Endocrine Abstracts

Background: HIV-infected paediatric patients usually show impaired growth. Data reporting abnormalities in GH–IGF–IGFBPs system are scarce and inconclusive.Aim: To analyse blood concentration of the major components of IGF–IGFBPs system in these children and compare them to growth parameters and to cytokines levels.Methods: prepubertal HIV-infected children, aged 8.2±1.7 years, were evaluated every 6 months duri...

Background: Gestational diabetes (GD) prevalence is increasing as the obesity epidemic continues. Its management involves hospital visits every 1–2 weeks. In 2016 our team developed a web-based telemedicine platform (SineDie©). This tool operated as a clinical decision support system designed to manage the treatment of patients with GD. SineDie© automatically prescribed diet recommendations and identified the necessity of insulin treatment....

The ingestion of high-fat diet has been considered a crucial factor in the genesis of subclinical systemic inflammation and insulin resistance. The resistance training (RTr) can be an effective tool for the prevention and treatment of immune-metabolic disorders through physiological and morphological adaptations. The purpose of the present study was to analyze the effects of RTr and cessation of training on muscle inflammation and expression of genes related to glucose metabol...

Heat shock protein 90 (HSP90) plays a pivotal role in maturation and stabilization of proteins in conditions of stress. Many HSP90 client proteins are involved in oncogenic signaling and cancer progression, therefore HSP90 inhibitors have a potential as pharmaceutical agents. We reported a strong HSP90 overexpression in corticotroph adenomas and the treatment with C-terminal HSP90 inhibitors has potent anti-tumorigenic and anti-secretory effects in these tumors in vitro</e...

A major difficulty of obesity treatments is that patients stop losing weight after a period of responsiveness and often experience a rebound. This could be caused by an impairment in energy balance circuits that becomes irreversible as obesity progresses. To test this hypothesis, we generated a reversible knockout-mouse model of early onset obesity. These mice are unable to express the proopiomelanocortin gene (Pomc) in hypothalamic neurons (CNS-Pomc−/...

Introduction: Nodular thyroid disease is a common problem in clinical practice. Fine-needle aspiration (FNA) has become the principal test in the diagnosis of nodular thyroid disease. However, sometimes the information provided by this procedure is not definitive as it happens in those cases where the cytologic specimens are suspicious or indeterminate and a clear cytologic diagnosis can not be made. Based on that, we therefore undertook a study to investigate the histological...

The USMBDPCP is unique that it is the first study to consider the whole US- Mexico Border as one epidemiological unit. The project goal is to reduce the burden of diabetes among persons with type 2 diabetes living in the U.S.-Mexico border region. I Development of a Prevalence Study and identification of risk factors. II Implementation an intervention pilot study for diabetes prevention and control.Phase IThe diabetes prevalence su...

IntroductionDiabetes, a metabolic disorder characterized by abnormal blood glucose levels, is a serious chronic disease that implies an important public health problem. Being Insulin the main hormone for modulating blood glucose levels, subcutaneous injections are the main way for its administration in the diabetes treatment. However, this way of administration can lead to poor patient compliance, apart from several side-effects. Although other ways of a...

Obesity during gestation has been related to predisposition to endocrine and metabolic diseases in the offspring. Regarding reproductive effects, an increase in BMI in pregnant mothers is associated with precocious puberty in their offspring. This has been replicated in animal models of high fat diet (HFD) administration to mothers. Also, gestational obesity has been associated to higher susceptibility to developing breast cancer in the offspring. As both precocious puberty an...

Folliculostellate (FS) cells were found to regulate hormonal secretion in pituitary endocrine cells. This cell type share properties with components of the innate immune response such as dendritic cells and macrophages, and it is suggested that they are able to initiate immune responses and act as part of an immunoendocrine regulation system. Members of toll-like receptor (TLR) family recognize bacterial cell wall components and initiate an immune response. Recently, we detect...