Searchable abstracts of presentations at key conferences in endocrinology
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21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

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18-21 May 2019, Lyon, France

Poster Presentations

Reproductive Endocrinology 1

ea0063p297 | Reproductive Endocrinology 1 | ECE2019

The natural course of normal weight women with polycystic ovary syndrome: an insight into metabolic changes of a large Caucasian cohort

Livadas Sarantis , Macut Djuro , Bothou Christina , Kuliczkowska-Płaksej Justyna , Vryonidou Andromahi , Bjekic-Macut Jelica , Mouslech Zadalla , Milewicz Andrzej , Panidis Dimitrios

Objective: Polycystic ovary syndrome (PCOS) is hypothesized to originate in foetal life, while its long-term consequences extend beyond menopause. However, the natural course of the disorder has not as yet been elucidated, and recent data suggest differences in the evolution of PCOS according to a woman’s weight. We aimed to define the evolution of normal-weight Caucasian women with PCOS through the years.Design: Cross-sectional case control study</...

ea0063p298 | Reproductive Endocrinology 1 | ECE2019

Inhibin-B and FSH are the best predictors of spermatogenesis

Jankowska Katarzyna

Objective: Sperm cells are produced in the testes by the Sertoli cells. These cells produce Inhibin B too and they are stimulated by FSH. Can Inhibin B be a good marker of spermatogenesis? Should we use other marker (FSH?, testosterone?)Design: Prospective study.Patients: We examined 56 patients with infertility.Methods: Semen analysis and hormonal analysis was performed. Semen analysis was performed accordin...

ea0063p299 | Reproductive Endocrinology 1 | ECE2019

High prevalence of psychopathologies among transgender patients presenting at a large tertiary center: implication for the treating clinicians

Kerem Gil , Greenman Yona , Yaish Iris , Sofer Yael , Stern Naftali , Tordjman Karen

Background and aim of study: Endocrinologists play a central role in the gender affirming process that transgender people chose to undergo, and may be ill-prepared to recognize and manage psychologic difficulties that accompany gender dysphoria. We sought to characterize the patient population currently under our care with respect to their mental health, and to address the question of possible differences between transwomen (TW) and transmen (TM).Methods...

ea0063p300 | Reproductive Endocrinology 1 | ECE2019

Bardet-Biedl syndrome in two siblings: a rare entity

Al Salam Randa Abd , El Meligy Amr , Attia Waheed , Salam Randa

Introduction: Bardet–Biedl syndrome (BBS) is a rare genetic ciliopathy with a prevalence of 1 in 160,000 in Europeans and 1 in 13,500 in some Arab populations The primary clinical features of BBS include retinal dystrophy, obesity, postaxial polydactyly, renal dysfunction, learning difficulties, and hypogonadism. Traditionally, BBS is clinically diagnosed when a patient shows 4 primary featuresCase report: 17 year old male, single, worker, presented...

ea0063p301 | Reproductive Endocrinology 1 | ECE2019

After up to 11 years observation, testosterone undecanoat 1000 mg at 3 months did not increased Prostatic Specific Antigen level (January 2019)

Pisoschi Matei , Staicu Dana Cristina , Peretianu Dan , Oprisan Bogdan

Aim: Has testosterone undecanoat 1000 mg intramuscular injection (NebidoR; Bayer), 1 at 3month, negative effect on prostate? For this purpose, we appreciate the prostatic volume (see Pisoschi, this congress) and PSA (this study) in hypogonadic patients after testosterone injection up to 11 years.Material and method: A. PSA (ng/ml) was done in Bucharest accredited laboratories.B. Patients: PSA analysis was done before tre...

ea0063p302 | Reproductive Endocrinology 1 | ECE2019

Analysing by decade, testosterone undecanoat depot injectable does not increases prostate volume: Study during up to 11 years on hypogonadic patients. (January 2019)

Pisoschi Matei , Staicu Dana Cristina , Peretianu Dan , Oprisan Bogdan

Aim: Re-Analysing (study starting in 2007) the effect of injectable testosterone undecanoat depot (TUD) in hypogonadic patients.Material-method: A. Patients: at onset 278 men with hypogonadism (median: 61 y).B. Distribution: by decade (starting with 20y); no =6, 17, 25, 70, 86, 55, 18, 1.C. TUD (NebidoR-Bayer) 1000 mg injected one/3 months i.m.D. Prostate volume (PV) apprecia...

