higher mean temperature, greater thyroid function. Primary outcome of this study was to compa...

ea0063p354 | Thyroid 1 | ECE2019

How much the implementation of an expert surgical team can improve the incidence of postoperative hypoparathyroidism

Cabanas Manez , Atienza Elena , Romero Paula , Lallena Silvia , Rubio Jose Antonio , Blanco Concepcion

The experience and expertise of a thyroid surgery team is a relevant factor in the development of postsurgical hipoparathyroidism (hypoPP). In 2005, we published a 9.6% prevalence of permanent hipoparathyroidism among patients operated on for thyroid cancer (TC) at our centre between 1985 and 2001. Since 2002, an expert surgery team was implemented as part of a multidisciplinary committee. The aim of the present study is to assess the prevalence and risk factors associated wit...

ea0063p355 | Thyroid 1 | ECE2019

An ununsual thyroid cause for Pyrexia of unknown origin (PUO)

Panchangam Ramakanth Bhargav , Chakrapani B , Sabaretnam M , Ramesh B , Rajesh B

Introduction: Granulomatous thyroiditis (GT) is one of the various types of autoimmune thyroiditis. It usually occurs in women of reproductive age in perigestational period. Clinical picture in is predominantly painful goiter with radiating pain to ears with low grade fever lasting for few days, sometimes associated with mild hyper or hypothyroidism. The treatment is symptomatic and supportive with no curative option. There are meagre anecdotal reports of thyroidectomy role fo...

ea0063p356 | Thyroid 1 | ECE2019

Relationship among T- and B-lymphocytes of the peripheral blood and thyroid tissue in patients with Graves’ disease

Dudina Margarita A , Savchenko Andrey A , Dogadin Sergey A , Borisov Alexandr G , Kudryavcev Igor V , Moshev Anton V , Man'kovsky Vladimir A

The exact pathogenesis and causative interaction between T- and B-lymphocytes in peripheral blood and thyroid gland immune-mediated mechanisms of Graves disease (GD) are still unknown. Detailed knowledge about lymphocyte subpopulation composition in peripheral blood and thyroid tissue will therefore enhance our understanding of the pathogenesis of GD and might support the development of new immunomodulatory treatment approaches. Aim: to study the relationship between helper- (...

ea0063p357 | Thyroid 1 | ECE2019

Association between vitamin D receptor gene polymorphisms and Graves’ disease: a systematic review and meta-analysis

Anagnostis Panagiotis , Veneti Stavroula , Adamidou Fotini , Artzouchaltzi Aikterini-Maria , Boboridis Kostas , Kita Marina

Introduction: The pathogenesis of Graves’ disease (GD) and Graves’ orbitopathy (GO) is not completely understood. On the other hand, vitamin D receptor (VDR) gene polymorphisms have been associated with susceptibility to a variety of chronic autoimmune diseases. The primary aim of this study was to synthesize the best available evidence regarding the association between VDR gene polymorphisms and risk of GD. Secondary aim was to search for their association with GO.<...

ea0063p358 | Thyroid 1 | ECE2019

Thyroid dysfunction after Alemtuzumab treatment for multiple sclerosis: diagnostic and therapeutic modalities

Daniel Sara , Lommers Emilie , Hansen Isabelle , Dive Dominique , Geenen Vincent , Beckers Albert , Valdes-Socin Hernan

Introduction: Alemtuzumab is a humanized monoclonal antibody against CD52, located on the surface of the lymphocytes, used in the treatment of relapsing-remitting multiple sclerosis (RRMS), that can induce novel secondary autoimmune diseases. Autoimmunity may be related to the pattern of T- and B-cell depletion and repopulation following Alemtuzumab treatment. The most frequently reported autoimmune disorders observed with alemtuzumab involve the thyroid gland in up to a third...

ea0063p359 | Thyroid 1 | ECE2019

A rare cause of goiter

Schuldt Maria Belen Ojeda , Recio Carmen Bautista , Fernandez-Ladreda Mariana Tome

Introduction: Amyloidosis is a rare systemic disease of unknown etiology characterized by the extracellular deposition of proteinaceous (amyloid) material in different organs of the body. About 40-50% are of secondary cause (Amyloidosis AA) Amyloid goiter is a rare condition, usually associated with the secondary form.Case: We reported a 41-year-old male with a history of non-steroidal anti-inflammatories, high blood pressure and smoking habit. Maintains...

ea0063p360 | Thyroid 1 | ECE2019

Changing practice in the management of differentiated thyroid carcinoma – experience at Brugmann Hospital in Brussels

Laura Iconaru , Felicia Baleanu , Rafik Karmali , Ruth Duttmann , Pierre Bergmann , Linda Spinato , Sophie Hambye Anne

