Endocrine Abstracts

Introduction: Generously supported by IPSEN)-->The coexistence of acromegaly and secondary polycythemia has been described in a few patients. This association was ascribed to GH/IGF1 proliferative effect on bone marrow progenitor cells. In contrast, the presence of myeloproliferative neoplasm (MPN) with documented JAK2 mutation so far has been described in only one acromegalic patient.Methods: We analyzed the p...

The ‘European Young Endocrine Scientists’ (EYES) founded in 2011, is a committee under the patronage of the European Society of Endocrinology (ESE). The primary goal of this committee is to increase the mutual exchange of ideas and knowledge between early career endocrinologists across Europe, in both basic and clinical research. EYES enables young endocrinologists from all ESE member societies to actively contribute to all aspects of the society’s activities, e...

Type 2 diabetes mellitus (DM2) is often associated with obstructive sleep apnea (OSA), according to the literature. Current approach in choosing the hypoglycemic therapy is based on individualization, but do not take into account the effect on OSA. The research purpose: to evaluate the effect of various hypoglycemic agents on the characteristics of OSA in patients with type 2 diabetes.Materials and methods: The study included patients with OSA and DM2, t...

Objective: To analyze correlation between the duration of diabetes mellitus (DM), renal function and androgenic state indicators in patients with DM type 1.Material and methods: 191 males with DM 1 type in the age of 18–55 years. The control group included 25 almost healthy males in the age 21–41 years. The compensation of DM was estimated by the level of glycosylated hemoglobin. Also, the indicators of lipid profile, glomerular filtration rate...

PCOS is characterized by abdominal obesity along with conventional diagnostic features.Objective: To assess body composition in women with PCOS and normal body weight.Materials and methods: 35 women (24±1.1 years old) with confirmed diagnosis of PCOS according to Rotterdam criteria, 27 almost healthy women (25±1.2 years old), both groups wotn normal weight. Whole Body Dual-energy X-ray Absorptiometry (DEXA Total Body) sca...

Objective: To analyze correlation between the duration of diabetes mellitus (DM), renal function and androgenic state indicators in patients with DM type 1.One hundred and sixty three males with DM 1 type in the age of 18–55 years (39.75±9.69) with the duration of disease more than 1 year were examined. The control group included 25 almost healthy males in the age 21–41 years (34.60±7.80). The compensation of DM was estimated by the l...

Aim: To evaluate the base-line serum sICAM-1 levels among patients with GO and levels sICAM-1 at the end of 6 month follow up after different schemes of GO treatment.Material and methods: 72 patients with GO have been surveyed. Patients have been put into 4 groups depending on spent treatment: 1st group – 26 patients received methylprednisolone per os 1 mg/kg in a combination with plasmapheresis; 2nd group – 14 patients received p...

MELAS syndrome is a progressive neurodegenerative disorder characterized by a combination of mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes and endocrine disorders. The frequency of hypoparathyroidism in MELAS syndrome is less than 0.5%. A 22-year-old female was admitted to our center due to episodes of seizures. At admission her height was 147.5 cm, weight 30.5 kg, BMI 13.8 kg/m2. She reported whole life weight and growth retardation, hearin...

Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited endocrinopathy characterized by tumours of the parathyroid glands, adenohypophyseal and pancreatic tumours. We present a case of a young, 24 years old female patient with a positive familial background for MEN1 (on the fathers’ side of the family). She is one of two sisters with determined heterozigocity of the MEN 1 gene (Exon 2, codon 111). At the age of 12, insulinoma of the head of the pancreas was diagnos...

Primary adrenal insufficiency could be a rare manifestation of antiphospholipid syndrome (APS) and may be a consequence of bilateral adrenal hemorrhage. Rosai–Dorfman disease (RDD) is sinus histiocytosis with massive lymphadenopathy, a rare histiocytic proliferative disorder with a distinctive microscopic appearance. The retro-peritoneum is an infrequent site of involvement as well as extranodal sites.We report a case of a 39-year-old female patient...