Endocrine Abstracts

Introduction: Albright’s Hereditary Osteodystrophy (AHO, Pseudohypoparathyroidism type 1a) is inherited in an autosomal dominant manner. End-organ resistance is seen, primarily affecting parathyroid hormone (PTH) and thyroid hormones (TSH). The manifestation of hormone resistance, in particular resistance to PTH, depends on whether the mutated allele is inherited maternally or paternally.Cases: A 4 year old male child was incidentally found to have ...

Baseline cortisol values may not necessarily rule out Addison’s disease. We report a case with vague symptomatology,normal coritsol baseline values with high index of suspicion and positive low dose synacthen test which lead up to the diagnosis. Young boy age 9 presented with low serum sodium levels and intermittent concern with abdominal symptoms, exhaustion and altered behaviour. He had normal baseline pituitary function including cortisol of 223 that decreased to 156 (...

Aim: Previous studies have shown that diabetes associated antibodies are present in 85–90% of patients with Type 1 diabetes. NICE guidelines do not suggest routine use of antibodies screening at initial presentation. The aim of our study was to identify the incidence of antibody positivity in our centre and also review the clinical profile of children diagnosed with diabetes who were antibodies negative.Method: Retrospective case notes review of 243...

Introduction: Mast cells are critical effectors in inflammatory diseases, including cardiovascular and metabolic diseases and their associated complications. These cells exert their physiological and pathological activities by releasing granules containing histamine, cytokines, chemokines, and proteases, including mast cell-specific chymases and tryptases.Aim of the study: To detect the role of mast cell in diabetic obese and correlation to different dia...

Introduction: A poor vitamin D status has been related to an increased risk of cardiovascular disease. Carotid intima–media thickness (IMT) has shown to be an early marker of subclinical atherosclerotic Therefore, we aimed at examining the association between vitamin D status and the extent of carotid IMT in type 2 diabetics.Subjects and methods: In a cross sectional study 78 type 2 diabetic patients attending the Diabetes and Endocrinology Clinic i...

Background: Long term remission in paediatric onset hyperthyroidism (HT) is low at 20–30% compared to 40–50% in adult onset HT. There are very few studies which report long-term follow-up of paediatric onset HT especially into adulthood and factors which can predict a need for definitive treatment in the long-term.Objectives: To evaluate the long-term outcome of paediatric onset HT with follow-up into adulthood and identify any early predictors...

In this study, an antibacterial electrospun nanofibers for wound dressing application was successfully prepared from polyvinyl alcohol (PVA), Pluronic F127 (Plur), polyethyleneimine (PEI) blend solution with titanium dioxide nanoparticles (TiO2NPs). PVA–Plur–PEI nanofibers containing various ratios of TiO2 NPs were obtained. The formation and presence of TiO2 in the PVA–Plu–PEI/TiO2 composite was confirmed by X-ra...

Background: BCAAs up regulate glucose transporters and activate insulin secretion has been widely demonstrated. However, several researchers have suggested that excessive intake of amino acids could lead to inhibition ofinsulin signalling. BCAAs may induce insulin resistance throughm TOR activation insulin resistance may be linked with high intake of BCAAs, Controversiesremain on whether an increase in plasma BCAA levels is a cause or consequence of insulin resistance.<p c...

A 36-year-old man was referred to the neurologists for leg weakness and pain, fatigue and lethargy for 2 years. Sarcoidosis was diagnosed 6 years previously, on the basis of uveitis, lower motor neurone facial palsy, hilar lymphadenopathy and transbronchial biopsy. Prednisolone had been discontinued 3 years prior to his current presentation.His blood pressure was 99/71. Examination was otherwise unremarkable. His ACE was 109 U/l (10–70). His TSH was...

Introduction: Fahr’s disease, is a rare neurological disorder characterized by abnormal calcified deposits in the basal ganglia with a prevalence of <1/1 000 000Case report: A 15-year-old male presented with focal seizures in right upper and lower limbs that progressed to generalized tonic clonic seizure and status epilepticus. No history of head trauma, central nervous system infection, stroke, hypertension, diabetes, or autoimmune disease No f...