Endocrine Abstracts

Rationale/Objective: Diabetes Mellitus (DM) and Interstitial lung Disease (ILD) share common pathogenetic pathways involving inflammatory cells and in particular monocytes and macrophages. Diabetic patients are at higher risk of developing pulmonary fibrosis, whereas DM is a major comorbidity in ILD patients. In our study, we analyzed retrospectively patients with ILD and aimed to examine differential characteristics between patients with and without DM, including disease para...

A 65 year old government officer presented to ophthalmologist with sudden visual loss in the right eye. Noted to have a retinal haemorrhage and significantly elevated blood pressure. GP was asked to investigate further.For reasons unclear yet fortuitous, the initial imaging arranged was a CT CAP which demonstrated a large adrenal mass (9 cm well defined, heterodense, retroperitoneal right soft tissue mass of 40&#1...

A 65 year old government officer presented to ophthalmologist with sudden visual loss in the right eye. Noted to have a retinal haemorrhage and significantly elevated blood pressure. GP was asked to investigate further.For reasons unclear yet fortuitous, the initial imaging arranged was a CT CAP which demonstrated a large adrenal mass (9 cm well defined, heterodense, retroperitoneal right soft tissue mass of 40&#1...

A 51-year-old gentleman who has been diagnosed with bilateral pheochromocytoma at the age of 11 after developing classical symptoms of catecholamine excess and had bilateral adrenalectomy. At the age of 37, he underwent total thyroidectomy with preservation of the parathyroid glands for C-cell hyperplasia. Over the course of the years, it was presumed he had MEN2A syndrome, although no formal genetic testing was done. He does not have a family history of MEN syndrome and does ...

This is a case of a patient diagnosed with small cell lung carcinoma after presenting with severe hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) who was readmitted 7 months later with refractory hypokalemia and hyperglycaemia due to ectopic adrenocorticotrophic hormone secretion (EAS). A 65 year-old man presented in November 2018 with symptoms of nausea, vomiting, headaches and blurred vision. On examination he was clinically euvolemic. La...

Some individuals with normal weight but probably visceral fat excess, called Metabolically Obese Normal-Weight (MONW), have disturbances typical for metabolic syndrome. We analyzed relationships between body fat distribution (estimated by DXA) and insulin resistance, serum inflammatory markers levels (CRP, IL-6, IL-18) and polymorphisms of IL-6 promoter and PPARγ in healthy, non-obese Polish subjects: 232 women (age 31.4±5.5; BMI 21.5±2.5) and 199 men (age 30.3&...

Background: Pituitary neuroendocrine tumors (PitNETs) exhibiting treatment-refractory behavior are the rare subset that progress after radiation and are characterized by unrelenting growth and metastatic dissemination.Methods: To identify biomarkers of treatment-refractory behavior, two groups of patients with PitNETs were consented to matched tumor-normal whole exome and targeted next-generation DNA sequencing on a clinical protocol: a prospective group...

Background: Pheochromocytomas are rare tumors, with prevalence less than 0.2% of hypertensive patients, in general population being unknown. With increasing access to imaging and hormonal workup, more pheochromocytomas are diagnosed. This may have changed the occurrence of the classic presentation with hypertension and the classic triad.Methods: We present 3 cases of pheochromocytoma diagnosed in our departments over the last 2 years, with 3 different ph...

Introduction: Decreased function of the thyroid axis during aging is associated with a better functional performance and longer survival. This phenomenon can be a result not only of a lower production of thyroid hormones including bioavailable triiodothyronine, but also of age-associated alterations regarding triiodothyronine receptors.Methods: Functional studies regarding interaction between the 3′UTR of TRβ1 mRNA and in silico-ident...

In the 1980s the concept, that some individuals with normal weight (Metabolically Obese, Normal-Weight) have disturbances of metabolism, related to obesity was proposed. It is known, that obesity promotes atheromatosis by various mechanism, inter alia due to excess of inflammatory markers. This problem however, was not investigated in non-obese subjects.We analyzed anthropometric variables, body fat distribution by DXA and serum CRP, Il-6 and Il-18 in 43...