ea0063p303 | Reproductive Endocrinology 1 | ECE2019

Evidence for preserved ovarian reserve in transgender men receiving testosterone therapy: Anti-mullerian hormone serum levels decrease modestly after one year of treatment

Yaish Iris , Malinger Gad , Azem Foad , Sofer Yael , Golani Nechama , Tordjman Karen , Amir Hadar , Stern Naftali , Greenman Yona

Background: Although successful pregnancies carried by transgender men have been reported, long-term effects of testosterone therapy on fertility remain unknown.Aims: To study markers of ovarian reserve during testosterone therapy.Methods: Prospective open-label study of transgender men prior and during treatment with testosterone. Sampling was conducted at baseline and 12 months after treatment initiation.Ma...

ea0063p304 | Reproductive Endocrinology 1 | ECE2019

Female infertility: etiological factors and management

Dumitriu Roxana , Dumitrascu Mihai , Albu Andreea

Infertility affects milions of couples worldwide. Determining the exact cause represents a real challenge and may require a complex work-up.Objective: To asses the main etiological factors of female infertility and the best treatment.Methods: Retrospective study which included 150 women diagnosed with infertility in a Romanian tertiary center. The median age was 30.5 years (20–41), 65.3% (n=98) of the patients were di...

ea0063p305 | Reproductive Endocrinology 1 | ECE2019

Assessement of frequency of depression in women of reproductive age with polycystic ovarian syndrome

Naumenava Yana , Mahlina Elena , Rusalenko Marya , Savasteeva Iryna , Mokhort Tatyana

Objective: To study the frequency of depression in women of reproductive age with different phenotypes of polycystic ovarian syndrome (PCOS).Materials and Methods: Sixty-eight women with diagnosed polycystic ovarian syndrome aged 18–44 and 30 practically healthy women of the comparable age. Hospital Anxiety and Depression Scales (HADS) were used to diagnose depression. According to the results of the HADS assessment, the patients were counseled by p...

ea0063p306 | Reproductive Endocrinology 1 | ECE2019

A rare cause of the hypergonadotropic hypogonadism: GAPO sydrome

Guclu Metin , Gorukmez Ozlem , Gorukmez Orhan , Calışkan Yasemin , Kiyici Sinem , Kisakol Gurcan

GAPO syndrome (OMIM 230740) is a rare, multiple congenital anomalies syndrome characterized by Growth retardation, Alopecia, Pseudoanodontia and Ocular manifestations. Syndrome caused by anthrax toxin receptor 1 (ANTXR1) gene (NM_032208.2) mutation leading to deficiency of an enzyme involved in the metabolism and breakdown of extracellular matrix (ECM). Disease show parental consanguinity, autosomal recessive inheritance and since first description in 1947 a total of 38 patien...

ea0063p307 | Reproductive Endocrinology 1 | ECE2019

Menstrual disorders in patients with different etiology of hyperprolactinemia

Radojkovic Danijela , Pesic Milica , Radojkovic Milan , Ciric Vojislav , Kostic Sonja , Curkovic Sanja , Antic Slobodan

Introduction: Hyperprolactinemia (HP) is a common disorder in endocrinology. Based on the various etiology, HP could be divided into: physiological, pathological, drug-induced and idiopathic HP. Regardless of its origin, HP usually affects reproductive endocrine axis. The aim of the study was to determine differences in menstrual cycle abnormalities in patients with different causes of hyperprolactinemia.Patients and methods: The study included 81 patien...

ea0063p308 | Reproductive Endocrinology 1 | ECE2019

Reproductive phenotype in 265 men with congenital hypogonadotropic hypogonadism and 531 men with acquired hypogonadotropic hypogonadism: a monocentric comparative study

Maione Luigi , Sarfati Julie , Bernard Valerie , Gonfroy Celine , Jublanc Christel , Salenave Sylvie , Trabado Severine , Chanson Philippe , Young Jacques

Context: Hypogonadotropic hypogonadism (HH), defined by LH and FSH deficiencies, lead to impairment in testicular growth, testicular hormonal secretions and spermatogenesis. HH can have a prenatal (congenital HH, CHH) or post-natal (acquired HH, HHA) onset. Direct comparison of reproductive phenotypes (RP) between CHH and AHH has not been systematically performed in large series representative of these two populations.Patients and methods: 60 normal men,...