Aim of the work: In patients with differentiated thyroid cancer, the basic goal of the therapy is to improve overall and disease-specific survival, reduce the risk of persistent/recurrent disease while minimizing treatment-related morbidity and unnecessary therapy. In 2015, the American Thyroid Association (ATA) published evidence-based guidelines for the staging and management of differentiated thyroid cancer, including the possibility of avoiding systematic complementary 131...

ea0063p361 | Thyroid 1 | ECE2019

Intraoperative Neuromonitoring of the laryngeal nerves in thyroid surgery

Vozdvizhenskii Mikhail O , Orlov AE , Makhonin AA , Stadler VV , Matyash Ya.S

Topicality: Thyroid nodules are detected by palpation in 4–8% of the adult population and in ultrasound in 10–41%. However, most of them (90%) are benign tumors and require monitoring. Indications for surgery are compression symptoms and/or hyperthyroidism, as well as cosmetic issues. One of the severe complications of the operation is intraoperative damage of the recurrent laryngeal nerve.Research objective: Minimize the risk of damage to the ...

ea0063p362 | Thyroid 1 | ECE2019

Weekly dose of L-thyroxine as a first line treatment for hypothyroidism in young and middle aged working females

Wasoori Satish Chander , Naik Manoj Hari , Bhardwaj Chetan

Objective: To demonstrate the effectiveness and compliance to L-thyroxine in the treatment of hypothyroidism in a weekly dose of seven times of normal dose as an alternative to daily dosing in young and middle aged females.Methods: Randomized trial on 40 female patients aged between 25 to 55 years with long standing hypothyroidism of 5 years or more, currently on daily dose of L-thyroxine, were assigned weekly dose of seven ...

ea0063p363 | Thyroid 1 | ECE2019

Analysis of clinical and biological predictors of malignancy in thyroid nodules

Belaid Rym , Oueslati Ibtissem , Chaker Fatma , Rejeb Ons , Grira Wafa , Yazidi Meriem , Chihaoui Melika

Background: Thyroid nodules are the most common thyroid disease. In the majority of cases, they are benign. However, 5 to 15% of nodules are cancer. The aim of our study was to determine the clinical and biological predictive factors of malignancy in thyroid nodules.Methods: We performed a retrospective descriptive study including 100 patients collected in the endocrinology department of La Rabta hospital over 18 year old period (2000–2018). All the...

ea0063p364 | Thyroid 1 | ECE2019

Sensitivity and specificity of ultrasound features in predicting malignant thyroid nodules

Belaid Rym , Oueslati Ibtissem , Grira Wafa , Rejeb Ons , Yazidi Meriem , Chaker Fatma , Chihaoui Melika

Background: Ultrasound is valuable for identifying many malignant or potentially malignant thyroid nodules. The aim of this study was to evaluate the efficacy of ultrasonographic (US) features in predicting the malignancy of thyroid nodules in a group of Tunisian patients.Methods: We conducted a retrospective descriptive study including 100 patients collected in the endocrinology department of La Rabta hospital. All these patients underwent thyroidectomy...

ea0063p365 | Thyroid 1 | ECE2019

Comparison of G-CSF and non-G-CSF treatment of agranulocytosis in patients with hyperthyroidism: a meta-analysis

Wang Yonghui , Li Xiaoying , Yang Qian , Zhang Yanan , Liu Jun , Zheng Liang , Zha Bingbing

There are potential benefits and risks to receive Granulocyte-Colony Stimulating Factor (G-CSF) as a general treatment in hospital. To assess the clinical effect of G-CSF or non-G-CSF on recovery duration for agranulocytosis patients with hyperthyroidism, we analyzed the overall clinical outcomes by meta-analysis. We included published seven retrospective studies and 1 prospective study. Individual data were obtained from eight trials (376 patients: 215 with G-CSF, 161 with no...

ea0063p366 | Thyroid 1 | ECE2019

Ocular cavity metastasis from poorly differentiated thyroid carcinoma

Belis Constantinos , Gavriilidou Stavroula , Afentoulidi Aikaterini , Xydiari Kalliopi , Athanasiou Vasileios , Malaktari-Skarantavou Sofia , Savvidis Christos

Introduction: Poorly differentiated thyroid carcinoma is a tumor of follicular origin with morphological and biological characteristics between anaplastic and well differentiated carcinoma. It accounts for less than 5% of all thyroid tumors and is characterized by adverse prognosis, aggressive behavior and frequently distant metastases, mainly to lungs and bones and to a lesser extent to brain, liver, kidney, breast and skin. Incident presentation: We report a case of a patien...

