Endocrine Abstracts

This study aimed to compare the prevalence of metabolic syndrome (MetS) and its components in different degrees of obesity. A total of 2309 adults (aged 25–75 years) who were referred to a large university general hospital, divided into four groups according to their body mass index (BMI); 1511 subjects were non-obese (BMI<30 kg/m²); 535 subjects were moderate (30≤BMI<35); 176 subjects were severe (35≤BMI<40) and 87 subjects were very severe obese (BMI≥40).

Demographic data and anthropometric characteristics of participants were recorded. Fasting blood samples were collected and fasting plasma glucose (FPG), serum creatinine, lipids, insulin and HbA1c were measured The homeostasis model assessment of insulin resistance (HOMA-IR) and HOMA derived Beta-cell function (HOMA-B) were also calculated. The prevalence of MetS according to the definitions of the International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel III (ATPIII), compared between increasing grades of BMI and the related age and sex adjusted ORs calculated, using multivariate logistic regression models. IDF and ATP III defined MetS and their components consist of central obesity, high BP, high triglyceride, low HDL cholesterol, high FPG, high HOMA-IR raised across increasing grades of obesity. Furthermore, as presented in Table, ATP III and IDF defined MetS and high HOMA-IR had significant ORs, across overall BMI categories and when comparing the groups next to each other. In conclusion, our data demonstrated that MetS and its component increase in parallel with raising obesity grades.