ea0063p309 | Reproductive Endocrinology 1 | ECE2019

Ano-genital distance in children born of mothers with polycystic ovary syndrome – Odense Child Cohort

Glintborg Dorte , Jensen Richard Christian , Schmedes Anne Vibeke , Brandslund Ivan , Kyhl Henriette Boye , Nielsen Tina Kold , Andersen Marianne Skovsager

Background: Higher testosterone levels during pregnancy in women with polycystic ovary syndrome (PCOS) could be associated with longer offspring ano-genital distance (AGD).Aims: To compare AGD between offspring of mothers with PCOS and controls and to determine possible associations between maternal 3rd trimester testosterone levels and offspring AGD at three months of age.Methods: The study was part of the prospective s...

ea0063p310 | Reproductive Endocrinology 1 | ECE2019

Diagnosis and management of severe hyperandrogenism in the context of tumoral suspicion: case-series report from a tertiary hospital

Ortiz-Flores Andres , Luque-Ramirez Manuel , Fernandez-Duran Elena , Vega-Pineiro Belen , Escobar-Morreale Hector

Background: The finding of severe hyperandrogenemia, rapidly progressive clinical hyperandrogenism, defeminization and/or virilization in women of any age should raise the suspicion of an ovarian or adrenal malignancy. Similarly, moderate to severe hyperandrogenemia after menopause, and its clinic consequences, force clinicians to rule out a tumoral source.Matherial and methods: Observational cross-sectional study conducted in patients derived to our cli...

ea0063p311 | Reproductive Endocrinology 1 | ECE2019

Ovarian reserve and exposure to environmental pollutants (ORExPo study)

Santi Daniele , Marca Antonio La , Michelangeli Marco , Casonati Andrea , Grassi Roberto , Baraldi Enrica , Simoni Manuela

Background: Many chemicals present within the environment, as well as natural and artificial components of our diet, have the potential to interfere with the physiological role of hormones, interfering with hormone biosynthesis, signalling or metabolism. In the last years AMH, a protein secreted by granulosa cells, has emerged as a reliable marker of ovarian reserve. It is largely accepted the influence of age and smoking on AMH serum levels, although a clear effect of environ...

ea0063p312 | Reproductive Endocrinology 1 | ECE2019

Normosmic hypogonadotropic hypogonadism associated with a novel TACR3 mutation

Valdes-Socin Hernan , Libioulle Cecile , Lebrethon Marie Christine , Corman Vinciane , Debray Francois Guillaume , Dideberg Vinciane , Beckers Albert

Introduction: Neurokinin B (NKB) is a neurotransmitter, regulating GnRH. NKB activates its receptor TACR3. Recessive mutations of TACR3 are associated with a phenotype of normosmic hypogonadism.Case report: A 17 years old man born in Turkey, present with pubertal delay. He is treated 3 years with testosterone and he is reevaluated without treatment. He is 1.79 m and 1.85 arm span, testicular volume: 3 and 4 ml. He has no olfactory troubles. Testosterone ...

ea0063p313 | Reproductive Endocrinology 1 | ECE2019

A novel rare case of normosmic congenital hypogonadotropic hypogonadism associating a GnRHR and a KISS1R variants

Valdes-Socin Hernan , Libioulle Cecile , Debray Francois-Guillaume , Dideberg Vinciane , Bours Vincent , Beckers Albert

Case report: We describe a 28 years old male patient born in IRAK, beeing referred to us because of suspicion of congenital hypogonadism. The patient was 1.86 m tall and 1.97 spam arm and he was no anosmic. He had a 2.5 cm micropenis, and a bilateral reduced testicular volume (3.6 and 3.9 ml). LH 1.7 U/l (2–10), FSH 3.1 U/l (1–8), testosterone 0.7 mmol/l, estradiol <12 ng/l, inhibine B 54 ng/l (105–439) Pituitary MRI was normal.Genetic...