ea0063p367 | Thyroid 1 | ECE2019

Giant cystic pheochromocytoma: A clinically silent entity

Afentoulidi Aikaterini , Markogiannakis Haridimos , Kekis Panagiotis , Natoudi Maria , Gavriilidou Stavroula , Belis Constantinos , Xydiari Kalliopi , Athanasiou Vasileios , Malaktari-Skarantavou Sofia , Leandros Emmanouil , Savvidis Christos

Introduction: Pheochromocytomas (PCCs) are rare neuroendocrine catecholamine secreting-tumors derived from chromaffin cells of the adrenal medulla. PCCs are usually solid tumors but rarely occur as a cystic lesion. Cystic pheocromocytomas (CPCCs) are usually asymptomatic, unilateral and of a large size without typical radiological and biochemical features of pheochromocytomas. Non-specific abdominal pain has been reported in several cases.Case Presentati...

ea0063p368 | Thyroid 1 | ECE2019

Glucocorticoid Functional Reserve in Hashimoto Hypothyroidism before and after LT4 replacement

Taieb Ach , Abdelkarim Asma Ben , Yosra Hasni , Amel Maaroufi , Maha Kacem , Molka Chaieb , Koussay Ach

Introduction: It has been generally accepted that adrenal function might be impaired in patients with primary hypothyroidism. A transitory low glucocorticoid production has been identified in cases with severe hypothyroidism. We tried to evaluate adrenocortical glucocorticoid function using the low-dose Synacthen test, in patients with primary hypothyroidism. The primary endpoint was to contrast the cortisol response to low-dose Synacthen before L-T4 replacement and after norm...

ea0063p369 | Thyroid 1 | ECE2019

Impact of thyroid autoimmunity on obstetric and perinatal outcomes in pregnant women with subclinical hypothyroidism

Oleaga Amelia , Jimenez-Telleria Patricia , Goni Fernando , Moreno Cristina , Arrizabalaga Cristina , Izuzquiza Ana , Espiga Javier , Martinez Adela , Zabalegui Alba , Paja Miguel

Introduction: Maternal clinical thyroid disorders can cause reproductive complications. However, the effects of mild thyroid dysfunction are controversial. The impact of SH and thyroid autoimmunity on miscarriages, obstetric and perinatal outcomes are not yet well established and the effect of levothyroxine replacement in pregnant women with SH is unclear. The aim of this study was to evaluate the impact of thyroid autoimmunity in early pregnancy on obstetric and perinatal out...

ea0063p370 | Thyroid 1 | ECE2019

Abstract Unavailable....

ea0063p371 | Thyroid 1 | ECE2019

Navigating thyroid storm: The role of plasmapheresis in a patient also needing urgent aortic valve replacement surgery

Parihar Richa , Hull Stephen

Thyroid storm requires a multiple-step pharmacological approach. While there is limited evidence for it, plasmapheresis has been shown to be an effective treatment when patients fail conventional therapy and other comorbidities complicate the clinical course. A 65-year-old woman presented with 6 months of symptoms of thyrotoxicosis and dyspnea, treated initially as an outpatient for pneumonia with no improvement. Eventually requiring admission for her dyspnea, laboratory testi...

ea0063p372 | Thyroid 1 | ECE2019

Prognostic factors for lymph node metastases in patients with papillary thyroid microcarcinoma

Sastre Julia , Cruz Gordillo Andrea , Aznar Silvia , Alvarez Visitacion , Torres Belvis , Delgado Manuel , Gonzalez Javier , Quiroga Ivan , Herranz Sandra , Aguirre Miguel

Background and objective: Papillary thyroid microcarcinoma (PTMC) is recognized as a separate entity by the World Health Organization. Biological behaviour and clinical outcomes of PTMC are heterogenous. Presence of lymph node metastases (LNM) in this group of patients increases the risk of recurrence and makes optimal management in PTMC controversial (observation, lobectomy with or without preventive central ipsilateral dissection). The aim of this study was to describe risk ...

ea0063p373 | Thyroid 1 | ECE2019

Histological characteristics in thyroid carcinoma: our experience in the last fifteen years

Torres Arroyo Belvis , Gonzalez Lazaro Paloma , Silva Fernandez Julia , Javier Gomez Alfonso Francisco , Del Val Zaballos Florentino , Contreras Pascual Cristina , Garcia Manzanares Alvaro , Lopez Iglesias Maria , Gomez Garcia Ines

Background and objective: The incidence of differentiated thyroid carcinoma (DTC) is increasing worldwide. Due to a increased use of improved radiological techniques, especially ultrasound. This study aims to analyze histological characteristics of DTC diagnosed in our hospital in the last fifteen years.Patients and methods: It is a restrospective descriptive study. We have included all operated patients in our center between 2001 and 2015 with a final b...

ea0063p374 | Thyroid 1 | ECE2019

Impact of total thyroidectomy on quality of life: the prospective ThyrQoL multicenter trial

