Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2007) 14 P300

ECE2007 Poster Presentations (1) (659 abstracts)

Soluble intercellular adhesion molecule-1(sICAM-1) levels and different schemes of Graves’ ophthalmopathy (GO) treatment

Elena Bogomazova & Tatjana Mokhort

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The Republican Clinical Hospital of Medical Rehabilitation, Minsk Region, Belarus, The State Medical University, Minsk, Belarus.


Aim: To evaluate the base-line serum sICAM-1 levels among patients with GO and levels sICAM-1 at the end of 6 month follow up after different schemes of GO treatment.

Material and methods: 72 patients with GO have been surveyed. Patients have been put into 4 groups depending on spent treatment: 1st group – 26 patients received methylprednisolone per os 1 mg/kg in a combination with plasmapheresis; 2nd group – 14 patients received pulse-therapy by methylprednisolone; 3rd group – 18 patients received methylprednisolone per os 1 mg/kg in a combination with plasmapheresis and autogemomagnitotherapy; 4th group – 14 patients received methylprednisolone per os 1 mg/kg.

We used «Human sICAM ELISA, BMS 201» kits for measured serum sICAM-1 levels.

Results: Serum levels sICAM-1 were 48.13±12.61 in the control group.

1st group2nd group3rd group4th group
Baseline serum sICAM-1 (M±σ, ng/ml)81.82±33.3b93.03±33.32b79.04±21.94b90.34±29.53b
sICAM-1 (M±σ, ng/ml) after 6 month follow up after GO treatment course56.16±10.99a, c50.82±13.77c55.02±12.89a, c64.27±29.87a, c
Δ sICAM-1 (Me)17.55d41.1620.32d23.07d
aP<0.05, bP<0.00001 –vs control group; cP<0.05 –vs same groups before GO treatment; dP<0.05 – vs 2nd group).

Conclusions: The base-line serum sICAM-1 levels was significantly higher in all groups vs control and sICAM-1 levels significantly decreased in all groups at the end of 6 months follow up after the complete course of GO treatment. The treatment of GO with used pulse-therapy by methylprednisolone was better among different schemes of Graves’ ophthalmopathy treatment, taking into account that ΔsICAM-1 was significantly higher in this group.

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