Endocrine Abstracts

Background: Minimally invasive parathyroidectomy (MIP) for primary hyperparathyroidism is routinely performed in many centres. Various preoperative and intraoperative localisation techniques are used along with intraoperative PTH monitoring (IOPTH).Results: We report the results of 110 consecutive patients presenting to our unit with a diagnosis of primary hyperparathyroidism from January 2004 until November 2007. All patients had sestamibi scintigraphy ...

Background: Peptide receptor radionuclide therapy (PRRT) is a form of targeted systemic radiopharmaceutical therapy that has been approved for treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors. Persistent hematologic dysfunction is a recognized potential long-term toxicity after PRRT, including the development of hematologic malignancies and persistent cytopenias. Therapy-related myeloid neoplasms (t-MN) are a well-recognized entity that ...

Background: Lu177 has shown efficacy in advanced NET with significant hematologic toxicity, including therapy-related myeloid neoplasm (t-MN). CH is defined by acquisition of somatic mutations in hematopoietic stem cells with potential for expansion over time. In this study, we aimed to assess the prevalence of CH in NET patients (pts) prior to Lu177 along with the incidence of cytopenia in NET pts treated with lu177 based on the CH status at baselineMet...

Orchidectomy performed during breeding season (winter) in the adult male gerbil, Gerbillus tarabuli, live trapped in its natural biotope in Béni Abbès area (30°7 N., 2°10 W.) in algerian Sahara desert, induced 50 days later, important weight, histological and hormonal changes on the adrenal gland.Adrenal weight increases by 69.7% (P=0.06) and adrenal cortex height by 48.6% (P=0.00) with hypertrophy of reticularis ...

In the Saharan gerbil Meriones libycus, live trapped in the south west of Algeria, castration, carried out during the breeding season (Winter–Spring), induced, 50 days later, important modifications in adrenal gland activity. The adrenal weight and cortex volume increased by 11.7% and 25.0% respectively, with hypertrophy of reticularis zona (+57%, P<0.001) and hypotrophy of fasciculata zona (−13.4%, P<0.001) while glomerulosa exhibited o...

The effect of gonadectomy and gonadal hormone replacement on the adrenal cortex activity was studied in the adult male sand rat Psammomys obesus, a diurnal gerbillid rodent living in Beni-Abbes area, in the Algerian Sahara desert (30°7 N, 2°10 W). Animals freshly captured were orchiectomized during the breeding season and some animals received testosterone oenanthate (75 μg per 40 μl olive’s oil) twice a day during 7 days, 3 weeks after gonadect...

Background: Everolimus, a mammalian target of rapamycin inhibitor, is licensed for use in adult pts with advanced well-differentiated pNETs in the UK. Limited Health-Related Quality-of-Life (HrQOL) data are available for everolimus therapy in these pts.Methods: This prospective study assessed changes in HrQoL (by monthly patient-reported EORTC QLQ-C30, -G.I.NET21 and EQ-5D questionnaires), in pts with pNETs during the first 6 months (mo) of treatment wit...

Introduction: Macroprolactin (MacroPRL), a variant of human prolactin may interfere with hormonal assay and falsely increase serum prolactin levels. Therefore, failure to identify macroprolactinemia can lead to inappropriate investigations and treatment in women who are already susceptible to anxiety and stress. We aimed to identify macroprolactinemia among women of childbearing age with hyperprolactinemia.Materials and methods: We conducted a cross-sect...

Objectives: To determine the mean and normative values of anthropometry among the inhabitants of a coastal Nigerian city.Methods: A cross sectional survey comprising 1134 subjects (645 males and 489 females) representative of the entire population of Calabar metropolis aged 15–79 was studied. A multistage sampling method was applied to select the subjects. Using a modification of WHO STEPS instrument the information obtained included anthropometric ...

Introduction: Adrenal incidentaloma is an adrenal mass found on imaging studies done for other reason than suspected adrenal disease. The majority of them are non-functioning adenomas, however pheochromocytomas could be also observed. Currently, in diagnosis of incidentalomas, the assessment of hormones of adrenal cortex and medulla is performed. The aim of the study was to assess the incidence of pheochromocytoma in patients with incidentaloma.Methods: ...