Borel Frederic , Mirallie Eric , Tresallet Christophe , Hamy Antoine , Mathonnet Muriel , Lifante Jean-Christophe , Brunaud Laurent , Marret Olivier , Caillard Cecile , Espitalier Florent , Menegaux Fabrice , Drui Delphine , Hardouin Jean-Benoit , Blanchard Claire

Introduction: Health-related Quality of Life (HR-QoL) is usually impaired in patients with thyroid diseases compared to the general population. Thyroidectomy is largely performed in case of benign thyroid disease, and can be associated with severe long-term complications: vocal cord palsy (VCP), hypoparathyroidism. Our goal was to report the long-term HR-QoL outcomes after thyroidectomy using the MOS 36-item short form health survey (SF-36) self-questionnaire.<p class="abs...

ea0063p375 | Thyroid 1 | ECE2019

Can urinary iodine be used in the diagnosis and follow up of subacute thyroiditis?

Ozdemir Didem , Evranos Berna , Gedik Gulsum , Ersoy Reyhan , Cakir Bekir

Introduction: Subacute thyroiditis is an iflammatory disease of the thyroid gland characterized by pain, tenderness and swelling in the neck. Less frequently, it may present with painless or silent thyroiditis that occurs spontaneously or in the postpartum period. In a few studies in the literature, urinary iodine was reported to be high in patients with postpartum thyroiditis, but it was not evaluated in patients with subacute thyroiditis. We aimed to evaluate urinary iodine ...

ea0063p376 | Thyroid 1 | ECE2019

Comparative analysis of Hashimoto’s and Riedel’s thyroiditis morphology and immunohistochemistry

Gvianishvili Tamuna , Gogiashvili Liana , Chkhobadze Maguli

The issues of Riedel’s Thyroiditis etiology are controversial: There are two different topical pathogenic theories: Riedel’s Thyroiditis as an autoimmune disease or as independent, primary fibroplastic process. Problem is to determine the possibility of malignisation in thyroid parenchym during the autoimmune thyroiditis - Hashimoto and Riedel’s. Just due this questions, In parallel to the routine histological research, has been studied follow markers: 1. Highly...

ea0063p377 | Thyroid 1 | ECE2019

Is total thyroidectomy and bilateral central lymph node dissection essential for patients with unilateral cN1a papillary thyroid carcinoma?

Back Kyorim , Yoon So Jeong , Kim Min Jhi , Choe Jun-Ho , Kim Jung-Han , Kim Jee Soo

Background: The 2015 ATA guidelines recommend total thyroidectomy with therapeutic central lymph node dissection (CND) for papillary thyroid carcinoma (PTC) patients with clinical central lymph node metastasis (CLNM). The purpose of this study is to verify that total thyroidectomy with therapeutic bilateral CND is necessary for all patients with unilateral cN1a PTC.Methods: This study retrospectively reviewed 899 PTC patients who had total thyroidectomy ...

ea0063p378 | Thyroid 1 | ECE2019

Should the dose of levothyroxine be changed in hypothyroidism patients fasting during Ramadan?

Koca Arzu Or , Dağdeviren Murat , Altay Mustafa

Objective: Muslims worship by fasting from pre-dawn (suhoor) until sunset (iftar) for 30 days in the religious month of Ramadan. In addition to prolonged hunger, patients fasting with a diagnosis of hypothyroidism take their doses of levothyroxine outside of daytime fasting hours. This study compares thyroid functions of fasting hypothyroidism patients with the values before Ramadan.Methods: One hundred patients aged 18–65 years were included in the...

ea0063p379 | Thyroid 1 | ECE2019

Iodine status of schoolchildren of Belarus in 2017–2018

Mokhort Tatiana , Petrenko Sergei , Kolomiets Natalia , Mokhort Alena , Fedorenko Ekaterina , Leushev Boris , Shyshko Alena

Background: The problem of iodine deficiency in Belarus remains topical, due to the historical understanding of iodine deficiency in the environment and the negative impact of iodine deficiency on health. Strategy for elimination of iodine deficiency among the population was developed and implemented in the Republic of Belarus.Aims: To determine iodine sufficiency in children living in Belarus.Materials and methods: The study inclu...

ea0063p380 | Thyroid 1 | ECE2019

The Effect of Ramadan fasting on thyroid hormone levels in patients on levothyroxine treatment

Dellal Fatma Dilek , Ogmen Berna , Ozdemir Didem , Cuhaci Fatma Neslihan , Polat Sefika Burcak , Ersoy Reyhan , Cakir Bekir

Aim: Contradictory results in limited number of studies were reported about the effects of Ramadan fasting on thyroid hormones. We aimed to evaluate the thyroid functions in Ramadan, and compare late evening or pre-sahour use of levothyroxine in patients being treated for hypothyroidism.Methods: Patients taking levothyroxine for hypothyroidism who were seen in the last one week before Ramadan (8–15 May 2018) and had normal thyroid functions were rec...

ea0063p381 | Thyroid 1 | ECE2019

Switch from tablet to oral liquid or softgel capsule L-thyroxine ensures lower serum TSH levels and favorable effects on blood pressure, total cholesterolemia and glycemia in thyroxine-replaced postmenopausal women under simultaneous calcium supplementation.