ea0063p314 | Reproductive Endocrinology 1 | ECE2019

Azoospermia revealing the uncommon Jacob’s syndrome

Yahi Abdelkader , Haffaf Lounes , Ould-kablia Samia

Introduction: Dysgonosomies are abnormalities of the number of gonosomes X and Y. They have fewer Phenotypic repercussions than the aneuploidies involving autosomes, and are mostly viable. The 47 XYY are generally boys with normal phenotype. The prevalence is around 1 per 1000 birth boy but undoubtedly under diagnosed given the often normal phenotype associated with this chromosomal formula, in addition to the lack of large-scale studies. There is no gonadal dysgenesis and oft...

ea0063p315 | Reproductive Endocrinology 1 | ECE2019

Pituitary tumor as a cause of male infertility

Jankowska Katarzyna , Zgliczyński Wojciech

Context: Pituitary tumor can cause infertility. It can be hormonally active adenoma (mostly prolactinoma) or hormonally inactive. Hyperprolactinemia is the most common disorder. Prolactin interferes with pulsatile secretion of the hypothalamus gonadoliberin (GnRH) and consequent pituitary gonadotropins (FSH and LH), and then leads to abnormal gonadal function. As a result, a man gets impaired spermatogenesis and endocrine function of the testicles. Infertility and reduced test...

ea0063p316 | Reproductive Endocrinology 1 | ECE2019

The differences in steroid hormones levels in the peripartum period caused by fetal sex and delivery type

Duskova Michaela , Kolatorova Lucie , Adamcova Karolina , Šimkova Marketa , Škodova Tereza , Parizek Antonin , Starka Luboslav

The production and activities of steroid hormones during pregnancy have many interesting aspects. Their synthesis and metabolism are the result of complex metabolic pathways encompassing activities in the fetus, placenta, and mother. Progesterone, estrogens, androgens and glucocorticoids all play important roles during pregnancy, from implantation to delivery. Focusing on selected steroid hormones in the peripartum period, we defined reference ranges measured using LS-MS/MS, a...

ea0063p317 | Reproductive Endocrinology 1 | ECE2019

Characterization of the expression and physiological roles of thyroid-stimulating hormone receptor in the male testis

Wang Hsun , Luo Ching-Wei

Thyroid-stimulating hormone receptor (TSHR) is typically known to be expressed in the thyroid gland of mammals for the control of body metabolism. However, because the TSHR ancestor is the only glycoprotein hormone receptor found in invertebrates, we hypothesized that TSHR evolves much earlier than FSHR and LHR and thus can be expressed in mammalian gonads for certain uncharacterized impacts. To prove this, real-time PCR quantification against Tshr in all male mouse r...

ea0063p318 | Reproductive Endocrinology 1 | ECE2019

Semen quality in uncontrolled acromegalic patients with hypogonadism

Andreassen Mikkel , Juul Anders , Feldt-Rasmussen Ulla , Jorgensen Niels

Objective: Growth hormone (GH) activity might be implicated in male reproductive function. One previous study has suggested significantly reduced semen quality in untreated acromegalic patients due to both reduced sperm counts and motility.Design and methods: A retrospective study comprising 10 uncontrolled hypogonadal acromegalic patients (median age 29y) who delivered semen for cryopreservation before initiation of testosterone therapy. Semen ...

ea0063p319 | Reproductive Endocrinology 1 | ECE2019

Characteristics, geographical distribution and age at diagnosis of patients with Klinefelter syndrome in Italy: a cohort study from the Klinefelter Italian Group (KING)

Pasquali Daniela , Garolla Andrea , Accardo Giacomo , di Fraia Rosa , Simeon Vittorio , Ferlin Alberto , Maggi Mario , Foresta Carlo , Vignozzi Linda , Corona Giovanni , Lanfranco Fabio , Rochira Vincenzo , Calogero Aldo E , Giagulli Vito A , Bonomi Marco , Pivonello Rosario , Balercia Giancarlo , Pizzocaro Alessandro , Salacone Pietro , Aversa Antonio , Barbonetty Arcangelo

Introduction: Klinefelter syndrome (KS) is the most frequent chromosomal disorders, occurring in 1:500 to 1:1000 live male births, associated to male infertility. Although significant research has been conducted, KS remains frustratingly underdiagnosed with a remarkable portion of cases being unidentified. Under diagnosis may be due to man’s hesitancy about seeking medical counseling, low awareness of KS among health professionals, and failure by health professionals to p...

