In the 1980s the concept, that some individuals with normal weight (Metabolically Obese, Normal-Weight) have disturbances of metabolism, related to obesity was proposed. It is known, that obesity promotes atheromatosis by various mechanism, inter alia due to excess of inflammatory markers. This problem however, was not investigated in non-obese subjects.
We analyzed anthropometric variables, body fat distribution by DXA and serum CRP, Il-6 and Il-18 in 431 healthy, non-obese Polish subjects: 232 women (age 32±5.5; BMI 21.3±2.7) and 199 men (age 30±6; BMI 24.9±2.9).
In our study abdominal fat volume was significantly correlated with CRP (r=0.3; P<0.001) in women, but there were no significant correlations between abdominal fat volume and serum Il-6 (r=0.02; P=0.7) or Il-18 (r=0.07; P=0.3). We demonstrated strong correlations between WHR and CRP (r=0.2; P=0.004), and Il-18 (r=0.16; P=0.02), but not with Il-6 (r=0.005; P=0.9).
Similar significant correlation between abdominal fat volume and CRP (r=0.3; P<0.001) was noticed in men. In this group also Il-18 (r=0.16; P=0.03) was strongly correlated with abdominal fat. On the contrary, there were no significant correlations between abdominal fat depot and serum levels of Il-6 (r=−0.1; P=0.16). Strong correlation between WHR and CRP (r=0.2; P=0.002), and Il-18 (r=0.19; P=0.02), but not Il-6 (r=−0.05; P=0.5) was seen.
In conclusion, not only in obese, but also in non-obese young healthy subjects visceral fat influences some inflammatory markers of atheromatosis: CRP in women, and CRP and Il-18 in men.
03 - 07 May 2008
European Society of Endocrinology