Morini Elisabetta , Catalano Antonino , Morabito Nunziata , Lasco Antonino , Benvenga Salvatore

Fifty postmenopausal hypothyroid women (age 71.7±5.1 year) had been under replacement L-T4 therapy for 4.4±2.0 years before adding calcium carbonate (CC) (taken 1–2 h after L-T4). CC and tablet L-T4 were taken for the subsequent 2.3±1.1 years. Because serum TSH increased compared to L-T4 taken alone (3.33±1.0 vs 2.0±0.5 mU/l (baseline), P<0.001), with 9/50 having TSH values >4.12 mU/l, we instructed all 50 women to postpone CC aft...

ea0063p382 | Thyroid 1 | ECE2019

Targeting the pentose phosphate pathway in thyroid cancer cells

Cheng Shih-Ping , Liu Chien-Liang , Lee Jie-Jen , Hsu Yi-Chiung , Huang Shih-Yuan

The pentose phosphate pathway (PPP) plays an important role in the biosynthesis of ribonucleotide precursor ribose-5-phosphate and NADPH. Glycolytic reprogramming of cancer cells frequently involves dysregulation of PPP flux. A previous study suggested that the expression of transketolase like 1 (TKTL1) was associated with invasiveness of papillary thyroid cancer. In the present study, we found that the combination of G6PD and transketolase inhibitors exerted a synergic effect...

ea0063p383 | Thyroid 1 | ECE2019

Clinical presentation of patients with Autoimmune Polygranular Syndrome III (APS III)

Sapera Ageliki , Papadakis Georgios , Tampouratzi Dimitra , Kalaitzidou Styliani , Karavasili Chrysi , Kotis Michail , Aravantinou Ageliki , Roumpidaki Zoi , Dracopoulou Anna , Kaltzidou Victoria , Veniou Irini , Tertipi Athanasia

Background: The autoimmune polyglandular syndromes are clusters of endocrine abnormalities that occur in discreet patterns in subjects with immune dysregulation and that permit treatment and anticipation of associated systemic or other hormonal deficiencies. Three major entities are recognized, APS I, APS II and APS III. They are considered rare syndromes, but they are possibly not always thoroughly investigated. APS III, in contrast to APS I and II, does not involve the adren...

ea0063p384 | Thyroid 1 | ECE2019

Prevalence of celiac disease in autoimmune thyroid diseases, and its associaton with other autoimmune disesases: a single center study in Argentina

Gil Susana Mallea , Aparicio Maria Marta , Ercoli Viviana , Peressotti Bruno , Aldabe Noel , de los Angeles Sosa Maria , Latorre-Villacorta Laura , Sankowicz Silvia , Palazzo Adriana , Ballarino Carolina

Patients with autoimmune thyroid diseases (AITDs) are likely to develop celiac disease (CD) among other autoimmune disorders. The prevalence of CD in general population is about 1–1.5% and the frequency of AITDs-CD association is about 1.2–4.8%. CD can be asymptomatic in adults. Our objectives were to determine the prevalence of CD in adult patients with AITDs and the presence of other endocrine and non-endocrine autoimmune diseases in a single center in Buenos Aires...

ea0063p385 | Thyroid 1 | ECE2019

Synchronous papillary carcinomas in thyroglossal duct cyst and micro carcinomas in thyroid gland: report of 3 new cases

Ghammem Monia , Houas Jihene , Bellakdher Mouna , Meherzi Abir , Kermani Wassim , Abdelkafi Mohamed

Introduction: Thyroglossal duct carcinoma (TDCCa) is a very rare finding and its presentation is similar to a benign cyst. Carcinoma arising in this tract is uncommon. It is still debated whetherTDCCa originates from the thyroid gland, from the thyroglossalduct it self (de novo theory) or from both. Although the differentiation may be difficult, this distinction can play a crucial role in treatment decisions regarding the inclusion of thyroidectomy as part of the treatment.</p...

ea0063p386 | Thyroid 1 | ECE2019

Evaluation of the diagnostic algorithm when a suppressed tsh is found in the laboratory

Paja Miguel , Monzon Andoni , Martinez Adela L , de la Prieta M Concepcion , Aguayo Francisco J , Lizarraga Aitzol , Oleaga Amelia