ea0063p320 | Reproductive Endocrinology 1 | ECE2019

Gonadal Function in Human Immunodeficiency Virus (HIV)-Infected Men: comparison between Isotopic Dilution-Liquid Chromatography-Tandem Mass Spectrometry (ID-LC-MS/MS) and Chemiluminescent Immunoassay (CI)

De Vincentis Sara , Decaroli Maria Chiara , Fanelli Flaminia , Mezzullo Marco , Diazzi Chiara , Morini Fabio , Bertani Davide , Santi Daniele , Baraldi Enrica , Tagliavini Simonetta , Roli Laura , Trenti Tommaso , Pagotto Uberto , Guaraldi Giovanni , Rochira Vincenzo

Background: HIV-infection is associated to premature decline of serum T. However, prevalence and biochemical characterization of hypogonadism in HIV-infected men are still to be well defined.Aim: To evaluate the gonadal status in HIV-infected men by assessing circulating total T (TT) with either ID-LC-MS/MS or CI.Methods: Prospective, cross-sectional, observational study on HIV-infected men with ongoing Highly Active Antiretroviral...

ea0063p321 | Reproductive Endocrinology 1 | ECE2019

Automated free testosterone assay: validation and usual values

Bonnet-Serrano Fideline , Bouzerara Amina , Rousselle Theo , Menet Marie-Claude , Guibourdenche Jean

Introduction: Testosterone circulates under different forms in blood, mainly bound to proteins i.e. Sex Hormone Binding Globulin (SHBG) and albumin. Free testosterone (FT), the biologically active form, represents 2% of total testosterone (TT). FT measurement is mainly indicated when TT level is discordant with clinical picture but remains technically challenging. Indeed, as for all free hormones, gold standard method relies on equilibrium dialysis, unusable in routine. Direct...

ea0063p322 | Reproductive Endocrinology 1 | ECE2019

Assessment of biochemical hyperandrogenism in PCOs by liquid chromatography tandem mass spectrometry using a multisteroid kit: focus on testosterone and androstenedione

Grassi Giorgia , Morelli Valentina , Polledri Elisa , Fustinoni Silvia , Chiodini Iacopo , Ceriotti Ferruccio , D'Agostino Simona , Filippi Francesca , Somigliana Edgardo , Mantovani Giovanna , Arosio Maura

Objective: The identification of hyperandrogenism represents the cornerstone for the assessment of polycystic ovary syndrome (PCOs). However, its definition has always been troubling, mostly because of the poor accuracy shown by routine androgens assays. As suggested by literature, the application of more precise steroid measurement methods (such as liquid chromatography tandem mass spectrometry, LC-MS/MS) could improve the diagnostic workup. The aim of our study is to evaluat...

ea0063p323 | Reproductive Endocrinology 1 | ECE2019

Effects of fludioxonil on cardiac differentiation of mouse embryonic stem cells

Ko Eul-Bee , Hwang Kyung-A , Choi Kyung-Chul

Fludioxonil, a phenylpyrrole fungicide, is extensively used to protect particularly fruits and vegetables from fungi. On the contrary, it has been reported that fludioxonil caused low weight birth in rats at parentally toxic doses. However, its developmental toxicity on cardiac differentiation has not yet been understood. In the present study, the early developmental toxicity of fludioxonil on the cardiac differentiation of mouse embryonic stem cells (mESCs) was evaluated. Fir...

ea0063p324 | Reproductive Endocrinology 1 | ECE2019

Monitoring testosterone gel administration: timing and dosage

Sansone Andrea , Sansone Massimiliano , Selleri Raffaella , Seraceno Silvia , Scipione Valeria , Sellasie Sium Wolde , Schiavo Anna , Lenzi Andrea , Romanelli Francesco

Background: Many testosterone (T) formulations are now available for treating male hypogonadism. Intramuscular injectable T esters and transdermal T gel are the most commonly used in clinical practice. Transdermal T gel is often preferred by patients due to ease of use and reduced fluctuations in serum T compared to injectable esters. A daily dosage of 20 mg – 80 mg mimicking circadian profile is recommended to adequately treat hypogonadal men.Aim: ...

ea0063p325 | Reproductive Endocrinology 1 | ECE2019

Menstrual cycle characteristics in women with premature ovarian insufficiency

Ivovic Miomira , Marina Ljiljana , Tancic-Gajic Milina , Arizanovic Zorana , Stankovic Magdalena , Cirkovic Andja , Kendereski Aleksandra , Vujovic Svetlana

