Endocrine Abstracts

Introduction: Endocrine complications are common in beta thalassemia major (BTM) patients receiving blood transfusions. Chelation therapy has a role in preventing such complications. However, patients may have difficulties adhering to chelation therapy. We aimed in this study to determine the endocrine complications in BTM patients.Methods: This was a descriptive study with cross-sectional data collection over a 6 month period from February 2022 to July ...

Background: Primary Ovarian Insufficiency (POI) is defined as the loss of ovarian function before age 40. It is characterized by menstrual disturbance with raised gonadotropins (>25 UI/l). It can manifest as primary amenorrhea (PA) or secondary amenorrhea (SA). The causes of POI include chromosomal and genetic defects, autoimmune processes, chemotherapy, radiation, infections, and surgery. However, the etiology remains unidentified in 80% of cases referred to as idiopathic...

Background : Infertility affects 15% of couples. In 50% of cases, it can be explained by male infertility with abnormal spermatogenesis. Cytogenetic causes are identified in 15% of men with infertility.Materials and Methods: We report the results of a cytogenetic study performed in infertile men with spermogram abnormalities collected at the Department of Congenital and Hereditary Diseases of Charles Nicolle Hospital in Tunis, over 12 years from January ...

Recently, special attention has been paid to the relationship between doctors and the pharmaceutical industry. The aim of this work was to evaluate the attitude of Tunisian endocrinologists towards pharmaceutical promotion.Methods: It was a cross-sectional study based on an anonymous 9-item survey about the attitudes and behaviors of physicians towards the pharmaceutical promotion. The study included 120 participants.Results: One-t...

IntroductionPremature ovarian insufficiency (POI) is defined by menstrual disturbance (oligomenorrhea or amenorrhea) before 40 years and confirmed by two FSH levels in the menopausal range, obtained at least a month apart. Some POI cases are syndromic such as Turner’s syndrome or Blepharophimosis–Ptosis–Epicanthus inversus Syndrome type 1 (BPES). BPES type 1 (MIM: 110100) is a rare autosomal dominant syndrome caused by mutations in FOX...

IntroductionPremature ovarian insufficiency (POI) is characterized by the loss of ovarian activity before the age of 40. It is associated with hypoestrogenism, raised gonadotrophins and oligomenorrhea or amenorrhea. POI is a heterogeneous disease that can result from different etiologies, including genetic, autoimmune, and iatrogenic. Of the genetic causes, single-gene mutations and chromosomal imbalances involving X chromosome or autosomes have been ass...

Introduction: Pituitary adenomas are common, and their impact on visual function is often significant, given the intimate relationship between the anterior pituitary and the optic pathways. Ocular symptoms may be indicative. Compressive optic neuropathy and oculomotor paralysis present a diagnostic challenge. This report details four cases where ocular manifestations played an essential role in establishing the diagnosis of pituitary macroadenomas.Observ...

Thyroid hormone (TH) plays an important role for brain development. As the fetal thyroid gland only starts providing hormone at the end of pregnancy, the developing brain crucially depends on maternal thyroid hormone in early developmental periods. In previous studies, we have observed that in particular the central control of cardiovascular functions critically depends on maternal thyroid hormone for proper development; however, the precise window when the hormone is benefici...

This study aimed to compare the prevalence of metabolic syndrome (MetS) and its components in different degrees of obesity. A total of 2309 adults (aged 25–75 years) who were referred to a large university general hospital, divided into four groups according to their body mass index (BMI); 1511 subjects were non-obese (BMI<30 kg/m2); 535 subjects were moderate (30≤BMI<35); 176 subjects were severe (35≤BMI<40) and 87 subjects were very se...

Thyroid hormones play an essential role for the embryonal development of the cardiovascular system including its central control mechanisms. Particularly the latter critically depends on maternal thyroid hormone, as the embryo doesn’t produce own thyroid hormone until late in pregnancy. However, the precise window of action has remained undetermined, and it is therefore unclear whether alterations in maternal thyroid hormone directly affect the offspring’s cardiac fu...