Introduction: Abnormal thyroid function is the most common disease in endocrinology and its screening of made by plasmatic (TSH), followed by (fT4) determination if abnormal. (fT3) determination is only used when pathological (TSH) and normal (fT4) are found, even if there is no evidence supporting this procedure, apart from the greater technical difficulty of measuring (fT3) due to its lower plasma concentration.Material and Methods: Observational retro...

ea0063p387 | Thyroid 1 | ECE2019

A novel TPO mutation by next generation sequencing in congenital hypothyroidism and the functional analysis of thyroid peroxidase activity

Yakou Fumiyoshi , Suwanai Hirotsugu , Ishikawa Takuya , Abe Hironori , Sakai Hiroyuki , MIwa Takashi , Suzuki Ryo , Odawara Masato

Thyroid peroxidase(TPO) deficiency due to biallelic TPO mutation is known as a representative genotype of congenital hypothyroidism (CH). CH is a congenital endocrine disorder that appears in 1/2,000 to 4,000 newborns. In most cases CH is caused by embryogenesis of the thyroid but the minority is caused by errors in thyroid metabolism. TPO mutation is known as a cause of rare genetic defects in thyroid metabolism. We hereby report a new homozygous TPO mutation (9491; ex 11; c....

ea0063p388 | Thyroid 1 | ECE2019

Isotretinoin associated hypothyroidism

Ong Yan Ling , Teo Nicholas , Seow Cherng Jye

Background: Many drugs are known to cause thyroid dysfunction. We describe a patient with hypothyroidism due to isotretinoin.Case: A 28 year-old Chinese gentleman presented with 2-year history of fatigue and cold intolerance. He has acne vulgaris and has been taking isotretinoin for the last 3 years (20 mg daily for 1 year then 10 mg daily). He has a positive family history of thyroid disorders. He did not report any history of thyroiditis or known autoi...

ea0063p389 | Thyroid 1 | ECE2019

Role of subclinical hypothyroidism in modification of metabolic syndrome key components in the Chernobyl accident survivors within three decades

Muraviova Iryna , Chikalova Iryna , Afanasyev Dmitriy , Kaminskyi Alexey

More that three decades have passed since the Chernobyl nuclear power plant accident (ChNPPA). Several million survivors of the accident were exposed to radioactive iodine and mixture of other radioactive isotopes. Endocrine glands occurred among the target organs of radiation exposure in survivors. Insulin resistance and metabolic syndrome (MS) are among the ChNPPA health consequences.Objective: Evaluation of the role of abnormal thyroid function in pre...

ea0063p390 | Thyroid 1 | ECE2019

Cofilin is a mediator of RET-promoted medullary thyroid carcinoma cell migration, invasion and proliferation

Giardino Elena , Catalano Rosa , Barbieri Annamaria , Treppiedi Donatella , Mangili Federica , Spada Anna , Arosio Maura , Mantovani Giovanna , Peverelli Erika

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor that originates from parafollicular thyroid C cells and accounts for 5% -10% of thyroid cancers. In all inherited cases of MTC, and in about 40% of sporadic cases, activating mutations of the receptor tyrosine kinase proto-oncogene RET are found. Constitutively active RET triggers signaling pathways involved in cell proliferation, survival and motility, but the mechanisms underlying malignant transformation of C-...

ea0063p391 | Thyroid 1 | ECE2019

Frequency of comorbidity in primary care patients with hypothyroidism

Pankiv Ivan

There are few valid data that describe the frequency of comorbidity in primary hypothyroidism patients seen in family practice. This study aimed to investigate the prevalence of comorbidities and their association with elevated (≥4.0%) thyroid-stimulating hormone (TSH) using a large sample of hyhpothyroidism patients from primary care practices.Materials and methods: A cross-sectional study in which multivariate logistic regression was applied to e...

ea0063p392 | Thyroid 1 | ECE2019

The presence of tall cells, even if

Matrone Antonio , Gambale Carla , Torregrossa Liborio , Valerio Laura , Molinaro Eleonora , Basolo Fulvio , Vitti Paolo , Elisei Rossella

Background: CV-PTC is often indolent with excellent long-term response, while TCV-PTC (≥50% of tall cells) have aggressive features and worse clinical behavior. Less is known about the clinical behavior of CV-PTC with tall cells <50% (TC/CV-PTC) that, so far, is considered as low risk tumor.Aim: To evaluate the histological presentation of CV-PTC, TC/CV-PTC, TCV-PTC and their clinical behavior after 6 years of follow up.M...

ea0063p393 | Thyroid 1 | ECE2019

A rare case of suppurative lymphadenitis after treatment with granulocyte-stimulating factor for carbimazole-induced agranulocytosis