Premature ovarian insufficiency (POI) is characterized by cessation of ovarian function before the age of 40. Variable clinical presentation often postpones the diagnosis. The aim of our study was to assess whether there is a typical menstrual cycles pattern in patients with POI. We have evaluated 101 women, age 36.7±5.78 y. FSH=78.81±37.43 IU/l, E2<50 pg/dl, with confirmed POI referred to our Clinic between 2014 and 2018. Menstrual cycles characteristics were de...

ea0063p326 | Reproductive Endocrinology 1 | ECE2019

Endocrine and menstrual disorders in adolescent girls: clinical parallels

Gumeniuk Olga , Chernenkov Yiriy , Ribakova Irina , Kutina Tatyana

Menstrual disorders are common during adolescence. In many cases menstrual disorders associated with endocrine violations.Objective: To study the frequency menstrual disorders and endocrine violations in adolescent girls.Patients and methods: The study included 2527 adolescents- schoolgirls (aged 12–17 years, mean age was 15.5±1.9 years). The main outcome measures were menstrual disorders. Adolescent girls without menstru...

ea0063p327 | Reproductive Endocrinology 1 | ECE2019

Effects of percutaneous treatment of left varicocele on spermatogenetic and endocrine function of the testis: results from a 12-month follow-up

Sansone Andrea , Fegatelli Danilo Alunni , Pozza Carlotta , Fattorini Giorgio , Lauretta Rosa , Minnetti Marianna , Carlomagno Francesco , Petrozzi Alessandra , Radicioni Antonio Francesco , Anzuini Antonella , Romanelli Francesco , Lombardo Francesco , Paoli Donatella , Isidori Andrea M , Lenzi Andrea , Gianfrilli Daniele

Background: Varicocele repair is often suggested to improve reproductive outcomes, but there is no clear indications on which subjects are more likely to benefit from treatment. We assessed spermatogenetic and endocrine function of the testis in a population of young subjects with a 12-month follow-up following percutaneous treatment.Methods: We retrospectively reviewed data from 77 young patients (mean age 23.3 years, range 18–35) followed in our c...

ea0063p328 | Reproductive Endocrinology 1 | ECE2019

Predictive factors of polycystic ovary syndrome in women with morbid obesity

Belaid Rym , Hassen Hana Ben Hadj , Oueslati Ibtissem , Hammami Bassem , Boukriba Seif , Rejeb Ons , Grira Wafa , Mizouni Habiba , Feki Moncef , Chaker Fatma , Chihaoui Melika

Introduction: Polycystic ovary syndrome (PCOS) is a common disorder in women. Hyperandrogenism and chronic oligo-anovulation are the prominent clinical features. The aim of our study was to determine the prevalence and the predictive factors of PCOS in a group of women with morbid obesity.Methods: We performed a cross sectional study in 50 women with a body mass index (BMI) ≥ 40 kg /m2 collected over a period of 6 months (October 2017&#1...

ea0063p329 | Reproductive Endocrinology 1 | ECE2019

Randomised Controlled Trials in women with polycystic ovary syndrome do not represent the majority of patients who are in a primary care setting: systematic review and meta-analysis

Liarakos Alexandros Leonidas , Levy Miles , Mani Hamidreza

Introduction: Polycystic Ovary Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, with important long term health consequences such as higher chance of developing Type 2 diabetes, reduced overall wellbeing with poor quality of life. Such a common condition is mainly treated and investigated in the primary care setting.We therefore set out to see if the randomized controlled trials (RCT) represent the most common setting of care.<p class="abstex...

ea0063p330 | Reproductive Endocrinology 1 | ECE2019

The awareness of the side effects of the use of AAS as a factor of the conscious rejection of their use: The price of a beautiful body

Lykhonosov Mykola , Babenko Alina , Lykhonosov Pavlo

Background: The motivation for the use of AAS by men engaged in recreational activities is the improvement of body composition and strength indicators. A deterrent to the use of AAS can be awareness of the side effects of their use, in particular the development of secondary hypogonadism.Aim: To study the awareness of AAS users about the negative impact of this class of drugs on the body.Methods: An individual anonymous corresponde...

ea0063p331 | Reproductive Endocrinology 1 | ECE2019

Fenhexamid increased the cell viability and metastasis of breast cancer cells via an estrogen receptor-dependent and PI3K/AKT pathway

Go Ryeo-Eun , Hwang Kyung-A , Choi Kyung-Chul

Fenhexamid (Fen) is a fungicide used to treat the gray mold of fruits and vegetables. In this study, the ER positive-MCF-7 breast cancer cells were used to examine the effects of Fen on breast cancer progression. MCF-7 cells were cultured with 0.1% DMSO (control), 17β-estradiol (E2; 1×10−9 M) and Fen (10−5–10−7 M) in the absence or presence of ICI 182,780 (ICI, ER antagonist, 10−8 M) or Pictilis...

ea0063p332 | Reproductive Endocrinology 1 | ECE2019

Natural estradiol in combined oral contraceptive has a favorable inflammation and lipid profile compared with preparation containing ethinyl estradiol– a randomized controlled trial

Kangasniemi Marika , Haverinen Annina , Heikinheimo Oskari , Luiro Kaisu , Arffman Riikka , Tapanainen Juha , Piltonen Terhi

Study question: Does the combination of estradiol valerate (EV) and dienogest (DNG) have favorable effects on inflammation and lipids compared with ethinyl estradiol (EE) + DNG?What is known already: Use of combined oral contraceptives (COCs) increases HDL-cholesterol and triglycerides and promotes low-grade inflammation. The metabolic effects of COCs depend on both estrogen and progestin components. To our knowledge this is the first study comparing COC...

ea0063p333 | Reproductive Endocrinology 1 | ECE2019

Modes and actions of inter-individual transfer of estradiol and progesterone among conspecifics in both mice and bats

deCatanzaro Denys , Pollock Tyler , Greville Lucas , Faure Paul

We have investigated inter-individual transfer of 17β-estradiol (E2) and progesterone (P-4), and related it to mammalian ‘pheromonal’ effects. Assays of unconjugated E2 and P4 revealed their presence in male and female urine of laboratory mice and big brown bats (Eptesicus fuscus), which are phylogenetically very distant from each other. These small and lipophilic steroids readily pass through biological membr...

ea0063p334 | Reproductive Endocrinology 1 | ECE2019

Definition of hormonal cut-off values for discriminating polycystic ovary syndrome from non classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Oriolo Claudia , Menabo Soara , Gasparini Daniela Ibarra , Altieri Paola , Corzani Francesca , Baldazzi Lilia , Castelli Silvia , Pagotto Uberto , Gambineri Alessandra

Objective: The aim of this study was to define which hormonal cut-off values can discriminate polycystic ovary syndrome (PCOS) from non classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21-NCAH).Patients and methods: We included 70 women in reproductive age who attended our Unit from 2003 to 2018 for a diagnosis of PCOS with a basal 17hydroxyprogesterone (17OHP) level in the follicular phase of the menstrual cycle ≥200 ng/d...

ea0063p335 | Reproductive Endocrinology 1 | ECE2019

Lipid parameters during pregnancy

Mladenovic Violeta , Andjelkovic Marija , Gluvic Zoran , Mitrovic Milena , Macut Djuro

Introduction: The basic characteristics of metabolism in pregnancy are changes from anabolic to catabolic conditions with an increase in insulin resistance, moderate, reversible increase in lipid concentration in the blood, and accumulation of fat stores in the mother’s tissues. Lipid metabolism is essential for the development of healthy pregnancy, and fatty acids are a significant source of energy and a key element for membrane synthesis, while cholesterol, in addition ...

ea0063p336 | Reproductive Endocrinology 1 | ECE2019

Dysmenorrhea prevalence and its impact on daily functioning of university nursing students in greece

Vlachou Eugenia , Owens Dimitra Anna , Papakonstantinou Katerina , Mouslech Zadalla , Kanakis George , Tsartsalis Athanasios

Background: Dysmenorrhea is defined as pain during menstruation and might be caused by increased endometrial prostaglandin production. It is a highly prevalent medical condition (45–95% of women internationally) which can be part of a woman’s reproductive life. Throughout the literature, dysmenorrhea has been shown to affect daily functioning such as socialization, work and academic performance during menstruation and quality of life. However, dysmenorrhea and its im...