Chin Han Xin , Tan Joanne Wei Ping , Seow Cherng Jye

Objective: Agranulocytosis is a rare but severe side effect of thionamide use in patients with hyperthyroidism. Treatment involves cessation of offending drug, treatment of sepsis, and the use of haematopoietic growth factors. Most patients recover uneventfully, and rarely present with further complications after treatment of the acute episode. We present a case report of suppurative lymphadenitis after treatment with granulocyte-stimulating factor (GCSF) and recovery from car...

ea0063p394 | Thyroid 1 | ECE2019

Gastric acidity determines the more appropriate preparation of oral thyroxine

Virili Camilla , Stramazzo Ilaria , Capriello Silvia , Santaguida Maria Giulia , Centanni Marco

Recent reports have proven gastric pH as key for both dissolution and bioavailability of oral thyroxine. This is clinically relevant in patients with gastric disorders to tailor an individualized treatment. In vitro, the softgel preparation of thyroxine possess a superior dissolution profile at increasing pH than the tablet T4. No data are available analyzing the correlation between the gastric pH and the softgel T4 performance in vivo and the present study i...

ea0063p395 | Thyroid 1 | ECE2019

An unexpected finding of a bronchogenic cyst mimicking thyroid cyst

Ghammam Monia , Houas Jihene , Bellakhdher Mouna , Meherzi Abir , kermani Wassim , Abdelkefi Mohamed

Introduction: Bronchogenic cysts are rare benign congenital anomalies related to the abnormal budding of the tracheobronchial tree during embryological development. They are usually located in the mediastinum and intrapulmonary regions. Localization in the cervical area is unusual, and specially, bronchogenic cysts presenting as thyroid cyst are quite rare.Case report: A 43-year-old woman presented with a seven months’ thyroid mass. The patient had ...

ea0063p396 | Thyroid 1 | ECE2019

Is detection of braf mutation enough to decide prophylactic central neck dissection (CND)?

Paja Miguel , Exposito Amaia , Arrizabalaga Cristina , Martinez Adela L , Monzon Andoni , Oleaga Amelia

Introduction: Most recent ATA thyroid nodule/DTC guidelines recommend thyroidectomy without prophylactic CND for small (T1 or T2), non-invasive, clinically node-negative PTC (cN0). However, some studies have suggested an association between the BRAFV600E mutation and the risk of nodal disease. Moreover, BRAF V600E mutation have recently showed significant association with recurrence in solitary intrathyroidal PTC between 2 and 4 cm (pT2) making suitable a more aggressive treat...

ea0063p397 | Thyroid 1 | ECE2019

Assessment of attainment of recommended TSH target levels in thyroid cancer patients following in Dubai hospital

Alsaeed Maryam , Mehdi Rommana , Siddiqui Ayesha , Bachet Fawzi

Objectives: Thyroid cancer long-term treatment requires suppression of thyroid stimulating hormone (TSH) levels to below normal range based on risk stratification of the patient at time of diagnosis. This audit aimed to assess the practicality of implementation of the guideline recommendations of the American Thyroid Association (ATA) for target TSH levels in high, intermediate and low risk thyroid cancer patients. It also aimed to identify whether lack of implementation of th...

ea0063p398 | Thyroid 1 | ECE2019

Intellectual outcome in children with subclinical hypothyroidism: effects of two years of levothyroxine treatment

Ciccarelli Gian Paolo , Improda Nicola , Anselmi Federica , Polizzi Miriam , Bravaccio Carmela , Capalbo Donatella , Salerno Mariacarolina

Introduction: Subclinical hypothyroidism (SH) is characterized by serum TSH levels above the upper limit of the reference range, in the presence of normal serum concentrations of total T4 and free T4. Associ-ation between SH in childhood and adverse neurocognitive outcomes remains controversial.Objective: To evaluate the intellectual outcome of children with SH before and after 2 years of treatment with levothyroxine (L-T4).Methods...

ea0063p399 | Thyroid 1 | ECE2019

Cardiac size and function in children with subclinical hypothyroidism

Alfano Sara , D'Acunzo Ida , Cittadini Antonio , Capalbo Donatella , Improda Nicola , Salerno Mariacarolina

Background: The management of subclinical hypothyroidism (SH) is still challenging in particular for mild forms with TSH levels ranging between 4.5 and 10 mU/L. Although SH in children seems to be a bening condition, ongoing scientific investigations have highlighted the presence of subtle proatherogenic abnormalities among children with modest elevations in their TSH levels. Data on cardiac performance in children with SH are still scanty.Aim: To compar...

ea0063p400 | Thyroid 1 | ECE2019

Bone homeostasis in children with Subclinical hypothyroidism: effects of two-years treatment with levothyoxine

Gaeta Valeria , Bufalo Lorenzo , Lorello Paola , Mase Raffaella Di , Capalbo Donatella , Salerno Mariacarolina

Background: Thyroid hormone plays a key role in bone mineral homeostasis and significant alterations in its circulating levels has been associated with impairment in skeletal growth during childhood. To date, bone effects of subclinical hypothyroidism (SH) has not been demonstrated yet, therefore the management of this condition is still debated.Aim: To evaluate bone mineral density (BMD) in children with mild, persistent SH and the effects of two-years ...

ea0063p401 | Thyroid 1 | ECE2019

Jejunum metastasis and perforation from anaplastic thyroid cancer

Gavriilidou Stavroula , Belis Constantinos , Afentoulidi Aikaterini , Xydiari Kalliopi , Fotou Maria , Oikonomou Vassiliki , Zoumpouli Christina , Stroumpouli Evangelia , Athanasiou Vasileios , Malaktari-Skarantavou Sofia , Savvidis Christos

Introduction: Anaplastic thyroid carcinoma (ATC) accounts for 1.7% of all thyroid cancers with poor prognosis and a median survival of 4 to 12 months. We report a case of ATC with small intestine perforation due to metastasis in the jejunum.Case report: A 57-year-old woman was referred to our department for a rapidly enlarging goiter and dyspnea. Her latest thyroid ultrasound was performed about a month ago and demonstrated 2 nodules measuring 21×16...

ea0063p402 | Thyroid 1 | ECE2019

FNAB results of 520 patients in a mild-to-moderate iodine deficient city in Turkey

Yorulmaz Goknur , Celik Ozgur Ilhan , Celik Serkan Yasar , Taskiran Bengur

Introduction: Thyroid nodules are common in population. High resolution ultrasound and fine needle aspiration biopsy (FNAB) are advised as the first line diagnostic methods. Bethesda classification system is used to provide standardization of cytologic reports. We aimed to evaluate ultrasound guided FNAB results in a mild-to-moderate iodine deficient city of Turkey.Methods: The patients (n=520), who underwent FNAB between December 2011 and Decem...

ea0063p403 | Thyroid 1 | ECE2019

Thyroid lesions in patients with acromegaly: Experience of diabetology-endocrinology department of Oujda’s Mohammed VI university hospital

Yakhlef Salma Ben , Khadija Boujtat , Latrech Hanane

Introduction: Acromegaly is a quite rare and insidious disease caused by the oversecretion of growth hormone and subsequently insulin - like growth factor 1. Recent studies have demonstrated an increased co-existence of different thyroid lesions with acromegaly. However the data concerning this co-occurrence remains a matter of debate. The purpose of this study is to shed light on the different thyroid lesions concerning the patients with acromegaly who are followed up in the ...

ea0063p404 | Thyroid 1 | ECE2019

Pancytopenia and reversible cardiomyopathy - complications of thyrotoxicosis: case report

Klimaite Raimonda , Kinderyte Marija , Dauksaite Neda , Barsiene Lina , Zilaitiene Birute

Introduction: Grave’s disease is frequently associated with cytopenia. Pancytopenia, however, is rare. Thyroid hormones have a direct effect on myocardial contractility and left ventricle (LV) diastolic function. Only less than 1% of the patients with hyperthyroidism develop cardiomyopathy with impaired left ventricular systolic function.Case: A 51-year old woman was admitted to the Hospital of Lithuanian University of Health Sciences, Kaunas clinic...

ea0063p405 | Thyroid 1 | ECE2019

Radiofrequency ablation in the treatment of benign thyroid nodules: a good alternative to surgery

Moreno Cristina , Paja Miguel , Izuzquiza Ana , Espiga Javier , Arrizabalaga Cristina , Martinez Adela Leyre , Monzon Andoni , Zabala Rosa , Iglesias Natalia , Calles Laura

Introduction: To date, benign thyroid nodules complainig of symptomatic or cosmetic problems and autonomous functioning thyroid nodules (AFTN) have generally been treated with surgery or I131. Radiofrequency ablation (RFA) is a novel technique that has demonstrated safety and efficacy in the treatment of these nodules. We describe the clinical experience at our hospital.Material and method: We include 33 patients (28 women, 5 men) from January 2013 to Se...

ea0063p406 | Thyroid 1 | ECE2019

Exacerbation of thyrotoxicosis following radioiodine therapy in benign thyroid diseases: can it be predicted?

Hanafy Ahmed , Holmes Simon , Britton Jason , Pereira Olivia

Introduction: Radioactive iodine (RAI) is an effective and widely used treatment for thyrotoxicosis. Post-radioiodine thyrotoxicosis is a well-known side effect of RAI. This is usually mild and easily controlled mostly with beta blockers but sometimes needs anti-thyroid drugs (ATD).Aim of the study: To assess the incidence and predictors of post-radioiodine thyrotoxicosis.Methods: Retrospective analysis of 86 patients who had RAI t...